John Karanicolas
Adjunct Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Contact information
Molecular Therapeutics Group
Fox Chase Cancer Center
333 Cottman Ave.
Philadelphia, PA 19111
Fox Chase Cancer Center
333 Cottman Ave.
Philadelphia, PA 19111
Office: 215-728-7067
Education:
B. Sc. (Honours Chemistry, Minor in Computer Science, Minor in Mathematics and Statistics)
McGill University, 1998.
Ph. D. (Program in Macromolecular and Cellular Structure and Chemistry)
The Scripps Research Institute., 2003.
Permanent linkB. Sc. (Honours Chemistry, Minor in Computer Science, Minor in Mathematics and Statistics)
McGill University, 1998.
Ph. D. (Program in Macromolecular and Cellular Structure and Chemistry)
The Scripps Research Institute., 2003.
Selected Publications
Malhotra Shipra, Karanicolas John: Correction to When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode? Journal of medicinal chemistry 60(13): 5940, Jul 2017.Bazzoli Andrea, Karanicolas John: "Solvent hydrogen-bond occlusion": A new model of polar desolvation for biomolecular energetics. Journal of computational chemistry 38(16): 1321-1331, Jun 2017.
Dickson Alex, Bailey Christopher T, Karanicolas John: Optimal allosteric stabilization sites using contact stabilization analysis. Journal of computational chemistry 38(15): 1138-1146, Jun 2017.
Malhotra Shipra, Karanicolas John: When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode? Journal of medicinal chemistry 60(1): 128-145, Jan 2017.
Wahome Newton, Sully Erin, Singer Christopher, Thomas Justin C, Hu Lei, Joshi Sangeeta B, Volkin David B, Fang Jianwen, Karanicolas John, Jacobs Donald J, Mantis Nicholas J, Middaugh C Russell: Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice. Journal of pharmaceutical sciences 105(5): 1603-1613, May 2016.
Gowthaman Ragul, Miller Sven A, Rogers Steven, Khowsathit Jittasak, Lan Lan, Bai Nan, Johnson David K, Liu Chunjing, Xu Liang, Anbanandam Asokan, Aubé Jeffrey, Roy Anuradha, Karanicolas John: DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. Journal of medicinal chemistry 59(9): 4152-70, May 2016.
Johnson David K, Karanicolas John: Ultra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein-Protein Interactions. Journal of chemical information and modeling 56(2): 399-411, Feb 2016.
Xia Yan, DiPrimio Nina, Keppel Theodore R, Vo Binh, Fraser Keith, Battaile Kevin P, Egan Chet, Bystroff Christopher, Lovell Scott, Weis David D, Anderson J Christopher, Karanicolas John: The designability of protein switches by chemical rescue of structure: mechanisms of inactivation and reactivation. Journal of the American Chemical Society 135(50): 18840-9, Dec 2013.
Gowthaman Ragul, Deeds Eric J, Karanicolas John: Structural properties of non-traditional drug targets present new challenges for virtual screening. Journal of chemical information and modeling 53(8): 2073-81, Aug 2013.
Deckert Katelyn, Budiardjo S Jimmy, Brunner Luke C, Lovell Scott, Karanicolas John: Designing allosteric control into enzymes by chemical rescue of structure. Journal of the American Chemical Society 134(24): 10055-60, Jun 2012.