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Itzhak Nissim, Ph.D.
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Adjunct Professor of Pediatrics (Human Genetics)
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
2a Division of Metabolism and Genetic
3b 34th & Civic Center Blvd
Philadelphia, PA 19104
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2a Division of Metabolism and Genetic
3b 34th & Civic Center Blvd
Philadelphia, PA 19104
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Office: 6107152989
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Email:
NISSIM@chop.edu
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NISSIM@chop.edu
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Education:
21 a B.Sc. 19 (Life Science) c
40 Bar Ilan University, Ramat Gan, Israel , 1972.
21 a M.Sc. 19 (Life Science) c
3d Hebrew University, Jerusalem, Israel, 1974.
21 a Ph.D. 19 (Life Science) c
47 Weizmann Institute of Science, Rehovot, Israel, 1979.
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Permanent link21 a B.Sc. 19 (Life Science) c
40 Bar Ilan University, Ramat Gan, Israel , 1972.
21 a M.Sc. 19 (Life Science) c
3d Hebrew University, Jerusalem, Israel, 1974.
21 a Ph.D. 19 (Life Science) c
47 Weizmann Institute of Science, Rehovot, Israel, 1979.
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db As a member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, I have been involved in various projects dealing with hepatic metabolism and insulin resistance, obesity or diabetes.
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Description of Research Expertise
375 A pioneer and internationally prominent scientist in the application of stable isotopes to study metabolism. A long-standing scientific research focus on understanding the cause, mechanism(s) and outcome of metabolic disorders. The outcome of the research activity has profoundly alter the way we study disease processes as well as understanding the mechanism of metabolic malfunction in cases such as cancer, fatty liver disease, Metabolic Syndrome, neurological function, etc. Exemplar projects of the scientific endeavors including: (i) the mechanism(s) of hepatic metabolic dysfunction and exploration of metabolome/fluxome malfunction in Metabolic Syndrome;(ii) pathogenesis of disorders of mitochondrial integrity and function; (iii) brain metabolic functions and neurochemical aberrations; (iv) the molecular and metabolomic characteristics of cancer cells, etc.6e
Description of Other Expertise
216 As a scientific director of the Metabolomics Core Facility at Children’s Hospital of Philadelphia, I have collaborated and contributed to many projects investigating metabolomic and fluxomic profiling in normal and disease states. The Metabolomics core has been internationally recognized as metabolomics research center. The core provided state-of-the-art scientific and analytical services to CHOP and Penn investigators as well as to investigators from numerous academic centers in the U.S, Canada and Europe.db As a member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, I have been involved in various projects dealing with hepatic metabolism and insulin resistance, obesity or diabetes.
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110 Nissim I, Horyn O, Daikhin Y, Li C, Chen P, Wherli Z. Nissim Ilana and Yudkoff M: The Molecular and Metabolic Influence of Long Term Agmatine Consumption. J Biol Chem. 289(14): 9710-9729, 04 2014.
16d Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.: Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine. J. Biol. Chem. 288(3): 3938-3951, 2013.
123 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D.: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell 152(4): 778-790, 2013.
fb Nissim I, Horyn O, Ilana Nissim, Daikhin Y, Wehrl SL,Yudkoff M and Matschinsky FM: : Effects of a glucokinase activator onhepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. 38 Biochem J. 444: 537-551, 2012.
fe Changhong Li, Chengyang Liu, Itzhak Nissim , et al.: : Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Gamma-Hydroxybutyrate and Glycine. J Biol Chem, 2012.
174 Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, Gasser DL: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. EMBO Mol Med. 7: 410-427, 2011.
145 Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, Cervera J, Tuchman M,Yudkoff M.: Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase. J Biol Chem. 286: 22055-22068, 2011.
1c9 Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA. : Mechanism of hyperinsulinism in short-chain 3- hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 285: 1806-1818, 2010.
fd Nissim I, , Horyn O, Daikhin Y, Nissim I, Luhovyy B., Phillips, PC, and Yudkoff M.: Ifosfamide-Induced Nephrotoxicity: Mechanism and Prevention Cancer Res. 66 66: 7824-7831, 2006.
f3 Yudkoff M, Ah Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, Payan I, Tuchman M. : Measuring in vivo ureagenesis with stable isotopes. Mol Genet Metab. 100: 37-41, 2010.
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Selected Publications
162 Bo Li, Bo Qiu, David S.M. Lee, Zandra E. Walton, Joshua D. Ochocki, Lijoy K. Mathew, Anthony Mancuso, Terence P.F. Gade, Brian Keith, Itzhak Nissim, and M. Celeste Simon: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513(7517): 251-255, September 12 2014.110 Nissim I, Horyn O, Daikhin Y, Li C, Chen P, Wherli Z. Nissim Ilana and Yudkoff M: The Molecular and Metabolic Influence of Long Term Agmatine Consumption. J Biol Chem. 289(14): 9710-9729, 04 2014.
16d Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.: Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine. J. Biol. Chem. 288(3): 3938-3951, 2013.
123 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D.: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell 152(4): 778-790, 2013.
fb Nissim I, Horyn O, Ilana Nissim, Daikhin Y, Wehrl SL,Yudkoff M and Matschinsky FM: : Effects of a glucokinase activator onhepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. 38 Biochem J. 444: 537-551, 2012.
fe Changhong Li, Chengyang Liu, Itzhak Nissim , et al.: : Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Gamma-Hydroxybutyrate and Glycine. J Biol Chem, 2012.
174 Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, Gasser DL: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. EMBO Mol Med. 7: 410-427, 2011.
145 Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, Cervera J, Tuchman M,Yudkoff M.: Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase. J Biol Chem. 286: 22055-22068, 2011.
1c9 Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA. : Mechanism of hyperinsulinism in short-chain 3- hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 285: 1806-1818, 2010.
fd Nissim I, , Horyn O, Daikhin Y, Nissim I, Luhovyy B., Phillips, PC, and Yudkoff M.: Ifosfamide-Induced Nephrotoxicity: Mechanism and Prevention Cancer Res. 66 66: 7824-7831, 2006.
f3 Yudkoff M, Ah Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, Payan I, Tuchman M. : Measuring in vivo ureagenesis with stable isotopes. Mol Genet Metab. 100: 37-41, 2010.
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