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Xinying Hong, Ph.D.
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Assistant Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
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Department: Pathology and Laboratory Medicine
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Contact information
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Childrens Hospital of Philadelphia
39 3401 Civic Center Blvd
Philadelphia, PA 19104
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39 3401 Civic Center Blvd
Philadelphia, PA 19104
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Education:
21 9 B.S. 16 (Chemistry) c
2a Peking University, 2015.
21 a Ph.D. 16 (Chemistry) c
31 University of Washington, 2020.
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Permanent link21 9 B.S. 16 (Chemistry) c
2a Peking University, 2015.
21 a Ph.D. 16 (Chemistry) c
31 University of Washington, 2020.
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216 Austin Shaff, Khaja Basheeruddin, Soumeya Bekri, Heather A. Brown, Heather J. Church, Justin Gianares, Xinying Hong, Simon A. Jones, Tate Kappell, Francyne Kubaski, Petra Oliva, Joseph Orsini, Abdellah Tebani, Teresa H.Y. Wu, Gojko Lalic, Michael H. Gelb: Newborn screening for metachromatic leukodystrophy: Preparation of reagents and methodology for measurement of Sulfatides and arylsulfatase a enzymatic activity in dried blood spots. Mol Genet Metab 2025.
1a0 Pham V, Tricoli L, Hong X, Wongkittichote P, Castracani CC, Guerra A, Schlotawa L, Adang LA, Kuhs A, Cassidy MM, Kane O, Tsai E, Presa M, Lutz C, Rivella SB, Ahrens-Nicklas RC. : Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of Multiple Sulfatase Deficiency. Mol Ther. 32(11): 3829-3846, Nov 2024.
143 Wongkittichote P, Cho S, Miller A, King K, Herbst ZM, Ren Z, Gelb MH, Hong X. : UPLC-MS/MS Analysis of Urinary Oligosaccharides and Glycoamino Acids for the Diagnosis of Mucopolysaccharidosis and Glycoproteinosis. Clin Chem 70(6): 865-877, June 2024.
16b Bekri S, Bley A, Brown HA, Chanson C, Church HJ, Gelb MH, Hong X, Janzen N, Kasper DC, Mechtler T, Morton G, Murko S, Oliva P, Tebani A, Wu T.: Higher precision, first tier newborn screening for metachromatic leukodystrophy using 16:1-OH-sulfatide. Mol Genet Metab 142(1): 108436, May 2024.
185 Pham V, Sertori Finoti L, Cassidy MM, Maguire JA, Gagne AL, Waxman EA, French DL, King K, Zhou Z, Gelb MH, Wongkittichote P, Hong X, Schlotawa L, Davidson BL, Ahrens-Nicklas RC.: A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency. Mol Genet Metab 141(2): 108116, Feb 2024.
13c Wongkittichote P, Pantano C, He M, Hong X, Demczko MM.: Clinical, biochemical and molecular characterization of a new case with FDX2-related mitochondrial disorder: Potential biomarkers and treatment options. JIMD Rep 65(2): 102-109, Jan 2024.
149 Herbst ZM, Hong X, Sadilek M, Fuller M, Gelb MH.: Newborn screening for the full set of mucopolysaccharidoses in dried blood spots based on first-tier enzymatic assay followed by second-tier analysis of glycosaminoglycans. Mol Genet Metab 140(3), Nov 2023.
1aa Herbst ZM, Hong X, Urdaneta L, Klein T, Waggoner C, Liao HC, Kubaski F, Giugliani R, Fuller M, Gelb MH.: Endogenous, non-reducing end glycosaminoglycan biomarkers are superior to internal disaccharide glycosaminoglycan biomarkers for newborn screening of mucopolysaccharidoses and GM1 gangliosidosis. Mol Genet Metab 140(1-2), September–October 2023.
1a1 Kubaski F, Sousa I, Amorim T, Pereira D, Silva C, Chaves V, Brusius-Facchin AC, Netto ABO, Soares J, Vairo F, Poletto E, Trometer J, Souza A, Ranieri E, Polo G, Hong X, Herbst ZM, Burlina A, Gelb MH, Giugliani R.: Pilot study of newborn screening for six lysosomal diseases in Brazil. Mol Genet Metab 140(1-2): 107654, September–October 2023.
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Selected Publications
15c Quigley, A., Jindal, I., Campion, T., Rutherford, D., Han, Y., Quigley, W., Qu, P., Musunuru, K., Ahrens-Nicklas, R., Hong, X. and Wang, X.: Base editing strategies for in vivo correction of two highly recurrent phenylketonuria variants. Molecular Therapy Nucleic Acids 2025.216 Austin Shaff, Khaja Basheeruddin, Soumeya Bekri, Heather A. Brown, Heather J. Church, Justin Gianares, Xinying Hong, Simon A. Jones, Tate Kappell, Francyne Kubaski, Petra Oliva, Joseph Orsini, Abdellah Tebani, Teresa H.Y. Wu, Gojko Lalic, Michael H. Gelb: Newborn screening for metachromatic leukodystrophy: Preparation of reagents and methodology for measurement of Sulfatides and arylsulfatase a enzymatic activity in dried blood spots. Mol Genet Metab 2025.
1a0 Pham V, Tricoli L, Hong X, Wongkittichote P, Castracani CC, Guerra A, Schlotawa L, Adang LA, Kuhs A, Cassidy MM, Kane O, Tsai E, Presa M, Lutz C, Rivella SB, Ahrens-Nicklas RC. : Hematopoietic stem cell gene therapy improves outcomes in a clinically relevant mouse model of Multiple Sulfatase Deficiency. Mol Ther. 32(11): 3829-3846, Nov 2024.
143 Wongkittichote P, Cho S, Miller A, King K, Herbst ZM, Ren Z, Gelb MH, Hong X. : UPLC-MS/MS Analysis of Urinary Oligosaccharides and Glycoamino Acids for the Diagnosis of Mucopolysaccharidosis and Glycoproteinosis. Clin Chem 70(6): 865-877, June 2024.
16b Bekri S, Bley A, Brown HA, Chanson C, Church HJ, Gelb MH, Hong X, Janzen N, Kasper DC, Mechtler T, Morton G, Murko S, Oliva P, Tebani A, Wu T.: Higher precision, first tier newborn screening for metachromatic leukodystrophy using 16:1-OH-sulfatide. Mol Genet Metab 142(1): 108436, May 2024.
185 Pham V, Sertori Finoti L, Cassidy MM, Maguire JA, Gagne AL, Waxman EA, French DL, King K, Zhou Z, Gelb MH, Wongkittichote P, Hong X, Schlotawa L, Davidson BL, Ahrens-Nicklas RC.: A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency. Mol Genet Metab 141(2): 108116, Feb 2024.
13c Wongkittichote P, Pantano C, He M, Hong X, Demczko MM.: Clinical, biochemical and molecular characterization of a new case with FDX2-related mitochondrial disorder: Potential biomarkers and treatment options. JIMD Rep 65(2): 102-109, Jan 2024.
149 Herbst ZM, Hong X, Sadilek M, Fuller M, Gelb MH.: Newborn screening for the full set of mucopolysaccharidoses in dried blood spots based on first-tier enzymatic assay followed by second-tier analysis of glycosaminoglycans. Mol Genet Metab 140(3), Nov 2023.
1aa Herbst ZM, Hong X, Urdaneta L, Klein T, Waggoner C, Liao HC, Kubaski F, Giugliani R, Fuller M, Gelb MH.: Endogenous, non-reducing end glycosaminoglycan biomarkers are superior to internal disaccharide glycosaminoglycan biomarkers for newborn screening of mucopolysaccharidoses and GM1 gangliosidosis. Mol Genet Metab 140(1-2), September–October 2023.
1a1 Kubaski F, Sousa I, Amorim T, Pereira D, Silva C, Chaves V, Brusius-Facchin AC, Netto ABO, Soares J, Vairo F, Poletto E, Trometer J, Souza A, Ranieri E, Polo G, Hong X, Herbst ZM, Burlina A, Gelb MH, Giugliani R.: Pilot study of newborn screening for six lysosomal diseases in Brazil. Mol Genet Metab 140(1-2): 107654, September–October 2023.
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