Hongzhe Li (Lee)
Perelman Professor in Biostatistics, Epidemiology, and Informatics
Member, Biomedical Graduate Studies (BGS), University of Pennsylvania Perelman School of Medicine
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine
Director, Program in Statistical Evaluation of the Human Microbiome, University of Pennsylvania Perelman School of Medicine
Director, Center for Statistical Methods for Big Data, Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine
Member, Penn Center for Precision Medicine, University of Pennsylvania Perelman School of Medicine
Vice Chair of Integrative Research, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine
Member, Executive Committee, University of Pennsylvania Perelman School of Medicine, Applied Mathematics and Computational Sciences (AMCS)
Member, University of Pennsylvania Perelman School of Medicine,Faculty Advisory Committee for Research Computing
Department: Biostatistics and Epidemiology
Contact information
Department of Biostatistics and Epidemiology
University of Pennsylvania Perelman School of Medicine
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
University of Pennsylvania Perelman School of Medicine
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-5038
Fax: 215-573 1050
Fax: 215-573 1050
Email:
hongzhe@upenn.edu
hongzhe@upenn.edu
Graduate Group Affiliations
Education
B.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Permanent linkB.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Description of Research Expertise
My methods reserach was mostly motivated by problems in genetics and genoimics. I have worked on a variety problems in statistical genetics and genomics, including methods for family-based genetic linkage and association analysis, methods for admixture mapping, methods for genome-wide association analysis, methods for analysis of microarray time course gene expression data, high dimensional regression analysis for genomic data, methods for copy number variation analysis and methods for analysis of next generation sequence data. I have published both statistical methodological research in top statistics/biostatistics journals (JASA, AOS, AOAS, Biometrika, Biometrics, Biostatistics etc ) and in top genetics journals (AJHG, Plos Genetics, etc) and collaborative research in top scientific journals (Science, NEJM, Nature, Nature Genetics, PNAS, Developmental Cell etc).Selected Publications
Mirda D, Hao J, Dungan M, Youngman J, Ren Y, Li H, Long JM, Katona BW: Factors Associated with Adherence to Recommended Colorectal Surveillance Intervals in Lynch Syndrome. Cancers 18(12): 2010, Jun 2026.Li C, Richards SM, Quinn G, Abedini A, Zhu M, Verma T, Mohandes S, Pitts R, Barros V, Qiu X, Shin T, Loureiro JJ, Finkel N, Surapaneni A, Coresh J, Grams ME, Karihaloo A, Li H, Verma A, Ritchie M, Rader DJ; Penn Medicine BioBank; Dietrich WF, Jennings LL, Susztak K: Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes. Nature Medicine 32(5): 1701-1707, May 2026.
Zhang J, Cui E, Li H, Shou H: Rejoinder to the discussion on "INTACT: A method for integration of longitudinal physical activity data from multiple sources" Biometrics 82(2): ujag117, Apr 2026.
Zhang J, Cui E, Li H, Shou H: INTACT: a method for integration of longitudinal physical activity data from multiple sources. Biometrics 82(2): ujag112, Apr 2026.
Ostner J, Li H, Müller CL: Score Matching for Differential Abundance Testing of Compositional High-Throughput Sequencing Data. Statistics in Medicine 45(8-9): e70534, Apr 2026.
Damani R, Vasisht S, Luks V, Vargas G, Compher C, Titchenell PM, Tasian G, Li H, Wu GD, Witschey WR, Gershuni VM : Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients. Nutrients 18(5): 839, Mar 2026.
Mayer LS, Arnold J, Roettele F, Reuter N, Pattekar A, Ohtani T, Ribeiro MM, Siwicki R, Bruder K, Obwegs D, Stahl E, Buechel S, Roehlen N, Kolter J, Mansoori Moghadam Z, Alaswad A, Zhumalidova Z, Li G, Liu X, Li Y, Singh A, Villacorta Hidalgo J, Paraskevopoulou MD, Yajnik V, Juarez J, Ren Y, Li H, Wherry EJ, Lewis JD, Wu GD, Bewtra M, Tomov VT, Thimme R, Bengsch B, Hasselblatt P, Picelli S, Hofmann M, Sagar: Single-cell Profiling Reveals Diverse γδ T Cell Subsets in Ulcerative Colitis. Science Immunology 11(116): eadx8474, Feb 2026.
Hu X, Huang J, Yuan J, Sun Y, Wang Y, Hu Z, Jiang J, Wang Z, Wang B, Long M, Maxwell KN, Fan Y, Tanyi JL, Montone KT, Li H, Kim SH, Nathanson KL, Rebbeck TR, Domchek SM, Vonderheide RH, Zhang L: Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations. Cell reports 45(2): 116882, Feb 2026.
Hu F, Tong J, Gardner M, Lifespan Brain Chart Consortium, Chen AA, Bethlehem RAI, Seidlitz J, Li H, Alexander=Bloch A, Chen Y, Shinohara RT : dGAMLSS: an exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts. Bioinformatics (Oxford, England) 42(1): btaf625, Jan 2026.
Whiteside SA, McGinniss JE, Deek RA, Merenstein C, Britton N, Simon-Soro A, Oyster M, Kalman L, Brown MC, Graham-Wooten J, McDyer JF, Shah P, D'Alessio F, Cantu E, Clausen ES, Li H, Diamond JM, Bushman FD, Christie JD, Collman RG: Lung transplant for CF: Low lung bacterial burden and immune mediators in year one associate with CLAD development. Journal of Cystic Fibrosis 25(1): 52-62, Jan 2026.