Center Faculty and Staff Bios

Daniel D. Langleben, MD

Associate Professor, Psychiatry


Education and Training

  • B.S. - 1983
  • M.D. - 1989
  • The Mount Sinai Hospital, New York, 1991-1994, Adult Psychiatry
  • The Mount Sinai Hospital, New York, 1994-1995, Diagnostic Radiology
  • University of California San Francisco, 1995-1997, Addiction Psychiatry
  • Stanford University Medical Center, 1997-1999, Nuclear Medicine



Langleben DD, Ruparel K, Elman I, Loughead JW, Busch EL, Cornish J, Lynch KG,  Nuwayser ES, Childress AR, O'Brien CP. Extended-release naltrexone modulates brain response to drug cues in abstinent heroin-dependent patients. Addict Biol.  2012 Jul 2. In Press. 

Langleben, D. D., & Moriarty, J. C. (2012, September 17). Using Brain Imaging for Lie Detection: Where Science, Law, and Policy Collide. Psychology, Public Policy, and Law. Advance online publication. doi: 10.1037/a0028841

Langleben DD, Busch EL, O'Brien CP, Elman I. Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence. Psychopharmacology (Berl). 2012 Apr;220(3):559-64. 

Glocker ML, Langleben DD, Ruparel K, Loughead JW, Gur RC, Sachser N. Baby schema in infant faces induces cuteness perception and motivation for caretaking in adults. Ethology. 2009; 257-263.

Langleben DD, Loughead JW, Ruparel K, Hakun JG, Busch-Winokur S, Holloway MB, Strasser AA, Cappella JN, Lerman C. Reduced prefrontal and temporal processing and recall of high "sensation value" ads (PDF File). Neuroimage. 2009 May 15;46(1):219-25.

Glocker ML, Langleben DD, Ruparel K, Loughead JW, Valdez JN, Griffin MD, Sachser N, Gur RC. Baby schema modulates the brain reward system in pulliparous woman (PDF File). Proc Natl Acad Sci USA. 2009 Jun 2;106(22):9115-9.

Langleben, DD, Dattilio FM. Commentary: the future of forensic functional brain imaging (PDF File). J Am Acas Psychiatry Law. 2008:36(4):502-4.

Hakun JG., Ruparel K, Seelig D, Busch E, Loughead JW, Gur RC, and Langleben DD. Towards clinical trials of lie detection with fMRI (PDF File). Social Neuroscience. 2009; 4(6):518-27.

Langleben DD, and De Jesus M. (2008). Detection of deception: magnetic resonance imaging (MRI) (PDF File). In Encyclopedia of Psychology and Law (pp. 199-200). Thousand Oaks, CA: Sage.

Langleben DD. Detection of deception with fMRI: Are we there yet? (PDF File). Legal and Criminological Psychology. 2008; 13:1-9.

Langleben DD, Ruparel K, Elman I, Busch-Winokur S, Pratiwadi R, Loughead JW, O'Brien CP, and Childress AR. Acute effect of methadone maintenance dose on brain fMRI response to heroin-related cues (PDF File). The American Journal of Psychiatry. 2008; 165(3):390-4.

Hakun JG, Seelig D, Ruparel K, Loughead JW, Busch E, Gur RC, and Langleben DD. fMRI investigation of the cognitive structure of the Concealed Information Test (PDF File). Neurocase. 2008; 14(1):59-67.

Langleben DD, Monterosso J, Elman I, Ash B, Krikorian G, Austin G. Effects of methylphenidate on Stroop Color-Word task performance in children with attention deficit hyperactivity disorder. Psychiatry Res. 2006 Mar 30;141(3):315-20.

Langleben DD, Dattilio FM, and Gutheil TG. True lies: delusions and lie-detection technology (PDF File). The Journal of Psychiatry & Law. 2006 Fall; 34(3):351-370.

Langleben DD, Monterosso, J., Elman, I, Ash, B, Krikorian, G, Austin, G. The effect of methylphenidate on the performance of the Stroop Color Word Interference Test in children with Attention Deficit Hyperactivity Disorder (PDF file). Psychiatry Research. 2006 March;141(3):315-320.

Platek SM, Loughead JW, Gur RC, Busch S, Ruparel K, Phend N, Panyavin IS, Langleben DD. Neural substrates for functionally discriminating self-face from personally familiar faces (PDF file). Hum Brain Mapp, 2006 Feb;27(2): 91-8.

Langleben DD, Loughead JW, Bilker WB, Ruparel K, Childress AR, Busch SI, Gur RC. Telling truth from lie in individual subjects with fast event-related fMRI (PDF file). Hum Brain Mapp. 2005 Dec;26(4):262-72.

Davatzikos C, Ruparel K, Fan Y, Shen DG, Acharyya M, Loughead JW, Gur RC, Langleben DD. Classifying spatial patterns of brain activity with machine learning methods: Application to lie detection (PDF file). Neuroimage, 2005 Nov;28(3):663-8.

Wolpe PR, Foster KR, Langleben DD. Emerging neurotechnologies for lie-detection: promises and perils (PDF file). Am J Bioeth, 2005 Spring;5(2):39-49.

Bloomer CW, Langleben DD, Meyerhoff DJ. Magnetic resonance detects brainstem changes in chronic, active heavy drinkers (PDF file). Psychiatry Res, 2004 Dec 30;132(3):209-18.

Elman I, Rott D, Green AI, Langleben DD, Lukas SE, Goldstein DS, Breier A. Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia (PDF file). Psychopharmacology (Berl), 2004 Nov;176(3-4):369-75.

Szobot CM, Ketzer C, Cunha RD, Parente MA, Langleben DD, Acton PD, Kapczinski F, Rohde LA. The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder (PDF file). Eur J Nucl Med Mol Imaging, 2003 Mar;30(3):423-6.

Langleben DD, Acton PD, Austin G, Elman I, Krikorian G, Monterosso JR, Portnoy O, Ridlehuber HW, Strauss HW. Effects of Methylphenidate Discontinuation on Cerebral Blood Flow in Prepubescent Boys with Attention Deficit Hyperactivity Disorder (PDF file). J Nucl Med. 2002 Dec; 43(12):1624-1629. Commentary by F. X. Castellanos

Langleben D, Schroeder L, Maldjian J, Gur R, McDonald S, Ragland, JD, O’Brien CP, Childress AR. Brain activity during simulated deception: An event-related functional magnetic resonance study (PDF file). Neuroimage 2002, Mar; 15(3):727-732.

Langleben, D, Austin G, Goris M, Strauss H. W. Interhemispheric asymmetry of regional cerebral blood flow in prepubescent boys with Attention Deficit Hyperactivity Disorder (PDF file). Nuclear Medicine Commun, 2001 Dec; 22(12):1333-40.

Krausz Y, Ikeda DM, Jadvar H, Langleben D, Birdwell R, Strauss HW. Non-visualization of sentinel lymph node in patients with breast cancer. Nucl Med Commun. 2001 Jan; 22(1):25-32.

Langleben DD, Segall GM. PET in differentiation of recurrent brain tumor from radiation injury (PDF file). J Nucl Med. 2000 Nov; 41(11):1861-7.

Selected Abstracts

Langleben, D.D., Busch, S.I., Sciortino, N., Holloway, M.B., Pratwadi, R., Wang, J., Wang, Z., Detre, J.A., O’Brien, C.P., Childress, A.R. Methadone Reduces Limbic System Response to Salient Drug Cues in Patients with a History of Heroin Dependence. Presented at the 35th annual meeting of the Society for Neuroscience. Washington, D.C. November 2005.

Loughead, J., Busch, S., Phend, N., Childress, A.R., Gur, R.C., & Langleben, D.D. Brain activity during deception: an event-related functional MRI study.  Human Brain Mapping.  Budapest, Hungary. June 2004.

Langleben, D.D., Busch, S., Sciortino, N., Listerud, J., Wang, J.J., Detre, J., Childress, A.R., & O’Brien, C.P. Gender differences in brain activity during heroin related cues in opiate-dependent subjects: a perfusion functional magnetic resonance imaging (fMRI) study. Presentation given at the annual meeting of the College on Problems of Drug Dependence. San Juan, Puerto Rico. June 2004.

Merritt, C.K., Busch, S.I., Nioka, S., Weissman A.S., Zak, P.D., & Langleben, D.D. Are the brain correlates of responding yes and no different? Presentation given at the 33rd annual meeting of the Society for Neuroscience Conference. New Orleans, LA. November 2003.

Langleben M, Langleben D: " Iterational structures in Anomalous Texts." In: Organization in Discourse. Proceedings from the Turku Conference", Anglicana Turkuensia 14, 329-340, Turku, Finland, 1995.

Invited Talks 

"Forensic Functional NeuroImaging." The Autumn School on Experimental Research in Forensic Population,  Monastery Seeon,  September 12, 2009, sponsored by the Volkswagen Foundation.

"Lie Detection with fMRI". Functional Imaging Laboratory. University College London, England. September 29, 2007.

"The Truth about Lie Detection with fMRI". Autumn School in Cognitive Neuroscience. University of Oxford, England. September 25, 2007.

"Naltrexone Modulates Brain Response to Drug Cues in Abstinent Heroin Addicts". 100th Jubilee Conference of the V.M. Bekhterev Psychoneurological Institute. St. Petersburg, Russia. May, 2007. Bekhterev Institute

"Studies of Deception with Functional MRI and their Application to Lie-Detection". Gottlieb Daimler- And Karl Benz-Foundation: 11th Berlin Colloquium. Berlin, Germany. May, 2007. Statements of the Speakers

"Perfusion magnetic resonance imaging of opiate dependent patients exposed to drug-related cues".  College on Problems of Drug Dependence. Orlando, FL. June 2005.

"Brain Imaging Technologies".  8th National Undergraduate Bioethics Conference. April 2, 2005.

"Imaging deception with fMRI: The effects of salience and ecological relevance".  Society for Neuroscience Conference. San Diego, CA. November 2004.

"FMRI of deception".  McLean/Harvard Hospital Neuroscience Series. April 21, 2004.

"Functional MRI of craving".  European College of Psychopharmacology, Prague, the Czech Republic. September 21, 2003.

"Brain correlates of intentional deception".  University of Pennsylvania Health System Administrative Forum, February 13, 2003.

"Forensic brain imaging".  The Wharton School of Business Administration, University of Pennsylvania, January 2003.


  • The effects of depot-naltrexone on the brain and behavioral correlates of intravenous heroin and prescription opioid dependence: multiple projects funded by the National Institute on Drug Abuse and the Commonwealth of Pennsylvania
  • Functional Magnetic Resonance Imaging (fMRI) and Electroencephalography (EEG) of the brain response to anti-smoking and HIV prevention advertising: multiple projects funded by the NCI, NIDA and the UPenn Centers for Aids Research
  • Neuroimaging of deception of self and others
  • Biological correlates of caretaking motivation

Media Coverage

Philadelphia Daily News: Penn researchers use MRI to study drug addiction

NPR Part 3: Listen to Audio | PDF

NPR Part 2: Listen to Audio | PDF

NPR Part 1: Listen to Audio | PDF

PBS Wired Science - Lie Detectors

The New Yorker: The Mail: Telling Lies

The New Yorker - Duped

New York Times Magazine - The Brain on the Stand

Washington Post - Brain on Fire

Time Magazine - How to spot a Liar

San Francisco Chronicle: Lies Wide Open - Researchers say technology can show when and how a lie is created inside the brain

Nature: Lure of Lie Detectors Spook Ethicists

Wired Magazine: How Brain Scans are Reinventing the Science of Lie Detection

The New York Times: Looking for the Lie

Philadelphia Magazine: The End of the Lie

Nature: Brain Imaging Ready to Detect Terrorists, Say Neuroscientists

Newsday: Your Brain Can't Handle the Lies

Popular Science: Liar Liar Pants on Fire

Nature: The Truth About Lying

The Economist: Making Windows in Men's Souls

Nature: Brain Imaging Could Spot Liars

The Pennsylvania Gazette: Whose Minding the Brain

Scientific American: Mind Readers

PBS: Brain Imaging

National Post: Brain Scan Can Detect Lies, Researchers Find

Society for Neuroscience: Understanding Human Behavior

San Francisco Chronicle: Study Shows that Brain Scan Detects Patterns of Neural Activity When Someone Lies

New York Times: Zeroing in a Lie's Homebase

Washington Post: Researchers Find that Brain Scans can be a Powerful Tool in Detecing Lies

Die Welt

BBC News: Your Cheating Brain

ABC News Tonight with Peter Jennings

Scientific American: MRI Study Shows Lying Brains Look Different


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