Perelman School of Medicine at the University of Pennsylvania

Kahn Lab

  • Derek's Cell Picture Show titled

    Derek's Cell Picture Show titled "Immunofluorescence II"

  • MicroCT rendering of CCM lesions from Hong et al. 2020, Journal of Experimental Medicine.

    MicroCT rendering of CCM lesions from Hong et al. 2020, Journal of Experimental Medicine.

  • The Kahn Lab

    The Kahn Lab celebrates the holidays (virtually!)

  • Mouse gut stained for enterocytes (yellow), blood vessels (cyan), and lymphatics (red)

    Mouse gut stained for enterocytes (yellow), blood vessels (cyan), and lymphatics (red)

  • Embryonic skin whole mount stained for lymphatics (green) and blood vessels (magenta).

    Embryonic skin whole mount stained for lymphatics (green), blood vessels (magenta), and VE-cadherin (blue).

Welcome to the Kahn Laboratory

The Kahn Lab is interested in signaling pathways at the intersection of cardiovascular development and disease.  We study lymphatic and blood vascular pathways and the interactions between blood cells and vascular endothelium.  Our focus is on human cardiovascular diseases such as venous thrombosis, cerebral cavernous malformation, and heart valve disease.

We combine complex mouse genetics with state-of-the-art biochemical and molecular approaches to understand the function of these pathways during normal development and in postnatal disease models. We have collaborations across Penn, CHOP, and many other academic institutions.

 

 

 

 

 

 

 

 

 

 

The Kahn Lab is committed to promoting a diverse and inclusive environment for individuals of all backgrounds, particularly those who are underrepresented in science and medicine. Our lab is committed to social justice and anti-racism, and we welcome all aspiring scientists to join our lab.

We are currently accepting graduate students and applications for postdoctoral research fellows! Please email Dr. Kahn at markkahn@pennmedicine.upenn.edu if interested in joining the lab.

 

Lab News

CONGRATULATIONS to Dr. Aileen Ren on successfully defending her thesis!

Aileen Ren's co-first author on the synergistic role of CCM and PIK3CA in cavernoma formation is published in NaturePIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.

Steven Keller, PhD, is awarded the American Heart Association Postdoctoral Fellowship. Congratulations, Steven!

CONGRATULATIONS to Dr. Courtney Hong on successfully defending her thesis! Read about her work in the Journal of Experimental Medicine: Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.

Derek receives the cover of Developmental Biology with the publication of his work from the NIH on non-muscle myosin 2 in testes development. See the cover and read the paper here!

The Kahn Lab celebrates its first virtual holiday party with trivia! Check out our lab photo!

Siqi Gao, PhD joins the lab after finishing her graduate studies with Courtney Griffin at the University of Oklahoma. Welcome, Siqi!

Martin Dominguez, MD, PhD, a former cardiology and postdoctoral fellow at UCSF and Gladstone, joins the lab as a postdoctoral fellow. Welcome, Martin!