Jeremy Binder Katzen, MD
Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
Attending Physician, Hospital of the University of Pennsylvania
Investigator, Lung Biology Institute
Department: Medicine
Contact information
Edward J Stemmler Hall Suite 216
3450 Hamilton Walk
Philadelphia, PA 19104-6118
3450 Hamilton Walk
Philadelphia, PA 19104-6118
Email:
jeremy.katzen@uphs.upenn.edu
jeremy.katzen@uphs.upenn.edu
Education:
BA
Bowdoin College, 2004.
MD
University of Rochester School of Medicine and Dentistry, 2011.
Permanent linkBA
Bowdoin College, 2004.
MD
University of Rochester School of Medicine and Dentistry, 2011.
Description of Clinical Expertise
Interstitial Lung DiseasePulmonary Fibrosis
Genetic Interstitial Lung Disease
Description of Research Expertise
Lung Epithelial BiologyLung Development
Surfactant Biology
Cell Stress
Lung Fibrosis
Selected Publications
Hoffman ET, Shah A, Roque WB, Rodriguez LR, Dherwani R, Dooley PE, Minakin K, Tomer Y, Ayers LJ, Jones D, Murthy M, Bennett A, Lange AN, Babu B, Bawa PS, Wang F, Chavez K, Cooper CH, Nakamoto RS, Basil MC, Brickman MS, Kotton DN, Konstantinos AD, Katzen J: Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling. Nat Commun Aug 2025 Notes: doi:10.1038/s41467-025-63735-1 / NCOMMS-24-68971.Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS.: Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape. Nat Nanotechnol Aug 2025.
Murthy A, Rodríguez LR, Barboza WR, Tomer Y, Bui S, Carson P, Dimopoulos T, Iyer S, Chavez K, Cooper CH, Katzen JB, Beers MF.: Regulatory t cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis. bioRxiv Jul 2025.
Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF.: Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight 10: e182578, Jul 2025.
Snitow ME, Michki SN, Chaudhry FN, Dherwani R, Katzen JB, Frank DB, Zepp JA.: Stc1-expressing myofibroblasts are a developmentally distinct lineage cleared through intrinsic apoptosis in the neonatal lung. bioRxiv Jun 2025.
Patel MN, Tiwari S, Wang Y, O'Neill S, Wu J, Omo-Lamai S, Espy C, Chase LS, Majumder A, Hoffman E, Shah A, Sárközy A, Katzen J, Pardi N, Brenner JS.: Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat Biotechnol Feb 2025.
Banaschewski BJH, Michki SN, Sitaraman S, Pan R, Wang JY, Stewart D, Goldy MK, Lin SM, Cantu E, Katzen JB, Basil MC, Emtiazjoo AM, Todd JL, Gokey JJ, Kropski JA, Frank DB, Zepp JA, Young LR.: Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis. Commun Biol 8: 284, Feb 2025.
Katzen J and Knipe R: Animal and Translational Models for Precision Medicine in ILD. Precision Medicine in Interstitial Lung Disease. Collins BF and Montesi SB (eds.). Springer Nature, Page: 159-175, 2025.
Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight Dec 2024.
Peers de Nieuwburgh M, Hunt M, Chandrasekaran P, Vincent TL, Hayes KB, Randazzo IR, Gunder M, De Bie FR, Colson A, Lu M, Wen H, Michki SN, Rychik J, Debiève F, Katzen J, Young LR, Davey MG, Flake AW, Gaynor JW, Frank DB.: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol. Page: epub ahead of print, Oct 2024.