Caroline Diorio, MD
Assistant Professor of Pediatrics (Oncology)
Instructor A of Pediatrics, University Of Pennsylvania School of Medicine
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Oncology
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Division of Oncology
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Education:
BSc (Biology and Psychology)
Wilfrid Laurier University, 2010.
MD (Medicine)
University of Toronto Faculty of Medicine, 2014.
MTR (Translational Research)
University of Pennsylvania School of Medicine, 2021.
Permanent linkBSc (Biology and Psychology)
Wilfrid Laurier University, 2010.
MD (Medicine)
University of Toronto Faculty of Medicine, 2014.
MTR (Translational Research)
University of Pennsylvania School of Medicine, 2021.
Description of Clinical Expertise
High risk leukemia, relapsed/refractory T-ALL, HLH, CARTDescription of Research Expertise
Serum proteomics, immune dysregulation, T-cell ALL immunotherapySelected Publications
Dain AS, Diorio C, Fisher BT, Hankins JS, Witmer CM, Boustany M, Burton M, Ferrolino J, Sadaf S, Ross HS, Maron G, for the Pediatric COVID-19 US Registry: Description of a National, Multi-Center Cohort of Patients with Sickle Cell Disease and SARS-CoV-2 Infection: Data from the Pediatric COVID-19 Registry. Pediatr Blood Cancer 12(1): e30909, March 2024.Ligon JA, Ramakrishna S, Ceppi F, Calkoen FGJ, Diorio C, Davis KL, Jacoby E, Gottschalk S, Schultz L, Capitini CM.: INSPIRED Symposium Part 4B: CAR T cell correlative studies – established findings and future priorities. Transplant Cell Ther 30(2): 155-170, Feb 2024.
Tardif-Theriault C, Schechter T, Culos-Reed N, Lewis V, Orsey A, Diorio C, Tomlinson GA, Sung L: Yoga versus iPad active control for fatigue in paediatric cancer therapy: a randomised controlled trial. BMJ Support Palliat Care 245(2): 2023-004609, Dec 2023.
Niswander LM, Chung P, Diorio C, Tasian SK: Clinical responses in pediatric patients with relapsed/refractory leukemia treated with azacitidine and venetoclax. Haematologica 108(11): 3142-3147, Nov 2023 Notes: doi: 10.3324/haematol.2022.282637.
Bai Z, McClory S, Feng B, Diorio C, Zhao Z, Baysoy A, Su G, Zhou X, Peng L, Chen S, Camara P, Tang L, June C, Melenhorst J, Grupp S, Fan R: Single-cell multi-omics reveals type-2 function and metabolic fitness in maintaining CAR T cell longevity associated with 8-year leukemia remission. In Review Nature 142(1): 352, Nov 2023 Notes: https://doi.org/10.1182/blood-2023-179480.
Biery DN, Turicek DP, Diorio C, Schroeder BA, Shah NN: Cytokine Profiling in CAR T-Cell Therapy: Another Biomarker in Need of Standardization, Scoping Review (Part 2) J Immunother Cancer 11(15): e006596, Sep 2023.
Glisovic-Aplenc T, Diorio C*, Chukinas JA*, Veliz K, Shestova O, Vincent T, Shen F, Nunez-Cruz S, Miao F, Milone MC, June CH, Teachey DT, Tasian SK, Aplenc R, Gill S.: CD38 as a pan-hematologic target for chimeric antigen receptor T cells. blood advances 7(16): 4418-4430, Aug 2023 Notes: doi: 10.1182/bloodadvances.2022007059.
Schuelke M, Bassiri H, Behrens EM, Canna S, Croy C, Dinofia A, Gollomp K, Grup SA, Lambert MP, Lambrix A, Maude SL, Myers RM, Newman H, Petrosa W, Seif AE, Sullivan KE, Teachey DT, Diorio C. : Emapalumab for the treatment of Cytokine Release Syndrome in Pediatric Patients. Blood Adv 7(18): 5603-5607, July 2023 Notes: doi.org/10.1182/bloodadvances.2023010712.
Diorio C, Teachey DT, Canna SW. : Cytokine Storm Syndromes in Pediatric Patients. J Allergy Clin Immunol Pract 11(6): 1636-1644, Jun 2023.
Chu Y, Gardenswartz A, Diorio C, Marks LJ, Lowe E, Teahey DT, Cairo M. : Cellular and Humoral Immunotherapy in Children, Adolescents and Young Adults with Non-Hodgkin Lymphoma. Best Practice & Research Clinical Haematology 36(1): 101442, March 2023.