Perelman School of Medicine at the University of Pennsylvania

Granato Lab

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All PubMed Articles click here

Recent Publications

Nelson JC, Granato M. Zebrafish behavior as a gateway to nervous system assembly and plasticity. Development. 2022 May 1;149(9):dev177998. doi: 10.1242/dev.177998. Epub 2022 May 12. PMID: 35552393. Click to read it here. 

Murphy PL, Isaacman-Beck J, Granato M. Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals. J Neurosci. 2022 Feb 2;42(5):762-776. doi: 10.1523/JNEUROSCI.1528-21.2021. Epub 2021 Dec 16. PMID: 34916258; PMCID: PMC8808733. Click to read it here

Walker LJ, Roque RA, Navarro MF, Granato M. Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle. Development. 2021 Nov 1;148(21):dev199790. doi: 10.1242/dev.199790. Epub 2021 Oct 29. PMID: 34714331; PMCID: PMC8602948. Click to read it here

Madden ME, Suminaite D, Ortiz E, Early JJ, Koudelka S, Livesey MR, Bianco IH, Granato M, Lyons DA. CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish. J Neurosci. 2021 Nov 3;41(44):9099-9111. doi: 10.1523/JNEUROSCI.0842-21.2021. Epub 2021 Sep 20. PMID: 34544838; PMCID: PMC8570833. Click to read it here

Meserve JH, Nelson JC, Marsden KC, Hsu J, Echeverry FA, Jain RA, Wolman MA, Pereda AE, Granato M. (2021) A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1. 17(6):e1008943. Click to read it here.

Madden ME, Suminaite D, Ortiz E, Early JE, Koudelka S, Livesey MR, Bianco IH, Granato M, Lyons DA. (2021). Central nervous system hypomyelination disrupts axonal conduction and behaviour in larval Zebrafish. Journal of Neuroscience  0842-21.2021. Click here to read it.

Nelson, J. C, Witze, E., Ma, Z., Ciocco, F. , Frerotte A, Randlett, O., Foskett,  J. K., Granato, M. (2020). Acute regulation of habituation learning via posttranslational palmitoylation. S0960-9822(20)30655-2. Click here to read it.

Walker, L. D., & Granato M.(2020). Vagus Topographic maps: wandering through a gRAdient. Developmental Cell 53. 53(3):257-258. Click here to read it.

Campbell, P.D. & Granato, M. (2020). Zebrafish as a tool to study schizophrenia- associated copy number variants. Disease Models and Mechanisms. dmm043877. doi:10.1242/dmm.043877. Click here to read it.

Harvey, B. M., Baxter, M., & Granato, M. (2019). Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting. PloS one14(6), e0218667. Click here to read it.

Bremer, J., Marsden, K. C., Miller, A., & Granato, M. (2019). The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology2(1), 195. Click here to read it.

Randlett, O., Haesemeyer, M., Forkin, G., Shoenhard, H., Schier, A. F., Engert, F., & Granato, M. (2019). Distributed plasticity drives visual habituation learning in larval zebrafish. Current Biology29(8), 1337-1345. Click here to read it.

Ducommun Priest M, Navarro MF, Bremer J, Granato M. 2019. Dynein promotes sustained axonal growth and Schwann cell remodelling early during peripheral nerve regeneration. Click here to read it. 

Jain, R. A. Jain, Wolman M.A., Marsden K.C. Nelson J.C., Shoenhard, H., Echeverry F.A., Christina Szi, C., Bell, H., Skinner, J., Cobbs E.N., Sawada, K., Zamora, A, Pereda, A.E., Granato, M. 2018. A forward genetic screen identifies the G-protein coupled receptor CaSR as a regulator of sensorimotor decision making. Current Biology. Click here to read it.

Marsden, K.C., Jain , R.A , Wolman, M.A., Echeverry, F.A., , Nelson, J.C,, Hayer, K.E., Miltenberg, Pereda, A.E., Granato, M. A Cyfip2-dependent excitatory interneuron pathway establishes the innate startle threshold. Cell ReportsClick here to read it.

Bremer, J., Skinner, J., Granato, M. 2017: A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoSOne e0178854. Click here to read it.

Miller, A.C, Whitebirch, A.C, Shah, A.N, Marsden, K.C, Granato, M, O'Brien, J, Moens C.B. 2017. A genetic basis for molecular asymmetry at vertebrate electrical synapses. Elife. pii: e25364. Click here to read it.

Bremer, J. and Granato, M. (2016)  Myosin phosphatase fine-tunes zebrafish motoneuron position during axonogenesis. PloS Genetics, e1006440 Click here to read it.

Hoffman EJ, Turner KJ, Fernandez JM, Cifuentes D, Ghosh M, Ijaz S, Jain RA, Kubo F, Bill BR, Baier H, Granato M, Barresi MJ, Wilson SW, Rihel J, State MW, Giraldez AJ. 2016: Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene CNTNAP2. Neuron. 17;89(4):725-33.

Remédio L, Gribble KD, Lee JK, Kim N, Hallock PT, Delestrée N, Mentis GZ, Froemke RC, Granato M, Burden SJ. 2016: Divergent roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes Dev. 30(9):1058-69. Click here to read it.

Marsden, K.C. & Granato, M. 2015: In vivo Ca imaging reveals that decreased dentritic excitability drives startle habituation. Cell Reports 13, 1733-40. Click here to read it.

Isaacman-Beck, J., Schneider, V., Franzini-Armstrong, C, Granato, M. 2015: The lh3 glycosyltransferase directs target selective peripheral nerve regeneration. Neuron 88, 1-13. Click here to read itUPENN Press ReleaseHighlight in Nature Review Neuroscience.

Wolman, M.A., Jain, R.A., Marsden, K.C., Bell, H., Skinner, J., Hayer, K.E., Hogenesch, J.B., Granato, M. 2015: A genome-wide screen identifies PAPP-AA mediated IGFR signaling as a novel regulator of habituation learning. Neuron 85 1200-11. Click here to read it. Preview by Ardie and Rankin. Click here to read itUPENN Press Release!

Banerjee, S., Hayer, K., Hogenesch, J., Granato, M. 2015: Zebrafish foxc1a drives appendage -specific neural circuit development. Development (142), 753-762. Click here to read it.

Rosenberg, A., Isaacman-Beck, J, Franzini-Armstrong, C, Granato, M. 2014: Schwann cells and DCC direct regenerating motor axons towards their original path. J. Neuroscience (44) 14668-81. Click here to read it. This work is featured in 'This week in the Journal'

Wolman, M.A., DeGroh, E., McBride, S.M., Jongens, T.A., Granato*, M., Epstein*, J.A. (*senior co-authors) 2014. Modulation of cAMP and Ras signaling pathways improve distinct behavioral deficits in a zebrafish model of Neurofibromatosis Type 1. Cell Reports 8, 2014. Click here to read it.
UPENN Press release

Jain, RA., Bell, H., Lim A., Chien, C.B. and Granato, M. 2014. Mirror movement-like defects in startle behavior of zebrafish DCC mutants are caused by abberant midline guidance of identified descending hindbrain neurons. J. Neuroscience (34), 2898-2909. Click here to read it.

Sainath, R., Granato, M. 2013. Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish. Click here to read it.

Banerjee, S., Isaacman-Beck, J., Schneider, V., and Granato, M. 2013. A novel role for LH3 dependent ECM modifications during neural crest cell migration in zebrafish. Click here to read it.

Gyda, M. Wolman, M., Lorent, K. and Granato, M. The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish. 2012. PLoS Genetics e1003106. Click here to read it.

Rosenberg, A., Wolman, M, Franzini-Armstrong, C, Granato, M. In vivo macrophage-nerve interactions following peripheral nerve injury. 2012. J. Neuroscience (32), 4440-56. Click here to read it and read a comment about the article.

Gordon, L.R., Gribble, K.D., Syrett, C. M. & Granato, M. 2012 . Initiation of synapse formation by Wnt-induced MuSK endocytosis. Click here to read it.

Jain, R.A., Wolman, M. A., Schmidt, .LA., Burgess, H.A. & Granato, M. 2011. Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance. PLoS OneClick here to read it. .

Wolman, M. A., Jain, R.A., Liss, L. & Granato, M. 2011. Chemical modulation of memory formation in larval zebrafish PNAS, Click here to read it

Banerjee, S., Gordon, L.R., Donn, T.M., Berti, C., Moens, C.B., Burden, S.J. and Granato, M. 2011. A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration. Development, Click here to read it

Burgess, H.A, Schoch, H., Granato, M. 2010. Distinct retinal pathways drive spatial orientation behaviors in zebrafish navigation. Current BiologyClick here to read it

Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development.2010. Jing L, Gordon L.R, Shtibin E, Granato M. PLoS One. 22;5(1):e8843.

Jing, L, Lefebvre, J., Gordon, L. and Granato, M. 2009. Wnt signals organize synaptic prepattern and axon guidance through the unplugged/MuSk receptor. Neuron Click here to read it.

Burgess, H. A., GranatoM2008. The neurogenetic frontier-lessons from misbehaving zebrafish. Briefings in Functional Genomics and Proteomics, 7, 474-482.

Lefebvre, J., Becaficco, S., Franzini-Armstrong, C. and Granato, M. 2007. Differential requirement for MuSK and Dystroglycan in generating patterns of neuromuscular innervation. PNAS,Click here to read it.

Burgess, H. A., Granato, M. 2007. Sensorimotor gating of the startle response in larval zebrafish. J. Neuroscience Click here to read it

Palaisa, K. A. , Granato, M. 2007. Analysis of zebrafish sidetracked mutants reveals a novel role for plexin-A3 in intraspinal motor axon guidance. Development, 134(18), 3251-7.

Schneider, V. A. , Granato, M. 2006. The myotomal diwanka (lh3) glycosyltransferase and type VIII collagen are critical for motor growth cone migration. Neuron, 50, 1-13.

Birely, J., Schneider, V. A., Santana, E., Dosch, R., Wagner, D. S., Mullins, M. C., Granato, M. 2005 Genetic screens for genes controlling nerve-muscle development and interactions. Developmental Biology, 280, 162-76.

Zhang, J., Lefebvre, J. L, Zhao, S. and Granato, M. 2004. The zebrafish unplugged gene encodes a receptor tyrosine kinase essential for motor axon pathfinding. Nature Neuroscience, 7, 1303-1309

Lefebvre, J. L. , Ono, F., Puglielli, C., Seidner, G., Brehm, P., Franzini-Armstrong, C. and Granato, M. 2004. Increased neuromuscular activity causes axonal defects and muscular Degeneration. Development 1312605-18.

Rauch, G.J., Granato, M., Haffter, P. A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels. Technical Tips Online.
(This is the original paper describing the WIK L11 line and using non-radioactive electrophoresis for CA repeat mapping).