Symposium on Analytical Ultracentrifugation

The modern applications of analytical ultracentrifugation will be highlighted, with special topical talks on applications of flow cytometry.

Sponsored by:
Johnson Foundation Biophysical & Structural Biology Core Facilities, The Institute for Structural Biology, and the Department of Biochemistry and Biophysics, with kind support from Beckman-Coulter

Tuesday March 10th, 2026

Campus of The University of Pennsylvania

Reunion Auditorium, John Morgan Building

Philadelphia, Pennsylvania

Lunch Provided | Registration Required | Free Event | Space Limited

Register here

Questions?
Contact Kushol Guptakgupta@pennmedicine.upenn.edu

Program 

Final Program

Time

Speaker

Title

Location

8:30 – 9:00 AM (30)

Registration Begins; Continental Breakfast

 

KRB Auditorium

 (1st Floor)

(formerly BRBII/III Building)

9:00 – 9:20 AM (20)

Amy Henrickson (Beckman-Coulter)

Beckman Coulter AUC and Centrifugation Updates 

9:20 – 10:00 AM (40)

Alexander Yarawsky (BioAnalysis, LLC.)

Analyzing high concentration antibody therapeutics in the AUC

10:00 – 10:40 AM (40)

Karen Fleming (The Johns Hopkins University)

Understanding Unfolded Protein Ensembles Using Sedimentation Velocity

10:40 – 10:55 AM (15)

Break

 

10:55  – 11:30 AM (35)

Kushol Gupta (The University of Pennsylvania)

Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure

11:30 – 12:30 PM (60)

Lunch Break

 

KRB Lounge

(14th Floor)

(formerly BRBII/III Building)

12:30 – 12:50 AM (20)

Carley Ross (Beckman-Coulter)

Peptide characterization using AUC: a case study with Semaglutide

RRB Austrian Auditorium (1st Floor)

(formerly CRB Building)

12:50 – 1:30 PM (40)

Luca Musante (University of Pennsylvania)

Resolving EV Heterogeneity: Density Gradient Ultracentrifugation Enables High-Resolution Density and Size Fractionation for Robust AUC Analysis

1:30 – 2:10 PM (40)

Korey Patwari (Mitchell Group, University of Pennsylvania)

Single-particle characterization potentiates mRNA delivery via PD-L1-targeted lipid nanoparticles for cancer immunotherapy applications

2:10 – 2:30 PM (20)

Jonel Chong (Beckman-Coulter)

TBA

2:30 – 2:45 PM (15)

Break

 

2:45 – 3:15 PM (30)

Roger Turner (Science History Institute)

History of the Ultracentrifuge: Highlights at the Science History Institute

3:15 – 3:55 PM (40)

Yung Yang (Columbia University)

Breakdown of the Einstein Relation in Ultracentrifugation

3:55 – 4:45 PM (50)

Borries Demeler (University of Lethbridge)

What AUC can teach you about AAVs, LNPs, and EVs

4:45 PM

End of Event

 

 

Contact | Dr. Gupta will be your host for the day. Contact at 267-259-0082 (cell) if you encounter any issues and need assistance.

Public Transit | If you are arriving by regional rail, the Penn Medicine stop is the closest to the day’s events. If subway, the Green Line Trolley to 37th and Spruce would be the closest stop.

Parking | These indoor parking garages are closest to where we will be for the day –

Location | 14th Floor, BRBII/III Building

Internet | All visitors are welcome to use the SSID “Air-Pennnet Guest” for WiFi. After connecting, use a web browser to complete registration.