Daniel T Ohm, PhD
Research Assistant Professor of Neurology
Department: Neurology
Contact information
415 Curie Blvd.
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Office: 6317071953
Publications
Education:
BS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
Permanent linkBS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
Description of Research Expertise
I have expertise in human neuroanatomy, cellular and systems neuroscience, and neurodegenerative proteinopathies including Alzheimer's disease and frontotemporal lobar degeneration. I investigate patterns of pathology and neurodegeneration in large-scale neuroanatomical studies of postmortem human tissue by using a combination of novel methods including digital histopathology, computer vision, machine learning, and bioinformatic analyses. I have strong experience performing translational research with multi-disciplinary approaches designed to determine the relationships between pathologic inclusions, neurodegeneration, neuroinflammation, structural MRI, and clinical impairments characteristic of neurodegenerative disorders including behavioral variant frontotemporal dementia and primary progressive aphasia. My long-term career goal and translational research program is to support the discovery of emerging biomarkers to improve diagnostics and inform therapeutic studies dedicated to developing neuroprotective treatments in neurodegenerative disorders.Selected Publications
Sadeghpour N, Lim SA, Wuestefeld A, Denning AE, Ittyerah R, Trotman W, Chung E, Sadaghiani S, Prabhakaran K, Bedard ML, Ohm DT, Artacho-Pérula E, de Onzoño Martin MMI, Muñoz M, Romero FJM, González JCD, Del Arroyo Jiménez M, Del Marcos Rabal M, Insausti Serrano AM, González NV, Sánchez SC, de la Rosa Prieto C, Insausti R, McMillan C, Lee EB, Detre JA, Das SR, Xie L, Tisdall MD, Irwin DJ, Wolk DA, Yushkevich PA, Wisse LEM.: Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases. Hippocampus Sep 2025.Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun May 2025.
Ohm DT, Xie SX, Capp N, Arezoumandan S, Cousins KAQ, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Irwin DJ.: Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia. Brain Jan 2025.
Denning AE, Ittyerah R, Levorse LM, Sadeghpour N, Athalye C, Chung E, Ravikumar S, Dong M, Duong MT, Li Y, Ilesanmi A, Sreepada LP, Sabatini P, Lowe M, Bahena A, Zablah J, Spencer BE, Watanabe R, Kim B, Sørensen MH, Khandelwal P, Brown C, Hrybouski S, Xie SX, de Flores R, Robinson JL, Schuck T, Ohm DT, Arezoumandan S, Porta S, Detre JA, Insausti R, Wisse LEM, Das SR, Irwin DJ, Lee EB, Wolk DA, Yushkevich PA. : Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum. Acta Neuropathol 148(1): 37, Sep 2024.
Khandelwal P, Duong MT, Sadaghiani S, Lim S, Denning AE, Chung E, Ravikumar S, Arezoumandan S, Peterson C, Bedard M, Capp N, Ittyerah R, Migdal E, Choi G, Kopp E, Loja B, Hasan E, Li J, Bahena A, Prabhakaran K, Mizsei G, Gabrielyan M, Schuck T, Trotman W, Robinson J, Ohm DT, Lee EB, Trojanowski JQ, McMillan C, Grossman M, Irwin DJ, Detre JA, Tisdall MD, Das SR, Wisse LEM, Wolk DA, Yushkevich PA.: Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases. Imaging Neurosci (Camb) May 2024.
Arezoumandan S, Cousins KAQ, Ohm DT, Lowe M, Chen M, Gee J, Phillips JS, McMillan CT, Luk KC, Deik A, Spindler MA, Tropea TF, Weintraub D, Wolk DA, Grossman M, Lee V, Chen-Plotkin AS, Lee EB, Irwin DJ.: Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Ann Clin Transl Neurol 11(3): 673-685, Mar 2024.
Ohm DT, Rhodes E, Bahena A, Capp N, Lowe M, Sabatini P, Trotman W, Olm CA, Phillips J, Prabhakaran K, Rascovsky K, Massimo L, McMillan C, Gee J, Tisdall MD, Yushkevich PA, Lee EB, Grossman M, Irwin DJ.: Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient. Front Neurol 14: 1245886, Oct 2023.
Giannini LA, Mol MO, Rajicic A, van Buuren R, Sarkar L, Arezoumandan S, Ohm DT, Irwin DJ, Rozemuller AJ; Netherlands Brain Bank; van Swieten JC, Seelaar H.: Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol Commun 11: 126, Aug 2023.
Sadaghiani S, Trotman W, Lim SA, Chung E, Ittyerah R, Ravikumar S, Khandelwal P, Prabhakaran K, Lavery ML, Ohm DT, Gabrielyan M, Das SR, Schuck T, Capp N, Peterson CS, Migdal E, Artacho-Pérula E, Jiménez MDMA, Rabal MDPM, Sánchez SC, Prieto CR, Parada MC, Insausti R, Robinson JL, McMillan C, Grossman M, Lee EB, Detre JA, Xie SX, Trojanowski JQ, Tisdall MD, Wisse LEM, Irwin DJ, Wolk DA, Yushkevich PA.: Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI. Alzheimers Dement 19(6): 2355-2364, Jun 2023.
Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ; Netherlands Brain Bank.: Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol 145(5): 711, May 2023.