Selected Publications from the Lab

Accepted/Published 

• Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.
  Neurology. 2024 Oct 22;103(8):e209832 Epub 2024 Sep 25; Authors: Vandebergh M, Ramos EM, Corriveau-Lecavalier N, Ramanan VK, Kornak J, Mester C, Kolander T, Brushaber DE, Staffaroni AM, Geschwind DH, Wolf AA, Kantarci K, Gendron T, Petrucelli L, Van den Broeck M, Wynants S, Baker M, Borrego-Écija S, Appleby B, Barmada S, Bozoki AC, Clark D, Darby RR, Dickerson BC, Domoto-Reilly K, Fields JA, Galasko D, Ghoshal N, Graff-Radford NR, Grant IM, Honig LS, Hsiung GR, Huey ED, Irwin DJ, Knopman DS, Kwan JY, Léger GC, Litvan I, Masdeu JC, Mendez MF, Onyike CU, Pascual B, Pressman PS, Ritter A, Roberson ED, Snyder A, Sullivan AC, Tartaglia MC, Wint D, Heuer HW, Forsberg LK, Boxer AL, Rosen HJ, Boeve BF, Rademakers R, ALLFTD Consortium

• Murray Grossman, MD, EdD (1952-2023).
  Neurology. 2024 Oct 8;103(7):e209890 Epub 2024 Sep 9; Authors: Mcmillan CT, Irwin DJ, Grossman SN, Massimo L

• Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia.
  Brain : a journal of neurology. 2024 Oct 3;147(10):3522-3533; Authors: Reus LM, Jansen IE, Tijms BM, Visser PJ, Tesi N, van der Lee SJ, Vermunt L, Peeters CFW, De Groot LA, Hok-A-Hin YS, Chen-Plotkin A, Irwin DJ, Hu WT, Meeter LH, van Swieten JC, Holstege H, Hulsman M, Lemstra AW, Pijnenburg YAL, van der Flier WM, Teunissen CE, Del Campo Milan M

• C9orf72 repeat expansions modify risk for secondary motor and cognitive-behavioral symptoms in behavioral-variant frontotemporal degeneration and amyotrophic lateral sclerosis.
  medRxiv : the preprint server for health sciences. 2024 Sep 19; Authors: Spencer BE, Xie SX, Elman L, Quinn CC, Amado D, Baer M, Lee EB, Van Deerlin VM, Dratch L, Massimo L, Irwin DJ, McMillan CT

• Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum.
  Acta neuropathologica. 2024 Sep 3;148(1):37; Authors: Denning AE, Ittyerah R, Levorse LM, Sadeghpour N, Athalye C, Chung E, Ravikumar S, Dong M, Duong MT, Li Y, Ilesanmi A, Sreepada LP, Sabatini P, Lowe M, Bahena A, Zablah J, Spencer BE, Watanabe R, Kim B, Sørensen MH, Khandelwal P, Brown C, Hrybouski S, Xie SX, de Flores R, Robinson JL, Schuck T, Ohm DT, Arezoumandan S, Porta S, Detre JA, Insausti R, Wisse LEM, Das SR, Irwin DJ, Lee EB, Wolk DA, Yushkevich PA

• Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of Frontotemporal Dementia.
  medRxiv : the preprint server for health sciences. 2024 Aug 20; Authors: Hok-A-Hin YS, Vermunt L, Peeters CFW, van der Ende EL, de Boer SCM, Meeter LH, van Swieten JC, Hu WT, Lleó A, Alcolea D, Engelborghs S, Sieben A, Chen-Plotkin A, Irwin DJ, van der Flier WM, Pijnenburg YAL, Teunissen CE, Del Campo M

• Microstructural changes in the inferior tuberal hypothalamus correlate with daytime sleepiness in Lewy body disease.
  medRxiv : the preprint server for health sciences. 2024 Aug 16; Authors: Cohen JS, Radhakrishnan H, Olm CA, Das SR, Cook PA, Wolk DA, Weintraub D, Irwin DJ, McMillan CT

• Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies.
  Neurology. 2024 Aug 13;103(3):e209656 Epub 2024 Jul 16; Authors: Coughlin DG, MacLeod KR, Middleton JS, Bozoki AC, Galvin JE, Irwin DJ, Lippa CF, Litvan I, Lopez OL, Berman S, Tsuang DW, Zabetian CP, Honig LS, Marder KS, Fleisher JE, Sabbagh M, Wint D, Taylor AS, Bekris L, Leverenz JB, Galasko D

• Cytoarchitectonic gradients of laminar degeneration in behavioural variant frontotemporal dementia.
  Brain : a journal of neurology. 2024 Aug 9; Authors: Ohm DT, Xie SX, Capp N, Arezoumandan S, Cousins KAQ, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Irwin DJ

• Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic bvFTD.
  medRxiv : the preprint server for health sciences. 2024 Jul 27; Authors: Shen T, Vogel JW, Van Deerlin VM, Suh E, Dratch L, Phillips JS, Massimo L, Lee EB, Irwin DJ, McMillan CT

• Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.
  medRxiv : the preprint server for health sciences. 2024 Jun 25; Authors: Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Gorno Tempini ML, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene DC, Lee-Way J, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R

• Annexin A11 aggregation in FTLD-TDP type C and related neurodegenerative disease proteinopathies.
  Acta neuropathologica. 2024 Jun 19;147(1):104; Authors: Robinson JL, Suh E, Xu Y, Hurtig HI, Elman L, McMillan CT, Irwin DJ, Porta S, Van Deerlin VM, Lee EB

• Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer's disease.
  Nature communications. 2024 Jun 5;15(1):4803; Authors: Ravikumar S, Denning AE, Lim S, Chung E, Sadeghpour N, Ittyerah R, Wisse LEM, Das SR, Xie L, Robinson JL, Schuck T, Lee EB, Detre JA, Tisdall MD, Prabhakaran K, Mizsei G, de Onzono Martin MMI, Arroyo Jiménez MDM, Mũnoz M, Marcos Rabal MDP, Cebada Sánchez S, Delgado González JC, de la Rosa Prieto C, Irwin DJ, Wolk DA, Insausti R, Yushkevich PA

• Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.
  Brain : a journal of neurology. 2024 Jun 3;147(6):2169-2184; Authors: Barbour AJ, Gourmaud S, Lancaster E, Li X, Stewart DA, Hoag KF, Irwin DJ, Talos DM, Jensen FE

• Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Jun;20(6):3889-3905 Epub 2024 Apr 21; Authors: Cousins KAQ, Phillips JS, Das SR, O'Brien K, Tropea TF, Chen-Plotkin A, Shaw LM, Nasrallah IM, Mechanic-Hamilton D, McMillan CT, Irwin DJ, Lee EB, Wolk DA

• Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases.
  Imaging neuroscience (Cambridge, Mass.). 2024 May 1;2:1-30 Epub 2024 May 8; Authors: Khandelwal P, Duong MT, Sadaghiani S, Lim S, Denning AE, Chung E, Ravikumar S, Arezoumandan S, Peterson C, Bedard M, Capp N, Ittyerah R, Migdal E, Choi G, Kopp E, Loja B, Hasan E, Li J, Bahena A, Prabhakaran K, Mizsei G, Gabrielyan M, Schuck T, Trotman W, Robinson J, Ohm DT, Lee EB, Trojanowski JQ, McMillan C, Grossman M, Irwin DJ, Detre JA, Tisdall MD, Das SR, Wisse LEM, Wolk DA, Yushkevich PA

• Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories.
  Hippocampus. 2024 May;34(5):241-260 Epub 2024 Feb 28; Authors: Wuestefeld A, Baumeister H, Adams JN, de Flores R, Hodgetts CJ, Mazloum-Farzaghi N, Olsen RK, Puliyadi V, Tran TT, Bakker A, Canada KL, Dalton MA, Daugherty AM, La Joie R, Wang L, Bedard ML, Buendia E, Chung E, Denning A, Del Mar Arroyo-Jiménez M, Artacho-Pérula E, Irwin DJ, Ittyerah R, Lee EB, Lim S, Del Pilar Marcos-Rabal M, Iñiguez de Onzoño Martin MM, Lopez MM, de la Rosa Prieto C, Schuck T, Trotman W, Vela A, Yushkevich P, Amunts K, Augustinack JC, Ding SL, Insausti R, Kedo O, Berron D, Wisse LEM

• Digital markers of motor speech impairments in spontaneous speech of patients with ALS-FTD spectrum disorders.
  Amyotrophic lateral sclerosis & frontotemporal degeneration. 2024 May;25(3-4):317-325 Epub 2023 Dec 5; Authors: Shellikeri S, Cho S, Ash S, Gonzalez-Recober C, Mcmillan CT, Elman L, Quinn C, Amado DA, Baer M, Irwin DJ, Massimo L, Olm CA, Liberman MY, Grossman M, Nevler N

• Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results.
  Nature medicine. 2024 May;30(5):1406-1415 Epub 2024 May 14; Authors: Sevigny J, Uspenskaya O, Heckman LD, Wong LC, Hatch DA, Tewari A, Vandenberghe R, Irwin DJ, Saracino D, Le Ber I, Ahmed R, Rohrer JD, Boxer AL, Boland S, Sheehan P, Brandes A, Burstein SR, Shykind BM, Kamalakaran S, Daniels CW, David Litwack E, Mahoney E, Velaga J, McNamara I, Sondergaard P, Sajjad SA, Kobayashi YM, Abeliovich A, Hefti F

• Automatic classification of AD pathology in FTD phenotypes using natural speech.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 May;20(5):3416-3428 Epub 2024 Apr 4; Authors: Cho S, Olm CA, Ash S, Shellikeri S, Agmon G, Cousins KAQ, Irwin DJ, Grossman M, Liberman M, Nevler N

• Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia.
  bioRxiv : the preprint server for biology. 2024 Apr 9; Authors: Ohm DT, Xie SX, Capp N, Arezoumandan S, Cousins KAQ, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Irwin DJ

• Disparities in Genetic Testing for Neurologic Disorders.
  Neurology. 2024 Mar 26;102(6):e209161 Epub 2024 Mar 6; Authors: Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik A, Elman LB, Guo M, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn CC, Tropea TF, Scherer SS, Shinohara RT, Hamilton RH, Ellis CA

• Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.
  Frontiers in neuroscience. 2024;18:1353306 Epub 2024 Mar 18; Authors: Phillips JS, Adluru N, Chung MK, Radhakrishnan H, Olm CA, Cook PA, Gee JC, Cousins KAQ, Arezoumandan S, Wolk DA, McMillan CT, Grossman M, Irwin DJ

• Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Mar;20(3):1586-1600 Epub 2023 Dec 5; Authors: Lyu X, Duong MT, Xie L, de Flores R, Richardson H, Hwang G, Wisse LEM, DiCalogero M, McMillan CT, Robinson JL, Xie SX, Lee EB, Irwin DJ, Dickerson BC, Davatzikos C, Nasrallah IM, Yushkevich PA, Wolk DA, Das SR, Alzheimer's Disease Neuroimaging Initiative

• Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease.
  Annals of clinical and translational neurology. 2024 Mar;11(3):673-685 Epub 2024 Jan 23; Authors: Arezoumandan S, Cousins KAQ, Ohm DT, Lowe M, Chen M, Gee J, Phillips JS, McMillan CT, Luk KC, Deik A, Spindler MA, Tropea TF, Weintraub D, Wolk DA, Grossman M, Lee V, Chen-Plotkin AS, Lee EB, Irwin DJ

• Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024 Feb 7;44(6); Authors: Phillips JS, Robinson JL, Cousins KAQ, Wolk DA, Lee EB, McMillan CT, Trojanowski JQ, Grossman M, Irwin DJ

• Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies".
  Acta neuropathologica. 2024 Feb 3;147(1):30; Authors: Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat A, Tartaglia MC, Vandevrede L, Boxer A, Green AJ

• Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts.
  Journal of neurology. 2024 Feb;271(2):733-747 Epub 2023 Oct 27; Authors: Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA

• Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.
  The Lancet. Neurology. 2024 Feb;23(2):168-177; Authors: Chapleau M, La Joie R, Yong K, Agosta F, Allen IE, Apostolova L, Best J, Boon BDC, Crutch S, Filippi M, Fumagalli GG, Galimberti D, Graff-Radford J, Grinberg LT, Irwin DJ, Josephs KA, Mendez MF, Mendez PC, Migliaccio R, Miller ZA, Montembeault M, Murray ME, Nemes S, Pelak V, Perani D, Phillips J, Pijnenburg Y, Rogalski E, Schott JM, Seeley W, Sullivan AC, Spina S, Tanner J, Walker J, Whitwell JL, Wolk DA, Ossenkoppele R, Rabinovici GD, PCA International Work Group

• Evaluation of ATN(PD) Framework and Biofluid Markers to Predict Cognitive Decline in Early Parkinson Disease.
  Neurology. 2024 Feb;102(4):e208033 Epub 2024 Feb 2; Authors: Cousins KAQ, Irwin DJ, Tropea TF, Rhodes E, Phillips J, Chen-Plotkin AS, Brumm MC, Coffey CS, Kang JH, Simuni T, Foroud TM, Toga AW, Tanner CM, Kieburtz KD, Mollenhauer B, Galasko D, Hutten S, Weintraub D, Siderowf AD, Marek K, Poston KL, Shaw LM, Parkinson's Progression Markers Initiative

• Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.
  Neurology. 2024 Jan 23;102(2):e207926 Epub 2023 Dec 20; Authors: Nevler N, Cho S, Cousins KAQ, Ash S, Olm CA, Shellikeri S, Agmon G, Gonzalez-Recober C, Xie SX, Barker MS, Manoochehri M, Mcmillan CT, Irwin DJ, Massimo L, Dratch L, Cheran G, Huey ED, Cosentino SA, Van Deerlin VM, Liberman MY, Grossman M

• Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories.
  bioRxiv : the preprint server for biology. 2024 Jan 3; Authors: Wuestefeld A, Baumeister H, Adams JN, de Flores R, Hodgetts C, Mazloum-Farzaghi N, Olsen RK, Puliyadi V, Tran TT, Bakker A, Canada KL, Dalton MA, Daugherty AM, Joie R, Wang L, Bedard M, Buendia E, Chung E, Denning A, Arroyo-Jiménez MDM, Artacho-Pérula E, Irwin DJ, Ittyerah R, Lee EB, Lim S, Marcos-Rabal MDP, Martin MMIO, Lopez MM, Prieto CR, Schuck T, Trotman W, Vela A, Yushkevich P, Amunts K, Augustinack JC, Ding SL, Insausti R, Kedo O, Berron D, Wisse LEM

• ATN cerebrospinal fluid biomarkers in dementia with Lewy bodies: Initial results from the United States Dementia with Lewy Bodies Consortium.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Jan;20(1):549-562 Epub 2023 Sep 23; Authors: Jain L, Khrestian M, Formica S, Tuason ED, Pillai JA, Rao S, Oguh O, Lippa CF, Lopez OL, Berman SB, Tsuang DW, Zabetian CP, Irwin DJ, Galasko DR, Litvan I, Marder KS, Honig LS, Fleisher JE, Galvin JE, Bozoki AC, Taylor AS, Sabbagh MN, Leverenz JB, Bekris LM

• Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum.
  Translational neurodegeneration. 2023 Dec 7;12(1):57; Authors: Shen T, Vogel JW, Duda J, Phillips JS, Cook PA, Gee J, Elman L, Quinn C, Amado DA, Baer M, Massimo L, Grossman M, Irwin DJ, McMillan CT

• [(18)F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023 Dec 1;64(12):1980-1989; Authors: Blazhenets G, Soleimani-Meigooni DN, Thomas W, Mundada N, Brendel M, Vento S, VandeVrede L, Heuer HW, Ljubenkov P, Rojas JC, Chen MK, Amuiri AN, Miller Z, Gorno-Tempini ML, Miller BL, Rosen HJ, Litvan I, Grossman M, Boeve B, Pantelyat A, Tartaglia MC, Irwin DJ, Dickerson BC, Baker SL, Boxer AL, Rabinovici GD, La Joie R

• CSF proteomics in autosomal dominant Alzheimer's disease highlights parallels with sporadic disease.
  Brain : a journal of neurology. 2023 Nov 2;146(11):4495-4507; Authors: van der Ende EL, In 't Veld SGJG, Hanskamp I, van der Lee S, Dijkstra JIR, Hok-A-Hin YS, Blujdea ER, van Swieten JC, Irwin DJ, Chen-Plotkin A, Hu WT, Lemstra AW, Pijnenburg YAL, van der Flier WM, Del Campo M, Teunissen CE, Vermunt L

• Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology.
  Clinical chemistry. 2023 Nov 2;69(11):1247-1259; Authors: Kang JH, Korecka M, Lee EB, Cousins KAQ, Tropea TF, Chen-Plotkin AA, Irwin DJ, Wolk D, Brylska M, Wan Y, Shaw LM

• Racial Differences in Clinical Presentation in Individuals Diagnosed With Frontotemporal Dementia.
  JAMA neurology. 2023 Nov 1;80(11):1191-1198; Authors: Jin HA, McMillan CT, Yannatos I, Fisher L, Rhodes E, Jacoby SF, Irwin DJ, Massimo L

• Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient.
  Frontiers in neurology. 2023;14:1245886 Epub 2023 Oct 11; Authors: Ohm DT, Rhodes E, Bahena A, Capp N, Lowe M, Sabatini P, Trotman W, Olm CA, Phillips J, Prabhakaran K, Rascovsky K, Massimo L, McMillan C, Gee J, Tisdall MD, Yushkevich PA, Lee EB, Grossman M, Irwin DJ

• CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer´s disease.
  Nature communications. 2023 Sep 13;14(1):5635; Authors: Del Campo M, Vermunt L, Peeters CFW, Sieben A, Hok-A-Hin YS, Lleó A, Alcolea D, van Nee M, Engelborghs S, van Alphen JL, Arezoumandan S, Chen-Plotkin A, Irwin DJ, van der Flier WM, Lemstra AW, Teunissen CE

• Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum.
  Research square. 2023 Aug 10; Authors: Shen T, Vogel JW, Duda J, Phillips JS, Cook PA, Gee J, Elman L, Quinn C, Amado DA, Baer M, Massimo L, Grossman M, Irwin DJ, McMillan CT

• Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration.
  Acta neuropathologica communications. 2023 Aug 2;11(1):126; Authors: Giannini LA, Mol MO, Rajicic A, van Buuren R, Sarkar L, Arezoumandan S, Ohm DT, Irwin DJ, Rozemuller AJ, Netherlands Brain Bank, van Swieten JC, Seelaar H

• Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023 Aug;19(8):3563-3574 Epub 2023 Feb 24; Authors: Wolzak K, Vermunt L, Campo MD, Jorge-Oliva M, van Ziel AM, Li KW, Smit AB, Chen-Ploktkin A, Irwin DJ, Lemstra AW, Pijnenburg Y, van der Flier W, Zetterberg H, Gobom J, Blennow K, Visser PJ, Teunissen CE, Tijms BM, Scheper W

• Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
  Brain : a journal of neurology. 2023 Jul 3;146(7):2975-2988; Authors: Young AL, Vogel JW, Robinson JL, McMillan CT, Ossenkoppele R, Wolk DA, Irwin DJ, Elman L, Grossman M, Lee VMY, Lee EB, Hansson O

• Fluid and Biopsy Based Biomarkers in Parkinson's Disease.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023 Jul;20(4):932-954 Epub 2023 May 3; Authors: Coughlin DG, Irwin DJ

• Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.
  Journal of Alzheimer's disease reports. 2023;7(1):589-604 Epub 2023 Jun 8; Authors: Ash S, Nevler N, Irwin DJ, Shellikeri S, Rascovsky K, Shaw L, Lee EB, Trojanowski JQ, Grossman M

• Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023 Jun;19(6):2355-2364 Epub 2022 Dec 4; Authors: Sadaghiani S, Trotman W, Lim SA, Chung E, Ittyerah R, Ravikumar S, Khandelwal P, Prabhakaran K, Lavery ML, Ohm DT, Gabrielyan M, Das SR, Schuck T, Capp N, Peterson CS, Migdal E, Artacho-Pérula E, Jiménez MDMA, Rabal MDPM, Sánchez SC, Prieto CR, Parada MC, Insausti R, Robinson JL, McMillan C, Grossman M, Lee EB, Detre JA, Xie SX, Trojanowski JQ, Tisdall MD, Wisse LEM, Irwin DJ, Wolk DA, Yushkevich PA

• Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated.
  Brain : a journal of neurology. 2023 Jun 1;146(6):2557-2569; Authors: Robinson JL, Xie SX, Baer DR, Suh E, Van Deerlin VM, Loh NJ, Irwin DJ, McMillan CT, Wolk DA, Chen-Plotkin A, Weintraub D, Schuck T, Lee VMY, Trojanowski JQ, Lee EB

• Antemortem network analysis of spreading pathology in autopsy-confirmed frontotemporal degeneration.
  Brain communications. 2023;5(3):fcad147 Epub 2023 May 12; Authors: Chen M, Burke S, Olm CA, Irwin DJ, Massimo L, Lee EB, Trojanowski JQ, Gee JC, Grossman M

• Digital markers of motor speech impairments in natural speech of patients with ALS-FTD spectrum disorders.
  medRxiv : the preprint server for health sciences. 2023 May 1; Authors: Shellikeri S, Cho S, Ash S, Gonzalez-Recober C, McMillan CT, Elman L, Quinn C, Amado DA, Baer M, Irwin DJ, Massimo L, Olm C, Liberman M, Grossman M, Nevler N

• Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome.
  JAMA neurology. 2023 May 1;80(5):495-505; Authors: VandeVrede L, La Joie R, Thijssen EH, Asken BM, Vento SA, Tsuei T, Baker SL, Cobigo Y, Fonseca C, Heuer HW, Kramer JH, Ljubenkov PA, Rabinovici GD, Rojas JC, Rosen HJ, Staffaroni AM, Boeve BF, Dickerson BC, Grossman M, Huey ED, Irwin DJ, Litvan I, Pantelyat AY, Tartaglia MC, Dage JL, Boxer AL

• Cerebrospinal fluid biomarker panel of synaptic dysfunction in Alzheimer's disease and other neurodegenerative disorders.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023 May;19(5):1775-1784 Epub 2022 Oct 14; Authors: Nilsson J, Cousins KAQ, Gobom J, Portelius E, Chen-Plotkin A, Shaw LM, Grossman M, Irwin DJ, Trojanowski JQ, Zetterberg H, Blennow K, Brinkmalm A

• Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's disease.
  Neurobiology of aging. 2023 May;125:74-82 Epub 2023 Feb 1; Authors: Kim BJ, Grossman M, Aleman TS, Song D, Cousins KAQ, McMillan CT, Saludades A, Yu Y, Lee EB, Wolk D, Van Deerlin VM, Shaw LM, Ying GS, Irwin DJ

• Concomitant Alzheimer Disease Pathology in Parkinson Disease Dementia.
  Annals of neurology. 2023 May;93(5):1045-1046 Epub 2023 Mar 16; Authors: Tropea TF, Albuja I, Cousins KAQ, Irwin DJ, Lee EB, Chen-Plotkin AS

• Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration.
  Acta neuropathologica. 2023 May;145(5):711; Authors: Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ, Netherlands Brain Bank

• Plasma GFAP associates with secondary Alzheimer's pathology in Lewy body disease.
  Annals of clinical and translational neurology. 2023 May;10(5):802-813 Epub 2023 Mar 31; Authors: Cousins KAQ, Irwin DJ, Chen-Plotkin A, Shaw LM, Arezoumandan S, Lee EB, Wolk DA, Weintraub D, Spindler M, Deik A, Grossman M, Tropea TF

• Creating the Pick's disease International Consortium: Association study of MAPT H2 haplotype with risk of Pick's disease.
  medRxiv : the preprint server for health sciences. 2023 Apr 24; Authors: Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Warner TT, Jaunmuktane Z, Boeve BF, Christopher EA, DeTure M, Duara R, Graff-Radford NR, Josephs KA, Knopman DS, Koga S, Murray ME, Lyons KE, Pahwa R, Parisi JE, Petersen RC, Whitwell J, Grinberg LT, Miller B, Schlereth A, Seeley WW, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Trojanowski JQ, Van Deerlin VM, Wolk DA, Connors TR, Dooley PM, Frosch MP, Oakley DH, Aldecoa I, Balasa M, Gelpi E, Borrego-Écija S, de Eugenio Huélamo RM, Gascon-Bayarri J, Sánchez-Valle R, Sanz-Cartagena P, Piñol-Ripoll G, Molina-Porcel L, Bigio EH, Flanagan ME, Gefen T, Rogalski EJ, Weintraub S, Redding-Ochoa J, Chang K, Troncoso JC, Prokop S, Newell KL, Ghetti B, Jones M, Richardson A, Robinson AC, Roncaroli F, Snowden J, Allinson K, Green O, Rowe JB, Singh P, Beach TG, Serrano GE, Flowers XE, Goldman JE, Heaps AC, Leskinen SP, Teich AF, Black SE, Keith JL, Masellis M, Bodi I, King A, Sarraj SA, Troakes C, Halliday GM, Hodges JR, Kril JJ, Kwok JB, Piguet O, Gearing M, Arzberger T, Roeber S, Attems J, Morris CM, Thomas AJ, Evers BM, White CL, Mechawar N, Sieben AA, Cras PP, De Vil BB, De Deyn PPPP, Duyckaerts C, Le Ber I, Seihean D, Turbant-Leclere S, MacKenzie IR, McLean C, Cykowski MD, Ervin JF, Wang SJ, Graff C, Nennesmo I, Nagra RM, Riehl J, Kovacs GG, Giaccone G, Nacmias B, Neumann M, Ang LC, Finger EC, Blauwendraat C, Nalls MA, Singleton AB, Vitale D, Cunha C, Carvalho A, Wszolek ZK, Morris HR, Rademakers R, Hardy JA, Dickson DW, Rohrer JD, Ross OA

• Effect of Polar Hydrocarbon Contents on Oil-Water Interfacial Tension and Implications for Recent Observations in Smart Water Flooding Oil Recovery Schemes.
  ACS omega. 2023 Mar 14;8(10):9086-9100 Epub 2023 Feb 28; Authors: Miadonye A, Irwin DJG, Amadu M

• The status of digital pathology and associated infrastructure within Alzheimer's Disease Centers.
  Journal of neuropathology and experimental neurology. 2023 Feb 21;82(3):202-211; Authors: Scalco R, Hamsafar Y, White CL, Schneider JA, Reichard RR, Prokop S, Perrin RJ, Nelson PT, Mooney S, Lieberman AP, Kukull WA, Kofler J, Keene CD, Kapasi A, Irwin DJ, Gutman DA, Flanagan ME, Crary JF, Chan KC, Murray ME, Dugger BN

• Tau-Neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum.
  medRxiv : the preprint server for health sciences. 2023 Feb 15; Authors: Lyu X, Duong MT, Xie L, de Flores R, Richardson H, Hwang G, Wisse LEM, DiCalogero M, McMillan CT, Robinson JL, Xie SX, Grossman M, Lee EB, Irwin DJ, Dickerson BC, Davatzikos C, Nasrallah IM, Yushkevich PA, Wolk DA, Das SR, Alzheimer’s Disease Neuroimaging Initiative

• Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel.
  Alzheimer's & dementia (New York, N. Y.). 2023 Jan-Mar;9(1):e12375 Epub 2023 Feb 8; Authors: Sabbagh MN, Taylor A, Galasko D, Galvin JE, Goldman JG, Leverenz JB, Poston KL, Boeve BF, Irwin DJ, Quinn JF

• Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
  medRxiv : the preprint server for health sciences. 2023 Feb 2; Authors: Young AL, Vogel JW, Robinson JL, McMillan CT, Ossenkoppele R, Wolk DA, Irwin DJ, Elman L, Grossman M, Lee VM, Lee EB, Hansson O

• Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation.
  Neuropathology and applied neurobiology. 2023 Feb;49(1):e12865; Authors: Uemura MT, Suh ER, Robinson JL, Brunden KR, Grossman M, Irwin DJ, Lee VM, Trojanowski JQ, Lee EB, Van Deerlin VM

• Plasma phosphorylated tau181 predicts cognitive and functional decline.
  Annals of clinical and translational neurology. 2023 Jan;10(1):18-31 Epub 2022 Dec 14; Authors: Tropea TF, Waligorska T, Xie SX, Nasrallah IM, Cousins KAQ, Trojanowski JQ, Grossman M, Irwin DJ, Weintraub D, Lee EB, Wolk DA, Chen-Plotkin AS, Shaw LM, Alzheimer's Disease Neuroimaging Initiative

• Research Priorities of Individuals and Caregivers With Lewy Body Dementia: A Web-based Survey.
  Alzheimer disease and associated disorders. 2023 Jan-Mar 01;37(1):50-58 Epub 2023 Feb 23; Authors: Holden SK, Bedenfield N, Taylor AS, Bayram E, Schwilk C, Fleisher J, Duda J, Shill H, Paulson HL, Stacy K, Wood J, Corsentino P, Sha SJ, Litvan I, Irwin DJ, Quinn JF, Goldman JG, Amodeo K, Taylor JP, Boeve BF, Armstrong MJ

• Event-based modeling of T1-weighted MRI is related to pathology in frontotemporal lobar degeneration due to tau and TDP.
  NeuroImage. Clinical. 2023;37:103285 Epub 2022 Dec 7; Authors: Olm CA, Burke SE, Peterson C, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M, Gee JC

• TREM2 risk variants are associated with atypical Alzheimer's disease.
  Acta neuropathologica. 2022 Dec;144(6):1085-1102 Epub 2022 Sep 16; Authors: Kim B, Suh E, Nguyen AT, Prokop S, Mikytuck B, Olatunji OA, Robinson JL, Grossman M, Phillips JS, Irwin DJ, Mechanic-Hamilton D, Wolk DA, Trojanowski JQ, McMillan CT, Van Deerlin VM, Lee EB

• Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration.
  Acta neuropathologica. 2022 Dec;144(6):1065-1084 Epub 2022 Sep 6; Authors: Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ, Netherlands Brain Bank

• Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease.
  Acta neuropathologica. 2022 Dec;144(6):1103-1116 Epub 2022 Jul 23; Authors: Arezoumandan S, Xie SX, Cousins KAQ, Mechanic-Hamilton DJ, Peterson CS, Huang CY, Ohm DT, Ittyerah R, McMillan CT, Wolk DA, Yushkevich P, Trojanowski JQ, Lee EB, Grossman M, Phillips JS, Irwin DJ

• Evaluation of an educational conference for persons affected by hereditary frontotemporal degeneration and amyotrophic lateral sclerosis.
  PEC innovation. 2023 Dec;2:100108 Epub 2022 Nov 24; Authors: Dratch L, Mu W, Wood EM, Morgan B, Massimo L, Clyburn C, Bardakjian T, Grossman M, Irwin DJ, Cousins KAQ

• CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology.
  Neurology. 2022 Nov 14;99(20):e2303-e2312; Authors: Cousins KAQ, Arezoumandan S, Shellikeri S, Ohm D, Shaw LM, Grossman M, Wolk D, McMillan CT, Chen-Plotkin A, Lee E, Trojanowski JQ, Zetterberg H, Blennow K, Irwin DJ

• Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis.
  Annals of neurology. 2022 Nov;92(5):807-818 Epub 2022 Aug 17; Authors: Cousins KAQ, Shaw LM, Shellikeri S, Dratch L, Rosario L, Elman LB, Quinn C, Amado DA, Wolk DA, Tropea TF, Chen-Plotkin A, Irwin DJ, Grossman M, Lee EB, Trojanowski JQ, McMillan CT

• Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers.
  JAMA neurology. 2022 Nov 1;79(11):1155-1164; Authors: Cousins KAQ, Shaw LM, Chen-Plotkin A, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Grossman M, Irwin DJ

• CSF proteome profiling across the Alzheimer's disease spectrum reflects the multifactorial nature of the disease and identifies specific biomarker panels.
  Nature aging. 2022 Nov;2(11):1040-1053 Epub 2022 Nov 10; Authors: Del Campo M, Peeters CFW, Johnson ECB, Vermunt L, Hok-A-Hin YS, van Nee M, Chen-Plotkin A, Irwin DJ, Hu WT, Lah JJ, Seyfried NT, Dammer EB, Herradon G, Meeter LH, van Swieten J, Alcolea D, Lleó A, Levey AI, Lemstra AW, Pijnenburg YAL, Visser PJ, Tijms BM, van der Flier WM, Teunissen CE

• Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
  Movement disorders : official journal of the Movement Disorder Society. 2022 Oct;37(10):2110-2121 Epub 2022 Aug 23; Authors: Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, Höllerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Martí MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matěj R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, Alzheimer's Disease Genetics Consortium, Müller U, Schellenberg GD, Herms J, Kuhlenbäumer G, Höglinger G

• Differences in Motor Features of C9orf72, MAPT, or GRN Variant Carriers With Familial Frontotemporal Lobar Degeneration.
  Neurology. 2022 Sep 13;99(11):e1154-e1167 Epub 2022 Jul 5; Authors: Tipton PW, Deutschlaender AB, Savica R, Heckman MG, Brushaber DE, Dickerson BC, Gavrilova RH, Geschwind DH, Ghoshal N, Graff-Radford J, Graff-Radford NR, Grossman M, Hsiung GR, Huey ED, Irwin DJ, Jones DT, Knopman DS, McGinnis SM, Rademakers R, Ramos EM, Forsberg LK, Heuer HW, Onyike C, Tartaglia C, Domoto-Reilly K, Roberson ED, Mendez MF, Litvan I, Appleby BS, Grant I, Kaufer D, Boxer AL, Rosen HJ, Boeve BF, Wszolek ZK, ALLFTD Consortium

• Lexical and Acoustic Speech Features Relating to Alzheimer Disease Pathology.
  Neurology. 2022 Jul 25;99(4):e313-e322; Authors: Cho S, Cousins KAQ, Shellikeri S, Ash S, Irwin DJ, Liberman MY, Grossman M, Nevler N

• Non-tremor motor dysfunction in Lewy body dementias is associated with AD biomarkers.
  Parkinsonism & related disorders. 2022 Jul;100:33-36 Epub 2022 Jun 8; Authors: Walker IM, Cousins KA, Siderowf A, Duda JE, Morley JF, Dahodwala N, Tropea T, Vaishnavi S, Wolk DA, Chen-Plotkin AS, Shaw LM, Lee EB, Trojanowski JQ, Grossman M, Weintraub D, Irwin DJ

• Rates of longitudinal change in (18) F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022 Jun;18(6):1235-1247 Epub 2021 Sep 13; Authors: Phillips JS, Nitchie FJ 4th, Da Re F, Olm CA, Cook PA, McMillan CT, Irwin DJ, Gee JC, Dubroff JG, Grossman M, Nasrallah IM, Alzheimer's Disease Neuroimaging Initiative

• A tribute to John Q. Trojanowski (1946-2022).
  The Journal of clinical investigation. 2022 May 16;132(10); Authors: Irwin DJ, Lee EB

• Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome.
  Alzheimer's & dementia (New York, N. Y.). 2022;8(1):e12294 Epub 2022 May 11; Authors: Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ

• Divergent Histopathological Networks of Frontotemporal Degeneration Proteinopathy Subytpes.
  The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 May 4;42(18):3868-3877 Epub 2022 Mar 22; Authors: Chen M, Ohm DT, Phillips JS, McMillan CT, Capp N, Peterson C, Xie E, Wolk DA, Trojanowski JQ, Lee EB, Gee J, Grossman M, Irwin DJ

• Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology.
  Neurobiology of aging. 2022 May;113:95-107 Epub 2022 Feb 24; Authors: Burke SE, Phillips JS, Olm CA, Peterson CS, Cook PA, Gee JC, Lee EB, Trojanowski JQ, Massimo L, Irwin DJ, Grossman M

• Prosodic characteristics of prepausal words produced by patients with neurodegenerative disease.
  Speech prosody (Urbana, Ill.). 2022 May;2022:120-124; Authors: Cho S, Agmon G, Shellikeri S, Cousins KAQ, Ash S, Irwin DJ, Spindler M, Deik AF, Elman LB, Quinn C, Liberman M, Grossman M, Nevler N

• Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.
  Cell reports. Medicine. 2022 Apr 19;3(4):100607; Authors: Gendron TF, Heckman MG, White LJ, Veire AM, Pedraza O, Burch AR, Bozoki AC, Dickerson BC, Domoto-Reilly K, Foroud T, Forsberg LK, Galasko DR, Ghoshal N, Graff-Radford NR, Grossman M, Heuer HW, Huey ED, Hsiung GR, Irwin DJ, Kaufer DI, Leger GC, Litvan I, Masdeu JC, Mendez MF, Onyike CU, Pascual B, Ritter A, Roberson ED, Rojas JC, Tartaglia MC, Wszolek ZK, Rosen H, Boeve BF, Boxer AL, ALLFTD consortium, Petrucelli L

• Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration.
  Molecular neurodegeneration. 2022 Apr 8;17(1):29; Authors: Cervantes González A, Irwin DJ, Alcolea D, McMillan CT, Chen-Plotkin A, Wolk D, Sirisi S, Dols-Icardo O, Querol-Vilaseca M, Illán-Gala I, Santos-Santos MA, Fortea J, Lee EB, Trojanowski JQ, Grossman M, Lleó A, Belbin O

• The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
  Brain : a journal of neurology. 2022 Mar 29;145(1):324-339; Authors: Gourmaud S, Stewart DA, Irwin DJ, Roberts N, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos DM, Jensen FE

• Tau deposition patterns are associated with functional connectivity in primary tauopathies.
  Nature communications. 2022 Mar 15;13(1):1362; Authors: Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M

• Signature laminar distributions of pathology in frontotemporal lobar degeneration.
  Acta neuropathologica. 2022 Mar;143(3):363-382 Epub 2022 Jan 8; Authors: Ohm DT, Cousins KAQ, Xie SX, Peterson C, McMillan CT, Massimo L, Raskovsky K, Wolk DA, Van Deerlin VM, Elman L, Spindler M, Deik A, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ

• Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium.
  Frontiers in neurology. 2021;12:805135 Epub 2022 Jan 31; Authors: Scott GD, Arnold MR, Beach TG, Gibbons CH, Kanthasamy AG, Lebovitz RM, Lemstra AW, Shaw LM, Teunissen CE, Zetterberg H, Taylor AS, Graham TC, Boeve BF, Gomperts SN, Graff-Radford NR, Moussa C, Poston KL, Rosenthal LS, Sabbagh MN, Walsh RR, Weber MT, Armstrong MJ, Bang JA, Bozoki AC, Domoto-Reilly K, Duda JE, Fleisher JE, Galasko DR, Galvin JE, Goldman JG, Holden SK, Honig LS, Huddleston DE, Leverenz JB, Litvan I, Manning CA, Marder KS, Pantelyat AY, Pelak VS, Scharre DW, Sha SJ, Shill HA, Mari Z, Quinn JF, Irwin DJ

• Outcome Measures for Dementia With Lewy Body Clinical Trials: A Review.
  Alzheimer disease and associated disorders. 2022 Jan-Mar 01;36(1):64-72; Authors: Patel B, Irwin DJ, Kaufer D, Boeve BF, Taylor A, Armstrong MJ

• Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.
  Acta neuropathologica. 2022 Jan;143(1):15-31 Epub 2021 Dec 2; Authors: Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, Lee VM, Lee EB, Trojanowski JQ

• Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology.
  NeuroImage. Clinical. 2022;33:102913 Epub 2021 Dec 14; Authors: Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, Grossman M, Irwin DJ

• Neuropathological substrates of cognition in Parkinson's disease.
  Progress in brain research. 2022;269(1):177-193 Epub 2022 Feb 11; Authors: Coughlin DG, Irwin DJ

• Appropriateness of Applying Cerebrospinal Fluid Biomarker Cutoffs from Alzheimer's Disease to Parkinson's Disease.
  Journal of Parkinson's disease. 2022;12(4):1155-1167; Authors: Weinshel S, Irwin DJ, Zhang P, Weintraub D, Shaw LM, Siderowf A, Xie SX

• Frontal Atrophy and Executive Dysfunction Relate to Complex Numbers Impairment in Progressive Supranuclear Palsy.
  Journal of Alzheimer's disease : JAD. 2022;88(4):1553-1566; Authors: Howard E, Ballinger S, Kinney NG, Balgenorth Y, Ehrhardt A, Phillips JS, Irwin DJ, Grossman M, Cousins KAQ

• Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD): A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups.
  Journal of Alzheimer's disease : JAD. 2022;89(2):641-658; Authors: Dominguez Perez S, Phillips JS, Norise C, Kinney NG, Vaddi P, Halpin A, Rascovsky K, Irwin DJ, McMillan CT, Xie L, Wisse LEM, Yushkevich PA, Kallogjeri D, Grossman M, Cousins KAQ

• Common genetic variation is associated with longitudinal decline and network features in behavioral variant frontotemporal degeneration.
  Neurobiology of aging. 2021 Dec;108:16-23 Epub 2021 Aug 3; Authors: Massimo L, Rennert L, Xie SX, Olm C, Bove J, Van Deerlin V, Irwin DJ, Grossman M, McMillan CT

• Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau.
  Acta neuropathologica communications. 2021 Nov 18;9(1):184; Authors: Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, Grossman M, Irwin DJ

• Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.
  Annals of neurology. 2021 Nov;90(5):751-762 Epub 2021 Oct 15; Authors: Das SR, Lyu X, Duong MT, Xie L, McCollum L, de Flores R, DiCalogero M, Irwin DJ, Dickerson BC, Nasrallah IM, Yushkevich PA, Wolk DA, Alzheimer's Disease Neuroimaging Initiative

• SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network.
  Nature methods. 2021 Nov;18(11):1342-1351 Epub 2021 Oct 28; Authors: Hu J, Li X, Coleman K, Schroeder A, Ma N, Irwin DJ, Lee EB, Shinohara RT, Li M

• Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology.
  Acta neuropathologica communications. 2021 Oct 24;9(1):173; Authors: Ravikumar S, Wisse LEM, Lim S, Ittyerah R, Xie L, Bedard ML, Das SR, Lee EB, Tisdall MD, Prabhakaran K, Lane J, Detre JA, Mizsei G, Trojanowski JQ, Robinson JL, Schuck T, Grossman M, Artacho-Pérula E, de Onzoño Martin MMI, Del Mar Arroyo Jiménez M, Muñoz M, Romero FJM, Del Pilar Marcos Rabal M, Sánchez SC, González JCD, de la Rosa Prieto C, Parada MC, Irwin DJ, Wolk DA, Insausti R, Yushkevich PA

• Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe.
  Brain : a journal of neurology. 2021 Oct 22;144(9):2784-2797; Authors: Yushkevich PA, Muñoz López M, Iñiguez de Onzoño Martin MM, Ittyerah R, Lim S, Ravikumar S, Bedard ML, Pickup S, Liu W, Wang J, Hung LY, Lasserve J, Vergnet N, Xie L, Dong M, Cui S, McCollum L, Robinson JL, Schuck T, de Flores R, Grossman M, Tisdall MD, Prabhakaran K, Mizsei G, Das SR, Artacho-Pérula E, Arroyo Jiménez MDM, Marcos Raba MP, Molina Romero FJ, Cebada Sánchez S, Delgado González JC, de la Rosa-Prieto C, Córcoles Parada M, Lee EB, Trojanowski JQ, Ohm DT, Wisse LEM, Wolk DA, Irwin DJ, Insausti R

• Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies.
  Biomolecules. 2021 Oct 8;11(10); Authors: Campo MD, Pijnenburg YAL, Chen-Plotkin A, Irwin DJ, Grossman M, Twaalfhoven HAM, Hu WT, Meeter LH, van Swieten J, Vermunt L, Martens F, Heijboer AC, Teunissen CE

• Longitudinal naming and repetition relates to AD pathology and burden in autopsy-confirmed primary progressive aphasia.
  Alzheimer's & dementia (New York, N. Y.). 2021;7(1):e12188 Epub 2021 Aug 2; Authors: Cousins KAQ, Bove J, Giannini LAA, Kinney NG, Balgenorth YR, Rascovsky K, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ

• Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease.
  Neuropathology and applied neurobiology. 2021 Aug;47(5):707-708 Epub 2021 Feb 15; Authors: Coughlin DG, Grossman M, Trojanowski JQ, Irwin DJ

• Tau immunotherapy is associated with glial responses in FTLD-tau.
  Acta neuropathologica. 2021 Aug;142(2):243-257 Epub 2021 May 5; Authors: Kim B, Mikytuck B, Suh E, Gibbons GS, Van Deerlin VM, Vaishnavi SN, Spindler MA, Massimo L, Grossman M, Trojanowski JQ, Irwin DJ, Lee EB

• Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.
  Acta neuropathologica communications. 2021 Jul 21;9(1):128; Authors: Wisse LEM, Ravikumar S, Ittyerah R, Lim S, Lane J, Bedard ML, Xie L, Das SR, Schuck T, Grossman M, Lee EB, Tisdall MD, Prabhakaran K, Detre JA, Mizsei G, Trojanowski JQ, Artacho-Pérula E, de Iñiguez de Onzono Martin MM, M Arroyo-Jiménez M, Muñoz Lopez M, Molina Romero FJ, P Marcos Rabal M, Cebada Sánchez S, Delgado González JC, de la Rosa Prieto C, Córcoles Parada M, Wolk DA, Irwin DJ, Insausti R, Yushkevich PA

• Lewy Body Dementia Association's Industry Advisory Council: proceedings of the second annual meeting.
  Alzheimer's research & therapy. 2021 Jul 8;13(1):124; Authors: Goldman JG, Boeve BF, Armstrong MJ, Galasko DR, Galvin JE, Irwin DJ, Leverenz JB, Marder K, Abler V, Biglan K, Irizarry MC, Keller B, Lai R, Munsie L, Belleville M, Chaney O, Richard I, Taylor A, Graham T

• Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.
  Neurology. 2021 May 4;96(18):e2296-e2312 Epub 2021 Apr 7; Authors: Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, Pantelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Greaves CV, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL, ALLFTD and GENFI consortia

• ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 May;17(5):822-830 Epub 2020 Nov 23; Authors: Cousins KAQ, Phillips JS, Irwin DJ, Lee EB, Wolk DA, Shaw LM, Zetterberg H, Blennow K, Burke SE, Kinney NG, Gibbons GS, McMillan CT, Trojanowski JQ, Grossman M

• Cognitive Profile and Markers of Alzheimer Disease-Type Pathology in Patients With Lewy Body Dementias.
  Neurology. 2021 Apr 6;96(14):e1855-e1864 Epub 2021 Feb 16; Authors: Howard E, Irwin DJ, Rascovsky K, Nevler N, Shellikeri S, Tropea TF, Spindler M, Deik A, Chen-Plotkin A, Siderowf A, Dahodwala N, Weintraub D, Shaw LM, Trojanowski JQ, Vaishnavi SN, Wolk DA, Mechanic-Hamilton D, Morley JF, Duda JE, Grossman M, Cousins KAQ

• Automated analysis of lexical features in frontotemporal degeneration.
  Cortex; a journal devoted to the study of the nervous system and behavior. 2021 Apr;137:215-231 Epub 2021 Feb 6; Authors: Cho S, Nevler N, Ash S, Shellikeri S, Irwin DJ, Massimo L, Rascovsky K, Olm C, Grossman M, Liberman M

• Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration.
  Neurology. Clinical practice. 2021 Apr;11(2):105-116; Authors: Zhang JV, Irwin DJ, Blennow K, Zetterberg H, Lee EB, Shaw LM, Rascovsky K, Massimo L, McMillan CT, Chen-Plotkin A, Elman L, Lee VM, McCluskey L, Toledo JB, Weintraub D, Wolk D, Trojanowski JQ, Grossman M

• Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection.
  Antioxidants (Basel, Switzerland). 2021 Mar 9;10(3); Authors: Garcia-Mesa Y, Xu HN, Vance P, Gruenewald AL, Garza R, Midkiff C, Alvarez-Hernandez X, Irwin DJ, Gill AJ, Kolson DL

• Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology.
  Acta neuropathologica communications. 2021 Feb 23;9(1):30; Authors: Giannini LAA, Peterson C, Ohm D, Xie SX, McMillan CT, Raskovsky K, Massimo L, Suh E, Van Deerlin VM, Wolk DA, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ

• Lexical and Acoustic Characteristics of Young and Older Healthy Adults.
  Journal of speech, language, and hearing research : JSLHR. 2021 Feb 17;64(2):302-314 Epub 2021 Jan 13; Authors: Cho S, Nevler N, Shellikeri S, Parjane N, Irwin DJ, Ryant N, Ash S, Cieri C, Liberman M, Grossman M

• Cross-sectional and longitudinal medial temporal lobe subregional atrophy patterns in semantic variant primary progressive aphasia.
  Neurobiology of aging. 2021 Feb;98:231-241 Epub 2020 Nov 23; Authors: Wisse LEM, Ungrady MB, Ittyerah R, Lim SA, Yushkevich PA, Wolk DA, Irwin DJ, Das SR, Grossman M

• More Than Words: Extra-Sylvian Neuroanatomic Networks Support Indirect Speech Act Comprehension and Discourse in Behavioral Variant Frontotemporal Dementia.
  Frontiers in human neuroscience. 2020;14:598131 Epub 2021 Jan 14; Authors: Healey M, Howard E, Ungrady M, Olm CA, Nevler N, Irwin DJ, Grossman M

• Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis.
  EMBO molecular medicine. 2021 Jan 11;13(1):e12595 Epub 2020 Dec 3; Authors: Placek K, Benatar M, Wuu J, Rampersaud E, Hennessy L, Van Deerlin VM, Grossman M, Irwin DJ, Elman L, McCluskey L, Quinn C, Granit V, Statland JM, Burns TM, Ravits J, Swenson A, Katz J, Pioro EP, Jackson C, Caress J, So Y, Maiser S, Walk D, Lee EB, Trojanowski JQ, Cook P, Gee J, Sha J, Naj AC, Rademakers R, CReATe Consortium, Chen W, Wu G, Paul Taylor J, McMillan CT

• Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes.
  Journal of Alzheimer's disease : JAD. 2021;82(1):33-45; Authors: Parjane N, Cho S, Ash S, Cousins KAQ, Shellikeri S, Liberman M, Shaw LM, Irwin DJ, Grossman M, Nevler N

• Biomarker Use for Dementia With Lewy Body Diagnosis: Survey of US Experts.
  Alzheimer disease and associated disorders. 2021 Jan-Mar 01;35(1):55-61; Authors: Armstrong MJ, Irwin DJ, Leverenz JB, Gamez N, Taylor A, Galvin JE

• Brain volumetric deficits in MAPT mutation carriers: a multisite study.
  Annals of clinical and translational neurology. 2021 Jan;8(1):95-110 Epub 2020 Nov 28; Authors: Chu SA, Flagan TM, Staffaroni AM, Jiskoot LC, Deng J, Spina S, Zhang L, Sturm VE, Yokoyama JS, Seeley WW, Papma JM, Geschwind DH, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Forsberg LK, Brushaber DE, Grossman M, Coppola G, Dickerson BC, Bordelon YM, Faber K, Feldman HH, Fields JA, Fong JC, Foroud T, Gavrilova RH, Ghoshal N, Graff-Radford NR, Hsiung GR, Huey ED, Irwin DJ, Kantarci K, Kaufer DI, Karydas AM, Knopman DS, Kornak J, Kramer JH, Kukull WA, Lapid MI, Litvan I, Mackenzie IRA, Mendez MF, Miller BL, Onyike CU, Pantelyat AY, Rademakers R, Marisa Ramos E, Roberson ED, Carmela Tartaglia M, Tatton NA, Toga AW, Vetor A, Weintraub S, Wong B, Wszolek ZK, ARTFL/LEFFTDS Consortium, Van Swieten JC, Lee SE

• Alzheimer disease biomarker profiles in dementia with Lewy bodies: Does A plus T spell D-L-B?
  Neurology. 2020 Dec 15;95(24):1076-1077 Epub 2020 Sep 28; Authors: Koyama AK, Irwin DJ

• Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.
  Neuropathology and applied neurobiology. 2020 Dec;46(7):707-721 Epub 2020 Sep 24; Authors: Coughlin DG, Ittyerah R, Peterson C, Phillips JS, Miller S, Rascovsky K, Weintraub D, Siderowf AD, Duda JE, Hurtig HI, Wolk DA, McMillan CT, Yushkevich PA, Grossman M, Lee EB, Trojanowski JQ, Irwin DJ

• Clinical Conditions "Suggestive of Progressive Supranuclear Palsy"-Diagnostic Performance.
  Movement disorders : official journal of the Movement Disorder Society. 2020 Dec;35(12):2301-2313 Epub 2020 Sep 11; Authors: Grimm MJ, Respondek G, Stamelou M, Arzberger T, Ferguson L, Gelpi E, Giese A, Grossman M, Irwin DJ, Pantelyat A, Rajput A, Roeber S, van Swieten JC, Troakes C, Meissner WG, Nilsson C, Piot I, Compta Y, Rowe JB, Höglinger GU, Movement Disorder Society-Endorsed PSP Study Group

• Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.
  Neurobiology of aging. 2020 Dec;96:137-147 Epub 2020 Aug 21; Authors: Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT, Alzheimer’s Disease Neuroimaging Initiative

• Tau pathology associates with in vivo cortical thinning in Lewy body disorders.
  Annals of clinical and translational neurology. 2020 Dec;7(12):2342-2355 Epub 2020 Oct 27; Authors: Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, Weintraub D, Grossman M, Irwin DJ

• Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau.
  Science (New York, N.Y.). 2020 Nov 20;370(6519) Epub 2020 Oct 1; Authors: Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, Irwin DJ, McMillan CT, Nasrallah IM, Toro C, Aguirre GK, Van Deerlin VM, Lee EB

• Automated analysis of lexical features in Frontotemporal Degeneration.
  medRxiv : the preprint server for health sciences. 2020 Nov 4; Authors: Cho S, Nevler N, Ash S, Shellikeri S, Irwin DJ, Massimo L, Rascovsky K, Olm C, Grossman M, Liberman M

• An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline.
  Nature communications. 2020 Nov 2;11(1):5522; Authors: Trzeciakiewicz H, Ajit D, Tseng JH, Chen Y, Ajit A, Tabassum Z, Lobrovich R, Peterson C, Riddick NV, Itano MS, Tripathy A, Moy SS, Lee VMY, Trojanowski JQ, Irwin DJ, Cohen TJ

• Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum.
  Acta neuropathologica. 2020 Nov;140(5):675-693 Epub 2020 Aug 17; Authors: Ohm DT, Peterson C, Lobrovich R, Cousins KAQ, Gibbons GS, McMillan CT, Wolk DA, Van Deerlin V, Elman L, Spindler M, Deik A, Siderowf A, Trojanowski JQ, Lee EB, Grossman M, Irwin DJ

• Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials.
  Alzheimer's research & therapy. 2020 Oct 29;12(1):137; Authors: Goldman JG, Forsberg LK, Boeve BF, Armstrong MJ, Irwin DJ, Ferman TJ, Galasko D, Galvin JE, Kaufer D, Leverenz J, Lippa CF, Marder K, Abler V, Biglan K, Irizarry M, Keller B, Munsie L, Nakagawa M, Taylor A, Graham T

• Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders.
  Neurology. 2020 Sep 22;95(12):e1629-e1639 Epub 2020 Jul 16; Authors: Nevler N, Ash S, McMillan C, Elman L, McCluskey L, Irwin DJ, Cho S, Liberman M, Grossman M

• Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression.
  Journal of virology. 2020 Sep 15;94(19); Authors: Garcia-Mesa Y, Garza R, Diaz Ortiz ME, Gruenewald AL, Bastien BL, Lobrovich R, Irwin DJ, Betts MR, Silvestri G, Kolson DL

• Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease.
  Annals of neurology. 2020 Sep;88(3):574-587 Epub 2020 Jul 2; Authors: Irwin DJ, Fedler J, Coffey CS, Caspell-Garcia C, Kang JH, Simuni T, Foroud T, Toga AW, Tanner CM, Kieburtz K, Chahine LM, Reimer A, Hutten S, Weintraub D, Mollenhauer B, Galasko DR, Siderowf A, Marek K, Trojanowski JQ, Shaw LM, Parkinson's Progression Marker Initiative

• Distribution patterns of tau pathology in progressive supranuclear palsy.
  Acta neuropathologica. 2020 Aug;140(2):99-119 Epub 2020 May 7; Authors: Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU

• Defining and predicting transdiagnostic categories of neurodegenerative disease.
  Nature biomedical engineering. 2020 Aug;4(8):787-800 Epub 2020 Aug 3; Authors: Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS

• The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.
  iScience. 2020 Jul 24;23(7):101255 Epub 2020 Jun 10; Authors: Wander CM, Tseng JH, Song S, Al Housseiny HA, Tart DS, Ajit A, Ian Shih YY, Lobrovich R, Song J, Meeker RB, Irwin DJ, Cohen TJ

• Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes.
  JAMA neurology. 2020 Jul 1;77(7):829-839; Authors: Fleisher AS, Pontecorvo MJ, Devous MD Sr, Lu M, Arora AK, Truocchio SP, Aldea P, Flitter M, Locascio T, Devine M, Siderowf A, Beach TG, Montine TJ, Serrano GE, Curtis C, Perrin A, Salloway S, Daniel M, Wellman C, Joshi AD, Irwin DJ, Lowe VJ, Seeley WW, Ikonomovic MD, Masdeu JC, Kennedy I, Harris T, Navitsky M, Southekal S, Mintun MA, A16 Study Investigators

• ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration.
  Brain : a journal of neurology. 2020 Jul 1;143(7):2295-2311; Authors: Cousins KAQ, Irwin DJ, Wolk DA, Lee EB, Shaw LMJ, Trojanowski JQ, Da Re F, Gibbons GS, Grossman M, Phillips JS

• Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Jun;16(6):843-852 Epub 2020 Apr 22; Authors: de Flores R, Wisse LEM, Das SR, Xie L, McMillan CT, Trojanowski JQ, Robinson JL, Grossman M, Lee E, Irwin DJ, Yushkevich PA, Wolk DA

• Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease.
  Brain : a journal of neurology. 2020 May 1;143(5):1572-1587; Authors: Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE

• Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD.
  Journal of neuropathology and experimental neurology. 2020 Mar 1;79(3):296-304; Authors: Robinson JL, Yan N, Caswell C, Xie SX, Suh E, Van Deerlin VM, Gibbons G, Irwin DJ, Grossman M, Lee EB, Lee VM, Miller B, Trojanowski JQ

• Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
  The Lancet. Neurology. 2020 Feb;19(2):145-156 Epub 2019 Dec 3; Authors: Moore KM, Nicholas J, Grossman M, McMillan CT, Irwin DJ, Massimo L, Van Deerlin VM, Warren JD, Fox NC, Rossor MN, Mead S, Bocchetta M, Boeve BF, Knopman DS, Graff-Radford NR, Forsberg LK, Rademakers R, Wszolek ZK, van Swieten JC, Jiskoot LC, Meeter LH, Dopper EG, Papma JM, Snowden JS, Saxon J, Jones M, Pickering-Brown S, Le Ber I, Camuzat A, Brice A, Caroppo P, Ghidoni R, Pievani M, Benussi L, Binetti G, Dickerson BC, Lucente D, Krivensky S, Graff C, Öijerstedt L, Fallström M, Thonberg H, Ghoshal N, Morris JC, Borroni B, Benussi A, Padovani A, Galimberti D, Scarpini E, Fumagalli GG, Mackenzie IR, Hsiung GR, Sengdy P, Boxer AL, Rosen H, Taylor JB, Synofzik M, Wilke C, Sulzer P, Hodges JR, Halliday G, Kwok J, Sanchez-Valle R, Lladó A, Borrego-Ecija S, Santana I, Almeida MR, Tábuas-Pereira M, Moreno F, Barandiaran M, Indakoetxea B, Levin J, Danek A, Rowe JB, Cope TE, Otto M, Anderl-Straub S, de Mendonça A, Maruta C, Masellis M, Black SE, Couratier P, Lautrette G, Huey ED, Sorbi S, Nacmias B, Laforce R Jr, Tremblay ML, Vandenberghe R, Damme PV, Rogalski EJ, Weintraub S, Gerhard A, Onyike CU, Ducharme S, Papageorgiou SG, Ng ASL, Brodtmann A, Finger E, Guerreiro R, Bras J, Rohrer JD, FTD Prevention Initiative

• Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Jan;16(1):37-48 Epub 2020 Jan 6; Authors: Staffaroni AM, Cobigo Y, Goh SM, Kornak J, Bajorek L, Chiang K, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dever R, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Heuer HW, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kramer JH, Kremers WK, Kukull WA, Litvan I, Ljubenkov PA, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Rosen HJ, ARTFL/LEFFTDS consortium

• Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies.
  Movement disorders : official journal of the Movement Disorder Society. 2020 Jan;35(1):171-176 Epub 2019 Sep 30; Authors: Respondek G, Grimm MJ, Piot I, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Roeber S, Giese A, Grossman M, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Höglinger GU, Movement Disorder Society-Endorsed Progressive Supranuclear Palsy Study Group

• Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases.
  Movement disorders : official journal of the Movement Disorder Society. 2020 Jan;35(1):5-19 Epub 2019 Oct 29; Authors: Coughlin DG, Hurtig HI, Irwin DJ

• Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Jan;16(1):49-59 Epub 2020 Jan 6; Authors: Olney NT, Ong E, Goh SM, Bajorek L, Dever R, Staffaroni AM, Cobigo Y, Bock M, Chiang K, Ljubenkov P, Kornak J, Heuer HW, Wang P, Rascovsky K, Wolf A, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dickerson BC, Dickinson S, Domoto-Reilly K, Faber K, Ferrall J, Fields J, Fishman A, Fong J, Foroud T, Forsberg LK, Gearhart DJ, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford NR, Grant I, Grossman M, Haley D, Hsiung G, Huey ED, Irwin DJ, Jones DT, Kantarci K, Karydas AM, Kaufer D, Kerwin D, Knopman DS, Kramer JH, Kraft R, Kremers W, Kukull W, Lapid MI, Litvan I, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley EC, Mendez MF, Miller BL, Onyike C, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wong B, Wszolek Z, Boxer AL, Boeve BF, Rosen HJ, ARTFL and LEFFTDS consortia

• Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.
  Brain : a journal of neurology. 2020 Jan 1;143(1):191-209; Authors: Gourmaud S, Shou H, Irwin DJ, Sansalone K, Jacobs LM, Lucas TH, Marsh ED, Davis KA, Jensen FE, Talos DM

• Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2020 Jan;16(1):11-21; Authors: Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kremers WK, Kukull WA, Litvan I, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Kramer JH, Rosen HJ, ARTFL/LEFFTDS consortium

• Neuropathological Validation of Cerebrospinal Fluid Biomarkers in Neurodegenerative Diseases.
  The journal of applied laboratory medicine. 2019 Dec 6; Authors: Irwin DJ

• Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies.
  Radiology. 2019 Dec;293(3):646-653 Epub 2019 Oct 15; Authors: Spotorno N, Hall S, Irwin DJ, Rumetshofer T, Acosta-Cabronero J, Deik AF, Spindler MA, Lee EB, Trojanowski JQ, van Westen D, Nilsson M, Grossman M, Nestor PJ, McMillan CT, Hansson O

• Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers.
  Neurobiology of aging. 2019 Nov;83:54-62 Epub 2019 Aug 15; Authors: Chen Q, Boeve BF, Schwarz CG, Reid R, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova RH, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford NR, Grossman M, Haley D, Heuer HW, Hsiung GR, Huey E, Irwin DJ, Jack CR, Jones DT, Jones L, Karydas AM, Knopman DS, Kornak J, Kramer J, Kremers W, Kukull WA, Lapid M, Lucente D, Lungu C, Mackenzie IRA, Manoochehri M, McGinnis S, Miller BL, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Sengdy P, Shaw L, Syrjanen J, Tatton N, Taylor J, Toga AW, Trojanowski J, Weintraub S, Wong B, Boxer AL, Rosen H, Wszolek Z, Kantarci K, LEFFTDS Consortium

• Genetic predictors of survival in behavioral variant frontotemporal degeneration.
  Neurology. 2019 Oct 29;93(18):e1707-e1714 Epub 2019 Sep 19; Authors: Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM

• Cognitive and Neuroanatomic Accounts of Referential Communication in Focal Dementia.
  eNeuro. 2019 Sep/Oct;6(5) Epub 2019 Sep 26; Authors: Healey M, Spotorno N, Olm C, Irwin DJ, Grossman M

• Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia.
  Journal of neurology, neurosurgery, and psychiatry. 2019 Sep;90(9):997-1004 Epub 2019 May 23; Authors: Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija S, Diehl-Schmid J, Grimmer T, Goldhardt O, Santillo AF, Hansson O, Vestberg S, Borroni B, Padovani A, Galimberti D, Scarpini E, Rohrer JD, Woollacott IOC, Synofzik M, Wilke C, de Mendonca A, Vandenberghe R, Benussi L, Ghidoni R, Binetti G, Niessen WJ, Papma JM, Seelaar H, Jiskoot LC, de Jong FJ, Donker Kaat L, Del Campo M, Teunissen CE, Bron EE, Van den Berg E, Van Swieten JC

• How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy.
  Movement disorders : official journal of the Movement Disorder Society. 2019 Aug;34(8):1228-1232 Epub 2019 Mar 18; Authors: Grimm MJ, Respondek G, Stamelou M, Arzberger T, Ferguson L, Gelpi E, Giese A, Grossman M, Irwin DJ, Pantelyat A, Rajput A, Roeber S, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Colosimo C, van Eimeren T, Kassubek J, Levin J, Meissner WG, Nilsson C, Oertel WH, Piot I, Poewe W, Wenning GK, Boxer A, Golbe LI, Josephs KA, Litvan I, Morris HR, Whitwell JL, Compta Y, Corvol JC, Lang AE, Rowe JB, Höglinger GU, Movement Disorder Society-endorsed PSP Study Group

• Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration.
  Frontiers in neuroscience. 2019;13:682 Epub 2019 Jul 3; Authors: Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ

• A longitudinal study of speech production in primary progressive aphasia and behavioral variant frontotemporal dementia.
  Brain and language. 2019 Jul;194:46-57 Epub 2019 May 7; Authors: Ash S, Nevler N, Phillips J, Irwin DJ, McMillan CT, Rascovsky K, Grossman M

• Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.
  Acta neuropathologica. 2019 Jun;137(6):879-899 Epub 2019 Feb 9; Authors: Pottier C, Ren Y, Perkerson RB 3rd, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL 3rd, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R

• Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer's disease.
  Brain : a journal of neurology. 2019 Jun 1;142(6):1701-1722; Authors: Phillips JS, Da Re F, Irwin DJ, McMillan CT, Vaishnavi SN, Xie SX, Lee EB, Cook PA, Gee JC, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M

• Clinical Correlates of Alzheimer's Disease Cerebrospinal Fluid Analytes in Primary Progressive Aphasia.
  Frontiers in neurology. 2019;10:485 Epub 2019 May 10; Authors: Norise C, Ungrady M, Halpin A, Jester C, McMillan CT, Irwin DJ, Cousins KA, Grossman M

• Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.
  Annals of neurology. 2019 May;85(5):630-643 Epub 2019 Mar 28; Authors: Giannini LAA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ

• Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration.
  Frontiers in neuroscience. 2019;13:298 Epub 2019 Apr 4; Authors: Kim BJ, Grossman M, Song D, Saludades S, Pan W, Dominguez-Perez S, Dunaief JL, Aleman TS, Ying GS, Irwin DJ

• Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau).
  Acta neuropathologica communications. 2019 Mar 4;7(1):34; Authors: Gibbons GS, Kim SJ, Robinson JL, Changolkar L, Irwin DJ, Shaw LM, Lee VM, Trojanowski JQ

• Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders.
  JAMA neurology. 2019 Mar 1;76(3):318-325; Authors: Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K

• Occupational attainment influences longitudinal decline in behavioral variant frontotemporal degeneration.
  Brain imaging and behavior. 2019 Feb;13(1):293-301; Authors: Massimo L, Xie SX, Rennert L, Fick DM, Halpin A, Placek K, Williams A, Rascovsky K, Irwin DJ, Grossman M, McMillan CT

• Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD.
  Journal of neurology, neurosurgery, and psychiatry. 2019 Feb;90(2):180-186 Epub 2018 Oct 8; Authors: Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A

• Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.
  Annals of neurology. 2019 Feb;85(2):259-271 Epub 2019 Jan 7; Authors: Coughlin D, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig HI, Branch Coslett H, Hamilton RH, Siderowf AD, Duda JE, Rascovsky K, Lee EB, Lee VM, Grossman M, Trojanowski JQ, Irwin DJ

• Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2019 Jan;15(1):55-64 Epub 2018 Oct 12; Authors: Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, Kostanjevecki V, Vandijck M, McBride J, Trojanowski JQ, Blennow K

• UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis.
  Neurobiology of aging. 2019 Jan;73:190-199 Epub 2018 Sep 27; Authors: Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT

• Validated automatic speech biomarkers in primary progressive aphasia.
  Annals of clinical and translational neurology. 2019 Jan;6(1):4-14 Epub 2018 Nov 24; Authors: Nevler N, Ash S, Irwin DJ, Liberman M, Grossman M

• Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.
  Journal of neuropathology and experimental neurology. 2018 Nov 1;77(11):1005-1016; Authors: Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ

• Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.
  Annals of neurology. 2018 Nov;84(5):729-740; Authors: Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Kristensen N, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R

• Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology.
  Acta neuropathologica. 2018 Sep;136(3):363-376 Epub 2018 Apr 26; Authors: Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, Elman L, McBride J, Toledo JB, Trojanowski JQ, Blennow K

• Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2018 Aug;14(8):1052-1062 Epub 2018 Mar 28; Authors: Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, Shaw LM, Trojanowski JQ, Zhang J

• Perfusion alterations converge with patterns of pathological spread in transactive response DNA-binding protein 43 proteinopathies.
  Neurobiology of aging. 2018 Aug;68:85-92 Epub 2018 Apr 17; Authors: Ferraro PM, Jester C, Olm CA, Placek K, Agosta F, Elman L, McCluskey L, Irwin DJ, Detre JA, Filippi M, Grossman M, McMillan CT

• Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.
  Brain : a journal of neurology. 2018 Jul 1;141(7):2181-2193; Authors: Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, Duda JE, Irwin DJ, Wolk D, Elman L, McCluskey L, Chen-Plotkin A, Weintraub D, Arnold SE, Brettschneider J, Lee VM, Trojanowski JQ

• A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes.
  JAMA neurology. 2018 Jun 1;75(6):738-745; Authors: Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M

• Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
  The Lancet. Neurology. 2018 Jun;17(6):548-558 Epub 2018 Apr 30; Authors: Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL 3rd, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R

• Primary Progressive Aphasia and Stroke Aphasia.
  Continuum (Minneapolis, Minn.). 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):745-767; Authors: Grossman M, Irwin DJ

• Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers.
  NeuroImage. Clinical. 2018;19:497-506 Epub 2018 May 15; Authors: Olm CA, McMillan CT, Irwin DJ, Van Deerlin VM, Cook PA, Gee JC, Grossman M

• CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.
  Neurology. 2018 Mar 20;90(12):e1038-e1046 Epub 2018 Feb 21; Authors: Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ

• Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.
  Brain pathology (Zurich, Switzerland). 2018 Mar;28(2):274-283 Epub 2017 Jan 19; Authors: Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ

• Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease.
  Neurobiology of aging. 2018 Mar;63:75-87 Epub 2017 Nov 21; Authors: Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M

• Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.
  Journal of neuropathology and experimental neurology. 2018 Mar 1;77(3):216-228; Authors: Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY

• Zonisamide for DLB parkinsonism: An old drug used in a new context.
  Neurology. 2018 Feb 20;90(8):349-350 Epub 2018 Jan 24; Authors: Hershey LA, Irwin DJ

• Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease.
  Human brain mapping. 2018 Feb;39(2):691-708 Epub 2017 Nov 6; Authors: Phillips JS, Das SR, McMillan CT, Irwin DJ, Roll EE, Da Re F, Nasrallah IM, Wolk DA, Grossman M

• Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia.
  Brain : a journal of neurology. 2018 Jan 1;141(1):288-301; Authors: Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre GK, Lee EB, Lee VMY, Trojanowski JQ, Grossman M

• The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders.
  Journal of Alzheimer's disease & Parkinsonism. 2018;8(4) Epub 2018 Aug 10; Authors: Irwin DJ, Hurtig HI

• Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration.
  Neurology. 2017 Oct 10;89(15):1604-1611 Epub 2017 Sep 8; Authors: Kim BJ, Irwin DJ, Song D, Daniel E, Leveque JD, Raquib AR, Pan W, Ying GS, Aleman TS, Dunaief JL, Grossman M

• Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.
  Acta neuropathologica communications. 2017 Sep 6;5(1):68; Authors: Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ

• Emerging Diagnostic and Therapeutic Strategies for Tauopathies.
  Current neurology and neuroscience reports. 2017 Sep;17(9):72; Authors: Coughlin D, Irwin DJ

• Automatic measurement of prosody in behavioral variant FTD.
  Neurology. 2017 Aug 15;89(7):650-656 Epub 2017 Jul 19; Authors: Nevler N, Ash S, Jester C, Irwin DJ, Liberman M, Grossman M

• Longitudinal decline in speech production in Parkinson's disease spectrum disorders.
  Brain and language. 2017 Aug;171:42-51 Epub 2017 May 17; Authors: Ash S, Jester C, York C, Kofman OL, Langey R, Halpin A, Firn K, Dominguez Perez S, Chahine L, Spindler M, Dahodwala N, Irwin DJ, McMillan C, Weintraub D, Grossman M

• Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration.
  Annals of neurology. 2017 Aug;82(2):247-258 Epub 2017 Aug 19; Authors: Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M

• Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration.
  Acta neuropathologica. 2017 Jul;134(1):65-78 Epub 2017 Jan 27; Authors: Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ

• Which ante mortem clinical features predict progressive supranuclear palsy pathology?
  Movement disorders : official journal of the Movement Disorder Society. 2017 Jul;32(7):995-1005 Epub 2017 May 13; Authors: Respondek G, Kurz C, Arzberger T, Compta Y, Englund E, Ferguson LW, Gelpi E, Giese A, Irwin DJ, Meissner WG, Nilsson C, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Whitwell JL, Antonini A, Bhatia KP, Bordelon Y, Corvol JC, Colosimo C, Dodel R, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris H, Nestor P, Oertel WH, Rabinovici GD, Rowe JB, van Eimeren T, Wenning GK, Boxer A, Golbe LI, Litvan I, Stamelou M, Höglinger GU, Movement Disorder Society-Endorsed PSP Study Group

• Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).
  Journal of neuropathology and experimental neurology. 2017 Jul 1;76(7):605-619; Authors: Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ

• Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia.
  Frontiers in neuroscience. 2017;11:330 Epub 2017 Jun 14; Authors: Win KT, Pluta J, Yushkevich P, Irwin DJ, McMillan CT, Rascovsky K, Wolk D, Grossman M

• Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.
  Neurology. 2017 Jun 13;88(24):2276-2284 Epub 2017 May 17; Authors: Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M

• Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.
  Neuropathology and applied neurobiology. 2017 Jun;43(4):315-329 Epub 2016 Oct 18; Authors: Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, Trojanowski JQ

• Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria.
  Movement disorders : official journal of the Movement Disorder Society. 2017 Jun;32(6):853-864 Epub 2017 May 3; Authors: Höglinger GU, Respondek G, Stamelou M, Kurz C, Josephs KA, Lang AE, Mollenhauer B, Müller U, Nilsson C, Whitwell JL, Arzberger T, Englund E, Gelpi E, Giese A, Irwin DJ, Meissner WG, Pantelyat A, Rajput A, van Swieten JC, Troakes C, Antonini A, Bhatia KP, Bordelon Y, Compta Y, Corvol JC, Colosimo C, Dickson DW, Dodel R, Ferguson L, Grossman M, Kassubek J, Krismer F, Levin J, Lorenzl S, Morris HR, Nestor P, Oertel WH, Poewe W, Rabinovici G, Rowe JB, Schellenberg GD, Seppi K, van Eimeren T, Wenning GK, Boxer AL, Golbe LI, Litvan I, Movement Disorder Society-endorsed PSP Study Group

• Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases.
  Journal of neuropathology and experimental neurology. 2017 Apr 1;76(4):270-288; Authors: Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ

• Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology.
  Frontiers in neuroscience. 2017;11:53 Epub 2017 Feb 8; Authors: Grossman M, Irwin DJ, Jester C, Halpin A, Ash S, Rascovsky K, Weintraub D, McMillan CT

• Dissociable substrates underlie the production of abstract and concrete nouns.
  Brain and language. 2017 Feb;165:45-54 Epub 2016 Nov 29; Authors: Cousins KA, Ash S, Irwin DJ, Grossman M

• Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders.
  Frontiers in human neuroscience. 2016;10:693 Epub 2017 Jan 11; Authors: Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M

• Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.
  The Lancet. Neurology. 2017 Jan;16(1):55-65; Authors: Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ

• Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration.
  Acta neuropathologica. 2016 Dec;132(6):935-937 Epub 2016 Nov 4; Authors: McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M

• Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome.
  Neurology. 2016 Sep 20;87(12):1227-34 Epub 2016 Aug 19; Authors: McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M

• Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease.
  Neuropsychologia. 2016 Aug;89:141-152 Epub 2016 Jun 11; Authors: Ash S, Ternes K, Bisbing T, Min NE, Moran E, York C, McMillan CT, Irwin DJ, Grossman M

• CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study.
  Acta neuropathologica. 2016 Jun;131(6):935-49 Epub 2016 Mar 28; Authors: Kang JH, Mollenhauer B, Coffey CS, Toledo JB, Weintraub D, Galasko DR, Irwin DJ, Van Deerlin V, Chen-Plotkin AS, Caspell-Garcia C, Waligórska T, Taylor P, Shah N, Pan S, Zero P, Frasier M, Marek K, Kieburtz K, Jennings D, Tanner CM, Simuni T, Singleton A, Toga AW, Chowdhury S, Trojanowski JQ, Shaw LM, Parkinson’s Progression Marker Initiative

• The Mental Status Examination in Patients With Suspected Dementia.
  Continuum (Minneapolis, Minn.). 2016 Apr;22(2 Dementia):385-403; Authors: Grossman M, Irwin DJ

• Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.
  Acta neuropathologica. 2016 Mar;131(3):393-409 Epub 2015 Dec 31; Authors: Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, Adler CH, Beach TG, Trojanowski JQ

• Deep clinical and neuropathological phenotyping of Pick disease.
  Annals of neurology. 2016 Feb;79(2):272-87 Epub 2015 Dec 25; Authors: Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ

• Tauopathies as clinicopathological entities.
  Parkinsonism & related disorders. 2016 Jan;22 Suppl 1(0 1):S29-33 Epub 2015 Sep 8; Authors: Irwin DJ

• Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2016 Jan;64(1):54-66 Epub 2015 Nov 4; Authors: Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ

• Apathy in Frontotemporal Degeneration: Neuroanatomical Evidence of Impaired Goal-directed Behavior.
  Frontiers in human neuroscience. 2015;9:611 Epub 2015 Nov 10; Authors: Massimo L, Powers JP, Evans LK, McMillan CT, Rascovsky K, Eslinger P, Ersek M, Irwin DJ, Grossman M

• Processing ambiguity in a linguistic context: decision-making difficulties in non-aphasic patients with behavioral variant frontotemporal degeneration.
  Frontiers in human neuroscience. 2015;9:583 Epub 2015 Oct 27; Authors: Spotorno N, Healey M, McMillan CT, Rascovsky K, Irwin DJ, Clark R, Grossman M

• Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration.
  Acta neuropathologica. 2015 Sep;130(3):363-72 Epub 2015 May 29; Authors: Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM

• Beyond words: Pragmatic inference in behavioral variant of frontotemporal degeneration.
  Neuropsychologia. 2015 Aug;75:556-64 Epub 2015 Jul 4; Authors: Spotorno N, McMillan CT, Rascovsky K, Irwin DJ, Clark R, Grossman M

• Estimating frontal and parietal involvement in cognitive estimation: a study of focal neurodegenerative diseases.
  Frontiers in human neuroscience. 2015;9:317 Epub 2015 Jun 4; Authors: Bisbing TA, Olm CA, McMillan CT, Rascovsky K, Baehr L, Ternes K, Irwin DJ, Clark R, Grossman M

• Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).
  Acta neuropathologica. 2015 Jun;129(6):929; Authors: Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ

• The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.
  The Psychiatric clinics of North America. 2015 Jun;38(2):309-22 Epub 2015 Mar 18; Authors: Kansal K, Irwin DJ

• Occupational attainment influences survival in autopsy-confirmed frontotemporal degeneration.
  Neurology. 2015 May 19;84(20):2070-5 Epub 2015 Apr 22; Authors: Massimo L, Zee J, Xie SX, McMillan CT, Rascovsky K, Irwin DJ, Kolanowski A, Grossman M

• C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence.
  Neurology. 2015 Apr 21;84(16):1622-30 Epub 2015 Mar 20; Authors: McMillan CT, Russ J, Wood EM, Irwin DJ, Grossman M, McCluskey L, Elman L, Van Deerlin V, Lee EB

• Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.
  Acta neuropathologica. 2015 Apr;129(4):469-91 Epub 2014 Dec 31; Authors: Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ

• Deficits in sentence expression in amyotrophic lateral sclerosis.
  Amyotrophic lateral sclerosis & frontotemporal degeneration. 2015 Mar;16(1-2):31-9 Epub 2014 Dec 8; Authors: Ash S, Olm C, McMillan CT, Boller A, Irwin DJ, McCluskey L, Elman L, Grossman M

• Getting on the same page: the neural basis for social coordination deficits in behavioral variant frontotemporal degeneration.
  Neuropsychologia. 2015 Mar;69:56-66 Epub 2015 Jan 22; Authors: Healey ML, McMillan CT, Golob S, Spotorno N, Rascovsky K, Irwin DJ, Clark R, Grossman M

• Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier.
  Acta neuropathologica. 2015 Jan;129(1):39-52 Epub 2014 Nov 12; Authors: Russ J, Liu EY, Wu K, Neal D, Suh E, Irwin DJ, McMillan CT, Harms MB, Cairns NJ, Wood EM, Xie SX, Elman L, McCluskey L, Grossman M, Van Deerlin VM, Lee EB

• C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD.
  Acta neuropathologica. 2014 Oct;128(4):525-41 Epub 2014 May 8; Authors: Liu EY, Russ J, Wu K, Neal D, Suh E, McNally AG, Irwin DJ, Van Deerlin VM, Lee EB

• A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis.
  Acta neuropathologica. 2014 Oct;128(4):543-50 Epub 2014 Jun 12; Authors: Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ

• TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord.
  Acta neuropathologica. 2014 Sep;128(3):423-37 Epub 2014 Jun 12; Authors: Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, Braak H, Trojanowski JQ

• Narrative discourse deficits in amyotrophic lateral sclerosis.
  Neurology. 2014 Aug 5;83(6):520-8 Epub 2014 Jul 2; Authors: Ash S, Menaged A, Olm C, McMillan CT, Boller A, Irwin DJ, McCluskey L, Elman L, Grossman M

• Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.
  Neurology. 2014 Aug 5;83(6):502-9 Epub 2014 Jul 3; Authors: Irwin DJ, McMillan CT, Suh E, Powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee VM, Van Deerlin VM, Trojanowski JQ, Grossman M

• A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank.
  Alzheimer's & dementia : the journal of the Alzheimer's Association. 2014 Jul;10(4):477-484.e1 Epub 2013 Aug 24; Authors: Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, Karlawish J, Schellenberg G, Chen-Plotkin A, Wolk D, Grossman M, Arnold SE, Shaw LM, Lee VM, Trojanowski JQ

• Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration.
  Neurobiology of aging. 2014 Jun;35(6):1473-82 Epub 2013 Dec 2; Authors: McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh E, Irwin DJ, Powers J, Olm C, Elman L, McCluskey L, Schellenberg GD, Lee VM, Trojanowski JQ, Van Deerlin VM, Grossman M

• Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis.
  JAMA neurology. 2014 Apr;71(4):442-8; Authors: Grossman M, Elman L, McCluskey L, McMillan CT, Boller A, Powers J, Rascovsky K, Hu W, Shaw L, Irwin DJ, Lee VM, Trojanowski JQ

• Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.
  Acta neuropathologica communications. 2014 Mar 31;2:33; Authors: Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM

• Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.
  Journal of neurology, neurosurgery, and psychiatry. 2014 Mar;85(3):249-56 Epub 2013 Sep 13; Authors: Charles D, Olm C, Powers J, Ash S, Irwin DJ, McMillan CT, Rascovsky K, Grossman M

• Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD).
  Acta neuropathologica. 2014 Mar;127(3):423-439 Epub 2014 Jan 10; Authors: Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ

• Development and validation of pedigree classification criteria for frontotemporal lobar degeneration.
  JAMA neurology. 2013 Nov;70(11):1411-7; Authors: Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie SX, Van Deerlin VM, Grossman M

• Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease.
  JAMA neurology. 2013 Oct;70(10):1277-87; Authors: Kang JH, Irwin DJ, Chen-Plotkin AS, Siderowf A, Caspell C, Coffey CS, Waligórska T, Taylor P, Pan S, Frasier M, Marek K, Kieburtz K, Jennings D, Simuni T, Tanner CM, Singleton A, Toga AW, Chowdhury S, Mollenhauer B, Trojanowski JQ, Shaw LM, Parkinson's Progression Markers Initiative

• White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration.
  Journal of neurology, neurosurgery, and psychiatry. 2013 Sep;84(9):949-55 Epub 2013 Mar 9; Authors: McMillan CT, Irwin DJ, Avants BB, Powers J, Cook PA, Toledo JB, McCarty Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ, Grossman M

• Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.
  Nature reviews. Neuroscience. 2013 Sep;14(9):626-36 Epub 2013 Jul 31; Authors: Irwin DJ, Lee VM, Trojanowski JQ

• Comparative semantic profiles in semantic dementia and Alzheimer's disease.
  Brain : a journal of neurology. 2013 Aug;136(Pt 8):2497-509 Epub 2013 Jul 3; Authors: Libon DJ, Rascovsky K, Powers J, Irwin DJ, Boller A, Weinberg D, McMillan CT, Grossman M

• Many roads to Parkinson's disease neurodegeneration: head trauma-a road more traveled than we know?
  Movement disorders : official journal of the Movement Disorder Society. 2013 Aug;28(9):1167-70 Epub 2013 Jul 8; Authors: Irwin DJ, Trojanowski JQ

• Acetylated tau neuropathology in sporadic and hereditary tauopathies.
  The American journal of pathology. 2013 Aug;183(2):344-51; Authors: Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ

• Differentiating primary progressive aphasias in a brief sample of connected speech.
  Neurology. 2013 Jul 23;81(4):329-36 Epub 2013 Jun 21; Authors: Ash S, Evans E, O'Shea J, Powers J, Boller A, Weinberg D, Haley J, McMillan C, Irwin DJ, Rascovsky K, Grossman M

• Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.
  Annals of neurology. 2013 Jul;74(1):20-38 Epub 2013 Jun 19; Authors: Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, Feldengut S, Ludolph AC, Lee VM, Braak H, Trojanowski JQ

• Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.
  JAMA neurology. 2013 Apr;70(4):462-8; Authors: Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ

• Cerebrospinal fluid biomarkers for differentiation of frontotemporal lobar degeneration from Alzheimer's disease.
  Frontiers in aging neuroscience. 2013;5:6 Epub 2013 Feb 21; Authors: Irwin DJ, Trojanowski JQ, Grossman M

• Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis.
  Journal of neurology, neurosurgery, and psychiatry. 2013 Feb;84(2):163-9 Epub 2012 Oct 31; Authors: Irwin DJ, McMillan CT, Brettschneider J, Libon DJ, Powers J, Rascovsky K, Toledo JB, Boller A, Bekisz J, Chandrasekaran K, Wood EM, Shaw LM, Woo JH, Cook PA, Wolk DA, Arnold SE, Van Deerlin VM, McCluskey LF, Elman L, Lee VM, Trojanowski JQ, Grossman M

• APOE ε4 increases risk for dementia in pure synucleinopathies.
  JAMA neurology. 2013 Feb;70(2):223-8; Authors: Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP

• Can MRI screen for CSF biomarkers in neurodegenerative disease?
  Neurology. 2013 Jan 8;80(2):132-8 Epub 2012 Dec 26; Authors: McMillan CT, Avants B, Irwin DJ, Toledo JB, Wolk DA, Van Deerlin VM, Shaw LM, Trojanoswki JQ, Grossman M

• The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012.
  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2012 Oct 4;17(40):20292; Authors: Pebody RG, Chand MA, Thomas HL, Green HK, Boddington NL, Carvalho C, Brown CS, Anderson SR, Rooney C, Crawley-Boevey E, Irwin DJ, Aarons E, Tong C, Newsholme W, Price N, Langrish C, Tucker D, Zhao H, Phin N, Crofts J, Bermingham A, Gilgunn-Jones E, Brown KE, Evans B, Catchpole M, Watson JM

• Neuropathologic substrates of Parkinson disease dementia.
  Annals of neurology. 2012 Oct;72(4):587-98 Epub 2012 Oct 4; Authors: Irwin DJ, White MT, Toledo JB, Xie SX, Robinson JL, Van Deerlin V, Lee VM, Leverenz JB, Montine TJ, Duda JE, Hurtig HI, Trojanowski JQ

• Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms.
  Archives of neurology. 2012 Aug;69(8):1018-25; Authors: Irwin DJ, McMillan CT, Toledo JB, Arnold SE, Shaw LM, Wang LS, Van Deerlin V, Lee VM, Trojanowski JQ, Grossman M

• Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
  Acta neuropathologica. 2012 Jun;123(6):825-39 Epub 2012 Mar 18; Authors: Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, Trojanowski JQ

• Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies.
  Brain : a journal of neurology. 2012 Mar;135(Pt 3):807-18; Authors: Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VM, Trojanowski JQ

• Complex regional pain syndrome with associated chest wall dystonia: a case report.
  Journal of brachial plexus and peripheral nerve injury. 2011 Sep 26;6:6; Authors: Irwin DJ, Schwartzman RJ

• Purification of peroxidase from Horseradish (Armoracia rusticana) roots.
  Journal of agricultural and food chemistry. 2010 Aug 11;58(15):8471-6; Authors: Lavery CB, Macinnis MC, Macdonald MJ, Williams JB, Spencer CA, Burke AA, Irwin DJ, D'Cunha GB

• Infection control failures in a dental surgery--dilemmas in incident management.
  Journal of public health (Oxford, England). 2007 Sep;29(3):303-7 Epub 2007 Jun 22; Authors: Millership SE, Cummins AJ, Irwin DJ

• Description of an HIV patient notification exercise in Essex involving a dental healthcare worker.
  Communicable disease and public health. 2002 Dec;5(4):276-81; Authors: Irwin DJ, Millership S

• Disposal of syringes, needles, and lancets used by diabetic patients in North East Essex.
  Communicable disease and public health. 2002 Jun;5(2):134-7; Authors: Crawshaw G, Irwin DJ, Button J

• Antibody responses to Hepatitis A vaccine in healthy adults.
  Communicable disease and public health. 2001 Jun;4(2):139-40; Authors: Irwin DJ, Millership S

• Carriage of Neisseria meningitidis in residents and staff at a residential home for elderly people following a case of invasive disease.
  Communicable disease and public health. 2000 Sep;3(3):172-4; Authors: Irwin DJ, Crawshaw JG, Readman RA, Teare L, Kaczmarski EB

• Basis of rabies virus neurovirulence in mice: expression of major histocompatibility complex class I and class II mRNAs.
  Journal of neurovirology. 1999 Oct;5(5):485-94; Authors: Irwin DJ, Wunner WH, Ertl HC, Jackson AC

• Control of a community hepatitis A outbreak using hepatitis A vaccine.
  Communicable disease and public health. 1999 Sep;2(3):184-7; Authors: Irwin DJ, Millership S

• Screening child playgroup contacts of an adult with smear negative tuberculosis.
  Communicable disease and public health. 1998 Dec;1(4):283-4; Authors: Millership S, Roberts CM, Irwin DJ

• Sustained reduction in the carriage of Neisseria meningitidis as a result of a community meningococcal disease control programme.
  Epidemiology and infection. 1998 Dec;121(3):487-93; Authors: Neal KR, Irwin DJ, Davies S, Kaczmarski EB, Wale MC

• A case of invasive serogroup C meningococcal disease after a community vaccination programme in Rotherham, South Yorkshire.
  Journal of public health medicine. 1998 Mar;20(1):112-4; Authors: Irwin DJ, Kaczmarski EB, Miller JM

• Community immunization programme in response to an outbreak of invasive Neisseria meningitidis serogroup C infection in the Trent region of England 1995-1996.
  Journal of public health medicine. 1997 Jun;19(2):162-70; Authors: Irwin DJ, Miller JM, Milner PC, Patterson T, Richards RG, Williams DA, Insley CA, Stuart JM

• An outbreak of infection with Salmonella enteritidis phage type 4 associated with the use of raw shell eggs.
  Communicable disease report. CDR review. 1993 Dec 3;3(13):R179-83; Authors: Irwin DJ, Rao M, Barham DW, Pencheon DC, Lofts C, Jones PH, O'Mahony M, Soltanpoor N, Ward LR, Threlfall EJ

• Lumbar puncture in acute bacterial meningitis.
  BMJ (Clinical research ed.). 1993 Feb 20;306(6876):517; Authors: Irwin DJ