Zarazuela Zolkipli-Cunningham, MBChB, MRCP
Assistant Professor of Pediatrics (Human Genetics) at the Children's Hospital of Philadelphia
Attending Physician, Mitochondrial Medicine Frontier Program, Division of Human Genetics, Children's Hospital of Philadelphia
Clinical Research Director, Mitochondrial Medicine Frontier Program, Division of Human Genetics, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
6th Floor, Colket Translational Research Building
3501 Civic Center Boulevard
Philadelphia, PA 19104
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 2674264961
Publications
Links
Search PubMed for articles
CHOP Press release on Nutritional Deficiencies in Primary Mitochondrial Disease publication
Observational Study of Spinal Muscular Atrophy
CHOP Press release on expert review of nutritional interventions in Mitochondrial Disease
2019 United Mitochondrial Disease Foundation Early Stage Investigator Award
Department of Defense Congressionally Directed Medical Research Program Focused Program Award.
North American Mitochondrial Disease Consortium (NAMDC) Early Stage Investigator Blog
CHOP Press release of published review paper on Mitochondrial Supplements
Leigh syndrome gene curation
CHOP Mitochondrial Medicine Frontier Program web page
2016 United Mitochondrial Disease Foundation Clinical Grant Award
Announcement of the 2023 United Mitochondrial Disease Foundation (UMDF) Clinical Trial Pavillion, Charlotte, North Carolina
North American Mitochondrial Disease Consortium
CHOP Press release of MM-COAST manuscript publication
RDCRN Early Stage Investigator Spotlight
CHOP Percutaneous Needle Muscle Biopsy
Mitochondrial Myopathy Composite Outcome Measure Tool (MM-COAST)
Search PubMed for articles
CHOP Press release on Nutritional Deficiencies in Primary Mitochondrial Disease publication
Observational Study of Spinal Muscular Atrophy
CHOP Press release on expert review of nutritional interventions in Mitochondrial Disease
2019 United Mitochondrial Disease Foundation Early Stage Investigator Award
Department of Defense Congressionally Directed Medical Research Program Focused Program Award.
North American Mitochondrial Disease Consortium (NAMDC) Early Stage Investigator Blog
CHOP Press release of published review paper on Mitochondrial Supplements
Leigh syndrome gene curation
CHOP Mitochondrial Medicine Frontier Program web page
2016 United Mitochondrial Disease Foundation Clinical Grant Award
Announcement of the 2023 United Mitochondrial Disease Foundation (UMDF) Clinical Trial Pavillion, Charlotte, North Carolina
North American Mitochondrial Disease Consortium
CHOP Press release of MM-COAST manuscript publication
RDCRN Early Stage Investigator Spotlight
CHOP Percutaneous Needle Muscle Biopsy
Mitochondrial Myopathy Composite Outcome Measure Tool (MM-COAST)
Education:
MBChB
Edinburgh University Medical School, Scotland, UK, 1996.
MRCPCH
Royal College of Physicians, Edinburgh, Scotland, 1999.
Permanent linkMBChB
Edinburgh University Medical School, Scotland, UK, 1996.
MRCPCH
Royal College of Physicians, Edinburgh, Scotland, 1999.
Description of Clinical Expertise
Mitochondrial Myopathy diagnosis and managementPercutaneous Muscle Needle Biopsy
Mitochondrial Disease
Neuromuscular
Muscle
Description of Research Expertise
Mitochondrial Myopathy outcome measuresMitochondrial Myopathy exercise testing
Mitochondrial Myopathy clinical trials
Neuromuscular
Myopathy
Mitochondria
Muscle
Exercise
Spinal Muscular Atrophy
Nanosensor
Muscle Oxygen
Leigh syndrome
Longitudinal Studies
Selected Publications
McGrattan K, Cerchiari A, Conway E, Berti B, Finkel R, Muntoni F, Mercuri E; iSMAc working group : Bulbar function in spinal muscular atrophy (SMA): State of art and new challenges. 21st July 2023, Rome, Italy. Neuromuscul Disord 38: 44-50, May 2024 Notes: doi: 10.1016/j.nmd.2024.02.003. Epub 2024 Mar 8.Harding ER *, Kanner CA, Pasternak A, Glanzman AM, Young SD, Rao AK, McDermott MP, Zolkipli-Cunningham A, Day JW, Finkel RS, Darras BT,De Vivo DC, Montes J : Beyond Contractures in Spinal Muscular Atrophy: Identifying Lower-Limb Joint Hypermobility. Journal of Clinical Medicine April 2024.
Zolkipli-Cunningham Z, Flickinger J, Martin I, Santos JD, Balance E, Wellik A, Liebman M, Vishnubhatt S, Peterson P, Intarachumnum ND, Tindall A, McCormick E, Muraresku C, Bogush E, MacMullen L, Stanley K, Nguyen S, Goldstein A, Falk MJ, McDermott M, Xiao R: Natural History of Mitochondrial Disease Objective Measures reveals slow, progressive decline. Mitochondrial Medicine – Therapeutic Development 2024 conference, Hinxton UK March 2024 Notes: Scope: International. Notes: Poster and Pitch talk.
Flickinger J, Santos HD, Ballance E, Martin I, Intarachumnum ND, Xiao R, Zolkipli Cunningham Z: Validation of the Mitochondrial Myopathy Function Scale. Mitochondrial Medicine – Therapeutic Development 2024 conference, Hinxton, UK March 2024 Notes: Scope: International. Notes: Poster and Pitch talk
Wolfe A, Stimpson G, Ramsey D, Coratti G, Young SD, Mayhew A, Pane M, Rohwer A, Lofra RM, Duong T, O'Reilly E, Milev E, Civitello M, Sansone VA, D'Amico A, Bertini E, Messina S, Bruno C, Albamonte E, Mazzone E, Main M, Montes J, Glanzman AM, Zolkipli-Cunningham Z, Pasternak A, Marini-Bettolo C, Day JW, Darras BT, De Vivo DC, Baranello G, Scoto M, Finkel RS, Mercuri E, Muntoni F; international SMA consortium (iSMAc): Disease Trajectories in the Revised Hammersmith Scale in a Cohort of Untreated Patients with Spinal Muscular Atrophy types 2 and 3. Journal of Neuromuscular Disease February 2024 Notes: doi: 10.3233/JND-230211.
MacMullen L, George-Sankoh I, Stanley K, McCormick EM, Muraresku CC, Goldstein A, Zolkipli-Cunningham Z, Falk MJ: Bridging the Clinical-Research Gap: Harnessing an electronic data capture, integration, and visualization platform to systematically assess prospective patient-reported outcomes in mitochondrial medicine Molecular Genetics and Metabolism February 2024 Notes: Accepted February 2024.
Barca E, Kroopnick A, Houck A, Thakur K, Dugue R, Zolkipli-Cunningham Z, Falk M, Goldstein A, Demczko M, Gavrilova R, Larson A, Van Hove J, Saneto R, Buchsbaum R, Thompson J, Hirano M: Adult-onset Leigh Syndrome: An analysis of the North American Mitochondrial Disease Consortium Database (P3-11.017). for American Academy of Neurology Annual Conference, Denver CO 2024 Notes: Poster.
Trucco F, Ridout D, Weststrate H, Scoto M, Rohwer A, Coratti A, Main M, Mayhew A, Montes J, Sanctis RD, Pane M, Pera MC, Sansone VA, Albamonte E, D’Amico A, Bruno C, Messina S, Childs AM, Willis T, Ong M, Servais L, Majumdar A, Hughes I, Marini-Bettolo C, Parasuraman D, Gowda V, Baranello G, Bertini E, De Vivo DC, Darras B, Day JD, Mayer OH, Zolkipli-Cunningham Z, Finkel RS, Mercuri E, Muntoni F,on behalf of the iSMAC group: Therapeutic Role of Nusinersen on Respiratory Progression in Pediatric Patients with Spinal Muscular Atrophy Type 2 and Non-Ambulant Type 3. Neurology Clinical Practice 2024 Notes: Accepted March, 2024.
DiVito D, Wellik A, Burfield J, Peterson J, Flickinger J, Tindall A, Albanowski K, Vishnubhatt S, MacMullen L, Martin I, Muraresku C, McCormick E, George-Sankoh I, McCormack S, Goldstein A, Ganetzky R, Yudkoff M, Xiao R, Falk MJ, Mascarenhas MR, Zolkipli-Cunningham Z: Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life. Neurotherapeutics September 2023 Notes: https://doi.org/10.1007/s13311-023-01418-9.
Glanzman AM, Pasternak A, McDermott MP, Montes J, Coratti G, Young SD, Duong T, Martens WB, Day JW, Zolkipli-Cunningham Z, Sansone VA, D'Amico A, Messina S, Bruno C, Mercuri E, De Vio DC, Darras BT: The SMA Functional Composite Scope (SMA-FC) Updates with Inclusion of Longitudinal Data Pre and Post Imitation of Nusinersen CureSMA Annual SMA Research & Clinical Care Meeting, Orlando, FL July 2023 Notes: Poster.