Welcome to the Penn Center for AIDS Research
The Penn Center for AIDS Research (Penn CFAR) is one of 20 NIH-funded CFARs and includes HIV and AIDS investigators at the University of Pennsylvania, the Children's Hospital of Philadelphia (CHOP), and the Wistar Institute.
The Penn CFAR's mission is to support, encourage and facilitate research in all areas of HIV/AIDS on the Penn/CHOP/Wistar campus by (a) facilitating communication and interdisciplinary collaborations through workshops, working groups, strategic planning efforts, and a seminar series covering all topics in the field; (b) support innovative pilot research in HIV/AIDS through developmental pilot grant programs including nonhuman primate-based research; (c) mentoring and support of junior investigators; (d) services and training in support of HIV research through Shared Cores: Clinical, Viral/Molecular, Immunology, Biostatistics & Data Management; Behavioral and Social Sciences; International; Nonhuman Primate.
CLICK HERE TO REGISTER NOW for the 2019 CFAR Research Symposium!
Tuesday, May 14th, 2019
8:30 a.m. to 4:30 p.m.
Arthur M. Rubenstein Auditorium
Smilow Center for Translational Research
Samuel Weissman of the O’Doherty Lab won second place in this year's Regeneron Science Talent Search, the nation’s oldest and most prestigious science and math competition for high school seniors. The award includes $175,000 in prize money. Dr. O'Doherty met Sam through her son Liam. "Sam [a friend of Liam] started pestering me to volunteer in my lab several years ago. I was admittedly reluctant, but Sam soon proved useful. After learning to code in R, he developed methods to analyze longitudinal HIV sequences." Read more HERE.
- Recent News
José Bauermeister, Presidential Professor of Nursing and Director of the CFAR Technologies to Reduce HIV Disparities Scientific Working Group, has developed an online tool designed to decrease sexual risk-taking and promote HIV/STI prevention behaviors among young gay, bisexual, and other men who have sex with men (YGBMSM), many of whom frequently meet their partners online.
Dr. Drew Weissman, who has developed nucleoside-modified mRNA-lipid nanoparticle (LNP) as a novel platform for vaccines, showed that the vaccine and LNPs specifically induce high levels of T follicular helper cells (Tfh). Tfh cells form germinal centers (GC) and drive GC B cells to proliferate, somatically mutate, class switch, and form long-term memory, which are critical for HIV vaccine development. In addition to HIV, the vaccine platform has applications to many different viral, bacterial, and parasitic pathogens.
Dr. Mohamed Abdel-Mohsen and a multidisciplinary team from Wistar, Penn and several other institutions, found that CD32, previously implicated as a marker of the HIV latent reservoir, is actually expressed preferentially on a subset of activated CD4+ T cells enriched for transcriptionally active HIV. This has important implications for identifying and targeting HIV latency in infected people.
Dr. Laura Su and an international, transdisciplinary team have authored an article in Science Immunology that focuses on how follicular helper T cells (Tfh) play an essential role in shaping B-cell mediated antibody responses. The Su lab employed mass cytometry and TCR sequencing to directly examine the Tfh response to HIV and reported oligoclonal expansion of a functionally-restricted subset of Tfh cells in HIV infected lymph nodes. This lack of polyfunctionality may contribute to Tfh cell pathology in HIV infection and correlated with impaired isotype switching of B cells in the lymph nodes.
- HIV Grand Rounds
12:00- 1:00 pm, Class of '62 Auditorium, John Morgan Building (unless otherwise posted)
- HIV / Pathogenesis CURE Journal Club
Every Other Thursday (starting again 9/20/18)
1:30- 3:00 pm, Room 501, Johnson Pavilion
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