Jeremy Binder Katzen, MD
Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care)
Attending Physician, Hospital of the University of Pennsylvania
Investigator, Lung Biology Institute
Department: Medicine
Contact information
Edward J Stemmler Hall Suite 216
3450 Hamilton Walk
Philadelphia, PA 19104-6118
3450 Hamilton Walk
Philadelphia, PA 19104-6118
Email:
jeremy.katzen@uphs.upenn.edu
jeremy.katzen@uphs.upenn.edu
Education:
BA
Bowdoin College, 2004.
MD
University of Rochester School of Medicine and Dentistry, 2011.
Permanent linkBA
Bowdoin College, 2004.
MD
University of Rochester School of Medicine and Dentistry, 2011.
Description of Clinical Expertise
Interstitial Lung DiseasePulmonary Fibrosis
Genetic Interstitial Lung Disease
Description of Research Expertise
Lung Epithelial BiologyLung Development
Surfactant Biology
Cell Stress
Lung Fibrosis
Selected Publications
Patel MN, Tiwari S, Wang Y, O'Neill S, Wu J, Omo-Lamai S, Espy C, Chase LS, Majumder A, Hoffman E, Shah A, Sárközy A, Katzen J, Pardi N, Brenner JS.: Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat Biotechnol Feb 2025.Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight Dec 2024.
Peers de Nieuwburgh M, Hunt M, Chandrasekaran P, Vincent TL, Hayes KB, Randazzo IR, Gunder M, De Bie FR, Colson A, Lu M, Wen H, Michki SN, Rychik J, Debiève F, Katzen J, Young LR, Davey MG, Flake AW, Gaynor JW, Frank DB.: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol. Page: epub ahead of print, Oct 2024.
Hoffman ET, Roque Barboza W, Rodriguez LR, Dherwani R, Tomer Y, Murthy M, Bennett A, Nottingham A, Babu B, Chavez K, Cooper CH, Basil MC, Brickman Raredon MS, Katzen J: Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling. bioRxiv June 2024 Notes: doi: https://doi.org/10.1101/2024.06.17.599351.
Murthy A, Rodriguez LR, Dimopoulos T, Bui S, Iyer S, Chavez K, Tomer Y, Abraham V, Cooper C, Renner DM, Katzen JB, Bentley ID, Ghadiali SN, Englert JA, Weiss SR, Beers MF.: Activation of Alveolar Epithelial ER Stress by β-Coronavirus Infection Disrupt Surfactant Homeostasis in Mice: Implications for Covid-19 Respiratory Failure. Am J Physiol Lung Cell Mol Physiol 327(2): L232-L249, Jun 2024.
L. R. Rodriguez, W. Roque Barboza, A. Murthy, Y. Tomer, S. Bui, C. Cooper, K. Chavez, J. Katzen, M. F. Beers: Transitional AT2 Derived Lactate Promotes Alveolar Niche Dysfunction in the SftpcI73TMurine Model of IPF. American Thoracic Society 2024 International Conference May 2024 Notes: poster presentation.
E.T. Hoffman, W. Roque Barboza, L. R. Rodriguez, A. Murthy, R. Dherwani, A. Bennett, Y. Tomer, M.S.B. Raredon, J. Katzen: Aberrant Alveolar Epithelial Cells Alter the Alveolar Mesenchyme to Promote Fibrosis in a Clinical Sftpc Mutation Model of Lung Fibrosis American Thoracic Society 2024 International Conference May 2024 Notes: Abstract Award Recipient, poster presentation.
W. Roque Barboza, L. R. Rodriguez, A. Murthy, E. T. Hoffman, J. Katzen, M. F. Beers: A Novel Fibroblast Population Supports Repair of the Alveolar Niche: Insights From a Preclinical Mouse Model of Idiopathic Pulmonary Fibrosis. American Thoracic Society 2024 International Conference May 2024 Notes: poster presentation.
A. Murthy, L. R. Rodriguez, W. Roque Barboza, S. Bui, C. Cooper, K. Chavez, Y. Tomer, J. Katzen, M. F. Beers: Checkpoint Inhibitor Pathway Dysfunction in Pulmonary Fibrosis. American Thoracic Society 2024 International Conference May 2024 Notes: poster presentation.
S. Bui, L. R. Rodriguez, W. Roque Barboza, C. Cooper, K. Chavez, A. Murthy, S. Mulugeta, J. Katzen, M. F. Beers: Nuclear Factor E2-related Factor 1 (Nrf1) and ER-associated Degradation (ERAD) Coordinate the Proteasome Response to Surfactant Protein C Aggregates in Alveolar Epithelial Cells. American Thoracic Society 2024 International Conference May 2024 Notes: poster presentation.