Record Number of Scientific Contributions

Since 1999 the Penn EP team has published over 1200 original research studies, editorials, reviews, and clinical guideline documents that have advanced the field of cardiac electrophysiology

405 Original Peer-reviewed Scientific Studies
361 Editorials, Reviews, Chapters, and Case Reports
31 Guidelines and Consensus Documents
485 Scientific Abstracts


Download 1999-2017 Penn EP Publication List


Highlighted Recent Publications

​Atrial Fibrillation

  1. ​Patel PJ, Katz R, Borovskiy Y, Killian A, Levine JM, McNaughton NW, Callans D, Supple G, Dixit S, Epstein AE, Marchlinski FE, Deo R.  Race and Stroke in an Atrial Fibrillation Inception Cohort:  Findings from the Penn Atrial Fibrillation Free Study.  Heart Rhythm. 2018 Apr;15(4):487-493. This study demonstrated that although African Americans have a lower incidence of atrial fibrillation than Caucasians, atrial fibrillation is a stronger risk factor for stroke. Click here for more information.
  2. Marchlinski FE, Santangeli P.  When Does High Risk for Stroke Become Low Risk after Atrial Fibrillation Ablation.  JAMA Cardiol. 2017 Feb 1;2(2):152-154. This article highlights the lowering of risk of stroke with successful atrial fibrillation allowing some patients to stop anticoagulants while they remain vigilant for AFib recurrence. Click here for more information.
  3. Santangeli S, Marchlinski FE.  Techniques for the Provocation, Localization and Ablation of Non-Pulmonary Vein Triggers for Atrial Fibrillation. Heart Rhythm. 2017 Jul;14(7):1087-1096. The article described techniques for pinpointing triggers for atrial fibrillation that are outside the pulmonary veins. Click here for more information.

​Ventricular Tachycardia

  1. ​Liang JJ, Yang W, Santangeli P, Schaller RD, Supple GE, Hutchinson MD, Garcia F, Lin D, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Frankel DS. Amiodarone discontinuation or dose reduction following catheter ablation for ventricular tachycardia in structural heart disease. JACC Clinical Electrophysiol. 2017 May;3(5):503-511. This study shows the dramatic benefit for eliminating or reducing the need for antiarrhythmic medications. Click here for more information.
  2. Santangeli P, Rame, EJ, Birati EY, Marchlinski FE. Management of Ventricular Arrhythmias in Patients with Advanced Heart Failure. J Am Coll Cardiol. 2017 Apr 11;69(14):1842-1860. This article published in the Journal of the American College of Cardiology provides a detailed review of all the critical issues important in optimizing outcome in patients with ventricular arrhythmias in the setting of advanced heart failure. Click here for more information.
  3. Tschabrunn CM, Haqqani HM, Santangeli P, Zado ES, Marchlinski FE. 12-lead Electrocardiogram to Localize Region of Abnormal Electroanatomic Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy. JACC Clinical Electrophysiol. 2017 Jul;3(7):654-665. This article provides new ECG criteria for localizing the anatomic area of scar in the right ventricle in patients with arrhythmogenic right ventricular cardiomyopathy. Click here for more information.
  4. Enriquez A, Supple GE, Marchlinski FE, Garcia FC.  How to Map and Ablate Papillary Muscle Ventricular Arrhythmias.  Heart Rhythm 2017. Nov;14(11):1721-1728. This landmark article highlights the best approach to pinpointing and ablating complex ventricular arrhythmias that originate from the muscle bundles that support the tricuspid and mitral valves.  It emphasizes integration of imaging and electrical recordings to achieve best outcome. Click here for more information.
  5. Muser D, Santangeli P, Liang JJ, Castro SA, Magnani S, Hayashi T, Garcis FC, Frankel DS, Dixit S, Zado ES, Lin D, Desjardins B, Callans DJ, Alavi A, Marchlinski FE.  Characterization of the Electroanatomic Substrate in Cardiac Sarcoidosis: Correlation with Imaging Findings of Scar and Inflammation. JACC: Clinical Electrophysiol. 2018 Mar;4(3):291-303. This article provides a detailed portrayal of the electrical and imaging characteristics for patients with VT in the setting of sarcoidosis. Click here for more information.

Device Therapy

  1. ​Sadek MM, Cooper JM, Frankel DS, Santangeli P, Epstein AE, Marchlinski FE, Schaller RD.  Utility of Intracardiac Echocardiography During Transvenous Lead Extraction. Heart Rhythm. 2017 Dec;14(12):1779-1785. Patients are frequently sent to Penn for help in removing broken or infected device leads. Directly imaging of the leads and the heart with catheter-based echocardiography during the extraction procedure improves safety and efficacy. Click here for more information.
  2. Frankel DS, Burke MC, Callans DJ, Stivland TM, Duffy E, Epstein AE. Impact of body mass index on safety and efficacy of the subcutaneous implantable cardioverter-defibrillator.  JACC: Clinical Electrophysiol. 2018 Feb [In-Press]. The article describes the impact of body size on the effectiveness of the subcutaneous defibrillator device and highlights the facts that extreme increases in weight may prevent appropriate device function and may require careful device repositioning and additional testing. Click here for more information.