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Kristina Cole, MD, PhD
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Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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The Children's Hospital of Philadelphia
39 Colket Translational Research Building, Room 4026
3e 3501 Civic Center Boulevard
Philadelphia, PA 19104
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39 Colket Translational Research Building, Room 4026
3e 3501 Civic Center Boulevard
Philadelphia, PA 19104
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Education:
21 7 BS 16 (Chemistry) c
2a Dickinson College, 1992.
21 8 PhD 16 (Pathology) c
2f University of Maryland, 1999.
21 7 MD 15 (Medicine) c
2f University of Maryland, 2001.
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Permanent link21 7 BS 16 (Chemistry) c
2a Dickinson College, 1992.
21 8 PhD 16 (Pathology) c
2f University of Maryland, 1999.
21 7 MD 15 (Medicine) c
2f University of Maryland, 2001.
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206 Sussman JH, Oldridge DA, Yu W, Chen C, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Yang A, Tumulty JS, Xiong B, Wu DW, Sun Y, Bandyopadhyay S, Xu J, Brosius S, Barkardottir UY, Seka I, Ahn KJ, Elghawy O, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, De Raedt T, Cole KA, Tan K: A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. Cell Rep Med April 2026.
258 Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M.: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. Cancer Cell Jan 2026.
21d Corbett RJ, Kaufman RS, McQuaid SW, Vaksman Z, Phul S, Brown MA, Mason JL, Waszak SM, Zhang B, Zhong C, Desai H, Hausler R, Naqvi AS, Chroni A, Geng Z, Gonzalez EM, Zhu Y, Heath AP, Li M; Penn Medicine BioBank; Regeneron Genetics Center; Storm PB, Resnick AC, Maxwell KN, Cole KA, Waanders AJ, Bornhorst M, MacFarland SP, Rokita JL, Diskin SJ: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors. Nat Commun Nov 2025.
25c Yu B , Kline K, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn JE, Banerjee A, Leary S, Crotty EE, Abdelbaki M, Whipple NS, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips JJ , Prados M, Molinaro AM, Gupta N, Raffel C, Cole KA , Kasahara N, Diaz, Mueller S: Measles oncolytic virus as an immunotherapy for recurrent/refractory pediatric medulloblastoma and atypical teratoid rhabdoid tumor: results from PNOC005. Clin Cancer Res 2025.
41b Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundström E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schüller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG.: GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. Cancer Cell 27, August 2024.
697 Ercan AB, Aronson M, Fernandez NR, Chang Y, Levine A, Liu ZA, Negm L, Edwards M, Bianchi V, Stengs L, Chung J, Al-Battashi A, Reschke A, Alex Lion, Ahmad A, Lassaletta A, Reddy AT, Al-Darraji AF, Shah AC, Van Damme A, Bendel A, Rashid A, Margol AS, Kelly BL, Pencheva B, Heald B, Lemieux-Anglin B, Crooks B, Koschmann C, Gilpin C, Porter CC, Gass D, Samuel D, Ziegler DS, Blumenthal DT, Kuo DJ, Hamideh D, Basel D, Khuong-Quang D, Stearns D, Opocher E, Carceller F, Feldman HB, Toledano H, Winer I, Scheers I, Fedorakova I, Su JM, Vengoechea J, Sterba J, Knipstein J, Hansford JR, Gonzales-Santos JR, Bhatia K, Bielamowicz KJ, Minhas K, Nichols KE, Cole KA, Penney L, Aasved Hjort M, Sabel M, Gil-da-Costa MJ, Murray MJ, Miller M, Blundell ML, Massimino M, Al-Hussaini M, Al-Jadiry MF, Comito MA, Osborn M, Link MP, Zapotocky M, Ghalibafian M, Shaheen N, Mushtaq N, Waespe N, Hijiya N, Fuentes-Bolanos N, Ahmad O, Chamdine O, Roy P, Pichurin PN, Nyman P, Pearlman R, Auer RC, Sukumaran RK, Kebudi R, Dvir R, Raphael R, Elhasid R, McGee RB, Chami R, Noss R, Tanaka R, Raskin S, Sen S, Lindhorst S, Perreault S, Caspi S, Riaz S, Constantini S, Albert S, Chaleff S, Bielack S, Chiaravalli S, Cramer SL, Roy S, Cahn S, Penna S, Hamid SA, Ghafoor T, Imam U, Larouche V, Issai VM, Foulkes WD, Lee YY, Nathan PC, Maruvka YE, Greer MC, Durno C, Shlien A, Ertl-Wagner B, Villani A, Malkin D, Hawkins C, Bouffet E, Das A, Tabori U: Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study. Lancet Oncol 25(5), May 2024.
1ee Kim J, Vaksman Z, Egolf LE, Kaufman R, Evans JP, Conkrite KL, Danesh A, Lopez G, Randall MP, Dent MH, Farra LM, Menghani NL, Dymek M, Desai H, Hausler R, Hicks B, Auvil JG, Gerhard DS, Hakonarson H, Maxwell KN, Cole KA, Pugh TJ, Bosse KR, Khan J, Wei JS, Maris JM, Stewart DR, Diskin SJ: Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival. J Natl Cancer Inst Jan 2024.
1e1 Lim-Fat MJ, Cotter JA, Touat M, Vogelzang J, Sousa C, Pisano W, Geduldig J, Bhave V, Driver J, Kao PC, McGovern A, Ma C, Margol AS, Cole K, Smith A, Goldman S, Kaneva K, Truong A, Nazemi KJ, Wood MD, Wright KD, London WB, Warren KE, Wen PY, Bi WL, Alexandrescu S, Reardon DA, Ligon KL, Yeo KK: A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients. Neuro Oncol 2024.
30c Shapiro JA, Gaonkar KS, Savonen CL, Spielman SJ, Bethell CJ, Jin R, Rathi KS, Zhu Y, Egolf LE, Farrow BK, Miller DP, Yang Y, Koganti T, Noureen N, Koptyra MP, Duong N, Kraya AA, Kline C, Guo Y, Storm PB, Nazarian J, Mack SC, Raman P, Zheng S, Madsen PJ, Van Kuren N, Robins S, Huang X, Waanders AJ, Kim J, Hanson D, Koschmann CJ, Diskin SJ, Lulla RR, Brown MA, Wong J, Mason JL, Scolaro L, Kim MC, Xie HM, Rood BR, Cole KA, Margol AS, Vaksman Z, Kaufman RS, Heath AP, Ennis BM, Santi M, Poetsch AR, Viaene AN, Stewart DR, Foltz SM, Jain P, Zhang B, Kannan S, Prados M, Lilly JV, Mueller S, Resnick AC, Greene CS, Rokita JL, Taroni JN: OpenPBTA: An Open Pediatric Brain Tumor Atlas. Cell Genomics July 2023.
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Selected Publications
18d Song J, Baron J, Perez CC, Ramesh S, Minturn J, Desai K, Shah AC, Belasco JB, Cole KA, Fisher MJ, Storm PB, Madsen PM, Kurtz G, Lustig RA, Hill-Kayser C, LaRiviere MJ: Feasibility and Safety of High-Dose Proton Re-Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single-Institution Retrospective Study. Pediatr Blood Cancer 1e May 2026.206 Sussman JH, Oldridge DA, Yu W, Chen C, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Yang A, Tumulty JS, Xiong B, Wu DW, Sun Y, Bandyopadhyay S, Xu J, Brosius S, Barkardottir UY, Seka I, Ahn KJ, Elghawy O, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, De Raedt T, Cole KA, Tan K: A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. Cell Rep Med April 2026.
258 Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M.: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. Cancer Cell Jan 2026.
21d Corbett RJ, Kaufman RS, McQuaid SW, Vaksman Z, Phul S, Brown MA, Mason JL, Waszak SM, Zhang B, Zhong C, Desai H, Hausler R, Naqvi AS, Chroni A, Geng Z, Gonzalez EM, Zhu Y, Heath AP, Li M; Penn Medicine BioBank; Regeneron Genetics Center; Storm PB, Resnick AC, Maxwell KN, Cole KA, Waanders AJ, Bornhorst M, MacFarland SP, Rokita JL, Diskin SJ: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors. Nat Commun Nov 2025.
25c Yu B , Kline K, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn JE, Banerjee A, Leary S, Crotty EE, Abdelbaki M, Whipple NS, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips JJ , Prados M, Molinaro AM, Gupta N, Raffel C, Cole KA , Kasahara N, Diaz, Mueller S: Measles oncolytic virus as an immunotherapy for recurrent/refractory pediatric medulloblastoma and atypical teratoid rhabdoid tumor: results from PNOC005. Clin Cancer Res 2025.
41b Liu I, Alencastro Veiga Cruzeiro G, Bjerke L, Rogers RF, Grabovska Y, Beck A, Mackay A, Barron T, Hack OA, Quezada MA, Molinari V, Shaw ML, Perez-Somarriba M, Temelso S, Raynaud F, Ruddle R, Panditharatna E, Englinger B, Mire HM, Jiang L, Nascimento A, LaBelle J, Haase R, Rozowsky J, Neyazi S, Baumgartner AC, Castellani S, Hoffman SE, Cameron A, Morrow M, Nguyen QD, Pericoli G, Madlener S, Mayr L, Dorfer C, Geyeregger R, Rota C, Ricken G, Ligon KL, Alexandrescu S, Cartaxo RT, Lau B, Uphadhyaya S, Koschmann C, Braun E, Danan-Gotthold M, Hu L, Siletti K, Sundström E, Hodge R, Lein E, Agnihotri S, Eisenstat DD, Stapleton S, King A, Bleil C, Mastronuzzi A, Cole KA, Waanders AJ, Montero Carcaboso A, Schüller U, Hargrave D, Vinci M, Carceller F, Haberler C, Slavc I, Linnarsson S, Gojo J, Monje M, Jones C, Filbin MG.: GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant. Cancer Cell 27, August 2024.
697 Ercan AB, Aronson M, Fernandez NR, Chang Y, Levine A, Liu ZA, Negm L, Edwards M, Bianchi V, Stengs L, Chung J, Al-Battashi A, Reschke A, Alex Lion, Ahmad A, Lassaletta A, Reddy AT, Al-Darraji AF, Shah AC, Van Damme A, Bendel A, Rashid A, Margol AS, Kelly BL, Pencheva B, Heald B, Lemieux-Anglin B, Crooks B, Koschmann C, Gilpin C, Porter CC, Gass D, Samuel D, Ziegler DS, Blumenthal DT, Kuo DJ, Hamideh D, Basel D, Khuong-Quang D, Stearns D, Opocher E, Carceller F, Feldman HB, Toledano H, Winer I, Scheers I, Fedorakova I, Su JM, Vengoechea J, Sterba J, Knipstein J, Hansford JR, Gonzales-Santos JR, Bhatia K, Bielamowicz KJ, Minhas K, Nichols KE, Cole KA, Penney L, Aasved Hjort M, Sabel M, Gil-da-Costa MJ, Murray MJ, Miller M, Blundell ML, Massimino M, Al-Hussaini M, Al-Jadiry MF, Comito MA, Osborn M, Link MP, Zapotocky M, Ghalibafian M, Shaheen N, Mushtaq N, Waespe N, Hijiya N, Fuentes-Bolanos N, Ahmad O, Chamdine O, Roy P, Pichurin PN, Nyman P, Pearlman R, Auer RC, Sukumaran RK, Kebudi R, Dvir R, Raphael R, Elhasid R, McGee RB, Chami R, Noss R, Tanaka R, Raskin S, Sen S, Lindhorst S, Perreault S, Caspi S, Riaz S, Constantini S, Albert S, Chaleff S, Bielack S, Chiaravalli S, Cramer SL, Roy S, Cahn S, Penna S, Hamid SA, Ghafoor T, Imam U, Larouche V, Issai VM, Foulkes WD, Lee YY, Nathan PC, Maruvka YE, Greer MC, Durno C, Shlien A, Ertl-Wagner B, Villani A, Malkin D, Hawkins C, Bouffet E, Das A, Tabori U: Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study. Lancet Oncol 25(5), May 2024.
1ee Kim J, Vaksman Z, Egolf LE, Kaufman R, Evans JP, Conkrite KL, Danesh A, Lopez G, Randall MP, Dent MH, Farra LM, Menghani NL, Dymek M, Desai H, Hausler R, Hicks B, Auvil JG, Gerhard DS, Hakonarson H, Maxwell KN, Cole KA, Pugh TJ, Bosse KR, Khan J, Wei JS, Maris JM, Stewart DR, Diskin SJ: Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival. J Natl Cancer Inst Jan 2024.
1e1 Lim-Fat MJ, Cotter JA, Touat M, Vogelzang J, Sousa C, Pisano W, Geduldig J, Bhave V, Driver J, Kao PC, McGovern A, Ma C, Margol AS, Cole K, Smith A, Goldman S, Kaneva K, Truong A, Nazemi KJ, Wood MD, Wright KD, London WB, Warren KE, Wen PY, Bi WL, Alexandrescu S, Reardon DA, Ligon KL, Yeo KK: A comparative analysis of IDH-mutant glioma in pediatric, young adult, and older adult patients. Neuro Oncol 2024.
30c Shapiro JA, Gaonkar KS, Savonen CL, Spielman SJ, Bethell CJ, Jin R, Rathi KS, Zhu Y, Egolf LE, Farrow BK, Miller DP, Yang Y, Koganti T, Noureen N, Koptyra MP, Duong N, Kraya AA, Kline C, Guo Y, Storm PB, Nazarian J, Mack SC, Raman P, Zheng S, Madsen PJ, Van Kuren N, Robins S, Huang X, Waanders AJ, Kim J, Hanson D, Koschmann CJ, Diskin SJ, Lulla RR, Brown MA, Wong J, Mason JL, Scolaro L, Kim MC, Xie HM, Rood BR, Cole KA, Margol AS, Vaksman Z, Kaufman RS, Heath AP, Ennis BM, Santi M, Poetsch AR, Viaene AN, Stewart DR, Foltz SM, Jain P, Zhang B, Kannan S, Prados M, Lilly JV, Mueller S, Resnick AC, Greene CS, Rokita JL, Taroni JN: OpenPBTA: An Open Pediatric Brain Tumor Atlas. Cell Genomics July 2023.
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