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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

Bishal Basak, Erika L F Holzbaur PMID: 40783388 PMCID: PMC12335601 DOI: 10.1038/s41467-025-62379-5

Mechanical regulation of extracellular vesicle activity during tumour progression

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Breaking a Lewis Acidity Trend for Rare Earths by Excited State Quenching

Wilharm RK, Gau MR, Trauner D, Schelter EJ J Am Chem Soc. 2025 Aug 6;147(31):27143-27147. doi: 10.1021/jacs.5c05257. Epub 2025 Jul 24. PMID: 40705825.

What do we know of human fuel use during aerobic exercise and how do we know it?

Jessie Axsom, Zolt Arany – PMID: 40763088 DOI:10.1152/physiol.00002.2025

Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis

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Reprogramming of endolysosomes for melanogenesis in BLOC-1-deficient melanocytes

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A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment

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Matrix Stiffening Induces Mechanical Memory and Nuclear Fragility in Cardiomyocytes via Microtubule-Lamin Coupling

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Acidic Nanoparticles Prevent HIV Pre-Exposure Prophylaxis (PrEP)-Induced Oligodendrocyte Impairments by Restoring Lysosomal pH in Adolescent Models

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AAV-microutrophin gene therapy confers durable cardioprotection against pharmacologic and exercise-induced injury in the mdx mouse

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Autophagic stress activates distinct compensatory secretory pathways in neurons

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Structural-functional characterization of the MIRO1-TRAK1 complex

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Amino acid-level differences in alpha-tubulin sequences are uniquely required for meiosis

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Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

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Reversible Antagonism of Dopamine D1 Receptor using a Photoswitchable Remotely Tethered Ligand

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Predicting Pancreatitis in Children With Blunt Abdominal Trauma

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TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin

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Familial SYNGAP1 variants define the boundaries of a complex neurodevelopmental disorder with epilepsy

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Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding

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Venovenous extracorporeal membrane oxygenation with mechanical chest compression for cardiopulmonary resuscitation: a porcine model study

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Protocol for live imaging of axonal transport in iPSC-derived iNeurons

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Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states

Cail RC, Baez-Cruz FA, Winkelmann DA, Goldman YE, Ostap EM. J Biol Chem. 2025 Mar 19:108412. doi: 10.1016/j.jbc.2025.108412. Online ahead of print. PMID: 40118457

Precision Medicine Is in the Eye of the Beholder

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Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk

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Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

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High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory

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Priming and release of cytokine IL-1β in microglial cells from the retina

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Mechanism of actin filament severing and capping by gelsolin

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The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy

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Genes of the Fatty Acid Oxidation Pathway are Upregulated in Female as Compared to Male Cardiomyocytes

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ROR2 drives right ventricular heart failure via disruption of proteostasis

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Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor

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Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

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Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges

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Chronic Activation of Tubulin Tyrosination Improves Heart Function

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Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics

Doan KV, Luongo TS, Ts’olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA. Nat Cardiovasc Res. 2024 Oct;3(10):1236-1248. doi: 10.1038/s44161-024-00542-9. Epub 2024 Sep 18. PMID: 39294272

ECLiPSE: a versatile classification technique for structural and morphological analysis of 2D and 3D single-molecule localization microscopy data

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Extragustatory bitter taste receptors in head and neck health and disease

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Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks

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Cell-to-cell tunnels rescue neurons from degeneration

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ASCB statement of commitment to diversity, equity, and inclusion

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GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells

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Translating metabolic and cardiovascular research into effective treatments: What’s next?

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Putting the brakes on axonal branching

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SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice

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Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction

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Akt activator SC79 stimulates antibacterial nitric oxide generation in human nasal epithelial cells in vitro

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Enhanced MC1R-signalling and pH modulation facilitate melanogenesis within late endosomes of BLOC-1-deficient melanocytes

Goff PS, Patel S, Carter T, Marks MS, Sviderskaya EV. bioRxiv [Preprint]. 2024 Jul 8:2024.07.08.602505. doi: 10.1101/2024.07.08.602505. PMID: 39026869