Active Clinical Trials

The Cardiac Electrophysiology Program at HUP is among the most active arrhythmia research centers in the world, including a robust portfolio of both sponsored research and investigator initiated studies. Below is a selection of active sponsored arrhythmia clinical trials. If you would like to learn more about the studies listed here, you can contact Mary Gnap, RN - Research Project Manager (

Atrial Fibrillation Studies

AMULET - AMPLATZER™ Amulet™ Left Atrial Appendage Occluder 

Sponsor: Abbott Medical

PI: Pasquale Santangeli, MD, PhD

ARTESiA: Apixaban for the Reduction of Thrombro-embolism in Patients with Device Detected Sub-clinical Atrial Fibrillation 

Sponsor: Population Health Research Institute

PI: David Frankel, MD

CATCH-AF: Catheter Ablation vs. Medical Therapy in Congested Hearts with AF 

Sponsor: Cleveland Clinic

PI: Gregory Supple, MD

DECAAF II: Efficacy of DE-MRI-Guided Ablation vs. Conventional Catheter Ablation of Atrial Fibrillation

Sponsor: University of Utah

PI: Saman Nazarian, MD, PhD

OAT: Safety of Oral Anticoagulation Therapy Withdrawal after Successful PVI

Sponsor: Biosense Webster

PI: Michael Riley, MD, PhD

PRECISION: NavX Mapping System Registry

Sponsor: Abbott Medical

PI: David Lin, MD

RE-DO FIRM: Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation with Focal Impulse and Rotor Modulation Guided Procedures

Sponsor: Abbott Medical

PI: David Callans, MD

​Ventricular Tachycardia Studies

​LAST VT: Location of Ablation to Stop VT

Sponsor: CardioSolv

PI: David Callans, MD

EASYER: EpiAccess SYstEm Registry 

Sponsor: Epi Access, Inc.

PI: David Callans, MD

BIPOLAR VT: Bipolar Catheter Ablation for the Treatment of Refractory Scar-related Ventricular Arrhythmia

Sponsor: Biosense Webster, Inc.

PI: Pasquale Santangeli, MD, PhD

eMAP: Advanced Phenotyping in Non-Ischemic Cardiomyopathy

Sponsor: Biosense Webster, Inc.

PI: David Frankel, MD & Francis Marchlinski, MD

Unique EP Characteristics of Ventricular Tachycardia

Sponsor: NIH / University of Massachusetts 

PI: David Callans, MD

​Device Studies

JAVA CRT: Junctional AV Ablation in CRT-D patients with Atrial Fibrillation

Sponsor: University of Rochester 

PI: Robert Schaller, DO

SMART-CRT: Strategic Management to Optimize Response To Cardiac Resynchronization Therapy

Sponsor: Boston Scientific

PI: Robert Schaller, DO

ADAPT: Adapt Response Study

Sponsor: Medtronic

PI: David Frankel, MD