David C Schultz, Ph.D.
Adjunct Assistant Professor of Microbiology
Technical Director, High-throughput Screening Core, The University of Pennsylvania, Perelman School of Medicine, Department of Microbiology, Philadelphia, PA.
Department: Microbiology
Contact information
University of Pennsylvania
Perelman School of Medicine
67 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Perelman School of Medicine
67 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9641
Education:
B. S. (Biochemistry)
Albright College, 1991.
M. S. (Chemistry)
Lehigh University, 1993.
Ph.D. (Biochemistry)
Lehigh University, 1998.
Permanent linkB. S. (Biochemistry)
Albright College, 1991.
M. S. (Chemistry)
Lehigh University, 1993.
Ph.D. (Biochemistry)
Lehigh University, 1998.
Selected Publications
Basavappa MG, Ferretti M, Dittmar M, Stoute J, Sullivan MC, Whig K, Shen H, Liu KF, Schultz DC, Beiting DP, Lynch KW, Henao-Mejia J, Cherry S. : The lncRNA ALPHA specifically targets chikungunya virus to control infection. Mol Cell September 2022.Maio N, Cherry S, Schultz DC, Hurst BL, Linehan WM, Rouault TA.: TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model. iScience September 2022.
Zarkoob H, Allué-Guardia A, Chen YC, Garcia-Vilanova A, Jung O, Coon S, Song MJ, Park JG, Oladunni F, Miller J, Tung YT, Kosik I, Schultz D, Iben J, Li T, Fu J, Porter FD, Yewdell J, Martinez-Sobrido L, Cherry S, Torrelles JB, Ferrer M, Lee EM. : Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents. Commun Biol August 2022.
Lee YG, Guruprasad P, Ghilardi G, Pajarillo R, Sauter CT, Patel R, Ballard HJ, Hong SJ, Chun I, Yang N, Amelsberg KV, Cummins KD, Svoboda J, Gill S, Chong EA, North K, Church SE, Fraietta JA, Chang WJ, Lacey SF, Lu XM, Zhang Y, Whig K, Schultz DC, Cherry S, Gerson J, Schuster SJ, Porazzi P, Ruella M.: Modulation of BCL-2 in both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell Immunotherapy against Cancer. Cancer Discov July 2022.
Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Ardanuy J, Taylor L, Lee JS, Li M, Lee E, Shoffler C, Petucci C, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. : Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2 Nature April 2022.
Liu X, Verma A, Garcia G, Ramage H, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS: Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. Proc Natl Acad Sci October 2021.
Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, Schultz DC, Hand NJ, Cherry S, Radar DJ. : Lipid Droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism. Clin Transl Sci June 2021.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S.: Pharmacological activation of STING blocks SARS-CoV-2 infection. Sci Immunol May 2021.
Rivera OD, Mallory MJ, Quesnel-Vallièresa M, Chatrikhia R, Schultz DC, Carroll M, Barash Y, S Cherry, Lynch KW: Alternative splicing redefine landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci USA April 2021.
Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, Zhang F, Zhang X, Ba M, Szeto T, Kukuljac A, Marty MT, Schultz D, Cherry S, Xiang Y, Chen Y, Wang J.: Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem April 2021.