Publications

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Recent Publications

• Ortiz EA, Campbell PD, Nelson JC, Granato M. A single base pair substitution on Chromosome 25 in zebrafish distinguishes between development and acute regulation of behavioral thresholds. bioRxiv [Preprint]. 2023 Aug 26:2023.08.25.554673. doi: 10.1101/2023.08.25.554673. Update in: PLoS One. 2024 Mar 18;19(3):e0300529. PMID: 37662318; PMCID: PMC10473726.

• Meserve JH, Navarro MF, Ortiz EA, Granato M. Celsr3 drives development and connectivity of the acoustic startle hindbrain circuit. bioRxiv [Preprint]. 2024 Mar 7:2024.03.07.583806. doi: 10.1101/2024.03.07.583806. PMID: 38496637; PMCID: PMC10942420.

• Lamiré LA, Haesemeyer M, Engert F, Granato M, Randlett O. Functional and pharmacological analyses of visual habituation learning in larval zebrafish. Elife. 2023 Dec 18;12:RP84926. doi: 10.7554/eLife.84926. PMID: 38108818; PMCID: PMC10727501.

• Campbell PD, Lee I, Thyme S, Granato M. Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Mol Psychiatry. 2023 Oct 4. doi: 10.1038/s41380-023-02272-z. Epub ahead of print. PMID: 37794116.

• Walker LJ, Guevara C, Kawakami K, Granato M. Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus. PLoS Biol. 2023 Aug 17;21(8):e3002223. doi: 10.1371/journal.pbio.3002223. Epub ahead of print. PMID: 37590333.

• Nelson JC, Shoenhard H, Granato M. Integration of cooperative and opposing molecular programs drives learning-associated behavioral plasticity. PLoS Genet. 2023 Mar 27;19(3):e1010650. doi: 10.1371/journal.pgen.1010650. Epub ahead of print. PMID: 36972301.

• Harvey BM, Baxter M, Granato M. Assaying Optic Nerve Regeneration in Larval Zebrafish. Methods Mol Biol. 2023;2636:191-203. doi: 10.1007/978-1-0716-3012-9_10. PMID: 36881301.

• Shoenhard H, Granato M. Multivariate analysis of variegated expression in Neurons: A strategy for unbiased localization of gene function to candidate brain regions in larval zebrafish. PLoS One. 2023 Feb 14;18(2):e0281609. doi: 10.1371/journal.pone.0281609. PMID: 36787331; PMCID: PMC9928119.

• Walker LJ, Guevara C, Kawakami K, Granato M. A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration. bioRxiv [Preprint]. 2023 Jan 5:2023.01.05.522786. doi: 10.1101/2023.01.05.522786. PMID: 36712008; PMCID: PMC9881934.

• Campbell PD, Lee I, Thyme S, Granato M. Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation. bioRxiv [Preprint]. 2023 Jan 3:2023.01.03.522615. doi: 10.1101/2023.01.03.522615. PMID: 36711666; PMCID: PMC9881859.

• Shoenhard H, Jain RA, Granato M. The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons. Cell Rep. 2022 Dec 6;41(10):111790. doi: 10.1016/j.celrep.2022.111790. PMID: 36476852; PMCID: PMC9813870.

• Santistevan NJ, Nelson JC, Ortiz EA, Miller AH, Kenj Halabi D, Sippl ZA, Granato M, Grinblat Y. cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold. PLoS One. 2022 Jul 14;17(7):e0270903. doi: 10.1371/journal.pone.0270903. PMID: 35834485; PMCID: PMC9282658.

• Nelson JC, Granato M. Zebrafish behavior as a gateway to nervous system assembly and plasticity. Development. 2022 May 1;149(9):dev177998. doi: 10.1242/dev.177998. Epub 2022 May 12. PMID: 35552393.
• Murphy PL, Isaacman-Beck J, Granato M. Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals. J Neurosci. 2022 Feb 2;42(5):762-776. doi: 10.1523/JNEUROSCI.1528-21.2021. Epub 2021 Dec 16. PMID: 34916258; PMCID: PMC8808733. 
• Walker LJ, Roque RA, Navarro MF, Granato M. Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle. Development. 2021 Nov 1;148(21):dev199790. doi: 10.1242/dev.199790. Epub 2021 Oct 29. PMID: 34714331; PMCID: PMC8602948. 
• Madden ME, Suminaite D, Ortiz E, Early JJ, Koudelka S, Livesey MR, Bianco IH, Granato M, Lyons DA. CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish. J Neurosci. 2021 Nov 3;41(44):9099-9111. doi: 10.1523/JNEUROSCI.0842-21.2021. Epub 2021 Sep 20. PMID: 34544838; PMCID: PMC8570833. 
• Meserve JH, Nelson JC, Marsden KC, Hsu J, Echeverry FA, Jain RA, Wolman MA, Pereda AE, Granato M. (2021) A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1. 17(6):e1008943.
• Madden ME, Suminaite D, Ortiz E, Early JE, Koudelka S, Livesey MR, Bianco IH, Granato M, Lyons DA. (2021). Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval Zebrafish. Journal of Neuroscience  0842-21.2021.
• Nelson, J. C, Witze, E., Ma, Z., Ciocco, F. , Frerotte A, Randlett, O., Foskett,  J. K., Granato, M. (2020). Acute regulation of habituation learning via posttranslational palmitoylation. S0960-9822(20)30655-2.
• Walker, L. D., & Granato M.(2020). Vagus Topographic maps: wandering through a gRAdient. Developmental Cell 53. 53(3):257-258.
• Campbell, P.D. & Granato, M. (2020). Zebrafish as a tool to study schizophrenia- associated copy number variants. Disease Models and Mechanisms. dmm043877. doi:10.1242/dmm.043877.
• Harvey, B. M., Baxter, M., & Granato, M. (2019). Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting. PloS one, 14(6), e0218667.
• Bremer, J., Marsden, K. C., Miller, A., & Granato, M. (2019). The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology, 2(1), 195.
• Randlett, O., Haesemeyer, M., Forkin, G., Shoenhard, H., Schier, A. F., Engert, F., & Granato, M. (2019). Distributed plasticity drives visual habituation learning in larval zebrafish. Current Biology, 29(8), 1337-1345.
• Ducommun Priest M, Navarro MF, Bremer J, Granato M. 2019. Dynein promotes sustained axonal growth and Schwann cell remodelling early during peripheral nerve regeneration
• Jain, R. A. Jain, Wolman M.A., Marsden K.C. Nelson J.C., Shoenhard, H., Echeverry F.A., Christina Szi, C., Bell, H., Skinner, J., Cobbs E.N., Sawada, K., Zamora, A, Pereda, A.E., Granato, M. 2018. A forward genetic screen identifies the G-protein coupled receptor CaSR as a regulator of sensorimotor decision making. Current Biology. .
• Marsden, K.C., Jain , R.A , Wolman, M.A., Echeverry^{, F.A.,} , Nelson^{, J.C,}, Hayer, K.E., Miltenberg, Pereda, A.E., Granato, M. A Cyfip2-dependent excitatory interneuron pathway establishes the innate startle threshold. Cell Reports. .
• Bremer, J., Skinner, J., Granato, M. 2017: A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoSOne e0178854.
• Miller, A.C, Whitebirch, A.C, Shah, A.N, Marsden, K.C, Granato, M, O'Brien, J, Moens C.B. 2017. A genetic basis for molecular asymmetry at vertebrate electrical synapses. Elife. pii: e25364. 
• Bremer, J. and Granato, M. (2016) Myosin phosphatase fine-tunes zebrafish motoneuron position during axonogenesis. PloS Genetics, e1006440.
• Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. 2016: Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene CNTNAP2. Neuron. 17;89(4):725-33.
• Remédio L, Gribble KD, Lee JK, Kim N, Hallock PT, Delestrée N, Mentis GZ, Froemke RC, Granato M, Burden SJ. 2016: Divergent roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes Dev. 30(9):1058-69.
• Marsden, K.C. & Granato, M. 2015: In vivo Ca imaging reveals that decreased dentritic excitability drives startle habituation. Cell Reports 13, 1733-40.
• Isaacman-Beck, J., Schneider, V., Franzini-Armstrong, C, Granato, M. 2015: The lh3 glycosyltransferase directs target selective peripheral nerve regeneration. Neuron 88, 1-13. UPENN Press Release! Highlight in Nature Review Neuroscience.
• Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. 2015: A genome-wide screen identifies PAPP-AA mediated IGFR signaling as a novel regulator of habituation learning. Neuron 85 1200-11. Read the preview by Ardie and Rankin. See the UPenn Press Release! about this publication.
• Banerjee, S., Hayer, K., Hogenesch, J., Granato, M. 2015: Zebrafish foxc1a drives appendage -specific neural circuit development. Development (142), 753-762.
• Rosenberg, A., Isaacman-Beck, J, Franzini-Armstrong, C, Granato, M.  2014: Schwann cells and DCC direct regenerating motor axons towards their original path. J. Neuroscience (44) 14668-81. This work is featured in 'This week in the Journal'. 
• Wolman, M.A., DeGroh, E., McBride, S.M., Jongens, T.A., Granato*, M., Epstein*, J.A. (*senior co-authors) 2014. Modulation of cAMP and Ras signaling pathways improve distinct behavioral deficits in a zebrafish model of Neurofibromatosis Type 1. Cell Reports 8, 2014.
• UPENN Press release
• Jain, RA., Bell, H., Lim A., Chien, C.B. and Granato, M. 2014. Mirror movement-like defects in startle behavior of zebrafish DCC mutants are caused by abberant midline guidance of identified descending hindbrain neurons. J. Neuroscience (34), 2898-2909.
• Sainath, R., Granato, M. 2013. Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish.
• Banerjee, S., Isaacman-Beck, J., Schneider, V., and Granato, M. 2013. A novel role for LH3 dependent ECM modifications during neural crest cell migration in zebrafish. 
• Gyda, M. Wolman, M., Lorent, K. and Granato, M. The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. 2012. PLoS Genetics e1003106. 
• Rosenberg, A., Wolman, M, Franzini-Armstrong, C, Granato, M. In vivo macrophage-nerve interactions following peripheral nerve injury. 2012. J. Neuroscience (32), 4440-56. Read a comment about the article.
• Gordon, L.R., Gribble, K.D., Syrett, C. M. & Granato, M. 2012 . Initiation of synapse formation by Wnt-induced MuSK endocytosis.
• Jain, R.A., Wolman, M. A., Schmidt, .LA., Burgess, H.A. & Granato, M. 2011. Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance. PLoS One. 
• Wolman, M. A., Jain, R.A., Liss, L. & Granato, M. 2011. Chemical modulation of memory formation in larval zebrafish PNAS.
• Banerjee, S., Gordon, L.R., Donn, T.M., Berti, C., Moens, C.B., Burden, S.J. and Granato, M. 2011. A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development.
• Burgess, H.A, Schoch, H., Granato, M. 2010. Distinct retinal pathways drive spatial orientation behaviors in zebrafish navigation. Current Biology.
• Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development.2010. Jing L, Gordon L.R, Shtibin E, Granato M. PLoS One. 22;5(1):e8843.
• Jing, L, Lefebvre, J., Gordon, L. and Granato, M. 2009. Wnt signals organize synaptic prepattern and axon guidance through the unplugged/MuSk receptor. Neuron.
• Burgess, H. A., Granato, M. 2008. The neurogenetic frontier-lessons from misbehaving zebrafish. Briefings in Functional Genomics and Proteomics, 7, 474-482.
• Lefebvre, J., Becaficco, S., Franzini-Armstrong, C. and Granato, M. 2007. Differential requirement for MuSK and Dystroglycan in generating patterns of neuromuscular innervation. PNAS.
• Burgess, H. A., Granato, M. 2007. Sensorimotor gating of the startle response in larval zebrafish. J. Neuroscience 
• Palaisa, K. A. , Granato, M. 2007. Analysis of zebrafish sidetracked mutants reveals a novel role for plexin-A3 in intraspinal motor axon guidance. Development, 134(18), 3251-7.
• Schneider, V. A. , Granato, M. 2006. The myotomal diwanka (lh3) glycosyltransferase and type VIII collagen are critical for motor growth cone migration. Neuron, 50, 1-13.
• Birely, J., Schneider, V. A., Santana, E., Dosch, R., Wagner, D. S., Mullins, M. C., Granato, M. 2005 Genetic screens for genes controlling nerve-muscle development and interactions. Developmental Biology, 280, 162-76.
• Zhang, J., Lefebvre, J. L, Zhao, S. and Granato, M. 2004. The zebrafish unplugged gene encodes a receptor tyrosine kinase essential for motor axon pathfinding. Nature Neuroscience, 7, 1303-1309
• Lefebvre, J. L. , Ono, F., Puglielli, C., Seidner, G., Brehm, P., Franzini-Armstrong, C. and Granato, M. 2004. Increased neuromuscular activity causes axonal defects and muscular Degeneration. Development 131, 2605-18.
• Rauch, G.J., Granato, M., Haffter, P. A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels. Technical Tips Online.
• (This is the original paper describing the WIK L11 line and using non-radioactive electrophoresis for CA repeat mapping).