Kyra Feuer, Ph.D.
Contact
Department of Psychiatry
University of Pennsylvania
3535 Market Street, Suite 500
Philadelphia, PA 19104
Email: kyra.feuer@pennmedicine.upenn.edu
Phone: (215)-746-1824
Bio
Dr. Kyra Feuer is a postdoctoral fellow in the Department of Psychiatry who is passionate about multi-disciplinary approaches to mental illness research. Her dissertation focused on functional investigation of noncoding schizophrenia-associated genetic variants using CRISPR-Cas9 gene editing, stem cell and neuron models, and transcriptome analysis. In January 2024, Dr. Feuer was awarded the Penn T32 Postdoctoral Training Grant in Genomic Medicine, which she is utilizing to gain additional skills in bioinformatic analyses, machine learning, and natural language processing. Her current research is focused on combining electronic health record data, genetic information, and machine learning to improve the accuracy and timing of diagnosis and identify new therapeutic targets for psychiatric conditions in diverse populations.
Education
B.A. in Behavioral Neuroscience and Psychology, Lehigh University, 2016
Ph.D. In Human genetics and Molecular Biology, Johns Hopkins School of Medicine, 2023
Selected Publications
Davis CN, Toikumo S, Hatoum AS, Khan Y, Pham BK, Pakala SR, Feuer KL, Gelernter J, Sanchez-Roige S, Kember RL, Kranzler HR. Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits. medRxiv [Preprint]. 2024 Jul 29:2024.07.29.24310991. doi: 10.1101/2024.07.29.24310991. P
Khan Y, Davis CN, Jinwala Z, Feuer KL, Toikumo S, Hartwell EE, Sanchez-Roige S, Peterson RE, Hatoum AS, Kranzler HR, Kember RL. Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample. medRxiv [Preprint]. 2024 May 10:2024.05.09.24307111. doi: 10.1101/2024.05.09.24307111.
Das D, Sonthalia S, Stein-O’Brien G, Wahbeh M, Feuer K, Colantuoni C, Machairaki V, Avramopoulos D. Insights for disease modeling from single-cell transcriptomics of iPSC-derived neurons and astrocytes across differentiation time and co-culture. BMC Biology. 2024 April 2; 22(74). doi: 10.1186/s12915-024- 01867-4 Kyra Feuer Curriculum Vitae Page 3
Feuer KL, Peng X, Yovo C, Avramopoulos D. DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders. Molecular Psychiatry. 2023 July 21. doi: 10.1038/s41380-023-02186-w
Feuer KL, Wahbeh MH, Yovo C, Rabie E, Lam AN, Abdollahi S, Young LJ, Rike B, Umamageswaran A, Avramopoulos D. CRISPR Del/Rei: a simple, flexible, and efficient pipeline for scarless genome editing. Scientific Reports. 2022 Jul 13;12(1):11928.
Das D, Feuer K, Wahbeh M, Avramopoulos D. Modeling Psychiatric Disorder Biology with Stem Cells. Current Psychiatry Reports. 2020 Apr 21;22(5):24.
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