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Kushol Gupta is a Research Assistant Professor in the Department of Biochemistry & Biophysics at the Perelman School of Medicine of The University of Pennsylvania. He is a member of the BMB graduate group, and directs the Johnson Foundation Structural Biology and Biophysics Core, a departmental resource that serves Penn and the greater region.  He is a structural biologist with expertise in both X-ray crystallography and solution-based biophysical techniques, including small-angle X-ray and neutron scattering, light scattering, and analytical ultracentrifugation.

The Gupta Lab focuses on three main research areas:

1. Enzymes that underlie inborn errors of metabolism, including phenylalanine hydroxylase, cystathionine beta-synthase, and pantothenate kinase.

2. Retroviral integrases, their interactions with host factors, and a novel class of antiviral drugs known as allosteric integrase inhibitors (ALLINIs), which are effective against HIV.

3. Biophysical studies of mRNA lipid nanoparticles (mRNA LNPs), including emerging modalities of small angle X-ray and neutron scattering, multiangle light scattering, and analytical ultracentrifugation.

Additional research spans RNA splicing, viral proteins, chromatin, and site-specific recombination, reflecting the collaborative and interdisciplinary nature of research at Penn.