Publications By Year
Targeting solid cancers with a cancer-specific monoclonal antibody to surface expressed aberrantly O-glycosylated proteins
Aasted MKM, Groen AC, Keane JT, et al. Targeting solid cancers with a cancer-specific monoclonal antibody to surface expressed aberrantly O-glycosylated proteins. Molecular Cancer Therapeutics. 2023;22(10):1204-1214. doi:10.1158/1535-7163.mct-23-0221
Alternative splicing of its 5′-UTR limits CD20 mrna translation and enables resistance to CD20-directed immunotherapies
Ang Z, Paruzzo L, Hayer KE, et al. Alternative splicing of its 5′-UTR limits CD20 mrna translation and enables resistance to CD20-directed immunotherapies. Blood. 2023;142(20):1724-1739. doi:10.1182/blood.2023020400
CD38 as a pan-hematologic target for chimeric antigen receptor T cells
Glisovic-Aplenc T, Diorio C, Chukinas JA, et al. CD38 as a pan-hematologic target for chimeric antigen receptor T cells. Blood Advances. 2023;7(16):4418-4430. doi:10.1182/bloodadvances.2022007059
Lipid nanoparticle delivery of small proteins for potent In Vivo ras inhibition
Haley RM, Chan A, Billingsley MM, et al. Lipid nanoparticle delivery of small proteins for potent In Vivo ras inhibition. ACS Applied Materials & Interfaces. 2023;15(18):21877-21892. doi:10.1021/acsami.3c01501
Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters
Hayes BH, Zhu PK, Wang M, et al. Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters. Journal of Cell Science. 2023;136(11). doi:10.1242/jcs.260753
Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response
Hurwitz SN, Jung SK, Kobulsky DR, et al. Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response. Blood. 2023;142(20):1708-1723. doi:10.1182/blood.2023022147
Tissue-resident memory car T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors
Jung I-Y, Noguera-Ortega E, Bartoszek R, et al. Tissue-resident memory car T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors. Cell Reports Medicine. 2023;4(6):101053. doi:10.1016/j.xcrm.2023.101053
Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells
Katsuda T, Sussman J, Li J, et al. Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells. Stem Cell Reports. 2023;18(7):1436-1450. doi:10.1016/j.stemcr.2023.05.016
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia
Kumar A, Taghi Khani A, Duault C, et al. Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia. Journal for ImmunoTherapy of Cancer. 2023;11(5). doi:10.1136/jitc-2022-006649
LNS8801 inhibits acute myeloid leukemia by inducing the production of reactive oxygen species and activating the Endoplasmic Reticulum Stress Pathway
Lee I, Doepner M, Weissenrieder J, et al. LNS8801 inhibits acute myeloid leukemia by inducing the production of reactive oxygen species and activating the Endoplasmic Reticulum Stress Pathway. Cancer Research Communications. 2023;3(8):1594-1606. doi:10.1158/2767-9764.crc-22-0478
Combined disruption of T cell inflammatory regulators regnase-1 and roquin-1 enhances antitumor activity of engineered human T cells
Mai D, Johnson O, Reff J, et al. Combined disruption of T cell inflammatory regulators regnase-1 and roquin-1 enhances antitumor activity of engineered human T cells. Proceedings of the National Academy of Sciences. 2023;120(12). doi:10.1073/pnas.2218632120
[18f]fluorthanatrace ([18F]FTT) pet imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer, a pilot study
Pantel AR, Gitto SB, Makvandi M, et al. [18f]fluorthanatrace ([18F]FTT) pet imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer, a pilot study. Clinical Cancer Research. 2022;29(8):1515-1527. doi:10.1158/1078-0432.ccr-22-1602
RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. Journal of Clinical Investigation
Ren J-G, Xing B, Lv K, et al. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. Journal of Clinical Investigation. 2023;133(12). doi:10.1172/jci165510
C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia
Sabatier, M., Birsen, R., Lauture, L. et al. C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia. Cancer Discovery 03 April 2023.
TCRvβ-cart therapy mediates high-precision targeting of malignant T-cell clones
Shaw LC, Poussin M, Rodriguez-Garcia A, et al. TCRvβ-cart therapy mediates high-precision targeting of malignant T-cell clones. Blood Advances. 2023;7(9):1885-1898. doi:10.1182/bloodadvances.2022008798
Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma
Uslu U, Da T, Assenmacher C-A, et al. Chimeric antigen receptor T cells as adjuvant therapy for unresectable adenocarcinoma. Science Advances. 2023;9(2). doi:10.1126/sciadv.ade2526
Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
Wang XQ, Fan D, Han Q, et al. Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia. Cancer Discovery. 2022;13(3):724-745. doi:10.1158/2159-8290.cd-22-0424
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy
Wellhausen N, O’Connell RP, Lesch S, et al. Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy. Science Translational Medicine. 2023;15(714). doi:10.1126/scitranslmed.adi1145
Sequential exposure to IL21 and IL15 during human natural killer cell expansion optimizes yield and function
Zhang C, Kadu S, Xiao Y, et al. Sequential exposure to IL21 and IL15 during human natural killer cell expansion optimizes yield and function. Cancer Immunology Research. 2023;11(11):1524-1537. doi:10.1158/2326-6066.cir-23-0151
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin Lymphoma: A first-in-human study
Zhang Y, Patel RP, Kim KH, et al. Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin Lymphoma: A first-in-human study. Molecular Cancer. 2023;22(1). doi:10.1186/s12943-023-01886-9
Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells
Staupe, R. P., Lodge, K. E., Thambi, N. et al. Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells. Communications Biology 21 December 2022; 5(1399)
The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity
Song, E., Wang, X., Philipson, B. et al. The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity. Molecular Therapy Oncolytics 15 December 2022; 27: 288-304
Expression of inducible factors reprograms CAR-T cells for enhanced function and safety
Smole, A., Benton, A., Poussin, M. et al. Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell 12 December 2022; 12 (12): 1470-1487.e7
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Melenhorst, J. J., Chen, G. M., Wang, M., et al. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells. Nature 07 December 2022; 602: 503-509
Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
Pingul, B.Y., Huang, H., Chen, Q. et al. Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia. iScience 21 October 2022; 25(10)
Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer
Lee, Gu Y., Guruprasad, P., Ghilardi, G. et al. Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer. Cancer Discovery 05 October 2022; 12 (10): 2372–2391.
Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy
Kim, G., Bunk, S., Mahr, A. et al. Quantitative immunopeptidomics reveals a tumor stroma–specific target for T cell therapy. Science Translational Medicine 31 Aug 2022; 14(600)
Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia
Vergez, F., Largeaud, L., Bertoli, S. et al. Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia. Blood Cancer Journal 16 Aug 2022; 12 (117)
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
Huang, P., Peslak, S., Ren, R. et al. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics 08 August 2022; 54: 1417-1426
Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors
Yin, Y., Rodriguez, J., Nannan, Li. et al. Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors. Molecular Therapy 06 July 2022; 30 (7): 2537-2553
Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer
Silderberg, G., Walling, B., Wesa, A. et al. Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer. Preprint bioRxiv 01 July 2022
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
Qin, K., Huang, P., Feng, R. et al. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics 26 May 2022; 54: 874-884
Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains
Zappala, F., Higbee-Dempsey, E., Bian, J. et al. Rapid, site-specific labeling of “off-the-shelf” and native serum autoantibodies with T cell–redirecting domains. Science Advances 06 May 2022; 8(18)
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
Chaves-Moreira, D., Mitchell, M., Arruza, C. et al. The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17. Science Signaling 05 April 2022; 15(728)
CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies
Andrechak, J., Dooling, L., Tobin, M. et al. CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies. Cancers 5 April 2022; 14(8).
Metformin and Cancer, an Ambiguanidous Relationship
Skuli, S., Alomari, S., Gaitsch, H. et al. Metformin and Cancer, an Ambiguanidous Relationship. Pharmaceuticals 28 March 2022; 15(5), 626
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial
Narayan, V., Barber-Rotenberg, J.S., Jung, I-Y. et al. PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial. Nature Medicine 21 March 2022; 28: 724-734
KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
Yan, F., Li, J. Milosevic, J., et al. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discovery 01 March 2022; 12(3): 792-811
Rapid manufacturing of non-activated potent CAR T cells
Ghassemi, S., Durgin J., Nunez-Cruz, S. et al. Rapid manufacturing of non-activated potent CAR T cells. Nature Biomedical Engineering 21 February 2022; 6: 118–128
Subversion of Serotonin-Receptor Signaling in Osteoblasts by Kynurenine drives Acute Myeloid Leukemia
Marta Galan-Diez, Florence Borot, Abdullah Mahmood, et al. Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia. Cancer Discov 2022
Decade-long Leukaemia Remissions with Persistence of CD4+ CAR T cells
Melenhorst, J.J., Chen, G.M., Wang, M. et al. Decade-long leukaemia remissions with persistence of CD4+CAR T cells. Nature 602, 503–509 (2022).
KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
Fangxue Yan, Jinyang Li, Jelena Milosevic, et al. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discov 2022
Glucagon Signaling via Supraphysiologic GCGR can Reduce Cell Viability without Stimulating Gluconeogenic Gene Expression in Liver Cancer Cells
Godfrey, J., Riscal, R., Skuli, N. et al. Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells. Cancer Metab 10, 4 (2022).
CAR-T Cell-Mediated Depletion of Immunosuppressive Tumor-Associated Macrophages Promotes Endogenous Antitumor Immunity and Augments Adoptive Immunotherapy
Rodriguez-Garcia, A., Lynn, R.C., Poussin, M. et al. CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun 12, 877 (2021)
Variability in Biopsy Quality Informs Translational Research Applications in Hepatocellular Carcinoma
Weinfurtner, K., Cho, J., Ackerman, D. et al. Variability in biopsy quality informs translational research applications in hepatocellular carcinoma. Sci Rep 11, 22763 (2021)
CCNE1 Copy Number is a Biomarker for Response to Combination WEE1-ATR Inhibition in Ovarian and Endometrial Cancer Models
Haineng, X., George, E., Kinose, Y. et al. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Reports 2, 9 (2021)
Biochemical and Functional Characterization of Mutant KRAS Epitopes Validates this Oncoprotein for Immunological Targeting
Bear, A.S., Blanchard, T., Cesare, J. et al. Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Nat Commun 12, 4365 (2021)
Lentiviral Vector ALS20 Yields High Hemoglobin Levels with Low Genomic Integrations for Treatment of Beta-Globinopathies
Breda L, Ghiaccio V, Shan X, Danet-Desnoyers GA, et al. Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther. 2021 Apr 7;29(4):1625-1638
Tumor-Infiltrating Mast Cells are Associated with Resistance to Anti-PD-1 Therapy
Somasundaram R, Xiao M,, Secreto A, et al. Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy. Nat Commun. 2021 Jan 12;12(1):346
Pathology of Macrophage Activation Syndrome in Humanized NSGS Mice
Tarrant JC, Shan X, Danet-Desnoyers G, et al. Pathology of macrophage activation syndrome in humanized NSGS mice. Res Vet Sci. 2021
Lentiviral Vector ALS20 Yields High Hemoglobin Levels with Low Genomic Integrations for Treatment of Beta-Globinopathies
Breda L, Shan X, Danet-Desnoyers GA, et al. Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther. 2021 Apr 7;29(4):1625-1638
Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents
Fagre AC, Pugazhenthi U, & Cheleuitte-Nieves C, et al. Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents. Comp Med. 2021 Jun 1;71(3):210-214.
Dual CD4-based CAR T cells with Distinct Costimulatory Domains Mitigate HIV Pathogenesis In Vivo
Maldini, C.R., Claiborne, D.T., Okawa, K. et al. Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo. Nat Med 26, 1776–1787 (2020)
Menin Inhibitor MI-3454 Induces Remission in MLL1-Rearranged and NPM1-Mutated Models of Leukemia
Klossowski S, Danet-Desnoyers G, Trotman W, et al. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 2020 Feb 3;130(2):981-997.
Combinatorial Treatment with Menin and FLT3 Inhibitors Induces Complete Remission in AML Models with Activating FLT3 Mutations
Miao H, Danet-Desnoyers G, Grembecka J, et al. Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations. Blood. 2020 Dec 17;136(25):2958-2963
Hematopoietic Cytokines Mediate Resistance to Targeted Therapy in FLT3-ITD Acute Myeloid Leukemia
Pamela J. Sung, Mayumi Sugita, Holly Koblish, Alexander E. Perl, Martin Carroll. Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia. Blood Adv 2019; 3 (7): 1061–1072.
Human Tumor-Associated Monocytes/Macrophages and Their Regulation of T Cell Responses in Early-stage Lung Cancer
Singhal S, Stadanlick J, Annunziata MJ, Rao AS, et al. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Sci Transl Med. 2019 Feb 13;11(479)
Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice
Vedder AR, Miedel EL, & Ragland NH, et al. Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice. Comp Med. 2019 Aug 1;69(4):276-282.
Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice
Misic AM, Miedel EL & Brice AK, et al. Culture-independent Profiling of the Fecal Microbiome to Identify Microbial Species Associated with a Diarrheal Outbreak in Immunocompromised Mice. Comp Med. 2018 Aug 1;68(4):261-268.
Control of Triple-Negative Breast Cancer using Ex Vivo Self-Enriched, Costimulated NKG2D CAR T cells
Han, Y., Xie, W., Song, DG. et al. Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells. J Hematol Oncol 11, 92 (2018)
Dexamethasone in Hyperleukocytic Acute Myeloid Leukemia
Bertoli S, Carroll M, Danet-Desnoyers G, et al. Dexamethasone in hyperleukocytic acute myeloid leukemia. Haematologica. 2018 Jun;103(6):988-998