Circular Dichroism
In this approach, the absorption of circularly polarized light by biological macromolecules can yield insight into structure and folding in solution. Titration experiments can provide additional kinetic information about folding transitions and structural changes.
- The Aviv 202 Circular Dichroism Instrument allows for data collection from quartz cells at specified temperatures. Titration and temperature features allow for the performance of chemical and thermal melt experiments, respectively.
- Jasco Model J-815 Circular Dichroism Spectrometer with automated titration accessories and temperature control. The instrumental is operated by a dedicated computer for data collection and analysis.
Contact: Leland Mayne | mayne@pennmedicine.upenn.edu
Location: 1010 Stellar-Chance Laboratory