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Henry Kranzler, MD

Henry Kranzler, MD

Additional Information & Contact: Dept. of Psychiatry

Bio

Henry R. Kranzler, M.D. is Professor of Psychiatry and Director of the Center for Studies of Addiction at the University of Pennsylvania’s Perelman School of Medicine. His research focuses on the genetics, neuroimaging, and pharmacological treatment of substance use disorders, with a particular emphasis on precision addiction medicine. His research has been continuously supported since 1987 by grants from the National Institutes of Health and the US Department of Veterans Affairs. He has authored or co-authored more than 700 journal articles, book chapters, and books, with a particular focus on the molecular genetics of substance dependence and the personalized treatment of alcohol, opioid, and nicotine use disorders using a pharmacogenetic approach.

Grants & Funding

Contact Principal Investigator on Million Veterans Program grant I01 BX003341: “Genetic Vulnerability for Sustained Multi-Substance Use in MVP.”
Contact Principal Investigator on National Institute on Alcohol Abuse and Alcoholism grant R01 AA03005: “Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related Traits”

Selected Publications

Garbutt JC, Kranzler HR, O’Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, Loewy JW, Ehrich EW for the Vivitrol^® Study Group: Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence. JAMA, 293:1617-1625, 2005.

Kranzler HR, Covault J, Feinn R, Armeli S, Tennen T, Arias AJ, Gelernter J, Oncken C, Pond T, Kampman KM. Topiramate treatment for heavy drinkers: Moderation by a GRIK1 polymorphism, American Journal of Psychiatry, 171: 445-452, 2014. (PMCID: PMC3997125)

Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nature Communications. 10:1499, 2019. (PMCID: PMC6445072)

Kranzler HR, Morris PE, Pond T, Crist RC, Kampman KM, Hartwell EE, Lynch KG. Prospective pharmacogenetic study of topiramate for treating alcohol use disorder. Neuropsychopharmacology. 46:1407-1413, 2021. (PMCID: PMC8209023)

Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC Rentsch RT, VA Million Veteran Program, Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nature Neuroscience 25:1279-1287, 2022. (PMCID: PMC9682545)

Love T, Shabalin A, Kember R, Docherty A, Zhou H, Gelernter J, Baker A,Dubroff J, Hartwell E, Zubieta J, Kranzler HR. Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology, 47:1784-1790, 2022. (PMCID: PMC9372136)

DavietR, Aydogan G, Jagannathan K, Spilka N, Koellinger P, Kranzler HR, Nave G, Wetherill RR. Associations between alcohol consumption and gray and white matter volumes in the UK Biobank. Nature Communications, 13:1175, 2022. (PMCID: PMC8897479)

Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A; Million Veteran Program; Justice AC, Stein MB, Kranzler HR, Gelernter J. Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals. Nature Medicine, 29:3184-3192, 2023 (PMCID: PMC9901058).

Kember RL, Vickers-SmithR, ZhouH, XuH, DaoC, JusticeAC, GelernterJ, VujkovicM, Kranzler HR. Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample. American Journal of Psychiatry, 180: 584–593, 2023 (PMCID: PMC10731616).

Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Venegas MP, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Million Veteran Program, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. A multi-ancestry genetic study of pain intensity in 598,339 veterans. Nature Medicine. 30:1075-1084, 2024.

Kranzler HR, Davis CN, Feinn R, Jinwala Z, Khan Y, Oikonomou A, Silva-Lopez D, Burton I, Dixon M, Milone J, Ramirez S, Shifman N, Levey D, Gelernter J, Hartwell EE, Kember RL. Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence. Nature Human Behaviour 8:1616-1627, 2024. (PMCID: PMC10635185).