Partners
Association of Biomolecular Resource Facilities
- ABRF is a unique membership association comprising over 1500 members working within or in the support of resource and research biotechnology laboratories. Our members represent over 340 laboratories and administrative offices in government, academia, research, industry and commercial settings.
- ABRF promotes education and career advancement for scientists, core administrators, and staff through conferences, a quarterly journal, publication of research group studies and conference scholarships. The society also sponsors multi-center research studies designed to help members incorporate new biotechnologies into their laboratories.
- The Comparative Pathology Core (CPC), an Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering the expertise of board-certified veterinary pathologists and access to state-of-the-art histology, molecular staining of animal tissues, and digital pathology services.
Molecular Pathology and Imaging Core
- The Molecular Pathology and Imaging Core is a resource for researchers at Penn, CHOP, and beyond. They offer histological services, equipment, and technical expertise to assist in a variety of research projects.
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The SAIF combines state-of-the-art instrumentation and a nationally recognized staff to assist investigators with a wide range of imaging based experimental approaches. The SAIF currently provides a comprehensive suite of imaging modalities including:
- Magnetic resonance imaging (MRI) and spectroscopy (MRS)
- Optical imaging (including bioluminescence, fluorescence, and near-infrared imaging)
- Computed tomography (CT)
- Positron emission tomography (PET)
- Single photon emission computed tomography (SPECT)
- Ultrasound (US)
- The Transgenic and Chimeric Mouse Facility provides a centralized service to efficiently produce infection-free transgenic, chimeric, and genome-edited strains of mice. These mice carry randomly inserted transgenes and/or site-specific alterations in the mouse genome of specific interest to Penn researchers. The Facility offers services including DNA pronuclear injection into fertilized oocytes (along with genotyping of transgenic founders), ES cell injection into blastocysts, cytoplasmic/pronuclear injections into fertilized oocytes of CRISPR-Cas9 mix (gRNA, Cas9RNA, ssDNA/dsDNA templates), embryo and sperm cryopreservation, in vitro fertilization, and re-derivation of live and cryopreserved lines. The Core also oversees a cyropreservation facility for long-term storage of mouse embryos and sperm samples.