Kahn Lab

Publications

To see a complete list of our publications (including collaborator publications), please visit PubMed

Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection.

Tang AT, Buchholz DW, Szigety KM, Imbiakha B, Gao S, Frankfurter M, Wang M, Yang J, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, Monreal IA, Sahler J, August A, Zhu X, Jurado KA, Xu M, Morrisey EE, Millar SE, Aguilar HC, Kahn ML. PLoS Biol. 2023 Feb 6;21(2):e3001989. doi: 10.1371/journal.pbio.3001989. eCollection 2023 Feb. PMID: 36745682 

Sinusoidal and lymphatic vessel growth is controlled by reciprocal VEGF-C-CDH5 inhibition.

Sung DC, Chen M, Dominguez MH, Mahadevan A, Chen X, Yang J, Gao S, Ren AA, Tang AT, Mericko P, Patton R, Lee M, Jannaway M, Nottebaum AF, Vestweber D, Scallan JP, Kahn ML. Nat Cardiovasc Res. 2022 Nov 11;1:1006-1021. doi: 10.1038/s44161-022-00147-0.

Mouse placenta fetal macrophages arise from endothelial cells outside the placenta.

Chen X, Tang AT, Tober J, Yang J, Leu NA, Sterling S, Chen M, Yang Y, Mericko-Ishizuka P, Speck NA, Kahn ML. Dev Cell. 2022 Dec 5;57(23):2652-2660.e3. doi: 10.1016/j.devcel.2022.11.003. PMID: 36473461 

VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development.

Sung DC, Chen X, Chen M, Yang J, Schultz S, Babu A, Xu Y, Gao S, Stevenson Keller TC, Mericko P, Lee M, Yang Y, Scallan JP, Kahn ML. Elife. 2022 Apr 29;11:e77241. doi: 10.7554/eLife.77241. Online ahead of print. PMID: 35486098

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.

Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung DC, Keller TCS, Uzun Y, Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML. Blood. 2022 Mar 4:blood.2021013934. doi: 10.1182/blood.2021013934. Online ahead of print. PMID: 35245372

SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice.

Tang AT, Buchholz DW, Szigety KM, Imbhiaka B, Gao S, Frankfurter M, Wang M, Yang J, Hewins P, Mericko-Ishizuka P, Adrian Leu N, Sterling S, Monreal IA, Sahler J, August A, Zhu X, Jurado KA, Xu M, Morrisey EE, Millar SE, Aguilar HC, Kahn ML. bioRxiv. 2021 Dec 7:2021.12.04.471245. doi: 10.1101/2021.12.04.471245. Preprint. PMID: 34909769

Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction.

Keller TCS 4th, Lim L, Shewale SV, McDaid K, Martí-Pàmies Í, Tang AT, Wittig C, Guerrero AA, Sterling S, Leu NA, Scherrer-Crosbie M, Gimotty PA, Kahn ML. J Clin Invest. 2021 Oct 15;131(20):e147070. doi: 10.1172/JCI147070. PMID: 34403369 

Cerebral Cavernous Malformation: From Mechanism to Therapy.

Snellings DA, Hong CC, Ren AA, Lopez-Ramirez MA, Girard R, Srinath A, Marchuk DA, Ginsberg MH, Awad IA, Kahn ML. Circ Res. 2021 Jun 25;129(1):195-215. doi: 10.1161/CIRCRESAHA.121.318174. Epub 2021 Jun 24. PMID: 34166073

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.

Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Mueller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert M, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Nature. 2021 Apr 28. doi: 10.1038/s41586-021-03562-8. PMID: 33910229

Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.

Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. J Exp Med. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140.PMID: 32648916

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML. Sci Transl Med. 2019 Nov 27;11(520):eaaw3521. doi: 10.1126/scitranslmed.aaw3521.PMID: 31776290

Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis.

Welsh JD, Hoofnagle MH, Bamezai S, Oxendine M, Lim L, Hall JD, Yang J, Schultz S, Engel JD, Kume T, Oliver G, Jimenez JM, Kahn ML. J Clin Invest. 2019 Dec 2;129(12):5489-5500. doi: 10.1172/JCI124791.PMID: 31710307

Donor-host Lymphatic Anastomosis After Murine Lung Transplantation.

Outtz Reed H, Wang L, Kahn ML, Hancock WW. Transplantation. 2020 Mar;104(3):511-515. doi: 10.1097/TP.0000000000003041.PMID: 31688808

Why Don't Cerebral Cavernous Malformations Go With the Flow?

Tang AT, Kahn ML. Circ Res. 2019 Oct 25;125(10):871-873. doi: 10.1161/CIRCRESAHA.119.315984. Epub 2019 Oct 24. No abstract available.  PMID:  31647767

Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC.

Lim L, Bui H, Farrelly O, Yang J, Li L, Enis D, Ma W, Chen M, Oliver G, Welsh JD, Kahn ML. Blood. 2019 Nov 14;134(20):1764-1775. doi: 10.1182/blood.2019001736.PMID: 31562136

Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage.

Reed HO, Wang L, Sonett J, Chen M, Yang J, Li L, Aradi P, Jakus Z, D'Armiento J, Hancock WW, Kahn ML. J Clin Invest. 2019 Apr 4;129(6):2514-2526. doi: 10.1172/JCI125044.PMID: 30946031

Investigating Effects of Fluid Shear Stress on Lymphatic Endothelial Cells.

Sweet DT, Hall JD, Welsh J, Kahn ML, Jiménez JM. Methods Mol Biol. 2018;1846:213-227. doi: 10.1007/978-1-4939-8712-2_14.  PMID:  30242762

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis

Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML. Dev Cell. 2017 Oct 13. pii: S1534-5807(17)30782-7. doi: 10.1016/j.devcel.2017.09.023. PMID: 29056552

A BMPy Road for Venous Development

Goddard LM, Kahn ML. Dev Cell. 2017 Sep 11;42(5):435-436. doi: 10.1016/j.devcel.2017.08.016.

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML.

Lymphovenous hemostasis and the role of platelets in regulating lymphatic flow and lymphatic vessel maturation.

Welsh JD, Kahn ML, Sweet DT. Blood. 2016 Sep 1;128(9):1169-73. doi: 10.1182/blood-2016-04-636415. Epub 2016 Jul 6. Review. PMID: 27385789

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.

Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML.  J Clin Invest. 2016 Jun 1;126(6):2167-80. doi: 10.1172/JCI83967. Epub 2016 May 9. PMID:27159393

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML.  Nature. 2016 Apr 7;532(7597):122-6. doi: 10.1038/nature17178. Epub 2016 Mar 30. Erratum in: Nature. 2016 Aug 25;536(7617):488. PMID:27027284

HA-ving lymphatics improves lung transplantation.

Maltzman JS, Reed HO, Kahn ML. J Clin Invest. 2015 Nov 2;125(11):3999-4001. doi: 10.1172/JCI84549. Epub 2015 Oct 20. PMID:26524589

Lymph flow regulates collecting lymphatic vessel maturation in vivo.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML. J Clin Invest. 2015 Aug 3;125(8):2995-3007. doi: 10.1172/JCI79386. Epub 2015 Jul 27. PMID:26214523

Vascular development for climate control.

Kahn ML. Dev Cell. 2015 May 4;33(3):241-2. doi: 10.1016/j.devcel.2015.04.011. PMID:25942619

Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.

Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP.

J Biol Chem. 2015 May 1;290(18):11557-68. doi: 10.1074/jbc.M114.629527. Epub 2015 Mar 12.  PMID:25767114

Cell Adhesion Mediated by VCAM-ITGα9 Interactions Enables Lymphatic Development.

Yang Y, Enis D, Zheng H, Chia S, Yang J, Chen M, Dhillon V, Papayannapoulou T, Kahn ML.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1179-89. doi: 10.1161/ATVBAHA.114.304997. Epub 2015 Mar 5.  PMID:25745057

A critical role of platelet glycoprotein Ibα in arterial remodeling.

Kahn ML.  Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):498-9. doi: 10.1161/ATVBAHA.115.305213. No abstract available.  PMID:25717177

The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.

Zhou Z, Rawnsley DR, Goddard LM, Pan W, Cao XJ, Jakus Z, Zheng H, Yang J, Arthur JS, Whitehead KJ, Li D, Zhou B, Garcia BA, Zheng X, Kahn ML.  Dev Cell. 2015 Jan 26;32(2):168-80. doi: 10.1016/j.devcel.2014.12.009.  PMID:25625206

Lymphatic function is required prenatally for lung inflation at birth.

Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML.  J Exp Med. 2014 May 5;211(5):815-26. doi: 10.1084/jem.20132308. Epub 2014 Apr 14.  PMID:24733830

Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.

Boulaftali Y, Hess PR, Kahn ML, Bergmeier W.  Circ Res. 2014 Mar 28;114(7):1174-84. doi: 10.1161/CIRCRESAHA.114.301611. Review.  PMID:24677237

Cerebral cavernous malformations arise independent of the heart of glass receptor.

Zheng X, Riant F, Bergametti F, Myers CD, Tang AT, Kleaveland B, Pan W, Yang J, Tournier-Lasserve E, Kahn ML. Stroke. 2014 May;45(5):1505-9. doi: 10.1161/STROKEAHA.114.004809. Epub 2014 Mar 18.  PMID:24643410

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML.  J Clin Invest. 2014 Jan;124(1):273-84.  PMID:24292710

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L.  Nature. 2013 Oct 3;502(7469):105-9. doi: 10.1038/nature12501. Epub 2013 Sep 1. PMID:23995678