Publications By Topic

Combinatorial Treatment with Menin and FLT3 Inhibitors Induces Complete Remission in AML Models with Activating FLT3 Mutations

Miao H, Danet-Desnoyers G, Grembecka J, et al. Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations. Blood. 2020 Dec 17;136(25):2958-2963

Cytokines Increase Engraftment of Human Acute Myeloid Leukemia Cells in Immunocompromised Mice but not Engraftment of Human Myelodysplastic Syndrome Cells

Krevvata, Maria, Shan Xiaochuan, & Zhou Chenghui, et al. Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells. {Haematologica} Mar 2018. 

Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Farge Thomas, Saland Estelle, Carroll Martin, et al. Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism. {Cancer discovery} 7(7): 716-735, Apr 2017. 

Human Acute Myelogenous Leukemia Stem Cells are Rare and Heterogeneous when assayed in NOD/SCID/IL2Rγc-Deficient Mice

Sarry Jean-Emmanuel, Danet-Desnoyers G, Carroll Martin, et al: Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice. {The Journal of Clinical Investigation} 121(1): 384-95, Jan 2011. 

A Robust Xenotransplantation Model for Acute Myeloid Leukemia

Perl A E,  Danet-Desnoyers G, Carroll M, et al. A robust xenotransplantation model for acute myeloid leukemia. {Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K} 23(11): 2109-17, Nov 2009. 

Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma

Uslu, U., Da, T., Assenmacher, C.A. et al. Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma. Science Advances 11 Jan 2023; 9(2)

The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity

Song, E., Wang, X., Philipson, B. et al.  The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity. Molecular Therapy Oncolytics 15 December 2022; 27: 288-304

Expression of inducible factors reprograms CAR-T cells for enhanced function and safety

Smole, A., Benton, A., Poussin, M. et al.  Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell 12 December 2022; 12 (12): 1470-1487.e7.

Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells

Melenhorst, J. J., Chen, G. M., Wang, M., et al. Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells. Nature 07 December 2022; 602: 503-509 

Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer

Lee, Gu Y., Guruprasad, P., Ghilardi, G. et al.  Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer. Cancer Discovery 05 October 2022; 12 (10): 2372–2391.

TCRvβ-CART therapy mediates high precision targeting of malignant T-cell clones

Shaw, L., Poussin, M., Rodriguez, A. et al. TCRvβ-CART therapy mediates high precision targeting of malignant T-cell clones. Blood Advances 02 September 2022

Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy

Kim, G., Bunk, S., Mahr, A. et al.  Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy. Science Translational Medicine 31 Aug 2022; 14(600) 

Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors

Yin, Y., Rodriguez, J., Nannan, Li. et al.  Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors. Molecular Therapy 06 July 2022; 30 (7): 2537-2553

Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains

Zappala, F., Higbee-Dempsey, E., Bian, J. et al. Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains. Science Advances 06 May 2022; 8(18)

CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies

Andrechak, J., Dooling, L., Tobin, M. et al. CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies. Cancers 5 April 2022; 14(8). 

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Narayan, V., Barber-Rotenberg, J.S., Jung, I-Y. et al. PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. Nature Medicine 21 March 2022; 28: 724-734

Rapid manufacturing of non-activated potent CAR T cells

Ghassemi, S., Durgin J., Nunez-Cruz, S. et al. Rapid manufacturing of non-activated potent CAR T cells. Nature Biomedical Engineering 21 February 2022; 6(118–128). 

Decade-long Leukaemia Remissions with Persistence of CD4+ CAR T cells

Melenhorst, J.J., Chen, G.M., Wang, M. et al. Decade-long leukaemia remissions with persistence of CD4+CAR T cells. Nature 602, 503–509 (2022).

CAR-T Cell-Mediated Depletion of Immunosuppressive Tumor-Associated Macrophages Promotes Endogenous Antitumor Immunity and Augments Adoptive Immunotherapy

Rodriguez-Garcia, A., Lynn, R.C., Poussin, M. et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun 12, 877 (2021)

Lentiviral Vector ALS20 Yields High Hemoglobin Levels with Low Genomic Integrations for Treatment of Beta-Globinopathies

Breda L, Ghiaccio V, Shan X, Danet-Desnoyers GA, et al. Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther. 2021 Apr 7;29(4):1625-1638

Dual CD4-based CAR T cells with Distinct Costimulatory Domains Mitigate HIV Pathogenesis In Vivo

Maldini, C.R., Claiborne, D.T., Okawa, K. et al. Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Nat Med 26, 1776–1787 (2020)

Control of Triple-Negative Breast Cancer using Ex Vivo Self-Enriched, Costimulated NKG2D CAR T cells

Han, Y., Xie, W., Song, DG. et al. Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells. J Hematol Oncol 11, 92 (2018)

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level | Journal of Hematology & Oncology

Song, DG., Ye, Q., Poussin, M. et al. Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level. J Hematol Oncol 9, 56 (2016)

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity | Leukemia

Lynn, R., Feng, Y., Schutsky, K. et al. High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity. Leukemia 30, 1355–1364 (2016)

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T cells and Increased Antileukemic Efficacy In Vivo

Milone MC, Fish JD, Carpenito C, et al. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther. 2009 Aug;17(8):1453-64

Administration of Nucleoside-Modified mRNA Encoding Broadly Neutralizing Antibody Protects Humanized Mice from HIV-1 Challenge

Pardi N, Secreto AJ, Shan X, et al. Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Nat Commun. 2017

Pathology of Macrophage Activation Syndrome in Humanized NSGS Mice

Tarrant JC, Shan X, Danet-Desnoyers G, et al. Pathology of macrophage activation syndrome in humanized NSGS mice. Res Vet Sci. 2021

Lentiviral Vector ALS20 Yields High Hemoglobin Levels with Low Genomic Integrations for Treatment of Beta-Globinopathies

Breda L, Shan X, Danet-Desnoyers GA, et al. Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther. 2021 Apr 7;29(4):1625-1638

C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia

Sabatier, M., Birsen, R., Lauture, L. et al. C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia. Cancer Discovery 03 April 2023. 

Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

Xue, Q., Fan, D., Han, Q. et al. Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia. Cancer Discovery 01 March 2023; 13(3): 724-725

Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

Staupe, R. P., Lodge, K. E., Thambi, N. et al.  Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells. Communications Biology 21 December 2022; 5(1399)

Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells

Melenhorst, J. J., Chen, G. M., Wang, M., et al. Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells. Nature 07 December 2022; 602: 503-509 

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia

Pingul, B.Y., Huang, H., Chen, Q. et al. Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia. iScience 21 October 2022; 25(10)

TCRvβ-CART therapy mediates high precision targeting of malignant T-cell clones

Shaw, L., Poussin, M., Rodriguez, A. et al. TCRvβ-CART therapy mediates high precision targeting of malignant T-cell clones. Blood Advances 02 September 2022

Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia

Vergez, F., Largeaud, L., Bertoli, S. et al.  Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia. Blood Cancer Journal 16 Aug 2022; 12 (117) 

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

Huang, P., Peslak, S., Ren, R. et al.  HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics 08 August 2022; 54: 1417-1426

Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer

Silderberg, G., Walling, B., Wesa, A. et al.  Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer. Preprint bioRxiv 01 July 2022

Metformin and Cancer, an Ambiguanidous Relationship

Skuli, S., Alomari, S., Gaitsch, H. et al.  Metformin and Cancer, an Ambiguanidous Relationship. Pharmaceuticals 28 March 2022; 15(5), 626

KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs

Yan, F., Li, J. Milosevic, J., et al. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discovery 01 March 2022; 12(3): 792-811 

Subversion of Serotonin-Receptor Signaling in Osteoblasts by Kynurenine drives Acute Myeloid Leukemia

Marta Galan-Diez, Florence Borot, Abdullah Mahmood, et al. Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia. Cancer Discov 2022

KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs 

Fangxue Yan, Jinyang Li, Jelena Milosevic, et al. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discov 2022

Hematopoietic Cytokines Mediate Resistance to Targeted Therapy in FLT3-ITD Acute Myeloid Leukemia

Pamela J. Sung, Mayumi Sugita, Holly Koblish, Alexander E. Perl, Martin Carroll. Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia. Blood Adv 2019; 3 (7): 1061–1072.

Signaling Mechanisms that Regulate Ex Vivo Survival of Human Acute Myeloid leukemia Initiating Cells

Bhavanasi, D., Wen, K.W., Liu, X. et al. Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells. Blood Cancer Journal 7, 636 (2017).

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity

Lynn, R., Feng, Y., Schutsky, K. et al. High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity. Leukemia 30, 1355–1364 (2016) 

Eltrombopag Modulates Reactive Oxygen Species and Decreases Acute Myeloid Leukemia Cell Survival

Kalota A, Selak MA, Garcia-Cid LA, & Carroll M. Eltrombopag Modulates Reactive Oxygen Species and Decreases Acute Myeloid Leukemia Cell Survival

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Farge T, Saland E, Danet-Desnoyers G, Carroll M, et al. Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism. Cancer Discov. 2017 Jul;7(7):716-735

Menin Inhibitor MI-3454 Induces Remission in MLL1-Rearranged and NPM1-Mutated Models of Leukemia

Klossowski S, Danet-Desnoyers G, Trotman W, et al. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 2020 Feb 3;130(2):981-997.

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Borkin D, He S, Miao H, et al. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell. 2015 Apr 13;27(4):589-602

Dexamethasone in Hyperleukocytic Acute Myeloid Leukemia

Bertoli S, Carroll M, Danet-Desnoyers G, et al. Dexamethasone in hyperleukocytic acute myeloid leukemia. Haematologica. 2018 Jun;103(6):988-998

The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity

Song, E., Wang, X., Philipson, B. et al.  The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity. Molecular Therapy Oncolytics 15 December 2022; 27: 288-304

Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy

Kim, G., Bunk, S., Mahr, A. et al.  Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy. Science Translational Medicine 31 Aug 2022; 14(600)

Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors

Yin, Y., Rodriguez, J., Nannan, Li. et al.  Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors. Molecular Therapy 06 July 2022; 30 (7): 2537-2553

Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer

Silderberg, G., Walling, B., Wesa, A. et al.  Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer. Preprint bioRxiv 01 July 2022

Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains

Zappala, F., Higbee-Dempsey, E., Bian, J. et al. Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains. Science Advances 06 May 2022; 8(18)

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17

Chaves-Moreira, D., Mitchell, M., Arruza, C. et al. The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17. Science Signaling 05 April 2022; 15(728)

Metformin and Cancer, an Ambiguanidous Relationship

Skuli, S., Alomari, S., Gaitsch, H. et al.  Metformin and Cancer, an Ambiguanidous Relationship. Pharmaceuticals 28 March 2022; 15(5), 626

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

Narayan, V., Barber-Rotenberg, J.S., Jung, I-Y. et al. PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. Nature Medicine 21 March 2022; 28: 724-734

Glucagon Signaling via Supraphysiologic GCGR can Reduce Cell Viability without Stimulating Gluconeogenic Gene Expression in Liver Cancer Cells

Godfrey, J., Riscal, R., Skuli, N. et al. Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells. Cancer Metab 10, 4 (2022).

Variability in Biopsy Quality Informs Translational Research Applications in Hepatocellular Carcinoma

Weinfurtner, K., Cho, J., Ackerman, D. et al. Variability in biopsy quality informs translational research applications in hepatocellular carcinoma. Sci Rep 11, 22763 (2021). 

CCNE1 Copy Number is a Biomarker for Response to Combination WEE1-ATR Inhibition in Ovarian and Endometrial Cancer Models

Xu, H., George, E., Kinose, Y. et al. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep 2, 9 (2021).

Human Tumor-Associated Monocytes/Macrophages and Their Regulation of T Cell Responses in Early-stage Lung Cancer

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, et al. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci Transl Med. 2019 Feb 13;11(479)

Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents

Fagre AC, Pugazhenthi U, & Cheleuitte-Nieves C, et al. Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents. Comp Med. 2021 Jun 1;71(3):210-214.

Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice

Vedder AR, Miedel EL, & Ragland NH, et al. Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice. Comp Med. 2019 Aug 1;69(4):276-282.

Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice

Misic AM, Miedel EL & Brice AK, et al. Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice. Comp Med. 2018 Aug 1;68(4):261-268.

Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response

Hurwitz, S., Jung, S., Kobulsky, D., et al. Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response. Blood 12 September 2023. 

Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

Qin, K., Huang, P., Feng, R. et al. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics 26 May 2022; 54: 874-884

Lentiviral Vector ALS20 Yields High Hemoglobin Levels with Low Genomic Integrations for Treatment of Beta-Globinopathies

Breda L, Shan X, Danet-Desnoyers GA, et al. Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther. 2021 Apr 7;29(4):1625-1638

Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, NOG, and NXG Mice

Finesso G, Willis E, Tarrant JC, et al. Spontaneous early-onset neurodegeneration in the brainstem and spinal cord of NSG, Nog, and Nxg Mice. Veterinary Pathology. 2023;60(3):374-383. doi:10.1177/03009858231151403

Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice

Hasanali ZS, Garfall AL, Burzenski L, et al. Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice. JCI Insight. 2024;9(10). doi:10.1172/jci.insight.177300