Selected Publications

Roark RS*, Habib R*, Gorman J, Li H, Connell AJ, Bonsignori M, Guo Y, Hogarty MP, Olia AS, Sowers K, Zhang B, Bibollet-Ruche F, Bylund T, Callaghan S, Carey JW, Cerutti G, Harris DR, He W, Lewis E, Liu T, Mason RD, Qiao Y, Park Y, Rando JM, Singh A, Wolff J, Lei QP, Louder MK, Doria-Rose NA, Andrabi R, Saunders KO, Seaman MS, Haynes BF, Kulp DW, Mascola JR, Roederer M, Sheng Z, Hahn BH, Shaw GM, Kwong PD, Shapiro L.: Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies. Journal of Experimental Medicine 222(10), October 2025.

Habib R*, Roark RS*, Li H*, Connel AJ*, Hogarty MP, Wagh K, Wang S, Marchitto L, Skelly AN, Carey JW, Sowers KJ, Ayyanathan K, Plante SJ, Bibollet-Ruche F, Park Y, Agostino CJ, Sing A, Matella CL, Lewis E, Rando JM, Chohan N, Lora J, Ding W, Capion MS, Zhao C, Liu W, Li Y, Li X, Liang B, Chowdhury RR, Amereh K, Van Itallie E, Sheng Z, Ghosh AR, Bar KJ, Williams WB, Wiehe K, Saunders KO, Edwards RJ, Cain DW, Lewis M, Batista FD, Burton DR, Andrabi R, Kulp DW, Haynes BF, Korber B, Shapiro L, Kwong PD, Hahn BH, Shaw GM.: Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development. bioRxiv Preprint 2025.

Ghosh A*, Habib R*, Mishra N*, Roark RS*, Akauliya M, Albowaidey AA, Allen JD, Amereh K, Avillion G, Bottermann M, Liang B, Chaudhary N, Callaghan S, Dye J, Li X, Ellis-Pugh JR, Chowdhury RR, James NE, Liu X, Maiorino L, Maldonado P, Nedellec R, Oberoi, P, Sowers KJ, Park Y, Prum T, Rodriguez L, Ssozi M, Torres J, Walsh AA, Warner JE, Weldon SR, Xu L, Wiehe K, Crispin M, Ward AB, Nair U, Hahn BH, Burton DR, Shapiro L, Kwong PD, Irvine DJ, Andrabi R, Shaw GM, Batistia FD.: Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. bioRxiv 2025.

Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD.: Ultrapotent Broadly Neutralizing Human-Llama Bispecific Antibodies Against HIV-1. Advanced Science May 2024.

Habib R, Solieva SO, Lin ZJ, Ghosh S, Bayruns K, Singh M, Agostino CJ, Tursi, NJ, Sowers, KJ, Huang, J, Roark RS, Purwar M, Park Y, Ayyanathan K, Li H, Carey JW, Kim A, Park J, McCanna ME, Skelly AN, Chokkalingam N, Kriete S, Shupin N, Huynh A, Walker S, Laenger N, Du J, Cui J, Hahn BH, Patel A, Escolano A, Kwong PD, Shapiro L, Bowman GR, Shaw GM, Weiner DB, Pallensen J, Kulp DW.: Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques. bioRxiv 2024.

Wang H, Cheng C*, Dal Santo JL*, Shen C-H*, Bylund T*, Henry AR*, Howe CA*, Hwang J*, Morano NC*, Morris DJ*, Pletnev S*, Roark RS*, Zhou T*, Hansen BT, Hoyt FH, Johnston TS, Wang S, Zhang B, Ambrozak DR, Becker JE, Bender MF, Changel A, Chaudhary R, Corcoran M, Corrigan AR, Foulds KE, Guo Y, Doria-Rose NA, Georgiev IS, Karlsson Hedestam BG, Sheng Z, Woodward RA, Douek DC, Koup RA, Pierson TC, Shapiro L, Shaw GM, Mascola JR, Kwong PD.: Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell 25(187): 7214-7231, 2024.

Bibollet-Ruche F, Russell RM, Ding W, Liu W, Li Y, Wagh K, Wrapp D, Habib R, Skelly AN, Roark RS, Sherrill-Mix S, Wang S, Rando J, Lindemuth E, Cruickshank K, Park Y, Baum R, Carey JW, Connell AJ, Li H, Giorgi EE, Song GS, Ding S, Finzi A, Newman A, Hernandez GE, Machiele E, Cain DW, Mansouri K, Lewis MG, Montefiori DC, Wiehe KJ, Alam SM, Teng IT, Kwong PD, Andrabi R, Verkoczy L, Burton DR, Korber BT, Saunders KO, Haynes BF, Edwards RJ, Shaw GM, Hahn BH.: A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies. mBio 1(14), 2023.

Li H, Wang S, Lee FH, Roark RS, Murphy AI, Smith J, Zhao C, Rando J, Chohan N, Ding Y, Kim E, Lindemuth E, Bar KJ, Pandrea I, Apetrei C, Keele BF, Lifson JD, Lewis MG, Denny TN, Haynes BF, Hahn BH, Shaw GM.: New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure. Journal of Virology 11(95), May 2021.

Roark RS*, Li H*, Williams WB*, Hema C*, Mason RD*, Gorman J*, Wang S, Lee FH, Rando JM, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet- Ruche, F, Liu W, Connel J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond D, Doria-Rose NA, Schramm, CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM.: Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth. Science(371), 2021.

Doria-Rose NA, Altae-Tran HR, Roark RS, Schmidt SD, Sutton MS, Louder MK, Chuang G-YY, Bailer RT, Cortez V, Kong R, McKee K, O’Dell S, Wang F, Abdool Karim SS, Binley JM, Connors M, Haynes BF, Martin MA, Montefiori DC, Morris L, Overbaugh J, Kwong PD, Mascola JR, Georgiev IS.: Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting. PLoS Pathogens(13), 2017.