Henry Kranzler, MD

Additional Information & Contact: Dept. of Psychiatry



Henry R. Kranzler, M.D. is Professor of Psychiatry and Director of the Center for Studies of Addiction at the University of Pennsylvania’s Perelman School of Medicine. His research focuses on the genetics and pharmacological treatment of substance dependence, with a particular emphasis on precision addiction medicine. His research has been continuously supported since 1987 by grants from the National Institutes of Health. He has authored or co-authored more than 600 journal articles, book chapters, and books, is a member of the editorial board of three peer-review journals, and is the Editor of Alcohol: Clinical and Experimental Research. His work currently focuses on the molecular genetics of substance dependence and the personalized treatment of alcohol, opioid, and nicotine use disorders using a pharmacogenetic approach.

Grants & Funding
  • Co-Principal Investigator on Million Veterans Program grant I01 BX003341 01: Genetic Vulnerability for Sustained Multi-Substance Use in MVP.
  • Co-Principal Investigator on National Institute on Drug Abuse grant P30 DA046345: Penn PET Addiction Center of Excellence (Penn PACE)
Selected Publications

Garbutt JC, Kranzler HR, O’Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, Loewy JW, Ehrich EW for the Vivitrol® Study Group: Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence.  JAMA, 293:1617-1625, 2005.

Kranzler HR, Covault J, Feinn R, Armeli S, Tennen T, Arias AJ, Gelernter J, Oncken C, Pond T, Kampman KM.  Topiramate treatment for heavy drinkers: Moderation by a GRIK1 polymorphism, American Journal of Psychiatry, 171: 445-452, 2014. (PMCID: PMC3997125)

Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications. 10:1499, 2019. (PMCID: PMC6445072)

Kranzler HR, Morris PE, Pond T, Crist RC, Kampman KM, Hartwell EE, Lynch KG. Prospective pharmacogenetic study of topiramate for treating alcohol use disorder. Neuropsychopharmacology. 46:1407-1413, 2021. (PMCID: PMC8209023)

Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC Rentsch RT, VA Million Veteran Program, Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nature Neuroscience 25:1279-1287, 2022. (PMCID: PMC9682545)

Love T, Shabalin A, Kember R, Docherty A, Zhou H, Gelernter J, Baker A, Dubroff J, Hartwell E, Zubieta J, Kranzler HR. Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology, 47:1784-1790, 2022. (PMCID: PMC9372136)

Daviet R, Aydogan G, Jagannathan K, Spilka N, Koellinger P, Kranzler HR, Nave G, Wetherill RR. Associations between alcohol consumption and gray and white matter volumes in the UK Biobank. Nature Communications, 13:1175, 2022. (PMCID: PMC8897479)

Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals. Nature Medicine, 29:3184-3192, 2023 (PMCID: PMC9901058).

Kember RL, Vickers-Smith R, Zhou H, Xu H, Dao C, Justice AC, Gelernter J, Vujkovic M, Kranzler HR. Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample. American Journal of Psychiatry, 180: 584–593, 2023 (PMCID: PMC10731616).

Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Venegas MP, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Million Veteran Program, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine, in press. medRxiv [Preprint]. 2023 Mar 13:2023.03.09.23286958. doi: 10.1101/2023.03.09.23286958. (PMCID: PMC10055465).


Back to Top