Department of Psychiatry

Penn Behavioral Health

Mathias Basner, MD, PhD, MSc

Mathias Basner, MD, PhD, MSc 
Associate Professor of Sleep and Chronobiology in Psychiatry
University of Pennsylvania School of Medicine 
Division of Sleep and Chronobiology, Department of Psychiatry

Mathias Basner, MD, PhD, M.Sc. is an Associate Professor of Sleep and Chronobiology in Psychiatry at the University of Pennsylvania School of Medicine. Dr. Basner received his degree in Medicine and his Master in Research from the University of Bochum, Germany and Master of Science in Epidemiology from the University of Bielefeld, Germany. Dr. Basner trained at the Institute for Applied Physiology at the University of Bochum and worked as a Research Associate at the German Aerospace Center (DLR), Institute of Aerospace Medicine, Flight Physiology Division from 1999 until 2006 before moving to the United States to pursue his research interests in the neurobehavioral consequences of sleep loss as a Research Associate. He returned to DLR in 2008 to head the Flight Physiology Division for two years. In January 2010, Dr. Basner assumed the position of Assistant Professor of Sleep and Chronobiology in Psychiatry and was promoted to Associate Professor in 2015.

Dr. Basner's primary research interests concern the effects of sleep loss on neurobehavioral and cognitive functions, population studies on sleep time and waking activities, and the effects of traffic noise on sleep and recuperation. Dr. Basner conducted several large scale laboratory and field studies on the effects of traffic noise on sleep between 1999 and 2008 as PI. For this research, Dr. Basner was awarded the German Aerospace Center award for outstanding research in 2007 and the Science Award of the German Academy for Aviation and Travel Medicine in 2010.

Dr. Basner is Deputy Editor of the journal SLEEP, and ad-hoc reviewer for 50+ other scientific journals. He has reviewed proposals for NIH, the European Space Agency (ESA), the Australian Antarctic Science Program (AASP), and the German Research Foundation (DFG).

Research Interests

Effects of sleep loss on neurobehavioral and cognitive functions, population studies on sleep time and waking activities, effects of traffic noise on sleep and recuperation


Selected Bibliography

Shea, J.A., Basner, M., Bates, D.W., Bellini, L.M., Chaiyachati, K.H., Desai, S.V., Dinges, D.F., Even-Shoshan, O., Katz, J.T., Shade, D.M., Silber, J.H., Small, D.S., Sternberg, A.L., Tonascia, J., Volpp, K.G., Asch, D.A.: Development of the individualized Comparative Effectiveness of Models Optimizing Patient Safety and Resident Education (iCOMPARE) Trial: A national cluster-randomized trial of resident duty hour policies in Internal Medicine. BMJ Open, 8:e021711: 1-11, 2018.

Palanca, B.J.A., Maybrier, H.R., Mickle, A.M., Farber, N.B., Hogan, R.E., Trammel, E.R., Spencer, J.W., Bohnenkamp, D.D., Wildes, T.S., Ching, S., Lenze, E., Basner, M., Kelz, M.B., Avidan, M.S.: Cognitive and neurophysiological recovery following electroconvulsive therapy: a study protocol. Frontiers in Psychiatry, 9(171): 1-13, 2018.

Desai, S.V., Asch, D.S., Bellini, L.M., Chaiyachati, K.H., Liu, M., Sternberg, A.L., Tonascia, J., Yeager, A.M., Asch, J.M., Katz, J.T., Basner, M., Bates, D.W., Bilimoria, K.Y., Dinges, D.F., Even-Shoshan, O., Shade, D.M., Silber, J.H., Small, D.S., Volpp, K.G., Shea, J.A., and the iCOMPARE Research Group: Education outcomes from a duty-hour flexibility trial in Internal Medicine. New England Journal of Medicine, 378(16): 1494-1508, 2018.

Basner, M., Dinges, D.F.: Sleep duration in the United States 2003–2016: first signs of success in the fight against sleep deficiency? Sleep 41(2), zsy012, 1-16, 2018.

Basner, M., Nasrini, J., Hermosillo, E., McGuire, S., Dinges, D.F., Moore, T.M., Gur, R.C., Rittweger, J., Mulder, E., Wittkowski, M., Donoviel, D., Stevens, B., Bershad, E.M., and the SPACECOT investigator group: Effects of -12° head-down tilt with and without elevated levels of CO2 on cognitive performance: the SPACECOT study. Journal of Applied Physiology, 124(3), 750-60, 2018.

Basner, M., Hermosillo, E., Nasrini, J., McGuire, S., Saxena, S., Moore, T.M., Gur, R.C., Dinges, D.F.: Repeated administration effects on Psychomotor Vigilance Test (PVT) performance. Sleep, 41(1), zsx187, 1-6, 2018.

Moore, T.M., Basner, M., Nasrini, J., Hermosillo, E., Kabadi, S., Roalf, D.R., McGuire, S., Ecker, A.J., Ruparel, K., Port, Jackson, C.T., Dinges, D.F., Gur, R.C.: Validation of the Cognition test battery for spaceflight in a sample of highly educated adults. Aerospace Medicine and Human Performance, 88(10), 937-46, 2017.

Maier, K.L., McKinstry-Wu, A.R., Palanca, B.J.A., Tarnal, V., Blain-Moraes, S., Basner, M., Avidan, M.S., Mashour, G.A., Kelz, M.B.: Protocol for the Reconstructing Human Consciousness and Cognition Study. Frontiers in Human Neuroscience, 11(6), 284, 2017.

Schäffer, B., Pieren, R., Mendolia, F., Basner, M., Brink, M.: Noise exposure-response relationships established from repeated binary observations: Modeling approaches and applications. Journal of the Acoustic Society of America 141(5): 3175-3185, 2017.

Basner, M., Dinges, D.F., Shea, J.A., Small, D.S., Zhu, J., Norton, L., Ecker, A.J., Novak, C., Bellini, L.M., Volpp, K.G.: Sleep and alertness in medical interns and residents: an observational study on the role of extended shifts. Sleep 40(4): zsx027, 1-8, 2017.

Perlis, M.L., Grandner, M.A., Brown, G.K., Basner, M., Chakravorty, S., Morales, K.H., Gehrman, P.R., Chaudhary, N.S., Thase, M.E., Dinges, D.F.: Nocturnal wakefulness: a previously unrecognized risk factor for suicide. Journal of Clinical Psychiatry 77(6): e726-733, 2016.

McGuire, S., Müller, U., Elmenhorst, E.-M., Basner, M.: Inter-individual differences in the effects of aircraft noise on sleep fragmentation. Sleep 39(5): 1107-10, 2016.

Basner, M., McGuire, S., Goel, N., Rao, H., Dinges, D.F.: A new likelihood ratio metric for the Psychomotor Vigilance Test and its sensitivity to sleep loss. Journal of Sleep Research 24(6): 702-713, 2015.

Basner, M., Savitt, A., Moore, T.M., Port, A.M., McGuire, S., Ecker, A.J., Nasrini, J., Mollicone, D.J., Mott, C.M., McCann, C., Dinges, D.F., Gur, R.C.: Development and validation of the Cognition test battery for spaceflight. Aerospace Medicine and Human Performance 86(11): 942-52, 2015.

Lerchl, K., Rakova, N., Dahlmann, A., Rauh, M., Goller, U., Basner, M., Dinges, D.F., Beck, L., Agureev, A., Larina, I., Baranov, V., Morukov, B., Eckardt, K.-U., Vassilieva, G., Wabel, P., Vienken, J., Kirsch, K., Johannes, B., Krannich, A., Luft, F.C., Titze, J.: Agreement between twenty-four hour salt ingestion and sodium excretion in a controlled environment. Hypertension, 66(4): 850-7, 2015.

Johannes, B. Sitev, A.S., Vinokhodova, A.G., Salnitski, V.P. Savchenko, E.G., Artyukhova, A.E., Bubeev, Y.A., Morukov, B., Tafforin, C., Basner, M., Dinges, D.F., Rittweger, J.: Wireless monitoring of changes in crew relations during long-duration mission simulation. PLoS One, 10(8): e0134814, 2015.

Ma, N., Dinges, D.F., Basner, M., Rao, H.: How acute total sleep loss affects the attending brain: a meta-analysis of neuroimaging studies. Sleep, 38(2), 233-40, 2015.

Goel, N., Basner, M., Dinges, D.F.: Phenotyping of neurobehavioral vulnerability to circadian phase during sleep loss. Methods in Enzymology, 522: 285-308, 2015.

Basner, M., Brink, M., Bristow, A., de Kluizenaar, Y., Finegold, L., Hong, J., Janssen, S.A., Klaeboe, R., Leroux, T., Liebl, A., Matsui, T., Schwela, D., Sliwinska-Kowalska, M., Sörquist, P.: ICBEN review of research on the biological effects of noise 2011-2014, Noise & Health, 17(75), 57-82, 2015.

Basner, M., Spaeth, A.M., Dinges, D.F.: Sociodemographic characteristics and waking activities and their role in the timing and duration of sleep. Sleep 37(12): 1889-1906, 2014.

Vejvoda, M., Elmenhorst, E.-M., Pennig, S., Plath, G., Maaß, H., Tritschler, K., Basner, M., Aeschbach, D.: Significance of time awake for predicting pilots' fatigue on short-haul flights: implications for flight duty time regulations. Journal of Sleep Research 23(5): 564-7, 2014.

Yi, B., Rykova, M., Feuerecker, M., Jäger, B., Ladinig, C., Basner, M., Hörl, M., Matzel, S., Kaufmann, I., Strewe, C., Nichiporuk, I., Vassilieva, G., Rinas, K., Baatout, S., Schelling, G., Thiel, M., Dinges, D.F., Morukov, B., Choukèr, A.: 520-d isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype. Brain, Behavior, and Immunity 40: 203-10, 2014.

Shea, J.A., Bellini, L.M., Dinges, D.F., Curtis, M.L., Tao, Y., Zhu, J., Small, D.S., Basner, M., Norton, L., Novak, C., Dine, C., Rosen, I.M., Volpp, K.G.: The impact of protected sleep period for internal medicine interns on overnight call on depression, burnout, and empathy. Journal of Graduate Medical Education 6(2): 256-263, 2014.

Minkel, J.D., Moreta, M., Muto, J., Htaik, O., Jones, C., Basner, M., Dinges, D.F.: Sleep deprivation potentiates HPA axis stress reactivity in healthy adults. Health Psychology 33(11): 1430-4, 2014.

Elmenhorst, E.-M., Quehl, J., Müller, U., Basner, M.: Nocturnal air, road and rail traffic noise and daytime cognitive performance and annoyance. Journal of the Acoustical Society of America 135(1): 213-222, 2014.

Basner, M., Dinges, D.F., Mollicone, D.J., Savelev, I., Ecker, A.J., Di Antonio, A., Jones, C.W., Hyder, E., Kan, K., Morukov, B.V., Sutton, J.P.: Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to Mars. PLoS One 9(3): e93298, 2014.

Basner, M., Babisch, W., Davis, A., Brink, M., Clark, C., Janssen, S., Stansfeld, S.: Review of auditory and non-auditory effects of noise on health. The Lancet, 383(9925): 1325-1332, 2014.

Abe, T., Mollicone, D., Basner, M., Dinges, D.F.: Sleepiness and safety: where biology needs technology. Sleep and Biological Rhythms, 12: 74-78, 2014.

Münzel, T., Gori, T., Babisch, W., Basner, M.: Cardiovascular effects of environmental noise exposure. European Heart Journal, 35(13): 829-36, 2014.

Basner, M., Dinges, D.F., Mollicone, D.J., Ecker, A.J., Jones, C.W., Hyder, E.C., Di Antonio, A., Savelev, I., Kan, K., Goel, N., Morukov, B.V., Sutton, J.P.: Mars 520-day mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing. Proceedings of the National Academies of Science 110(7): 2635-2640, 2013.

Basner, M., Brink, M.: Sample size estimation for field studies on the effects of aircraft noise on sleep. Applied Acoustics 74(6): 812-817, 2013.

Schmidt, F.P., Basner, M., Kröger, G., Weck, S., Schnorbus, B., Muttray, A., Sariyar, M., Binder, H., Tommaso, G., Warnholtz, A., Münzel, T.: Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults. European Heart Journal 34(45): 3508-3514, 2013.

Schwanitz, S., Wittkowski, M., Rolny, V., Samel, C., Basner, M.: Continuous assessments of pressure comfort on a train - A field-laboratory comparison. Applied Ergonomics 44 (1): 11-17, 2013. 

Basner, M., Rao, H., Goel, N., Dinges, D.F.: Sleep deprivation and neurobehavioral dynamics. Current Opinions in Neurobiology, 23(5): 854–863, 2013.

Schwanitz, S., Wittkowski, M., Rolny, V., Basner, M.: Pressure variations on a train - where is the threshold to railway passengers' discomfort? Applied Ergonomics, 44(2): 200-209, 2013.

Schwanitz, S., Wittkowski, M., Rolny, V., Samel, C., Basner, M.: Continuous assessments of pressure comfort on a train - A field-laboratory comparison. Applied Ergonomics, 44 (1): 11-17, 2013.

Volpp, K.G., Shea, J.A., Small, D.S., Basner, M., Zhu, J., Norton, L., Ecker, A., Novak, C., Bellini, L.M., Dine, C.J., Mollicone, D.J., Dinges, D.F.: Effect of a protected sleep period on hours slept during extended overnight in-hospital duty hours among medical interns: A randomized trial. Journal of the American Medical Association, 308(21): 2208-2217, 2012.

Basner, M., Elmenhorst, E.-M., Brink, M.: Critical appraisal of methods for the assessment of noise effects on sleep. Noise & Health, 14(61): 301-309, 2012.

Pennig, S., Quehl, J., Müller, U., Rolny, V., Maaß, H., Basner, M., Elmenhorst, E.-M.: Annoyance and self-reported sleep disturbance due to night-time railway noise examined in the field. Journal of the Acoustical Society of America, 132(5): 3109-3117, 2012.

Elmenhorst, E.-M., Pennig, S., Rolny, V., Quehl, J., Müller, U., Maaß, H., Basner, M.: Examining nocturnal railway noise and aircraft noise in the field: Sleep, psychomotor performance, and annoyance. Science of the Total Environment 424: 48-56, 2012.

Basner, M., Dinges, D.F.: An adaptive duration version of the PVT accurately tracks changes in psychomotor vigilance induced by sleep restriction. Sleep 35(2): 193-202, 2012.

Brink, M., Omlin, S., Müller, C., Pieren, R., Basner, M.: An event-related analysis of awakening reactions due to nocturnal church bell noise. Science of the Total Environment, 409: 5210-20, 2011.

Basner, M., Mollicone, D.M., Dinges, D.F.: Validity and sensitivity of a brief psychomotor vigilance test (PVT-B) to total and partial sleep deprivation. Acta Astronautica 69: 949-59, 2011.

Basner, M., Rubinstein, J.: Fitness for duty: A 3 minute version of the Psychomotor Vigilance Test predicts fatigue related declines in luggage screening performance. Journal of Occupational and Environmental Medicine 53(10): 1146-54, 2011.

Basner, M., Dinges, D.F.: Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. Sleep 34(5): 581-91, 2011.

Griefahn, B., Basner, M.: Traffic noise - effects on sleep and performance. Arbeitsmed Sozialmed Umweltmed 46(4): 280-88, 2011.

Basner, M., Müller, U., Elmenhorst, E.-M.: Single and combined effect of air, road, and rail traffic noise on sleep and recuperation. Sleep 34(1):11-23, 2011.

Brink, M., Schreckenberg, D., Thomann, G., Basner, M.: Aircraft noise indexes for effect oriented noise assessment. Acta Acustica united with Acustica 96(6), 1012-25, 2010.

Elmenhorst, E.-M., Elmenhorst, D., Wenzel, J., Quehl, J., Müller, U., Maaß, H., Vejvoda, M., Basner, M.: Effects of nocturnal aircraft noise on cognitive performance in the following morning: dose-response relationships in laboratory and field. International Archives of Occupational and Environmental Health 83, 743-51, 2010.

Basner, M., van den Berg, M., Griefahn, B.: Aircraft noise effects on sleep: Mechanisms, mitigation, and research needs. Noise & Health, 12(47), 95-109, 2010.

Basner, M., Siebert, U.: Markov processes for the prediction of aircraft noise effects on sleep. Medical Decision Making 30(2), 275-89, 2010.

Basner, M.: Arousal threshold determination in 1862: Kohlschütter’s Measurements on the Firmness of Sleep. Sleep Medicine 11(4), 417-22, 2010.

Basner, M., Müller, U., Griefahn, B.: Practical guidance for risk assessment of traffic noise effects on sleep. Applied Acoustics 71(6), 518-22, 2010.

Brink, M., Basner, M., Schierz, C., Spreng, M., Scheuch, K., Bauer, G., Stahel, W.A.: Determining physiological reaction probabilities to noise events during sleep. Somnologie 13(4), 236-43, 2009.

Basner, M.: Validity of aircraft noise induced awakening predictions. Noise Control Engineering Journal 57(5), 524-35, 2009.

Basner, M., Dinges, D.F.: Dubious bargain: Trading sleep for Leno and Letterman. Sleep 32(6), 747-52, 2009.

Basner, M., Müller, U., Elmenhorst, E.-M., Kluge, G., Griefahn, B.: Aircraft noise effects on sleep: A systematic comparison of EEG-awakenings and automatically detected cardiac activations. Physiological Measurement 29(9), 1089-1103, 2008.

Basner, M., Rubinstein, J., Fomberstein, K.M., Coble, M.C., Ecker, A., Avinash, D., Dinges, D.F.: Effects of night work, sleep loss and time on task on simulated threat detection performance. Sleep 31(9), 1251-1259, 2008.

Basner, M.: Nocturnal aircraft noise exposure increases objectively assessed daytime sleepiness. Somnologie 12(2), 110-117, 2008.

Marks, A., Griefahn, B., Basner, M.: Event-related awakenings caused by nocturnal transportation noise. Noise Control Engineering Journal, 56(1), 52-62, 2008.

Griefahn, B., Bröde, P., Marks, A., Basner, M.: autonomic arousals related to traffic noise during sleep. Sleep 31(4), 569-577, 2008.

Basner, M., Griefahn, B., Penzel, T.: Inter-rater agreement in sleep stage classification between centers with different backgrounds. Somnologie 12(1), 75-84, 2008.

Basner, M., Glatz, C., Griefahn, B., Penzel, T., Samel, A.: Aircraft Noise: Effects on macro- and micro-structure of sleep. Sleep Medicine 9(4), 382-387, 2008.

Basner, M., Griefahn, B., Müller, U., Plath, G., Samel, A.: An ECG-based algorithm for the automatic identification of autonomic activations associated with cortical arousals. Sleep 30(10), 1349-61, 2007.

Basner, M., Fomberstein, K.M., Razavi, F.M., Banks, S., William, J.H., Rosa, R.R., Dinges, D.F.: American Time Use Survey: Sleep time and its relationship to waking activities. Sleep 30(9), 1085-95, 2007.

Basner, M., Siebert, U.: Markov state transition models for the prediction of noise-induced sleep disturbances. Somnologie 10(4), 176-91, 2006.

Quehl, J., Basner, M.: Annoyance from nocturnal aircraft noise exposure: laboratory and field-specific dose-response curves. Journal of Environmental Psychology 26(2), 127-40, 2006.

Basner, M., Isermann, U., Samel, A.: Aircraft noise effects on sleep: application of the results of a large polysomnographic field study. Journal of the Acoustical Society of America 119(5), 2772-84, 2006.

Basner, M., Samel, A.: Effects of nocturnal aircraft noise on sleep structure. Somnologie 9(2), 84-95, 2005.


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