Stephanie Jean, M.D.
Attending Physician, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Helen F. Graham Cancer Center and Research Institute, ChristianaCare Health System, Newark, DE
Adjunct Faculty, The Wistar Institute, Affiliate Member, The Wistar Cancer Center, University of Pennsylvania, Philadelphia, PA
Contact information
Helen F. Graham Cancer Center and Research Institute
4701 Ogletown-Stanton Rd., Suite 2335W
Newark, DE 19713
4701 Ogletown-Stanton Rd., Suite 2335W
Newark, DE 19713
Office: 631-793-3697
Education:
B.S. (Departmental Honors in Biological Sciences)
Stanford University, Stanford, CA, 2002.
MD (Alpha Omega Alpha)
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 2007.
Permanent linkB.S. (Departmental Honors in Biological Sciences)
Stanford University, Stanford, CA, 2002.
MD (Alpha Omega Alpha)
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 2007.
Selected Publications
Karakashev S, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog MG, Borowsky ME, Kossenkov AV, Liu Q, Zhang R: EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. Cancer Cell 37(2):157-167.e6, Feb 2020.Nacarelli T, Fukumoto T, Zundell JA, Fatkhutdinov N, Jean S, Cadungog MG, Borowsky ME, Zhang R: NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer. Cancer Res 80(4):890-900, Feb 2020.
Zhao B, Lin J, Rong L, Wu S, Deng Z, Fatkhutdinov N, Zundell J, Fukumoto T, Liu Q, Kossenkov A, Jean S, Cadungog MG, Borowsky ME, Drapkin R, Lieberman PM, Abate-Shen CT, Zhang R: ARID1A promotes genomic stability through protecting telomere cohesion. Nat Commun 10(1):4067, Sep 2019.
Fukumoto T, Zhu H, Nacarelli T, Karakashev S, Fatkhutdinov N, Wu S, Liu P, Kossenkov AV, Showe LC, Jean S, Zhang L, Zhang R: N6-methylation of adenosine (m6A) of FZD10 mRNA contributes to PARP inhibitor resistance. Cancer Res 79(11):2812-2820, Jun 2019.
Singha B, Harper SL, Goldman AR, Bitler BG, Aird KM, Borowsky ME, Cadungog MG, Liu Q, Zhang R, Jean S, Drapkin R, Speicher DW: CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer. Sci Rep 8(1):14725, Oct 2018.
Fukumoto T, Park P, Wu S, Fatkhutdinov N, Karakashev S, Nacarelli T, Kossenkov AV, Speicher DW, Jean S, Zhang L, Wang T, Shih I, Conejo-Garcia JR, Bitler BG, Zhang R: Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer. Cell Rep 22(13):3393-3400, Mar 2018.
George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F: A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight 2(1):e89760, Jan 2017.
Jean S, Li J, Katsaros D, Wubbenhorst B, Maxwell KN, Fishbein L, Mclane MW, Benedetto C, Canuto EM, Mitra N, Zhang L, Nathanson KL, Tanyi, JL: Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations. Oncotarget 7(30):48577-48585, Jul 2016.
Jean S, Marsh EB and Chu CS: Gynecology. The Surgical Review: An Integrated Basic and Clinical Science Study Guide, 4th Edition. PM Porrett (eds.). Wolters Kluwer, 28, 2016.
Jean S, Li J, Wubbenhorst B, Maxwell KN, Fishbein L, Mclane MW, Mitra N, Zhang L, Nathanson KL, Tanyi, JL: Paclitaxel is necessary for improved survival in epithelial ovarian cancers with somatic homologous recombination gene mutations. Abstract presented, American Association for Cancer Research Annual Meeting, Washington, DC Apr 2015.