Dario C. Altieri, MD
Wistar Institute Professor of Pathology and Laboratory Medicine
Director, The Wistar Institute Cancer Center, Philadelphia PA
Executive Vice-President and Chief Scientific Officer, The Wistar Institute, Philadelphia PA
Professor, The Wistar Institute of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
3601 Spruce Street
Philadelphia, PA 19104
Email:
daltieri@wistar.org
daltieri@wistar.org
Education:
BS (Medicine)
University of Milan School of Medicine, 1982.
MD (Medicine)
University of Milan School of Medicine, 1985.
MA
Yale University, New Haven CT, 1999.
Permanent linkBS (Medicine)
University of Milan School of Medicine, 1982.
MD (Medicine)
University of Milan School of Medicine, 1985.
MA
Yale University, New Haven CT, 1999.
Selected Publications
Kapinas, K., Kim, H., Mandeville, M., Martin-Buley, L. A., Croce, C. M., Lian, J. B., van Wijnen, A. J., Stein, J. L., Altieri, D. C., Stein, G. S.: MicroRNA-mediated survivin control of pluripotency. J. Cell Physiol 230: 63-70, 2014.Faversani, A., Vaira, V., Moro, G. P., Tosi, D., Lopergolo, A., Schultz, D. C., Rivadeneira, D., Altieri, D. C., Bosari, S. : Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic breast tumors. Breast Cancer Res 16(3), 2014.
Lisanti, S., Tavecchio, M., Chae, Y.C., Liu, Q., Bryce, A.K., Thakur, M.L., Languino, L.R., Altieri, D.C. : Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks. Cell Rep Page: 671-677, 2014.
Chae, Y. C., Angelin, A., Lisanti, S., Kossenkow, A. A., Speicher, K. D., Wang, H., Powers, J. F., Tischler, A. S., Pacak, K., Fliedner, S., Michalek, R. D., Karoly, E. D., Wallace, D. C., Languino, L. R., Speicher, D. W., Altieri, D. C. : Landscape of the mitochondrial Hsp90 metabolome in tumors. Nature Commun 4, Jul 2013.
Caino, M. C., Chae, Y. C., Vaira, V., Ferrero, S., Nosotti, M., Martin, N. M., Weeraratna, A., O’Connell, M., Jernigan, D., Fatatis, A., Languino, L. R., Bosari, S., Altieri, D. C.: Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J. Clin. Invest. J. Clin. Invest 123: 2907-2920, 2013.
1. Goel, H. L., Sayeed, A., Breen, M., Zarif, M. J., Garlick, D. S., Leav, I., Davis, R. J., Fitzgerald, T. J., Morrione, A., Hsieh. C.-C., Liu, Q., Dicker, A. P., Altieri, D. C., Languino, L. R. : β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino-terminal kinase 1. J. Cell Physiol 228: 1601-1609, 2013.
Vaira, V., Faversani, A., Martin, N. M., Garlick, D. S., Ferrero, S., Nosotti, M., Kissil, J. L., Bosari, S., Altieri, D.C.: Regulation of lung cancer metastasis by Klf4-Numb-like signaling. Cancer Res 73: 2695-2705, 2013.
Tavecchio, M., Lisanti, S., Lam, A., Ghosh, J. C., Martin, N. M., O’Connell, M., Weeraratna, A. T., Kossenkov, A. V., Showe, L. C., and Altieri, D. C.: Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. J. Biol. Chem 288: 5553-5561, 2013.
Simon-Keller, K., Paschen, A., Hombach, A.A., Ströbel, P., Coindre, J.M., Eichmüller, S.B., Vincent, A., Gattenlöhner, S., Hoppe, F., Leuschner, I., Stegmaier, S., Koscielniak, E., Leverkus, M., Altieri, D.C., Abken, H., Marx, A.: Survivin blockade sensitizes rhabdomyosarcoma for lysis by fetal by fetal acethylcholine receptor-redirected T cells. Am. J. Pathol Page: 2121-2131, 2013 Notes: doi: 10.1016/j.ajpath.2013.02.017.
Altieri, D.C.: TRAP-1, the mitochondrial Hsp90. Biochim Biophys Acta 3(767-773), March 2012.