John Q. Trojanowski, MD, PhD

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
M.D.
Tufts University School of Medicine, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Cali Christopher P, Patino Maribel, Tai Yee Kit, Ho Wan Yun, McLean Catriona A, Morris Christopher M, Seeley William W, Miller Bruce L, Gaig Carles, Vonsattel Jean Paul G, White Charles L, Roeber Sigrun, Kretzschmar Hans, Troncoso Juan C, Troakes Claire, Gearing Marla, Ghetti Bernardino, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q, Mok Kin Y, Ling Helen, Dickson Dennis W, Schellenberg Gerard D, Ling Shuo-Chien, Lee Edward B: C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta neuropathologica 138(5): 795-811, Nov 2019.

Uemura Norihito, Uemura Maiko T, Lo Angela, Bassil Fares, Zhang Bin, Luk Kelvin C, Lee Virginia M-Y, Takahashi Ryosuke, Trojanowski John Q: Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy. Journal of neuropathology and experimental neurology 78(10): 877-890, Oct 2019.

Prokop Stefan, Miller Kelly R, Labra Sergio R, Pitkin Rose M, Hoxha Kevt'her, Narasimhan Sneha, Changolkar Lakshmi, Rosenbloom Alyssa, Lee Virginia M-Y, Trojanowski John Q: Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica 138(4): 613-630, Oct 2019.

Chu Yaping, Muller Scott, Tavares Adriana, Barret Olivier, Alagille David, Seibyl John, Tamagnan Gilles, Marek Ken, Luk Kelvin C, Trojanowski John Q, Lee Virginia M Y, Kordower Jeffrey H: Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a journal of neurology Oct 2019.

Posavi Marijan, Diaz-Ortiz Maria, Liu Benjamine, Swanson Christine R, Skrinak R Tyler, Hernandez-Con Pilar, Amado Defne A, Fullard Michelle, Rick Jacqueline, Siderowf Andrew, Weintraub Daniel, McCluskey Leo, Trojanowski John Q, Dewey Richard B, Huang Xuemei, Chen-Plotkin Alice S: Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. PLoS medicine 16(10): e1002931, Oct 2019.

Spotorno Nicola, Hall Sara, Irwin David J, Rumetshofer Theodor, Acosta-Cabronero Julio, Deik Andres F, Spindler Meredith A, Lee Edward B, Trojanowski John Q, van Westen Danielle, Nilsson Markus, Grossman Murray, Nestor Peter J, McMillan Corey T, Hansson Oskar: Diffusion Tensor MRI to Distinguish Progressive Supranuclear Palsy from α-Synucleinopathies. Radiology Page: 190406, Oct 2019.

Caswell Carrie, McMillan Corey T, Xie Sharon X, Van Deerlin Vivianna M, Suh EunRan, Lee Edward B, Trojanowski John Q, Lee Virginia M-Y, Irwin David J, Grossman Murray, Massimo Lauren M: Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology Sep 2019.

Mollenhauer Brit, Caspell-Garcia Chelsea J, Coffey Christopher S, Taylor Peggy, Singleton Andy, Shaw Leslie M, Trojanowski John Q, Frasier Mark, Simuni Tanya, Iranzo Alex, Oertel Wolfgang, Siderowf Andrew, Weintraub Daniel, Seibyl John, Toga Arthur W, Tanner Caroline M, Kieburtz Karl, Chahine Lana M, Marek Kenneth, Galasko Douglas: Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 34(9): 1354-1364, Sep 2019.

Kunkle Brian W, Grenier-Boley Benjamin, Sims Rebecca, Bis Joshua C, Damotte Vincent, Naj Adam C, Boland Anne, Vronskaya Maria, van der Lee Sven J, Amlie-Wolf Alexandre, Bellenguez Céline, Frizatti Aura, Chouraki Vincent, Martin Eden R, Sleegers Kristel, Badarinarayan Nandini, Jakobsdottir Johanna, Hamilton-Nelson Kara L, Moreno-Grau Sonia, Olaso Robert, Raybould Rachel, Chen Yuning, Kuzma Amanda B, Hiltunen Mikko, Morgan Taniesha, Ahmad Shahzad, Vardarajan Badri N, Epelbaum Jacques, Hoffmann Per, Boada Merce, Beecham Gary W, Garnier Jean-Guillaume, Harold Denise, Fitzpatrick Annette L, Valladares Otto, Moutet Marie-Laure, Gerrish Amy, Smith Albert V, Qu Liming, Bacq Delphine, Denning Nicola, Jian Xueqiu, Zhao Yi, Del Zompo Maria, Fox Nick C, Choi Seung-Hoan, Mateo Ignacio, Hughes Joseph T, Adams Hieab H, Malamon John, Sanchez-Garcia Florentino, Patel Yogen, Brody Jennifer A, Dombroski Beth A, Naranjo Maria Candida Deniz, Daniilidou Makrina, Eiriksdottir Gudny, Mukherjee Shubhabrata, Wallon David, Uphill James, Aspelund Thor, Cantwell Laura B, Garzia Fabienne, Galimberti Daniela, Hofer Edith, Butkiewicz Mariusz, Fin Bertrand, Scarpini Elio, Sarnowski Chloe, Bush Will S, Meslage Stéphane, Kornhuber Johannes, White Charles C, Song Yuenjoo, Barber Robert C, Engelborghs Sebastiaan, Sordon Sabrina, Voijnovic Dina, Adams Perrie M, Vandenberghe Rik, Mayhaus Manuel, Cupples L Adrienne, Albert Marilyn S, De Deyn Peter P, Gu Wei, Himali Jayanadra J, Beekly Duane, Squassina Alessio, Hartmann Annette M, Orellana Adelina, Blacker Deborah, Rodriguez-Rodriguez Eloy, Lovestone Simon, Garcia Melissa E, Doody Rachelle S, Munoz-Fernadez Carmen, Sussams Rebecca, Lin Honghuang, Fairchild Thomas J, Benito Yolanda A, Holmes Clive, Karamujić-Čomić Hata, Frosch Matthew P, Thonberg Hakan, Maier Wolfgang, Roshchupkin Gennady, Ghetti Bernardino, Giedraitis Vilmantas, Kawalia Amit, Li Shuo, Huebinger Ryan M, Kilander Lena, Moebus Susanne, Hernández Isabel, Kamboh M Ilyas, Brundin RoseMarie, Turton James, Yang Qiong, Katz Mindy J, Concari Letizia, Lord Jenny, Beiser Alexa S, Keene C Dirk, Helisalmi Seppo, Kloszewska Iwona, Kukull Walter A, Koivisto Anne Maria, Lynch Aoibhinn, Tarraga Lluís, Larson Eric B, Haapasalo Annakaisa, Lawlor Brian, Mosley Thomas H, Lipton Richard B, Solfrizzi Vincenzo, Gill Michael, Longstreth W T, Montine Thomas J, Frisardi Vincenza, Diez-Fairen Monica, Rivadeneira Fernando, Petersen Ronald C, Deramecourt Vincent, Alvarez Ignacio, Salani Francesca, Ciaramella Antonio, Boerwinkle Eric, Reiman Eric M, Fievet Nathalie, Rotter Jerome I, Reisch Joan S, Hanon Olivier, Cupidi Chiara, Uitterlinden A G Andre, Royall Donald R, Dufouil Carole, Maletta Raffaele Giovanni, de Rojas Itziar, Sano Mary, Brice Alexis, Cecchetti Roberta, George-Hyslop Peter St, Ritchie Karen, Tsolaki Magda, Tsuang Debby W, Dubois Bruno, Craig David, Wu Chuang-Kuo, Soininen Hilkka, Avramidou Despoina, Albin Roger L, Fratiglioni Laura, Germanou Antonia, Apostolova Liana G, Keller Lina, Koutroumani Maria, Arnold Steven E, Panza Francesco, Gkatzima Olymbia, Asthana Sanjay, Hannequin Didier, Whitehead Patrice, Atwood Craig S, Caffarra Paolo, Hampel Harald, Quintela Inés, Carracedo Ángel, Lannfelt Lars, Rubinsztein David C, Barnes Lisa L, Pasquier Florence, Frölich Lutz, Barral Sandra, McGuinness Bernadette, Beach Thomas G, Johnston Janet A, Becker James T, Passmore Peter, Bigio Eileen H, Schott Jonathan M, Bird Thomas D, Warren Jason D, Boeve Bradley F, Lupton Michelle K, Bowen James D, Proitsi Petra, Boxer Adam, Powell John F, Burke James R, Kauwe John S K, Burns Jeffrey M, Mancuso Michelangelo, Buxbaum Joseph D, Bonuccelli Ubaldo, Cairns Nigel J, McQuillin Andrew, Cao Chuanhai, Livingston Gill, Carlson Chris S, Bass Nicholas J, Carlsson Cynthia M, Hardy John, Carney Regina M, Bras Jose, Carrasquillo Minerva M, Guerreiro Rita, Allen Mariet, Chui Helena C, Fisher Elizabeth, Masullo Carlo, Crocco Elizabeth A, DeCarli Charles, Bisceglio Gina, Dick Malcolm, Ma Li, Duara Ranjan, Graff-Radford Neill R, Evans Denis A, Hodges Angela, Faber Kelley M, Scherer Martin, Fallon Kenneth B, Riemenschneider Matthias, Fardo David W, Heun Reinhard, Farlow Martin R, Kölsch Heike, Ferris Steven, Leber Markus, Foroud Tatiana M, Heuser Isabella, Galasko Douglas R, Giegling Ina, Gearing Marla, Hüll Michael, Geschwind Daniel H, Gilbert John R, Morris John, Green Robert C, Mayo Kevin, Growdon John H, Feulner Thomas, Hamilton Ronald L, Harrell Lindy E, Drichel Dmitriy, Honig Lawrence S, Cushion Thomas D, Huentelman Matthew J, Hollingworth Paul, Hulette Christine M, Hyman Bradley T, Marshall Rachel, Jarvik Gail P, Meggy Alun, Abner Erin, Menzies Georgina E, Jin Lee-Way, Leonenko Ganna, Real Luis M, Jun Gyungah R, Baldwin Clinton T, Grozeva Detelina, Karydas Anna, Russo Giancarlo, Kaye Jeffrey A, Kim Ronald, Jessen Frank, Kowall Neil W, Vellas Bruno, Kramer Joel H, Vardy Emma, LaFerla Frank M, Jöckel Karl-Heinz, Lah James J, Dichgans Martin, Leverenz James B, Mann David, Levey Allan I, Pickering-Brown Stuart, Lieberman Andrew P, Klopp Norman, Lunetta Kathryn L, Wichmann H-Erich, Lyketsos Constantine G, Morgan Kevin, Marson Daniel C, Brown Kristelle, Martiniuk Frank, Medway Christopher, Mash Deborah C, Nöthen Markus M, Masliah Eliezer, Hooper Nigel M, McCormick Wayne C, Daniele Antonio, McCurry Susan M, Bayer Anthony, McDavid Andrew N, Gallacher John, McKee Ann C, van den Bussche Hendrik, Mesulam Marsel, Brayne Carol, Miller Bruce L, Riedel-Heller Steffi, Miller Carol A, Miller Joshua W, Al-Chalabi Ammar, Morris John C, Shaw Christopher E, Myers Amanda J, Wiltfang Jens, O'Bryant Sid, Olichney John M, Alvarez Victoria, Parisi Joseph E, Singleton Andrew B, Paulson Henry L, Collinge John, Perry William R, Mead Simon, Peskind Elaine, Cribbs David H, Rossor Martin, Pierce Aimee, Ryan Natalie S, Poon Wayne W, Nacmias Benedetta, Potter Huntington, Sorbi Sandro, Quinn Joseph F, Sacchinelli Eleonora, Raj Ashok, Spalletta Gianfranco, Raskind Murray, Caltagirone Carlo, Bossù Paola, Orfei Maria Donata, Reisberg Barry, Clarke Robert, Reitz Christiane, Smith A David, Ringman John M, Warden Donald, Roberson Erik D, Wilcock Gordon, Rogaeva Ekaterina, Bruni Amalia Cecilia, Rosen Howard J, Gallo Maura, Rosenberg Roger N, Ben-Shlomo Yoav, Sager Mark A, Mecocci Patrizia, Saykin Andrew J, Pastor Pau, Cuccaro Michael L, Vance Jeffery M, Schneider Julie A, Schneider Lori S, Slifer Susan, Seeley William W, Smith Amanda G, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Swerdlow Russell H, Tang Mitchell, Tanzi Rudolph E, Trojanowski John Q, Troncoso Juan C, Van Deerlin Vivianna M, Van Eldik Linda J, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Wilhelmsen Kirk C, Williamson Jennifer, Wingo Thomas S, Woltjer Randall L, Wright Clinton B, Yu Chang-En, Yu Lei, Saba Yasaman, Pilotto Alberto, Bullido Maria J, Peters Oliver, Crane Paul K, Bennett David, Bosco Paola, Coto Eliecer, Boccardi Virginia, De Jager Phil L, Lleo Alberto, Warner Nick, Lopez Oscar L, Ingelsson Martin, Deloukas Panagiotis, Cruchaga Carlos, Graff Caroline, Gwilliam Rhian, Fornage Myriam, Goate Alison M, Sanchez-Juan Pascual, Kehoe Patrick G, Amin Najaf, Ertekin-Taner Nilifur, Berr Claudine, Debette Stéphanie, Love Seth, Launer Lenore J, Younkin Steven G, Dartigues Jean-Francois, Corcoran Chris, Ikram M Arfan, Dickson Dennis W, Nicolas Gael, Campion Dominique, Tschanz JoAnn, Schmidt Helena, Hakonarson Hakon, Clarimon Jordi, Munger Ron, Schmidt Reinhold, Farrer Lindsay A, Van Broeckhoven Christine, O'Donovan Michael C, DeStefano Anita L, Jones Lesley, Haines Jonathan L, Deleuze Jean-Francois, Owen Michael J, Gudnason Vilmundur, Mayeux Richard, Escott-Price Valentina, Psaty Bruce M, Ramirez Alfredo, Wang Li-San, Ruiz Agustin, van Duijn Cornelia M, Holmans Peter A, Seshadri Sudha, Williams Julie, Amouyel Phillippe, Schellenberg Gerard D, Lambert Jean-Charles, Pericak-Vance Margaret A: Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics 51(9): 1423-1424, Sep 2019.

Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Beecham Gary, Kunkle Brian, Bush William S, Gifford Katherine A, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Deming Yuetiva, Chao Michael J, Huentelman Matt, Martin Eden R, Hamilton-Nelson Kara, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Cruchaga Carlos, Pericak-Vance Margaret A, Goate Alison M, Cox Nancy J, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Bennett David A, Schneider Julie A, Jefferson Angela L, Hohman Timothy J: Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a journal of neurology 142(9): 2581-2589, Sep 2019.

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Last updated: 10/21/2019
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