Welcome to the Kahn Laboratory
The Kahn Lab is interested in signaling pathways at the intersection of cardiovascular development and disease. We study lymphatic and blood vascular pathways and the interactions between blood cells and vascular endothelium. Our focus is on human cardiovascular diseases such as venous thrombosis, cerebral cavernous malformation, and heart valve disease.
We combine complex mouse genetics with state-of-the-art biochemical and molecular approaches to understand the function of these pathways during normal development and in postnatal disease models. We have collaborations across Penn, CHOP, and many other academic institutions.
The Kahn Lab is committed to promoting a diverse and inclusive environment for individuals of all backgrounds, particularly those who are underrepresented in science and medicine. Our lab is committed to social justice and anti-racism, and we welcome all aspiring scientists to join our lab.
We are currently accepting graduate students and applications for postdoctoral research fellows! Please email Dr. Kahn at markkahn@pennmedicine.upenn.edu if interested in joining the lab.
Lab News
Aileen Ren's co-first author on the synergistic role of CCM and PIK3CA in cavernoma formation is published in Nature: PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Steven Keller, PhD, is awarded the American Heart Association Postdoctoral Fellowship. Congratulations, Steven!
CONGRATULATIONS to Dr. Courtney Hong on successfully defending her thesis! Read about her work in the Journal of Experimental Medicine: Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Derek receives the cover of Developmental Biology with the publication of his work from the NIH on non-muscle myosin 2 in testes development. See the cover and read the paper here!
The Kahn Lab celebrates its first virtual holiday party with trivia! Check out our lab photo!
Siqi Gao, PhD joins the lab after finishing her graduate studies with Courtney Griffin at the University of Oklahoma. Welcome, Siqi!
Martin Dominguez, MD, PhD, a former cardiology and postdoctoral fellow at UCSF and Gladstone, joins the lab as a postdoctoral fellow. Welcome, Martin!
Spotlight
Derek's immunofluorescence is featured in Cell Press' online Cell Picture Show titled "Immunofluorescence II"
Aileen's publication on CCM and PIK3CA in Nature is highlighted as Penn CVI's Paper of the Week.
John and his paper were featured on the podcast "Beyond the Abstract." Listen here!
Derek is featured by Cell Press for his work in immunofluorescence art microscopy. Check out his interview on CrossTalk and Cell Press Picture Show!
PennMedicine News release of our latest study on CCMs published in Nature. Penn Study Describes the Molecular Cause of Common Cerebrovascular Disease
Contact Us
Kahn Lab
Mark L. Kahn, MD
Smilow Center for Translational Research
3400 Civic Center Blvd
11-123
Philadelphia, PA 19104
215-898-9007
Email Us
