Director Interventional Oncology, Abramson Cancer Center
Director of Research, Interventional Radiology
Vice Chair Clinical Trials Scientific Review and Monitoring Committee
Professor of Radiology at the Hospital of the University of Pennsylvania
Professor of Radiology in Surgery
Michael C. Soulen, MD FSIR FCIRSE is Professor of Radiology and Director of Interventional Oncology at the University of Pennsylvania Abramson Cancer Center and Director of Clinical Research in the Division of Interventional Radiology. His major clinical and research focus for the past 30 years has been image-guided cancer therapy (interventional oncology), with a specific focus on embolotherapy and ablative therapy of solid tumors in the liver and kidney. Animal research includes swine, rabbit, and rat models investigating novel embolic agents, novel ablation devices, and ultrasound-mediated drug delivery. Clinic trials focus on embolotherapies for primary liver cancers, liver metastases from colorectal and neuroendocrine tumors, and renal cell carcinomas. Current clinical investigations focus on synergy between locoregional and systemic therapies, including 1) pharmacologic modulation of the metabolic stress response under conditions of embolic ischemia; 2) embolization and ablation as immunostimulants combined with immune checkpoint inhibition, 3) radioembolization with radiosensitizing drugs; 4) biopsy for tumor cell culture, rapid drug screening, sequencing and testing in PDX mice, with the goal of personalized precision medicine; and 5) the first international randomized trial comparing embolotherapy techniques for neuroendocrine tumor liver metastases. Dr. Soulen received Research Mentor awards from the University of Pennsylvania Department of Radiology and the North American Neuroendocrine Tumor Society and the Gold Medal from the Society of Interventional Radiology.
Co-Director, Penn Image-Guided Interventions (PIGI) Laboratory
Chair, Interventional Radiology Resident Selection Committee
Associate Professor of Radiology at the Hospital of the University of Pennsylvania
My research and clinical interests include multimodality therapies for the treatment of hepatocellular carcinoma and liver dominant metastatic cancer.
I have initiated or participated in multiple clinical trials at the Hospital of the University of Pennsylvania for treating hepatocellular carcinoma and metastatic cancers to the liver. Several of these trials are multi-modality treatments in collaboration with other medical subspecialties. My other area of clinical and research interest is lymphatic injury, dysfunction, and malformations. Clinically, I perform thoracic duct embolization to treat chylothorax. I participate in research investigating novel lymphatic interventions to treat chylothorax, chylous ascites, refractory ascites and protein losing enteropathy. My clinical and research expertise center on lymphatic interventions and multimodality cancer therapies to treat primary and secondary liver tumors. I also conduct research on diseases of the liver such as treatment of portal hypertension and ascites.
Deepak Sudheendra, MD
Deepak Sudheendra, MD, RPVI (aka Dr. Sudi), is an Assistant Professor of Clinical Radiology & Surgery at the Hospital of the University of Pennsylvania. After graduating from Case Western Reserve University in 1996, he received his MD from New York Medical College in 2001. He then completed nearly a full general surgery residency at the Washington Hospital Center/Georgetown University before changing his field to Vascular Interventional Radiology (VIR). He went on to complete a Diagnostic Radiology residency at the University of Pittsburgh Medical Center followed by a fellowship in VIR at the George Washington University Medical Center under the direction of Dr. Anthony C. Venbrux. He is Board Certified in Diagnostic Radiology and Interventional Radiology and has additional certification as a Registered Physician in Vascular Interpretation (RPVI). He joined the faculty of Penn in 2011 and maintains a busy clinical practice that focuses on minimally invasive image-guided treatments for cancer, deep vein thrombosis (DVT), varicose veins, and peripheral vascular disease.