Perelman School of Medicine at the University of Pennsylvania

Kahn Lab

  • Mark Kahn and lab members

    Dr Mark Kahn and lab members

  • pulmonary lymphatics in prox1 GFP mice

    Smooth muscle actin staining in Prox1 GFP mouse vein.

  • Prox-GFP and VE-Cadherin labelled Lymphangion (red is VE-cadherin & green is ProxGFP)

    Prox-GFP and VE-Cadherin labelled Lymphangion

  • Prox GFP labelled lymphatics showing high expressing GFP valce

    Lymphatic vessels and valves

  • Lymphatic Valve showing high Prox1 expression in the leaflet and immediately downstream

    Prox1 GFP staining of lymphatic vessel and valve

Welcome to the Kahn Lab

Research Interests:

Our lab investigates signaling pathways that regulate cardiovascular biology and diseases.  We are interested in both lymphatic and blood vessel regulatory pathways, and in the interactions between blood cells and vascular endothelium.  Most of the pathways we investigate are known to cause human vascular diseases.  We apply vertebrate genetic approaches as well as biochemical and state of the art molecular approaches to understand the function of these pathways during normal development and in disease models.  

What's New?

Congratulations to Alan Tang, MD/PhD candidate, on receiving the 2017 Kaushal Family Awards in Genetics!

Read about Dr. Kahn and Lauren Goddard Raines' research in Cell Press… "Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis".

Read about Dr. Kahn and Alan Tang's research into CCM disease in the NY Times..."A Baffling Brain Defect Is Linked to Gut Bacteria, Scientists Say" by Gina Kolata.

Just Published in Nature!  Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.

We are currently accepting post-doctoral research fellow applications.