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Timothy Hue-Fung Chao, MD, PhD
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Assistant Professor of Clinical Pathology and Laboratory Medicine
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Director of Hematology Laboratory , Pennsylvania Hospital
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Department: Pathology and Laboratory Medicine
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Contact information
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801 Spruce Street
3d 10th Floor Spruce Building
Philadelphia, PA 19107
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3d 10th Floor Spruce Building
Philadelphia, PA 19107
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Fax: 215-829-7564
32 Lab: 215-829-3544
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32 Lab: 215-829-3544
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Education:
21 7 BA 19 (Biochemistry) c
31 University of Washington, 2008.
21 7 BS 1b (Bioengineering) c
31 University of Washington, 2008.
21 8 PhD 17 (Philosophy) c
56 Perelman School of Medicine at the University of Pennsylvania, 2017.
21 7 MD 1f (Doctor of Medicine) c
56 Perelman School of Medicine at the University of Pennsylvania, 2019.
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Permanent link21 7 BA 19 (Biochemistry) c
31 University of Washington, 2008.
21 7 BS 1b (Bioengineering) c
31 University of Washington, 2008.
21 8 PhD 17 (Philosophy) c
56 Perelman School of Medicine at the University of Pennsylvania, 2017.
21 7 MD 1f (Doctor of Medicine) c
56 Perelman School of Medicine at the University of Pennsylvania, 2019.
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1e Head and Neck Pathology
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Description of Clinical Expertise
46 Gastrointestinal and Hepatopancreatobiliary Pathology1e Head and Neck Pathology
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Description of Research Expertise
4c cancer immunology, tumor microenvironment, digital pathologye 29
23
fc Tapescu I, Kohler A, Sangal NR, Brant JA, Brody RM, Chao T, Carey RM.: Thyroid Malignancies With Thymic Differentiation: Outcomes of Rare SETTLE and CASTLE Tumors. Head Neck 2025.
109 Pearlstein H, Chao T, He Z, Molle-Rios Z.: Mast cells and corticotropin-releasing hormone receptors in duodenal tissue of children with functional dyspepsia. J Pediatr Gastroenterol Nutr 2025.
1a5 Chao T, Wang ZX, Bowne WB, Yudkoff CJ, Torjani A, Swaminathan V, Kavanagh TR, Roadarmel A, Sholevar CJ, Cannaday S, Krampitz G, Zhan T, Gorgov E, Nevler A, Lavu H, Yeo CJ, Peiper SC, Jiang W.: Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma. Arch Pathol Lab Med 148: 1299-1309, Dec 2024.
16e Meredith L, Chao T, Nevler A, Basu Mallick A, Singla RK, McCue PA, Bowne WB, Jiang W.: A rare metastatic mesenteric malignant PEComa with TSC2 mutation treated with palliative surgical resection and nab-sirolimus: a case report. Diagnostic Pathology 18(1): 45, April 2023 Notes: doi: 10.1186/s13000-023-01323-x 20 Case Report.
12d M.D. Gonzalez, T. Chao, M.A. Pettengill: Modern Blood Culture: Management Decisions and Method Options. Clinics in Laboratory Medicine 40(4): 379-392, December 2020 Notes: doi: 10.1016/j.cll.2020.07.001. Epub 2020 Sep 19.Review.
166 M.E. Smith, S.J. Farahani, T. Chao, M. Palmer, A. Arriola, P. Lal: PD-L1 positivity associated with presence of tertiary lymphoid structures and high-stage disease in upper tract urothelail carcinoma. American Journal of Clinical Pathology 154(6): 802-810, November 2020 Notes: doi: 10.1093/ajcp/aqaa105 26 Comparative Study.
15f K. Hafazalla, D.Y. Ye, T. Chao, M. Curtis, C.J. Farrell: Subependymal giant cell astrocytoma without clinically or genetically identifiable tuberous sclerosis complex: a case report. Case Reports and Series in Surgery 1(2): 1-4, July 2020 Notes: DOI: 10.31487/j.CRSS.2020.02.03.
26e J. Li, K.T. Byrne, F. Yan, T. Yamazoe, Z. Chen, T. Baslan, L.P. Richman, J.H. Lin, Y.H. Sun, A.J. Rech, D. Balli, C.A. Hay, Y. Sela, A.J. Merrell, S.M. Liudahl, N. Gordon, R.J. Norgard, S. Yuan, S. Yu, T. Chao, S. Ye, TS.K. Eisinger-Mathason, R.B. Faryabi, J.W. Tobias, S.W. Lowe, L.M. Coussens, E.J. Wherry, R.H. Vonderheide, B.Z. Stanger: Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy. Immunity 49(1): 178-193.e7. July 2018 Notes: doi: 10.1016/j.immuni.2018.06.006. Epub 2018 Jun 26.
29d V. Kumar, L. Donthireddy, D. Marvel, T. Condamine, F. Wang, S. Lavilla-Alonso, A. Hashimoto, P. Vonteddu, R. Behera, M.A. Goins, C. Mulligan, B. Nam, N. Hockstein, F. Denstman, S. Shakamuri, D.W. Speicher, A.T. Weeraratna, T. Chao, R.H. Vonderheide, L.R. Languino, P. Ordentlich, Q. Liu, X. Xu, A. Lo, E. Pure, C. Zhang, A. Loboda, M.A. Sepulveda, L.A. Snyder, D.I. Gabrilovich.: Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell 32(5): 654-668, November 2017 Notes: doi: 10.1016/j.ccell.2017.10.005.
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Selected Publications
25c Nova-Camacho LM, Ma C, Abukhiran I, Shaker N, Abdul Baki MN, Collins K, González I, Chao T, Yang Z, Vyas M, Feely M, Bellizzi AM, Agostini-Vulaj D, Huber AR, Polydorides AD, Xu X, La Rosa S, Paricio JJ, Uccella S, Alvarez ML, Ordoñez Arrillaga A, Ruiz Diaz I, Karamchandani DM, Luchini C, Verdú Martin E, Zudaire Fuertes T, Rubio Mediavilla S, Xiong W, Cox B, Gonzalez RS.: Composite gangliocytoma/neuroma and neuroendocrine tumour: a contemporary analysis of 71 cases shows risk factors for metastasis. Histopathology Aug 2025.fc Tapescu I, Kohler A, Sangal NR, Brant JA, Brody RM, Chao T, Carey RM.: Thyroid Malignancies With Thymic Differentiation: Outcomes of Rare SETTLE and CASTLE Tumors. Head Neck 2025.
109 Pearlstein H, Chao T, He Z, Molle-Rios Z.: Mast cells and corticotropin-releasing hormone receptors in duodenal tissue of children with functional dyspepsia. J Pediatr Gastroenterol Nutr 2025.
1a5 Chao T, Wang ZX, Bowne WB, Yudkoff CJ, Torjani A, Swaminathan V, Kavanagh TR, Roadarmel A, Sholevar CJ, Cannaday S, Krampitz G, Zhan T, Gorgov E, Nevler A, Lavu H, Yeo CJ, Peiper SC, Jiang W.: Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma. Arch Pathol Lab Med 148: 1299-1309, Dec 2024.
16e Meredith L, Chao T, Nevler A, Basu Mallick A, Singla RK, McCue PA, Bowne WB, Jiang W.: A rare metastatic mesenteric malignant PEComa with TSC2 mutation treated with palliative surgical resection and nab-sirolimus: a case report. Diagnostic Pathology 18(1): 45, April 2023 Notes: doi: 10.1186/s13000-023-01323-x 20 Case Report.
12d M.D. Gonzalez, T. Chao, M.A. Pettengill: Modern Blood Culture: Management Decisions and Method Options. Clinics in Laboratory Medicine 40(4): 379-392, December 2020 Notes: doi: 10.1016/j.cll.2020.07.001. Epub 2020 Sep 19.Review.
166 M.E. Smith, S.J. Farahani, T. Chao, M. Palmer, A. Arriola, P. Lal: PD-L1 positivity associated with presence of tertiary lymphoid structures and high-stage disease in upper tract urothelail carcinoma. American Journal of Clinical Pathology 154(6): 802-810, November 2020 Notes: doi: 10.1093/ajcp/aqaa105 26 Comparative Study.
15f K. Hafazalla, D.Y. Ye, T. Chao, M. Curtis, C.J. Farrell: Subependymal giant cell astrocytoma without clinically or genetically identifiable tuberous sclerosis complex: a case report. Case Reports and Series in Surgery 1(2): 1-4, July 2020 Notes: DOI: 10.31487/j.CRSS.2020.02.03.
26e J. Li, K.T. Byrne, F. Yan, T. Yamazoe, Z. Chen, T. Baslan, L.P. Richman, J.H. Lin, Y.H. Sun, A.J. Rech, D. Balli, C.A. Hay, Y. Sela, A.J. Merrell, S.M. Liudahl, N. Gordon, R.J. Norgard, S. Yuan, S. Yu, T. Chao, S. Ye, TS.K. Eisinger-Mathason, R.B. Faryabi, J.W. Tobias, S.W. Lowe, L.M. Coussens, E.J. Wherry, R.H. Vonderheide, B.Z. Stanger: Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy. Immunity 49(1): 178-193.e7. July 2018 Notes: doi: 10.1016/j.immuni.2018.06.006. Epub 2018 Jun 26.
29d V. Kumar, L. Donthireddy, D. Marvel, T. Condamine, F. Wang, S. Lavilla-Alonso, A. Hashimoto, P. Vonteddu, R. Behera, M.A. Goins, C. Mulligan, B. Nam, N. Hockstein, F. Denstman, S. Shakamuri, D.W. Speicher, A.T. Weeraratna, T. Chao, R.H. Vonderheide, L.R. Languino, P. Ordentlich, Q. Liu, X. Xu, A. Lo, E. Pure, C. Zhang, A. Loboda, M.A. Sepulveda, L.A. Snyder, D.I. Gabrilovich.: Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell 32(5): 654-668, November 2017 Notes: doi: 10.1016/j.ccell.2017.10.005.
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