Deepak M Sampathu, MD, PhD
Assistant Professor of Clinical Radiology
Active Radiologist, Penn Presbyterian Medical Center
Active Radiologist, Pennsylvania Hospital
Attending Radiologist, Hospital of the Univeristy of Pennsylvania
Department: Radiology
Contact information
Department of Radiology
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Education:
BA (Biochemistry, Economics)
University of Pennsylvania, 1999.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2006.
MD (Medicine)
University of Pennsylvania School of Medicine , 2007.
Permanent linkBA (Biochemistry, Economics)
University of Pennsylvania, 1999.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2006.
MD (Medicine)
University of Pennsylvania School of Medicine , 2007.
Description of Clinical Expertise
Neuroradiology, Diagnostic Radiology, MRI, CT, Radiography, Image-guided lumbar puncture, MyelographyDescription of Research Expertise
Pathobiology of Neurodegenerative Diseases, Cell and Molecular BiologySelected Publications
Neumann Manuela, Sampathu Deepak M, Kwong Linda K, Truax Adam C, Micsenyi Matthew C, Chou Thomas T, Bruce Jennifer, Schuck Theresa, Grossman Murray, Clark Christopher M, McCluskey Leo F, Miller Bruce L, Masliah Eliezer, Mackenzie Ian R, Feldman Howard, Feiden Wolfgang, Kretzschmar Hans A, Trojanowski John Q, Lee Virginia M-Y: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314(5796): 130-3, Oct 2006.Sampathu Deepak M, Neumann Manuela, Kwong Linda K, Chou Thomas T, Micsenyi Matthew, Truax Adam, Bruce Jennifer, Grossman Murray, Trojanowski John Q, Lee Virginia M-Y: Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. The American Journal of Pathology 169(4): 1343-52, Oct 2006.
Meulener Marc C, Graves Charles L, Sampathu Deepak M, Armstrong-Gold Cecilia E, Bonini Nancy M, Giasson Benoit I: DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. Journal of Neurochemistry 93(6): 1524-32, Jun 2005.
Pawlyk Aaron C, Giasson Benoit I, Sampathu Deepak M, Perez Francisco A, Lim Kah Leong, Dawson Valina L, Dawson Ted M, Palmiter Richard D, Trojanowski John Q, Lee Virginia M-Y: Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry 278(48): 48120-8, Nov 2003.
Sampathu Deepak M, Giasson Benoit I, Pawlyk Aaron C, Trojanowski John Q, Lee Virginia M-Y: Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. The American Journal of Pathology 163(1): 91-100, Jul 2003.
Giasson Benoit I, Sampathu Deepak M, Wilson Christina A, Vogelsberg-Ragaglia Vanessa, Mushynski Walter E, Lee Virginia M-Y: The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry 41(51): 15376-87, Dec 2002.
Galvin J E, Nakamura M, McIntosh T K, Saatman K E, Sampathu D, Raghupathi R, Lee V M, Trojanowski J Q: Neurofilament-rich intraneuronal inclusions exacerbate neurodegenerative sequelae of brain trauma in NFH/LacZ transgenic mice. Experimental Neurology 165(1): 77-89, Sep 2000.