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Kathleen M. Loomes, MD
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Professor of Pediatrics (Gastroenterology, Hepatology and Nutrition) at the Children's Hospital of Philadelphia
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Attending Physician, The Children's Hospital of Philadelphia
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Attending Physician, Consultant in Pediatric Gastroenterology, Hospital of the University of Pennsylvania
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Attending Physician, Consultant in Pediatric Gastroenterology, Pennsylvania Hospital, Philadelphia, PA
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Director, Fred and Suzanne Biesecker Pediatric Liver Center, The Children's Hospital of Philadelphia
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Section Chief of Research, Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia
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Associate Research Director, Division of Gastroenterology, Hepatology and Nutrition Fellowship Program
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Department: Pediatrics
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Contact information
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The Children's Hospital of Philadelphia
49 Division of Gastroenterology, Hepatology and Nutrition, 7th floor
3e 34th and Civic Center Blvd.
Philadelphia, PA 19104
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49 Division of Gastroenterology, Hepatology and Nutrition, 7th floor
3e 34th and Civic Center Blvd.
Philadelphia, PA 19104
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Office: 267-426-7223
32 Fax: 267-426-7814
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32 Fax: 267-426-7814
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Email:
loomes@chop.edu
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loomes@chop.edu
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Education:
21 9 B.A. 14 (Biology) c
34 Rice University (Cum laude), 1988.
21 9 M.D. 15 (Medicine) c
48 University of Texas Southwestern Medical School, 1992.
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Permanent link21 9 B.A. 14 (Biology) c
34 Rice University (Cum laude), 1988.
21 9 M.D. 15 (Medicine) c
48 University of Texas Southwestern Medical School, 1992.
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1d9 Kastenberg ZJ, Beil CA, Henn L, Alonso EM, Hsu EK, Wang K, Ng VL, Gupta NA, Magee JC, Merion RM, Horslen S, Karpen SJ, Kohli R, Loomes K, Miethke A, Tolliver KM, Rosenthal P, Harpavat S, Sokol RJ, Guthery SL; and the Childhood Liver Disease Research Network (ChiLDReN).: Demographic Factors and Biliary Atresia: A Childhood Liver Disease Research Network Study. Pediatrics 157: e2025071520, Mar 2026.
1b3 Keselman DJ, Small JC, Seneviratne T, McCague S, Kaschak TL, Yum SW, O'Brien A, Brandsema JF, Diamond T, Loomes KM, Lin KY, Wittlieb-Weber CA, Mayer OH, Daniel SG, Waldman AT, Samelson-Jones BJ, Matesanz SE, George LA.: Real-world outcomes of delandistrogene moxeparvovec gene therapy: Motor outcomes and emerging safety concerns. Mol Ther 34: 123-130, Jan 2026.
14b Bass LM, Hawthorne K, Magee JC, Shneider BL; Childhood Liver Disease Research Network (ChiLDReN).: Secondary prophylaxis of variceal hemorrhage in biliary atresia-Analysis of prospective multicenter studies. J Pediatr Gastroenterol Nutr 82(2): 383-388, 2026.
568 Huysentruyt K, Vandriel SM, Roelants M, Piccoli DA, Loomes KM, Rand EB, Ebel NH, Feinstein JA, Jankowska I, Czubkowski P, Gliwicz-Miedzinska D, Gonzales EM, Jacquemin E, Bouligand J, Karpen SJ, Romero R, Lin HC, Fischler B, Arnell H, Li LT, Wang JS, Fawaz R, Nastasio S, Kim KM, Oh SH, D'Antiga L, Nicastro E, Fischer RT, Siew SM, Stormon M, Lertudomphonwanit C, Hardikar W, Shankar S, Squires JE, Sundaram SS, Larson-Nath C, Kelly DA, Hartley J, Bulut P, Jensen MK, Jaramillo C, Roberts AJ, Evans HM, Sokal ÉM, Demaret T, Verkade HJ, Thompson RJ, Hansen BE, Cole TJ, Kamath BM, Debray D, Lacaille F, Brecelj J, El-Koofy NM, Elmonem MA, Lee WS, Sanchez MC, Cavalieri ML, Hajinicolaou C, Schwarz KB, Carvalho E, Rock N, Karnsakul W, Quiros-Tejeira RE, Alam S, Nebbia G, Mozer-Glassberg Y, Valentino PL, Santos-Silva E, Önal Z, Dezsofi-Gottl A, Melere M, Legarda Tamara M, Eshun J, Zellos A, Indolfi G, Rogalidou M, Blondet N, Luigi Calvo P, Beretta M, Zizzo AN, Arikan C, Kasahara M, Kerkar N, Aqul AA, Wolters VM, Borges Pinto R, Quintero Bernabeu J, Garcia J, Wiecek S, Tzivinikos C, Mujawar Q, Jimenez-Rivera C, Molera Busoms C, Gonçalves C, Bujanda L; Global Alagille Alliance (GALA) Study Group.: Condition-Specific Growth Charts for Children With Alagille Syndrome. JAMA Netw Open 8: e2545294, Nov 2025.
1f1 Shneider BL, Goodrich NP, Ye W, Molleston JP, Leung DH, Sokol RJ, Cavallo L, Wang K, Valentino PL, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Miethke AG, Loomes KM, Kohli R, Karpen SJ, Kamath BM, Jensen MK, Bezerra JA, Bass LM, Magee JC; ChiLDReN.: Prospective Multicenter Longitudinal Measurement of Liver Stiffness in School-Age Children With Cholestatic Liver Disease. Gastro Hep Adv 4: 100788, Sep 2025.
204 Shneider BL, Kanchi RS, Grimm SL, Devaraj S, Emamaullee J, Schraw J, Lupo PJ, Bezerra JA, Loomes KM, Magee JC, Sokol RJ, Wang KS, Kriegmeier A, Hsu E, Molleston JP, Rosenthal P, Kohli R, Karpen SJ, Horslen SP, Jensen MK, Barbetta A, Coarfa C; Childhood Liver Disease Research Network.: Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition. Hepatol Commun 9: e0796, Sep 2025.
163 Kennedy KV, Fawad JA, Neugut YD, Valenzuela-Araujo D, Coe A, Bhatti TR, Acord M, Manfredi MD, Mamula P, Loomes KM, Brownell JN.: SPNing our wheels-Pancreatic solid pseudopapillary neoplasm as an extraluminal etiology of persistent duodenal ulceration. JPGN Rep 6: 189-192, Feb 2025.
133 Bennett AD, Morales KH, Huang YV, Tam V, Shah A, Loomes KM, Serper M, Bittermann T.: Lower Child Opportunity Index is associated with increased health care utilization following pediatric liver transplantation. Liver Transpl Feb 2025.
1b7 Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S, Rosenthal P, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL; Childhood Liver Disease Research Network (ChiLDReN).: Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage. Pediatr Res Jan 2025.
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Selected Publications
24b Diamond T, Chapin CA, Diorio CJ, McCuaig S, Lau M, Chu N, Gibson NM, Kreiger PA, Horslen S, Loomes KM, Banc-Husu AM, Chu J, Jensen MK, Leung DH, Narang A, Carter BA, Elisofon S, Fischer R, Lobritto SJ, Leonis M, Peters AL, Rodriguez-Baez N, Romero R, Rosenthal P, Rudnick D, Squires J, Sundaram S, Tolliver KM, Valentino P, Durkalski V, Alonso EM, Behrens EM.: CD8 TRM-like T cells expressing perforin and IFN-γ define a pediatric activated T-cell acute liver failure endotype. Hepatol Commun 10: e0926, Mar 2026.1d9 Kastenberg ZJ, Beil CA, Henn L, Alonso EM, Hsu EK, Wang K, Ng VL, Gupta NA, Magee JC, Merion RM, Horslen S, Karpen SJ, Kohli R, Loomes K, Miethke A, Tolliver KM, Rosenthal P, Harpavat S, Sokol RJ, Guthery SL; and the Childhood Liver Disease Research Network (ChiLDReN).: Demographic Factors and Biliary Atresia: A Childhood Liver Disease Research Network Study. Pediatrics 157: e2025071520, Mar 2026.
1b3 Keselman DJ, Small JC, Seneviratne T, McCague S, Kaschak TL, Yum SW, O'Brien A, Brandsema JF, Diamond T, Loomes KM, Lin KY, Wittlieb-Weber CA, Mayer OH, Daniel SG, Waldman AT, Samelson-Jones BJ, Matesanz SE, George LA.: Real-world outcomes of delandistrogene moxeparvovec gene therapy: Motor outcomes and emerging safety concerns. Mol Ther 34: 123-130, Jan 2026.
14b Bass LM, Hawthorne K, Magee JC, Shneider BL; Childhood Liver Disease Research Network (ChiLDReN).: Secondary prophylaxis of variceal hemorrhage in biliary atresia-Analysis of prospective multicenter studies. J Pediatr Gastroenterol Nutr 82(2): 383-388, 2026.
568 Huysentruyt K, Vandriel SM, Roelants M, Piccoli DA, Loomes KM, Rand EB, Ebel NH, Feinstein JA, Jankowska I, Czubkowski P, Gliwicz-Miedzinska D, Gonzales EM, Jacquemin E, Bouligand J, Karpen SJ, Romero R, Lin HC, Fischler B, Arnell H, Li LT, Wang JS, Fawaz R, Nastasio S, Kim KM, Oh SH, D'Antiga L, Nicastro E, Fischer RT, Siew SM, Stormon M, Lertudomphonwanit C, Hardikar W, Shankar S, Squires JE, Sundaram SS, Larson-Nath C, Kelly DA, Hartley J, Bulut P, Jensen MK, Jaramillo C, Roberts AJ, Evans HM, Sokal ÉM, Demaret T, Verkade HJ, Thompson RJ, Hansen BE, Cole TJ, Kamath BM, Debray D, Lacaille F, Brecelj J, El-Koofy NM, Elmonem MA, Lee WS, Sanchez MC, Cavalieri ML, Hajinicolaou C, Schwarz KB, Carvalho E, Rock N, Karnsakul W, Quiros-Tejeira RE, Alam S, Nebbia G, Mozer-Glassberg Y, Valentino PL, Santos-Silva E, Önal Z, Dezsofi-Gottl A, Melere M, Legarda Tamara M, Eshun J, Zellos A, Indolfi G, Rogalidou M, Blondet N, Luigi Calvo P, Beretta M, Zizzo AN, Arikan C, Kasahara M, Kerkar N, Aqul AA, Wolters VM, Borges Pinto R, Quintero Bernabeu J, Garcia J, Wiecek S, Tzivinikos C, Mujawar Q, Jimenez-Rivera C, Molera Busoms C, Gonçalves C, Bujanda L; Global Alagille Alliance (GALA) Study Group.: Condition-Specific Growth Charts for Children With Alagille Syndrome. JAMA Netw Open 8: e2545294, Nov 2025.
1f1 Shneider BL, Goodrich NP, Ye W, Molleston JP, Leung DH, Sokol RJ, Cavallo L, Wang K, Valentino PL, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Miethke AG, Loomes KM, Kohli R, Karpen SJ, Kamath BM, Jensen MK, Bezerra JA, Bass LM, Magee JC; ChiLDReN.: Prospective Multicenter Longitudinal Measurement of Liver Stiffness in School-Age Children With Cholestatic Liver Disease. Gastro Hep Adv 4: 100788, Sep 2025.
204 Shneider BL, Kanchi RS, Grimm SL, Devaraj S, Emamaullee J, Schraw J, Lupo PJ, Bezerra JA, Loomes KM, Magee JC, Sokol RJ, Wang KS, Kriegmeier A, Hsu E, Molleston JP, Rosenthal P, Kohli R, Karpen SJ, Horslen SP, Jensen MK, Barbetta A, Coarfa C; Childhood Liver Disease Research Network.: Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition. Hepatol Commun 9: e0796, Sep 2025.
163 Kennedy KV, Fawad JA, Neugut YD, Valenzuela-Araujo D, Coe A, Bhatti TR, Acord M, Manfredi MD, Mamula P, Loomes KM, Brownell JN.: SPNing our wheels-Pancreatic solid pseudopapillary neoplasm as an extraluminal etiology of persistent duodenal ulceration. JPGN Rep 6: 189-192, Feb 2025.
133 Bennett AD, Morales KH, Huang YV, Tam V, Shah A, Loomes KM, Serper M, Bittermann T.: Lower Child Opportunity Index is associated with increased health care utilization following pediatric liver transplantation. Liver Transpl Feb 2025.
1b7 Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S, Rosenthal P, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL; Childhood Liver Disease Research Network (ChiLDReN).: Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage. Pediatr Res Jan 2025.
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