Kirk N. Campbell, MD
C. Mahlon Kline Professor
Attending Physician, Division of Renal, Electrolyte, and Hypertension, Hospital of the University of Pennsylvania
Chief, Division of Renal, Electrolyte, and Hypertension, Hospital of the University of Pennsylvania
Department: Medicine
Contact information
Department of Medicine
Division of Renal, Electrolyte, and Hypertension
3400 Spruce Street
1 Founders, Renal Suite
Philadelphia, PA 19104
Division of Renal, Electrolyte, and Hypertension
3400 Spruce Street
1 Founders, Renal Suite
Philadelphia, PA 19104
Education:
BS (Biochemistry--Magna cum laude)
City College of the City University of New York, New York, NY, 1996.
MD (Medicine)
University of Connecticut, Farmington, CT, 2000.
Permanent linkBS (Biochemistry--Magna cum laude)
City College of the City University of New York, New York, NY, 1996.
MD (Medicine)
University of Connecticut, Farmington, CT, 2000.
Description of Clinical Expertise
My clinical interest is in glomerular disease with a particular focus on IgA nephropathy and podocytopathies including focal segmental glomerulosclerosis (FSGS) and minimal change disease.Description of Research Expertise
Dr. Campbell leads an NIH-funded research program focused on podocyte cell biology, experimental glomerular disease and clinical trials in the rare kidney disease space. The projects center on advancing the understanding of the underlying mechanisms involved in glomerular disease progression while identifying targets for therapeutic intervention. The work has resulted in two patents and support from a Harrington Discovery Institute Scholar-Innovator Award, He has been a lead principal investigator, steering committee chair and data safety monitoring committee member for multiple clinical trials testing novel agents for FSGS, IgA nephropathy, lupus nephritis and membranous nephropathy. He is an elected member of the American Society for Clinical Investigation and a member of the Editorial Boards of Kidney360, Kidney International, American Journal of Kidney Disease, Frontiers in Medicine and the American Journal of Physiology – Renal Physiology.Selected Publications
Ojo AO, Adu D, Bramham K, Freedman BI, Gbadegesin RA, Ilori TO, Jefferson N, Olabisi OA, Susztak K, Young BA, Cheung M, King JM, Grams ME, Jadoul M, Ulasi II; Conference Participants.: APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int Jun 2025.He X, Ballestas ER, Zeng L, Zhang T, McEvoy CM, Misra PS, Ki V, Apostol A, Wong JS, Meliambro K, Ray J, De Cos M, Melica ME, Romagnani P, Feng Y, Krizova A, How I, Rosales IA, Colvin RB, He JC, Campbell KN, Yuen DA.: Podocyte YAP and TAZ hyperactivation drives glomerular epithelial proliferative diseases in mice and humans. Sci Transl Med 17: eadq3852, Jun 2025.
Sridhar A, Pivert K, Mohottige D, Campbell KN, Farouk SS.: Why Not Transplant Nephrology? A Survey of US Nephrology Fellows. Kidney Med 7: 101003, Apr 2025.
Selbach F, Maggiore U, Gentile M, Meliambro K, Campbell KN, Tucholski J, Julian BA, Placzek WJ, Alibrandi S, Kim-Schulze S, Lanau Martínez M, Fernandez-Lorente ML, Manrique J, Cravedi P.: Serum Cytokine Profile in IgA Nephropathy. Kidney Med 7: 100940, Jan 2025.
Siegerist F, Campbell KN, Endlich N.: A new era in nephrology: the role of super-resolution microscopy in research, medical diagnostic, and drug discovery. Kidney Int 2025.
Mon-Wei Yu S, Choi JY, Kady J, De Cos M, Wong JS, King E, Younis N, Al Rahy N, Al Chaar S, Djebli H, Eskandari S, Samuel S, Merhej T, Sukumar N, Lin JR, Chen JY, Xu Y, Santagata S, Weins A, Yeung M, Cravedi P, Campbell KN, Lemos D, Bonventre JV, Brehm MA, Azzi J.: Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. Kidney Int 2025.
Gentile M, Goerlich N, Lo IJ, Olson NE, McConnell M, Pospiech J, Bohnenpoll T, Skroblin P, Radresa O, Andag U, Campbell KN, Meliambro K, Sanchez-Russo L, Verlato A, Fiaccadori E, Kim-Schulze S, Lanau M, Fernandez-Lorente ML, Fribourg M, Manrique J, Cravedi P.: Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1-Coated Gut Bacteria. Kidney Int Rep 10: 475-488, Nov 2024.
Meliambro K, He JC, Campbell KN.: Podocyte-targeted therapies - progress and future directions. Nat Rev Nephrol 20(10): 643-658, Oct 2024.
Cantarelli C, Campbell KN, Cravedi P.: Parietal epithelial cells in glomerulosclerosis: a new piece in the puzzle? J Nephrol Oct 1 2024 Notes: doi: 10.1007/s40620-024-02100-9. Online ahead of print.
Veličković D, Shapiro JP, Parikh SV, Rovin B, Toto RD, Vazquez MA, Poggio ED, O'Toole JF, Sedor JR, Alexandrov T, Jain S, Bitzer M, Hodgin J, Veličković M, Sharma K, Anderton CR; Kidney Precision Medicine Project.: Protein N -Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease. J Am Soc Nephrol 35: 1198-1207, Sep 2024.