Home

The Gupta Lab seeks to understand how molecular structure, conformational dynamics, and higher-order assembly govern biological function in health and disease. Using an interdisciplinary toolkit that combines structural biology with quantitative solution biophysics, we investigate enzyme regulation in inborn errors of metabolism, viral protein complexes relevant to HIV, and the structure and heterogeneity of mRNA lipid nanoparticles. Our goal is to generate fundamental mechanistic insight while advancing strategies for therapeutic discovery and biomolecular engineering. Additional research spans RNA splicing, viral proteins, chromatin, and site-specific recombination, reflecting the collaborative and interdisciplinary nature of research at Penn.

Kushol Gupta is a Research Associate Professor in the Department of Biochemistry & Biophysics at the Perelman School of Medicine of The University of Pennsylvania. He is a member of the BMB graduate group, and directs the Johnson Foundation Structural Biology and Biophysics Core, a departmental resource that serves Penn and the greater region.  He is a structural biologist with expertise in both X-ray crystallography and solution-based biophysical techniques, including small-angle X-ray and neutron scattering, light scattering, and analytical ultracentrifugation.