Nuclear Magnetic Resonance

The biomolecular NMR facility allows studies of proteins, RNA and other important biomolecules in a physiologically relevant, aqueous environment.  Our facility is equipped with 600 MHz and 800 MHz Avance Neo NMR systems with 5mm 1H-optimized triple resonance cryoprobe designed for 1H or 19F observation with 13C/15N decoupling, and 13C observation with 1H decoupling due to superior sensitivity on 13C.  

These capabilities are utilized in structure determination, studies of intrinsically disordered proteins, ligand binding and fragment-based drug discovery applications which serve the broader structural biology community at Penn and CHOP.