Zhenhao Shi, PhD

Department of Psychiatry
University of Pennsylvania
3535 Market Street, Suite 500
Philadelphia, PA 19104
Email: zhshi@pennmedicine.upenn.edu
Phone: +1 (215) 746-1822



Zhenhao Shi is an Assistant Professor in the Department of Psychiatry at the University of Pennsylvania (UPenn). He specializes in applying experimental psychology and brain imaging methodologies to the studies of substance use disorders, with an emphasis on tobacco and opioid use disorders. Dr. Shi received his PhD in cognitive neuroscience from Peking University and completed postdoctoral training in addiction neuroscience at the UPenn Annenberg Public Policy Center (APPC) and Center for Studies of Addiction (CSA). His research has examined the neurobehavioral mechanisms of smoking cessation in response to anti-tobacco communications, as well as the neural biomarkers of the severity of and recovery from opioid use disorder. Dr. Shi is the Director of the Cognitive & Affective Addiction Neuroscience Lab (https://www.caanlab.com), where he currently leads a NIDA-funded K01 project (K01DA051709) on the predictive modeling of treatment outcomes in opioid use disorder using multimodal neuroimaging.


Selected Publications:

Shi, Z., Wang, A. L., Fairchild, V. P., Aronowitz, C. A., Loughead, J., Langleben, D. D. (in press). Addicted to green: priming effect of menthol cigarette packaging on brain response to smoking cues. Tobacco Control. http://doi.org/10.1136/tobaccocontrol-2021-056639

Shi, Z., Langleben, D. D., O'Brien, C. P., Childress, A. R., Wiers, C. E. (2021). Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder. NeuroImage: Clinical, 32, 102806. https://doi.org/10.1016/j.nicl.2021.102806

Shi, Z., Jagannathan, K., Padley, J. H., Wang, A. L., Fairchild, V. P., O’Brien, C. P., Childress, A. R., Langleben, D. D. (2021). The role of withdrawal symptoms in mesocorticolimbic drug cue-reactivity in opioid use disorder. Addiction Biology, 26(4), e12977. https://doi.org/10.1111/adb.12977

Shi, Z., Jagannathan, K., Fairchild, V. P., Wang, A. L., Suh, J. J., Childress, A. R., Langleben, D. D. (2019). Behavioral and accumbal responses during an affective Go/No-go task predict adherence to injectable naltrexone treatment in opioid use disorder. International Journal of Neuropsychopharmacology, 22(3), 180–185. https://doi.org/10.1093/ijnp/pyz002

Shi, Z., Wang, A. L., Jagannathan, K., Fairchild, V. P., O’Brien, C. P., Childress, A. R., Langleben, D. D. (2018). Effects of extended-release naltrexone on the brain response to drug-related stimuli in opioid use disorder. Journal of Psychiatry & Neuroscience, 43(4), 254–261. https://doi.org/10.1503/jpn.170036

Shi, Z., Han, S. (2018). Distinct effects of reminding mortality and physical pain on the default-mode activity and activity underlying self-reflection. Social Neuroscience, 13(3), 372–383. https://doi.org/10.1080/17470919.2017.1329165

Shi, Z., Wang, A. L., Emery, L. F., Sheerin, K. M., Romer, D. (2017). The importance of relevant emotional arousal in the efficacy of pictorial health warnings for cigarettes. Nicotine & Tobacco Research, 19(6), 750–755. https://doi.org/10.1093/ntr/ntw322

Shi, Z., Ma, Y., Wu, B., Wu, X., Wang, Y., Han, S. (2016). Neural correlates of reflection on actual versus ideal self-discrepancy. NeuroImage, 124, 573–580. https://doi.org/10.1016/j.neuroimage.2015.08.077

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