Perelman School of Medicine at the University of Pennsylvania

Penn PROMOTES Research on Sex and Gender in Health

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PCWBW Publications

Publications by Topic 

Sex Differences in Behavioral Health 

Bale TL, Epperson CN. Sex differences and stress across the lifespan. Nat Neurosci. 2015 Oct;18(10):1413-20. 
Goel N, Bale TL, Epperson CN, Kornstein SG, Leon GR, Palinkas LA, Stuster JW, Dinges DF. Effects of sex and gender on adaptation to space: behavioral health. JWomens Health (Larchmt). 2014 Nov;23(11):975-86. 
Epperson CN, Bale TL. BDNF Val66Met polymorphism and brain-derived neurotrophic factor levels across the female life span: implications for the sex bias in affective disorders. Biol Psychiatry. 2012 Sep 15;72(6):434-6. 
Epperson CN, Toll B, Wu R, Amin Z, Czarkowski KA, Jatlow P, Mazure CM, O'Malley SS. Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch. Drug Alcohol Depend. 2010 Nov 1;112(1-2):1-8. 

Menopause 

Smith AL, Hantsoo L, Malykhina AP, File DW, Valentino R, Wein AJ, Sammel MD, Epperson CN. Basal and stress-activated hypothalamic pituitary adrenal axisfunction in postmenopausal women with overactive bladder. Int Urogynecol J. 2016 Mar 4. [Epub ahead of print] 
Siegel AM, Mathews SB. Diagnosis and Treatment of Anxiety in the Aging Woman. Curr Psychiatry Rep. 2015 Dec;17(12):93.
Santoro N, Epperson CN, Mathews SB. Menopausal Symptoms and Their Management. Endocrinol Metab Clin North Am. 2015 Sep;44(3):497-515. 
Epperson CN, Shanmugan S, Kim DR, Mathews S, Czarkowski KA, Bradley J, Appleby DH, Iannelli C, Sammel MD, Brown TE. New onset executive function difficulties at menopause: a possible role for lisdexamfetamine. Psychopharmacology (Berl). 2015 Aug;232(16):3091-100. 
Epperson CN, Kim DR, Bale TL. Estradiol modulation of monoamine metabolism:one possible mechanism underlying sex differences in risk for depression and dementia. JAMA Psychiatry. 2014 Aug;71(8):869-70. 
Shanmugan S, Epperson CN. Estrogen and the prefrontal cortex: towards a new understanding of estrogen's effects on executive functions in the menopause transition. Hum Brain Mapp. 2014 Mar; 35(3):847-65. 
Epperson CN, Sammel MD, Freeman EW. Menopause effects on verbal memory: findings from a longitudinal community cohort. J Clin Endocrinol Metab. 2013Sep;98(9):3829-38. 
Epperson CN, Amin Z, Ruparel K, Gur R, Loughead J. Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women. Psychoneuroendocrinology. 2012 Mar;37(3):372-82.  
Epperson CN, Pittman B, Czarkowski KA, Bradley J, Quinlan DM, Brown TE. Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women. Menopause. 2011 May;18(5):542-8.

PMS/PMDD 

Hantsoo L, Epperson CN. Premenstrual Dysphoric Disorder: Epidemiology and Treatment. Curr Psychiatry Rep. 2015 Nov;17(11):87. 
Comasco E, Hahn A, Ganger S, Gingnell M, Bannbers E, Oreland L, Wikström J, Epperson CN, Lanzenberger R, Sundström-Poromaa I. Emotional fronto-cingulate cortex activation and brain derived neurotrophic factor polymorphism in premenstrual dysphoric disorder. Hum Brain Mapp. 2014 Sep;35(9):4450-8. 
Hantsoo L, Czarkowski KA, Child J, Howes C, Epperson CN. Selective serotonin reuptake inhibitors and endothelial function in women. J Womens Health (Larchmt). 2014 Jul;23(7):613-8. 
Nevatte T, O'Brien PM, Bäckström T, Brown C, Dennerstein L, Endicott J,Epperson CN, Eriksson E, Freeman EW, Halbreich U, Ismail K, Panay N, Pearlstein T, Rapkin A, Reid R, Rubinow D, Schmidt P, Steiner M, Studd J, Sundström-Poromaa I, Yonkers K; Consensus Group of the International Society for Premenstrual Disorders. ISPMD consensus on the management of premenstrual disorders. Arch Womens Ment Health. 2013 Aug;16(4):279-91.
Epperson CN. Premenstrual dysphoric disorder and the brain. Am J Psychiatry. 2013 Mar;170(3):248-52. 
Epperson CN, Steiner M, Hartlage SA, Eriksson E, Schmidt PJ, Jones I, Yonkers KA. Premenstrual dysphoric disorder: evidence for a new category for DSM-5. Am J Psychiatry. 2012 May;169(5):465-75. 
Kim DR, Czarkowski KA, Epperson CN. The relationship between bipolar disorder, seasonality, and premenstrual symptoms. Curr Psychiatry Rep. 2011 Dec;13(6):500-3. 
O'Brien PM, Bäckström T, Brown C, Dennerstein L, Endicott J, Epperson CN, Eriksson E, Freeman E, Halbreich U, Ismail KM, Panay N, Pearlstein T, Rapkin A, Reid R, Schmidt P, Steiner M, Studd J, Yonkers K. Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus. Arch Womens Ment Health. 2011 Feb;14(1):13-21. 

Pregnancy

Kim DR, Bale TL, Epperson CN. Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep. 2015 Feb;17(2):5. 
Kim DR, Hantsoo L, Thase ME, Sammel M, Epperson CN. Computer-assisted cognitive behavioral therapy for pregnant women with major depressive disorder. J Womens Health (Larchmt). 2014 Oct;23(10):842-8. 
Yonkers KA, Smith MV, Forray A, Epperson CN, Costello D, Lin H, Belanger K. Pregnant women with posttraumatic stress disorder and risk of preterm birth. JAMA Psychiatry. 2014 Aug;71(8):897-904. 
Sockol LE, Epperson CN, Barber JP. The relationship between maternal attitudes and symptoms of depression and anxiety among pregnant and postpartum first-time mothers. Arch Womens Ment Health. 2014 Jun;17(3):199-212.
Kornfield SL, Geller PA, Epperson CN. Maternal Fetal Attachment, Locus of Control and Adherence to STI/HIV Prevention and Prenatal Care Promotion Behaviors in Urban Women. Int J Gynecol Obstet Reprod Med Res. 2014;1(1):11-18. 
Kim DR, Sockol LE, Sammel MD, Kelly C, Moseley M, Epperson CN. Elevated risk of adverse obstetric outcomes in pregnant women with depression. Arch Womens MentHealth. 2013 Dec;16(6):475-82.
Hantsoo L, Epperson CN, Thase ME, Kim DR. Antepartum depression: treatment with computer-assisted cognitive-behavioral therapy. Am J Psychiatry. 2013 Aug;170(8):929-30. 
Gur TL, Kim DR, Epperson CN. Central nervous system effects of prenatal selective serotonin reuptake inhibitors: sensing the signal through the noise. Psychopharmacology (Berl). 2013 Jun;227(4):567-82. 
Sockol LE, Epperson CN, Barber JP. A meta-analysis of treatments for perinatal depression. Clin Psychol Rev. 2011 Jul;31(5):839-49.
Kim DR, Sockol L, Barber JP, Moseley M, Lamprou L, Rickels K, O'Reardon JP, Epperson CN. A survey of patient acceptability of repetitive transcranial magnetic stimulation (TMS) during pregnancy. J Affect Disord. 2011 Mar;129(1-3):385-90. 
Kim DR, Sockol L, Barber JP, Moseley M, Lamprou L, Rickels K, O'Reardon JP, Epperson CN. A survey of patient acceptability of repetitive transcranial magnetic stimulation (TMS) during pregnancy. J Affect Disord. 2011 Mar;129(1-3):385-90. 
Kim DR, O'Reardon JP, Epperson CN. Guidelines for the management of depression during pregnancy. Curr Psychiatry Rep. 2010 Aug;12(4):279-81. 

Postpartum 

Kim DR, Epperson CN, Weiss AR, Wisner KL. Pharmacotherapy of postpartum depression: an update. Expert Opin Pharmacother. 2014 Jun;15(9):1223-34.
Hantsoo L, Ward-O'Brien D, Czarkowski KA, Gueorguieva R, Price LH, Epperson CN. A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. Psychopharmacology (Berl). 2014 Mar;231(5):939-48. 
Sockol LE, Epperson CN, Barber JP. Preventing postpartum depression: ameta-analytic review. Clin Psychol Rev. 2013 Dec;33(8):1205-17. 
Guille C, Newman R, Fryml LD, Lifton CK, Epperson CN. Management of postpartum depression. J Midwifery Womens Health. 2013 Nov-Dec;58(6):643-53. 

Other 

Mathews SB, Arnold SE, Epperson CN. Hospitalization and cognitive decline: Can the nature of the relationship be deciphered? Am J Geriatr Psychiatry. 2014 May;22(5):465-80. 
Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN. The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T ¹H-MRS study. Neuropsychopharmacology. 2012 Dec;37(13):2764-71. 
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disord. 2010 Dec;12(8):813-24. 

Publications by Researcher

​Neill Epperson, MD 

Liisa Hantsoo, PhD 

Sarah Mathews, MD