Son C. Nguyen, PhD
Research Assistant Professor of Genetics
Department: Genetics
Contact information
415 Curie Boulevard
CRB 570
Philadelphia, PA 19104
CRB 570
Philadelphia, PA 19104
Lab: 215-746-5734
Email:
nson@upenn.edu
nson@upenn.edu
Education:
BA (Genetics, Minor in Computer Science)
Rutgers University, New Brunswick, NJ, 2007.
PhD (Biological and Biomedical Sciences )
Harvard University, Cambridge, MA, 2016.
Permanent linkBA (Genetics, Minor in Computer Science)
Rutgers University, New Brunswick, NJ, 2007.
PhD (Biological and Biomedical Sciences )
Harvard University, Cambridge, MA, 2016.
Description of Research Expertise
As a Research Assistant Professor in the laboratory of Dr. Eric Joyce, I am developing methodologies for spatial genomic organization at single-cell resolution, making contributions to the Oligopaints fluorescent in situ hybridization (FISH) technology platform and enabling advanced imaging of DNA and RNA. We have created a high-throughout imaging pipeline for the genetic screening and identification of novel regulators of organization, and we seek to incorporate high-content feature detection to address the limitations of traditional microscopy.Selected Publications
Park DS, Nguyen SC, Isenhart R, Shah PP, Kim W, Barnett RJ, Chandra A, Luppino JM, Harke J, Wai M, Walsh PJ, Abdill RJ, Yang R, Lan Y, Yoon S, Yunker R, Kanemaki MT, Vahedi G, Phillips-Cremins JE, Jain R, Joyce EF : High-throughput Oligopaint screen identifies druggable 3D genome regulators. Nature 620(7972): 209-217, Aug 2023.Shah PP, Keough KC, Gjoni K, Santini GT, Abdill RJ, Wickramasinghe NM, Dundes CE, Karnay A, Chen A, Salomon REA, Walsh PJ, Nguyen SC, Whalen S, Joyce EF, Loh KM, Dubois N, Pollard KS, Jain R.: An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype. Genome Biol 24(1): 16, Jan 2023.
Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Abdill RJ, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF.: Co-depletion of NIPBL and WAPL balance cohesin activity to correct gene misexpression. PLoS Genet 18(11): e1010528, Nov 2022.
Wang W, Chandra A, Goldman N, Yoon S, Ferrari EK, Nguyen SC, Joyce EF, Vahedi G.: TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. Nat Immunol 23(7): e1010528, Jul 2022.
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R.: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet 53(10): 1480-1492, Oct 2021.
Alexander KA, Coté A, Nguyen SC, Zhang L, Gholamalamdari O, Agudelo-Garcia P, Lin-Shiao E, Tanim KMA, Lim J, Biddle N, Dunagin MC, Good CR, Mendoza MR, Little SC, Belmont A, Joyce EF, Raj A, Berger SL.: p53 mediates target gene association with nuclear speckles for amplified RNA expression. Mol Cell 81(8): 1666-1681, Apr 2021.
Johnstone SE, Reyes A, Qi Y, Adriaens C, Hegazi E, Pelka K, Chen JH, Zou LS, Drier Y, Hecht V, Shoresh N, Selig MK, Lareau CA, Iyer S, Nguyen SC, Joyce EF, Hacohen N, Irizarry RA, Zhang B, Aryee MJ, Bernstein BE.: Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell 182(8): 1474-1489, Sep 2020.
Nguyen HQ, Chattoraj S, Castillo D, Nguyen SC, Nir G, Lioutas A, Hershberg EA, Martins NMC, Reginato PL, Hannan M, Beliveau BJ, Church GM, Daugharthy ER, Marti-Renom MA, Wu CT.: 3D mapping and accelerated super-resolution imaging of the human genome using in situ sequencing. Nat Methods 17(8): 822-832, Aug 2020.
Luppino JM, Park DS, Nguyen SC, Lan Y, Xu Z, Yunker R, Joyce EF.: Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. Nat Genet 52(8): 840-848, Aug 2020.
Gozalo A, Duke A, Lan Y, Pascual-Garcia P, Talamas JA, Nguyen SC, Shah PP, Jain R, Joyce EF, Capelson M.: Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Mol Cell 77(1): 67-81, Jan 2020.