Active Clinical Trials
The Cardiac Electrophysiology Program at HUP is among the most active arrhythmia research centers in the world, including a robust portfolio of both sponsored research and investigator initiated studies. Below is a selection of active sponsored arrhythmia clinical trials. If you would like to learn more about the studies listed here, you can contact Mary Gnap, RN - Research Project Manager (mary.gnap@uphs.upenn.edu).
Atrial Fibrillation Studies
AMULET - AMPLATZER™ Amulet™ Left Atrial Appendage Occluder
Sponsor: Abbott Medical
PI: Pasquale Santangeli, MD, PhD
ARTESiA: Apixaban for the Reduction of Thrombro-embolism in Patients with Device Detected Sub-clinical Atrial Fibrillation
Sponsor: Population Health Research Institute
PI: David Frankel, MD
CATCH-AF: Catheter Ablation vs. Medical Therapy in Congested Hearts with AF
Sponsor: Cleveland Clinic
PI: Gregory Supple, MD
DECAAF II: Efficacy of DE-MRI-Guided Ablation vs. Conventional Catheter Ablation of Atrial Fibrillation
Sponsor: University of Utah
PI: Saman Nazarian, MD, PhD
OAT: Safety of Oral Anticoagulation Therapy Withdrawal after Successful PVI
Sponsor: Biosense Webster
PI: Michael Riley, MD, PhD
PRECISION: NavX Mapping System Registry
Sponsor: Abbott Medical
PI: David Lin, MD
RE-DO FIRM: Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation with Focal Impulse and Rotor Modulation Guided Procedures
Sponsor: Abbott Medical
PI: David Callans, MD
Ventricular Tachycardia Studies
LAST VT: Location of Ablation to Stop VT
Sponsor: CardioSolv
PI: David Callans, MD
EASYER: EpiAccess SYstEm Registry
Sponsor: Epi Access, Inc.
PI: David Callans, MD
BIPOLAR VT: Bipolar Catheter Ablation for the Treatment of Refractory Scar-related Ventricular Arrhythmia
Sponsor: Biosense Webster, Inc.
PI: Pasquale Santangeli, MD, PhD
eMAP: Advanced Phenotyping in Non-Ischemic Cardiomyopathy
Sponsor: Biosense Webster, Inc.
PI: David Frankel, MD & Francis Marchlinski, MD
Unique EP Characteristics of Ventricular Tachycardia
Sponsor: NIH / University of Massachusetts
PI: David Callans, MD
Device Studies
JAVA CRT: Junctional AV Ablation in CRT-D patients with Atrial Fibrillation
Sponsor: University of Rochester
PI: Robert Schaller, DO
SMART-CRT: Strategic Management to Optimize Response To Cardiac Resynchronization Therapy
Sponsor: Boston Scientific
PI: Robert Schaller, DO
ADAPT: Adapt Response Study
Sponsor: Medtronic
PI: David Frankel, MD