Chelsea Kotch, MD, MSCE
Assistant Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Instructor A of Pediatrics, Division of Oncology, University of Pennsylvania School of Medicine
Assistant Professor of Pediatrics Division of Oncology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Children’s Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
3500 Civic Center Blvd
3rd floor, Office 3585
Philadelphia, PA 19104
3500 Civic Center Blvd
3rd floor, Office 3585
Philadelphia, PA 19104
Education:
B.A (Biology with a Specialization in Neuroscience, Minor in Spanish Literature)
Boston University, 2009.
MD
Tufts University School of Medicine, 2014.
MSCE (Epidemiology)
University of Pennsylvania, Perelman School of Medicine, 2021.
Permanent linkB.A (Biology with a Specialization in Neuroscience, Minor in Spanish Literature)
Boston University, 2009.
MD
Tufts University School of Medicine, 2014.
MSCE (Epidemiology)
University of Pennsylvania, Perelman School of Medicine, 2021.
Description of Clinical Expertise
Neurofibromatosis Type 1Selected Publications
Kotch C, de Blank PM, Romo C et al.: The Use of MEK Inhibitors for Neurofibromatosis Type 1-Associated High Grade Glioma and High-Grade Astrocytoma with Piloid Features in Children and Young Adults. International Symposium on Pediatric Neuro-Oncology, Sydney, AUS June 2026.Wong D, Lin F, Kline C, Wu J, Schubert J, Chen J, Golenberg N, Naveh N, Patel M, Xu F, Cao K, Fu W, Denenberg E, Fanning E, Gallo D, Zelley K, Belasco J, Desai K, Foster JB, Kotch C, Minturn J, Shah A, Lang Shih-Shan, Madsen PJ, Hill-Kayser CE, LaRiviere M, Li Yimei, Wertheim G, Luo M, Surrey LF, Zhong Y, Viaene A, Brodeur GM, MacFarland SP, Santi M, Resnick A, Storm PB, Fisher MJ, Cole KA, Li MM : Integrated Molecular and Clinical Analysis of over 500 Pediatric Central Nervous System Tumors Neuro-Oncology Pediatrics Neuro-Oncology Pediatrics May 2026.
Kotch C, Perreault S, Power P, Adams DJ, Aldape K, Avery RA, Bandopadhayay P, Capper D, de Blank P, Entz-Werle N, Fangusaro J, Hansford JR, Hawkins C, Jacques TS, Jones DTW, Kann BH, Kranendonk MEG, Levine A, Ligon KL, Martinez-Barbera JP, Meijer L, Milde T, Mueller S, Mulcahy Levy JM, Nakano Y, Packer RJ, Pfister S, Raabe E, Robison NJ, Tabori U, Yeo KK, Vinitsky A, Zhu Y, Fisher MJ, Hargrave D, Kilburn LB: Tempered Optimism: Advances in the Precision Medicine Era for Pediatric Low-Grade Glioma. Neuro-Oncology May 2026.
Kotch C, de Blank P, Fangusaro J, Fisher MJ: MEK Inhibitors for Neurofibromatosis Type 1-Associated Central and Peripheral Nervous System Tumors. Neuro Oncology Advances 8(2): ii14–ii24, May 2026.
Ahrens-Niklaus R, Kotch C, Roche A, Everett JK, Reddy S, Santi M, Madsen PJ, Martos-Rus C, Yrigollen CM, Small JC, McCague S, Davidson BL, Samelson-Jones BJ, Surrey LF, Li M, Ficicioglo C, Wang R, Bushman FD, George LA: Neuroepithelial Tumor Associated with AAV Integration After Intracisternal Magna Vector Delivery. New England Journal of Medicine May 2026.
Gilene S, Miller C, Cronk JC, Graham RT, Gross AM, Hummel T, Kotch C, Mochizuki AY, Raskin S, de Blank P: MEK Inhibitor-Induced Dropped Head Syndrome in Pediatrics. Neuro-Oncology Pediatrics April 2026.
Kotch C, Gomes A, Schatz K, Dombi E, Brown S, Gross AM, Alves M, Perreault S, Mueller S, Reddy AT, Romo C, Bornhorst M, Tonsgard J, Weiss BD, Widemann B, Fisher MJ: The spectrum of pathogenic NF1 variants in participants enrolling on clinical trials of MEK inhibitors for plexiform neurofibroma. Human Genetics 144(11-12): 1199-1206, Dec 2025.
Kotch C, Green K, Fisher MJ, Hargrave D: Pediatric-Type Diffuse Low Grade Glioma. Advances in Cancer Research 167: 1-35, Sep 2025.
Yogaratnam A, Melvin J, Omoteso O, Martin S, Wikstrom D, Little P, Rweikiza B, Dufek A, Stewart B, Fisher MJ, Kotch C, Romo C, Wolters P: Validation of NF1-specific patient-reported outcome measures to assess pain related to plexiform neurofibromas for clinical trials: A preliminary data analysis. Children’s Tumor Foundation Global NF Conference, Washington DC, USA June 2025.
Parry C, Al Nachar M, Markley M, Saunders C, Kotch C, Sundby RT, Allaway R: Clinical Metadata Representation in the NF Data Portal. Children’s Tumor Foundation Global NF Conference, Washington DC, USA June 2025.