John Q. Trojanowski, MD, PhD

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
M.D.
Tufts University School of Medicine, 1976.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Spiller Krista J, Khan Tahiyana, Dominique Myrna A, Restrepo Clark R, Cotton-Samuel Dejania, Levitan Maya, Jafar-Nejad Paymaan, Zhang Bin, Soriano Armand, Rigo Frank, Trojanowski John Q, Lee Virginia M-Y: Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of disease 124: 133-140, Apr 2019.

Tropea Thomas F, Mak Jordan, Guo Michael H, Xie Sharon X, Suh Eunran, Rick Jacqueline, Siderowf Andrew, Weintraub Daniel, Grossman Murray, Irwin David, Wolk David A, Trojanowski John Q, Van Deerlin Vivianna, Chen-Plotkin Alice S: TMEM106B Effect on Cognition in Parkinson's Disease and Frontotemporal Dementia. Annals of neurology Apr 2019.

Guerreiro Rita, Escott-Price Valentina, Hernandez Dena G, Kun-Rodrigues Celia, Ross Owen A, Orme Tatiana, Neto Joao Luis, Carmona Susana, Dehghani Nadia, Eicher John D, Shepherd Claire, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Dawson Ted, Rosenthal Liana, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaroslau, Van Deerlin Vivianna, Serrano Geidy E, Beach Thomas G, Lesage Suzanne, Galasko Douglas, Masliah Eliezer, Santana Isabel, Pastor Pau, Diez-Fairen Monica, Aguilar Miquel, Tienari Pentti J, Myllykangas Liisa, Oinas Minna, Revesz Tamas, Lees Andrew, Boeve Brad F, Petersen Ronald C, Ferman Tanis J, Graff-Radford Neill, Cairns Nigel J, Morris John C, Pickering-Brown Stuart, Mann David, Halliday Glenda M, Hardy John, Trojanowski John Q, Dickson Dennis W, Singleton Andrew, Stone David J, Bras Jose: Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of disease 127: 492-501, Apr 2019.

Stewart Tessandra, Shi Min, Mehrotra Aanchal, Aro Patrick, Soltys David, Kerr Kathleen F, Zabetian Cyrus P, Peskind Elaine R, Taylor Peggy, Shaw Leslie M, Trojanowski John Q, Zhang Jing: Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers. Journal of Alzheimer's disease : JAD Apr 2019.

Smith Douglas H, Johnson Victoria E, Trojanowski John Q, Stewart William: Chronic traumatic encephalopathy - confusion and controversies. Nature reviews. Neurology 15(3): 179-183, Mar 2019.

Stewart William, Allinson Kieren, Al-Sarraj Safa, Bachmeier Corbin, Barlow Karen, Belli Antonio, Burns Mark P, Carson Alan, Crawford Fiona, Dams-O'Connor Kristen, Diaz-Arrastia Ramon, Dixon C Edward, Edlow Brian L, Ferguson Scott, Fischl Bruce, Folkerth Rebecca D, Gentleman Steve, Giza Christopher C, Grady M Sean, Helmy Adel, Herceg Mark, Holton Janice L, Howell David, Hutchinson Peter J, Iacono Diego, Iglesias Juan E, Ikonomovic Milos D, Johnson Victoria E, Keene C Dirk, Kofler Julia K, Koliatsos Vassilis E, Lee Edward B, Levin Harvey, Lifshitz Jonathan, Ling Helen, Loane David J, Love Seth, Maas Andrew Ir, Marklund Niklas, Master Christina L, McElvenny Damien M, Meaney David F, Menon David K, Montine Thomas J, Mouzon Benoit, Mufson Elliott J, Ojo Joseph O, Prins Mayumi, Revesz Tamas, Ritchie Craig W, Smith Colin, Sylvester Richard, Tang Cheuk Y, Trojanowski John Q, Urankar Kathryn, Vink Robert, Wellington Cheryl, Wilde Elisabeth A, Wilson Lindsay, Yeates Keith, Smith Douglas H: Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology 18(3): 231-233, Mar 2019.

Gibbons Garrett S, Kim Soo-Jung, Robinson John L, Changolkar Lakshmi, Irwin David J, Shaw Leslie M, Lee Virginia M-Y, Trojanowski John Q: Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta neuropathologica communications 7(1): 34, Mar 2019.

Schindler Suzanne E, Li Yan, Todd Kaitlin W, Herries Elizabeth M, Henson Rachel L, Gray Julia D, Wang Guoqiao, Graham Danielle L, Shaw Leslie M, Trojanowski John Q, Hassenstab Jason J, Benzinger Tammie L S, Cruchaga Carlos, Jucker Mathias, Levin Johannes, Chhatwal Jasmeer P, Noble James M, Ringman John M, Graff-Radford Neill R, Holtzman David M, Ladenson Jack H, Morris John C, Bateman Randall J, Xiong Chengjie, Fagan Anne M: Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association Mar 2019.

Giannini Lucia A A, Xie Sharon X, McMillan Corey T, Liang Mendy, Williams Andrew, Jester Charles, Rascovsky Katya, Wolk David A, Ash Sharon, Lee Edward B, Trojanowski John Q, Grossman Murray, Irwin David J: Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia. Annals of neurology Mar 2019.

Kun-Rodrigues Celia, Orme Tatiana, Carmona Susana, Hernandez Dena G, Ross Owen A, Eicher John D, Shepherd Claire, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Dawson Ted, Rosenthal Liana, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaroslau, Van Deerlin Vivianna, Serrano Geidy E, Beach Thomas G, Lesage Suzanne, Galasko Douglas, Masliah Eliezer, Santana Isabel, Pastor Pau, Diez-Fairen Monica, Aguilar Miquel, Tienari Pentti J, Myllykangas Liisa, Oinas Minna, Revesz Tamas, Lees Andrew, Boeve Brad F, Petersen Ronald C, Ferman Tanis J, Escott-Price Valentina, Graff-Radford Neill, Cairns Nigel J, Morris John C, Pickering-Brown Stuart, Mann David, Halliday Glenda M, Hardy John, Trojanowski John Q, Dickson Dennis W, Singleton Andrew, Stone David J, Guerreiro Rita, Bras Jose: A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of aging 75: 223.e1-223.e10, Mar 2019.

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Last updated: 04/15/2019
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