Henry R Kranzler
Karl E. Rickels Professor of Psychiatry
Co-Associate Director of Research, VISN 4 Mental Illness Research, Education, and Clinical Center (VAMC)
Director, Center for Studies of Addiction (PSOM)
Department: Psychiatry
Contact information
Treatment Research Center
3535 Market Street, Suite 500
Philadelphia, PA 19104-6178
3535 Market Street, Suite 500
Philadelphia, PA 19104-6178
Office: 215-746-1943
Email:
kranzler@mail.med.upenn.edu
kranzler@mail.med.upenn.edu
Publications
Education
B.A. (Anthropology )
Monmouth University, 1976.
M.A. (Anthropology)
Rutgers University, 1980.
MD
UMDNJ - Robert Wood Johnson Medical School, 1982.
B.A. (Anthropology )
Monmouth University, 1976.
M.A. (Anthropology)
Rutgers University, 1980.
MD
UMDNJ - Robert Wood Johnson Medical School, 1982.
Post-Graduate Training
Psychiatry, University of Connecticut School of Medicine, 1982-1986.
Alcohol Studies, University of Connecticut School of Medicine, 1984-1987.
Permanent linkPsychiatry, University of Connecticut School of Medicine, 1982-1986.
Alcohol Studies, University of Connecticut School of Medicine, 1984-1987.
Selected Publications
Wu V, Qin XJ, Ashley-Koch A, Kimbrel NA, Gelernter J, Docherty AR, Kranzler HR, Feinn R, Davis CN.: Alcohol use disorder and childhood adversity in the association between polygenic risk and suicidality. J Affect Disord Aug 2026.Shi M, Gunawan T, Malone SG, Setzer M, Piserchia Z, Davis CN, Rentsch CT, Friligkou E, Zhou H, Polimanti R, Wang L, Vaitinadin NS, Kranzler HR, Gray JC.: Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders. Neuropsychopharmacology Jul 2026.
Han A, Soohoo J, Gelernter J, Feinn R, Kranzler HR, Davis CN.: Assessing measurement bias in substance withdrawal symptoms attributable to childhood adversity and genetic liability. Drug Alcohol Depend 286: 113261, Jul 2026.
Li EJ, Lammers S, Hsieh CJ, Pascale J, Chang J, Schubert E, Lee H, Mach RH, Karp JS, Wiers C, Kranzler HR, Dubroff J.: Brain-gut axis imaging, motion correction with [ (11) C]-carfentanil total-body PET. medRxiv Jun 2026.
Han S, Toikumo S, Colbert S, Mullins N, Hatoum AS, DiBlasi E, Krueger R, Kember R, Shabalin A, Kranzler H, Docherty A.: Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals. Res Sq Jun 2026.
Piccirillo ML, Votaw VR, Witkiewitz K, Roche DJO, Kranzler HR, Foster KT.: Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis. Drug Alcohol Depend 286: 113231, Jun 2026.
Colbert SM, O'Connell S, Edenberg HJ, Fajs N, Johnson EC, Lannoy S, Sanchez-Roige S, Bacanu SA, Ceja Z, Edwards AC, Garrett ME, Han S, Monson ET, Roberts EK, Vladimirov V, Bulik CM, Cabrera-Mendoza B, Davis CN, Fanelli G, Fischer IC, Fox-Jurkowitz H, Fries GR, Gaine ME, Guzman-Parra J, Koromina M, Kloiber S, Kranzler HR, Mehta D, Nurnberger JI, Stephenson M, Streit F, Toma C, Videtic Paska A; Suicide Working Group of the Psychiatric Genomics Consortium; Kimbrel NA, Ashley-Koch AE, Ruderfer D, Docherty AR, Hatoum AS, Mullins N.: Suicidality phenotypes reflect both shared and distinct genetic factors. medRxiv May 2026.
Shi M, Gunawan T, Setzer M, Okashah N, Liu Y, Wingo TS, Wingo AP, Weintraub D, Schwarzschild MA, Rentsch CT, Kranzler HR, Gray JC.: Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association. medRxiv Apr 2026.
Davis CN, Toikumo S, Hatoum AS, Khan Y, Pham BK, Pakala SR, Feuer KL, Gelernter J, Sanchez-Roige S, Kember RL, Kranzler HR; Penn Medicine BioBank.: Multivariate, Multi-Omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits. Complex Psychiatry 12: 27-39, Mar 2026.
Rentsch CT, Palzes VA, Shi M, Setzer MR, Malone SG, Kline-Simon AH, Piserchia Z, Winterlind EL, Leggio L, Lo Re V 3rd, Fiellin DA, Tazare J, Farokhnia M, Sterling S, Kranzler HR, Gray JC.: Brain penetrant calcium channel blockers do not reduce alcohol consumption: Converging results from two large independent cohort studies using electronic health records. medRxiv Mar 2026.