Joshua D Brandstadter, MD PhD MSc
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Director of Clinical Research, Center for Cytokine Storm Treatment & Laboratory, University of Pennsylvania
Department: Medicine
Contact information
Biomedical Research Building II/III
Bay 449
421 Curie Blvd
Philadelphia, PA 19014
Bay 449
421 Curie Blvd
Philadelphia, PA 19014
Publications
Education:
BA (Molecular Biology & Biochemistry; Economics)
Wesleyan University, 2006.
MSc (Integrated Immunology)
University of Oxford, 2007.
MD-PhD (Medicine; Molecular Cancer Biology)
Duke University, 2015.
Permanent linkBA (Molecular Biology & Biochemistry; Economics)
Wesleyan University, 2006.
MSc (Integrated Immunology)
University of Oxford, 2007.
MD-PhD (Medicine; Molecular Cancer Biology)
Duke University, 2015.
Description of Clinical Expertise
Castleman disease, histiocytic disorders, lymphoma, lymphoproliferative disordersDescription of Research Expertise
Castleman Disease, lymphoproliferative disorders, lymphoma, lymph node stromal cells, fibroblastic stromal cellsSelected Publications
Steven Rowe, Mariam Goubran, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Bridget Austin, Kathleen McNicholas, Marley Blommers, Junyan Shi, Lisa K Peterson, Lusia Sepiashvili, Andre Mattman, Joshua D Brandstadter, David C Fajgenbaum, Luke Y C Chen: Ferritin, C-Reactive Protein, and Soluble CD25 Distinguish TAFRO From HLH. Am J Hematol September 2025.Mechthild Lütge, Lisa Kurz, Yves Stanossek, Samuel Meili, Hung-Wei Cheng, Angelina De Martin, Joshua Brandstadter, Ivan Maillard, Mark D Robinson, Sandro J Stoeckli, Natalia B Pikor, Lucas Onder, Burkhard Ludewig: Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes. Science Immunology 10(107): eads6820, May 2025.
Dave Maurice De Sousa, Eric Perkey, Laure Le Corre, Salix Boulet, Daniela Gómez Atria, Anneka Allman, Frédéric Duval, Jean-François Daudelin, Joshua D Brandstadter, Katlyn Lederer, Sarah Mezrag, Livia Odagiu, Myriam Ennajimi, Marion Sarrias, Hélène Decaluwe, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W Siebel, Ivan Maillard, Nathalie Labrecque : Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation. J Exp Med 5(222): e20231758, May 2025.
Sheila K Pierson, Joshua D Brandstadter, Drew Torigian, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat MD, Corey Casper, Amy Chadburn, Shanmuganathan Chandrakasan, Angela Dispenzieri, Alexander Fosså, Christian Hoffmann, Makoto Ide, Razelle Kurzrock, Sudipto Mukherjee, Sunita D Nasta, José-Tomás Navarro, Ariela Noy, Eric Oksenhendler, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Matthew J Streetly, Raymond Siu Ming Wong, Lu Zhang, Megan S Lim, Gordan Srkalovic, Frits van Rhee, David C Fajgenbaum: Characterizing the heterogeneity of Castleman disease and oligocentric subtype: Findings from the ACCELERATE registry. Blood Advances February 2025.
Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard: Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity. CellPress, 58(1), January 2025.
Brandstadter JD, Lutge M, Lim MS, Bagg A, Miller ID, Gonzalez MV, Austin B, Priore SF, Ludewig B, Fajgenbaum DC, Maillard I.: Myofibroblast to T-Zone Reticular Cell Ratio Identifies Unicentric Castleman Disease Lymph Nodes. American Society of Hematology Annual Meeting, San Diego, CA.(1155), Dec 2024 Notes: "Oral Presentation"
Bustamante MS, Pierson SK, Ren Y, Bagg A, Brandstadter JD, Srkalovic G, Mango N, Alapat D, Lechowicz MJ, Li H, Van Rhee F, Lim MS, Fajgenbaum DC.: Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease. Haematologica 109: 2196-2206, Jul 2024.
Shyamsundar S, Pierson SK, Connolly CM, Teles M, Segev DL, Werbel WA, van Rhee F, Casper C, Brandstadter JD, Noy A, Fajgenbaum DC.: Castleman disease patients report mild COVID-19 symptoms and mount a humoral response to SARS-CoV-2 vaccination. Blood Neoplasia 1(1): 100002. doi: 10.1016/j.bneo.2024.100002. Mar 2024.
Rubenstein AI, Pierson SK, Shyamsundar S, Bustamante MS, Gonzalez MV, Milller ID, Brandstadter JD, Mumau MD, Fajgenbaum DC.: Immune-mediated thrombocytopenia and IL-6-mediated thrombocytosis observed in idiopathic multicentric Castleman disease. Br J Haematol 204(3): 921-930, Mar 2024.
Mango NA, Pierson SK, Sarmiento Bustamante M, Brandstadter JD, van Rhee F, Fajgenbaum DC.: Siltuximab administration results in spurious IL-6 elevation in peripheral blood. Am J Hematol 99(1): E15-E18. Jan 2024.