Perelman School of Medicine at the University of Pennsylvania

Kahn Lab

Cardiovascular Development and Disease

Fluid forces and ligand-receptor interactions regulate the development of the heart, blood, and lymphatic vessels and its function after development.

We have studied the role of flow-responsive signals KLF2 and KLF4 in heart development (Dev Cell 2015 and 2017) in addition to the secreted ligands ADAMTS3 and CCBE1 in VEGF-C/VEGFR3 signaling (Blood 2013) during lymphatic development and hematopoiesis. Recent work aims to integrate the role of blood flow and KLF2/4 in postnatal heart disease and the role of VEGF-C/VEGFR3 signaling in the growth of other vascular beds in the context of developmental hematopoiesis.

Collaborating Labs

  • Nancy Speck (University of Pennsylvania)
  • Kai Tan (University of Pennsylvania)
  • Dietmar Vestweber (Max Planck Institute for Molecular Biomedicine)
  • Joshua Scallan (University of South Florida)
See the below recent publications related to this project:

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis

Goddard et al. Developmental Cell, 2017.

The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression

Zhou et al. Developmental Cell, 2015.

The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis

Zou et al. Blood, 2013.

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

Kleaveland et al. Nature Genetics, 2009.