Selected Publications

Beltra, J. C., Manne, S., Abdel-Hakeem, M. S., Kurachi, M., Giles, J. R., Chen, Z., Casella, V., Ngiow, S. F., Khan, O., Huang, Y. J., Yan, P., Nzingha, K., Xu, W., Amaravadi, R. K., Xu, X., Karakousis, G. C., Mitchell, T. C., Schuchter, L. M., Huang, A. C., Wherry, E. J.: Developmental Relationships of Four Exhausted CD8(+) T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Immunity 52(5): 825-841 e8, 2020.

Pauken, K. E., Godec, J., Odorizzi, P. M., Brown, K. E., Yates, K. B., Ngiow, S. F., Burke, K. P., Maleri, S., Grande, S. M., Francisco, L. M., Ali, M. A., Imam, S., Freeman, G. J., Haining, W. N., Wherry, E. J., Sharpe, A. H.: The PD-1 Pathway Regulates Development and Function of Memory CD8(+) T Cells following Respiratory Viral Infection. Cell Rep 31(13): 107827, 2020.

Chen, Z., Ji, Z., Ngiow, S. F., Manne, S., Cai, Z., Huang, A. C., Johnson, J., Staupe, R. P., Bengsch, B., Xu, C., Yu, S., Kurachi, M., Herati, R. S., Vella, L. A., Baxter, A. E., Wu, J. E., Khan, O., Beltra, J. C., Giles, J. R., Stelekati, E., McLane, L. M., Lau, C. W., Yang, X., Berger, S. L., Vahedi, G., Ji, H., Wherry, E. J.: TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision. Immunity 51(5): 840-855 e5, 2019.

Kurachi, M., Ngiow, S. F., Kurachi, J., Chen, Z., Wherry, E. J.: Hidden Caveat of Inducible Cre Recombinase. Immunity 51(4): 591-592, 2019.

Khan, O., Giles, J. R., McDonald, S., Manne, S., Ngiow, S. F., Patel, K. P., Werner, M. T., Huang, A. C., Alexander, K. A., Wu, J. E., Attanasio, J., Yan, P., George, S. M., Bengsch, B., Staupe, R. P., Donahue, G., Xu, W., Amaravadi, R. K., Xu, X., Karakousis, G. C., Mitchell, T. C., Schuchter, L. M., Kaye, J., Berger, S. L., Wherry, E. J.: TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion. Nature 571(7764): 211-218, 2019.

Young, A., Ngiow, S. F., Gao, Y., Patch, A. M., Barkauskas, D. S., Messaoudene, M., Lin, G., Coudert, J. D., Stannard, K. A., Zitvogel, L., Degli-Esposti, M. A., Vivier, E., Waddell, N., Linden, J., Huntington, N. D., Souza-Fonseca-Guimaraes, F., Smyth, M. J.: A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment. Cancer Res 78(4): 1003-1016, 2018.

Casciello, F., Al-Ejeh, F., Kelly, G., Brennan, D. J., Ngiow, S. F., Young, A., Stoll, T., Windloch, K., Hill, M. M., Smyth, M. J., Gannon, F., Lee, J. S.: G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proc Natl Acad Sci U S A 114(27): 7077-7082, 2017.

Young, A., Ngiow, S. F., Madore, J., Reinhardt, J., Landsberg, J., Chitsazan, A., Rautela, J., Bald, T., Barkauskas, D. S., Ahern, E., Huntington, N. D., Schadendorf, D., Long, G. V., Boyle, G. M., Holzel, M., Scolyer, R. A., Smyth, M. J.: Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis. Cancer Res 77(17): 4684-4696, 2017.

Reinhardt, J., Landsberg, J., Schmid-Burgk, J. L., Ramis, B. B., Bald, T., Glodde, N., Lopez-Ramos, D., Young, A., Ngiow, S. F., Nettersheim, D., Schorle, H., Quast, T., Kolanus, W., Schadendorf, D., Long, G. V., Madore, J., Scolyer, R. A., Ribas, A., Smyth, M. J., Tumeh, P. C., Tuting, T., Holzel, M.: MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Cancer Res 77(17): 4697-4709, 2017.

Gao, Y., Souza-Fonseca-Guimaraes, F., Bald, T., Ng, S. S., Young, A., Ngiow, S. F., Rautela, J., Straube, J., Waddell, N., Blake, S. J., Yan, J., Bartholin, L., Lee, J. S., Vivier, E., Takeda, K., Messaoudene, M., Zitvogel, L., Teng, M. W. L., Belz, G. T., Engwerda, C. R., Huntington, N. D., Nakamura, K., Holzel, M., Smyth, M. J.: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nat Immunol 18(9): 1004-1015, 2017.