57
19
1
49
2
2
f
1b
1d
18
2f
4d
1d
2 29
1d
25
Douglas C Wallace
78
4d
Professor of Pediatrics (Human Genetics)
7
61
Department: Pediatrics
4
1
b
1d
46
Contact information
a0
4
3
23
a0
The Center for Mitochondrial and Epigenomic Medicine at The Children's Hospital of Philadelphia Research Institute
3b The Colket Translational Research Building, Rm 6060
43 3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
26
3b The Colket Translational Research Building, Rm 6060
43 3501 Civic Center Boulevard
Philadelphia, PA 19104-4302
2e
Office: 267-425-3034
30
91
30
Email:
wallaced1@email.chop.edu
12
wallaced1@email.chop.edu
1f
Graduate Group Affiliations
8
a
3
3
2
4
b
1f
13
Education:
21 9 B.S. 2c (Genetics, Developmental Biology) c
37 Cornell University, Ithaca, NY, 1968.
21 d M. Phil. 2c (Microbiology and Human Genetics) c
36 Yale University, New Haven CT, 1972.
21 8 PhD 2c (Microbiology and Human Genetics) c
36 Yale University, New Haven CT, 1975.
c
3
3
21
21 9 B.S. 2c (Genetics, Developmental Biology) c
37 Cornell University, Ithaca, NY, 1968.
21 d M. Phil. 2c (Microbiology and Human Genetics) c
36 Yale University, New Haven CT, 1972.
21 8 PhD 2c (Microbiology and Human Genetics) c
36 Yale University, New Haven CT, 1975.
c
1f
Post-Graduate Training
24 5f Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
24 5b Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
24 68 NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
c
3
25
24 5f Predoctoral Research, Department of Microbiology, Yale University, 1971-1975.
24 5b Predoctoral Research, Woods Hole Marine Biological Laboratory, 1971-1971.
24 68 NIH Postdoctoral Fellowship, Department of Human Genetics, Yale University, 1975-1976.
c
17
Certifications
28 5d American Board of Medical Genetics Diplomate, Ph.D. Medical Genetics, 1989.
28 62 American Board of Medical Genetics Diplomate, Clinical Molecular Genetics, 1993.
c
3
8d
Permanent link28 5d American Board of Medical Genetics Diplomate, Ph.D. Medical Genetics, 1989.
28 62 American Board of Medical Genetics Diplomate, Clinical Molecular Genetics, 1993.
c
2 29
21
1e
1d
24
2b
29
27
23
f8 Lee C, Chen Y, Wang P, Wallace DC, Burke PJ. : A Three-Dimensional Printed Inertial Microfluidic Platform for Isolation of Minute Quantities of Vital Mitochondria. Epub 2022.
e7 Schaefer PM, Rathi K, Butic A, Tan W, Mitchell K, Wallace DC: Mitochondrial mutations alter endurance exercise response and determinants in mice. Epub 2022.
192 Wang J, Balciuniene J, Diaz-Miranda MA, McCormick EM, Aref-Eshghi E, Muir AM, Cao K, Troiani J, Moseley A, Fan Z, Zolkipli-Cunningham Z, Goldstein A, Ganetzky RD, Muraresku CC, Peterson JT, Spinner NB, Wallace DC, Dulik MC, Falk MJ. : Advanced approach for comprehensive mtDNA genome testing in mitochondrial disease. Epub 2022.
189 Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX Jr, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. : Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis.Shock. Science 2022.
2cc Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett M, Meller R, View ORCID Profile Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA,Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin S, Wurtele E, Moraes-vieira P, Taylor D, Mason C, e Schisler JC, Schwartz RE, Beheshti A, Wallace DC. : Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. Science Translational Medicine 2022.
142 Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE.: Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock 2022.
cf Flierl A, Schriner SE, Hancock S, Coskun PE, Wallace DC.: The mitochondrial adenine nucleotide transporters in myogenesis. Epub 2022.
1dd Enguita FJ, Leitão AL, McDonald JT, Zaksas V, Das S, Galeano D, Taylor D, Wurtele ES, Saravia-Butler A, Baylin SB, Meller R, Porterfield DM, Wallace DC, Schisler JC, Mason CE, Beheshti A. : The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response. eCollection 2022.
bd Kopinski PK, Singh LN, Zhang S, Lott MT, Wallace DC: Mitochondrial DNA variation and cancer. Nat Rev Cancer. 2021.
2c
7
1d
1f
Selected Publications
df Weiss SL, Zhang D, Farooqi S, Wallace DC. : Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts. Epub 2022.f8 Lee C, Chen Y, Wang P, Wallace DC, Burke PJ. : A Three-Dimensional Printed Inertial Microfluidic Platform for Isolation of Minute Quantities of Vital Mitochondria. Epub 2022.
e7 Schaefer PM, Rathi K, Butic A, Tan W, Mitchell K, Wallace DC: Mitochondrial mutations alter endurance exercise response and determinants in mice. Epub 2022.
192 Wang J, Balciuniene J, Diaz-Miranda MA, McCormick EM, Aref-Eshghi E, Muir AM, Cao K, Troiani J, Moseley A, Fan Z, Zolkipli-Cunningham Z, Goldstein A, Ganetzky RD, Muraresku CC, Peterson JT, Spinner NB, Wallace DC, Dulik MC, Falk MJ. : Advanced approach for comprehensive mtDNA genome testing in mitochondrial disease. Epub 2022.
189 Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX Jr, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. : Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis.Shock. Science 2022.
2cc Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett M, Meller R, View ORCID Profile Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA,Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin S, Wurtele E, Moraes-vieira P, Taylor D, Mason C, e Schisler JC, Schwartz RE, Beheshti A, Wallace DC. : Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. Science Translational Medicine 2022.
142 Lindell RB, Zhang D, Bush J, Wallace DC, Rabinowitz JD, Lu W, Wherry EJ, Weiss SL, Henrickson SE.: Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and are Associated with Features of Immunometabolic Dysregulation. Shock 2022.
cf Flierl A, Schriner SE, Hancock S, Coskun PE, Wallace DC.: The mitochondrial adenine nucleotide transporters in myogenesis. Epub 2022.
1dd Enguita FJ, Leitão AL, McDonald JT, Zaksas V, Das S, Galeano D, Taylor D, Wurtele ES, Saravia-Butler A, Baylin SB, Meller R, Porterfield DM, Wallace DC, Schisler JC, Mason CE, Beheshti A. : The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response. eCollection 2022.
bd Kopinski PK, Singh LN, Zhang S, Lott MT, Wallace DC: Mitochondrial DNA variation and cancer. Nat Rev Cancer. 2021.
2c