Jacob Wheatley Myerson, PhD

faculty photo
Research Assistant Professor of Systems Pharmacology and Translational Therapeutics
Senior Research Investigator, University of Pennsylvania
Department: Systems Pharmacology and Translational Therapeutics

Contact information
Smilow Center for Translational Research
University of Pennsylvania
The Perelman School of Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Education:
SB (Materials Science and Engineering)
Massachusetts Institute of Technology, 2005.
MS (Biomedical Engineering)
Washington University in Saint Louis, 2010.
PhD (Biomedical Engineering)
Washington University in Saint Louis, 2014.
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Selected Publications

Marcos-Contreras OA, Myerson JW, Nong J, Brenner JS, Muzykantov VR, Glassman PM.: Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates. Molecular Pharmaceutics 20(11): 5476–5485, Oct 2023.

Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA: Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. bioRxiv 17(14): 13121-13136, July 2023 Notes: Preprint.

Omo-Lamai S, Zamora ME, Patel MN, Wu J, Nong J, Wang Z, Peshkova A, Chase LS, Essien EO, Muzykantov V, Marcos-Contreras O, Myerson JW, Brenner JS.: Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions. bioRxiv Jul 2023 Notes: Preprint.

Nong J, Glassman PM, Reyes-Esteves S, Descamps HC, Shuvaev VV, Kiseleva RY, Papp TE, Alameh MG, Tam YK, Mui BL, Omo-Lamai S, Zamora ME, Shuvaeva T, Arguiri E, Thaiss CA, Myerson JW, Weissman D, Kasner SE, Parhiz H, Muzykantov VR, Brenner JS, Marcos-Contreras OA.: Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke. bioRxiv Jun 2023 Notes: Preprint.

Macedo B, Patel M, Zaleski MH, Mody P, Ma X, Mei P, Myerson JW, Brenner JS, Glassman PM.: Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics. International Journal of Pharmaceutics 639: 122951, May 2023.

Ferguson, L., Ma, X., Wu, J., Myerson, J., Brenner, J.S.: Anti-fibrotic Loaded Drug Delivery Vesicles Survive in Surfactant, Dramatically Improve Lung Pharmacokinetics, and Reach Multiple Alveolar Cell Types. American Thoracic Society Page: A2241 - A2241, May 2023.

Reyes-Esteves S, Nong J, Glassman PM, Omo-Lamai S, Ohashi S, Myerson JW, Zamora ME, Ma X, Kasner SE, Sansing L, Muzykantov VR, Marcos-Contreras OA, Brenner JS.: Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage. Journal of Controlled Release 356: 185-195, April 2023.

Ferguson LT, Ma X, Myerson JW, Wu J, Glassman PM, Zamora ME, Hood ED, Zaleski M, Shen M, Essien EO, Shuvaev VV, Brenner JS.: Mechanisms by Which Liposomes Improve Inhaled Drug Delivery for Alveolar Diseases. Advanced NanoBiomed Research 3(3): 2200106, March 2023.

Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Marcos-Contreras OA, Glassman PM, Mazaleuskaya LL, Johnston I, Hood ED, Shuvaeva T, Wu J, Zhang HY, Gregory JV, Kiseleva RY, Nong J, Grosser T, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS.: Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nature Nanotechnology 17(1): 86-97, December 2022 Notes: Preprint.

Rubey KM, Mukhitov AR, Nong J, Wu J, Krymskaya VP, Myerson JW, Worthen GS, Brenner JS.: Nanoparticle-Induced Augmentation of Neutrophils' Phagocytosis of Bacteria. Frontiers in Pharmacology 13: 923814, Jul 2022.

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Last updated: 05/01/2024
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