Chafic Karam, MD
Professor of Clinical Neurology
Neuromuscular Fellowship Director, University of Pennsylvania
Neurology CME course director, University of Pennsylvania
Chief, Neuromuscular Division, University of Pennsylvania
Department: Neurology
Contact information
3400 Spruce St., 3 West Gates
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 2156153751
Fax: 2153495579
Fax: 2153495579
Publications
Education:
MD
St Joseph University, 2006.
Permanent linkMD
St Joseph University, 2006.
Description of Clinical Expertise
CIDP, MMN, Amyloid Neuropathy.Selected Publications
Karam C.: Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy. Muscle Nerve. Page: 73(1):86-92. Jan 2026.Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team.: BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med. 2026.
Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. : BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nat Med 2026.
Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A.: Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis Journal of Clinical Medicine.(14(19):6821.), Sep 2025.
Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. : Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. Jun 2025.
Hsu RT, Wilson J, Karam C. : Amyloid Spikes on Optical Coherence Tomography Demonstrating Ocular Involvement in ATTRv Amyloidosis Neurology. May 2025.
Bril V, Drużdż A, Grosskreutz J, Habib AA, Kaminski HJ, Mantegazza R, Sacconi S, Utsugisawa K, Vu T, Boehnlein M, Gayfieva M, Greve B, Woltering F, Vissing J; MG0004 study investigators. : Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study. J Neurol. March 2025.
Morganroth J, Karam C. : Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments Neurol Clin Pract. Feb 2025.
Rebello, S., Hsu, K., Nativi-Nicolau, J., Karam, C., Grogan, M., Lousada, I., & Maurer, M. S. : Factors associated with financial toxicity in patients with transthyretin amyloidosis: results from Amyloidosis Research Consortium’s treatment affordability patient and caregiver survey. Amyloid 1–10, Feb 2025.
Karam C, Pasnoor M, Barohn RJ, Dimachkie MM.: Acquired and Genetic Amyloid Neuropathies. Neurol Clin. 2025 Nov;43(4):837-849. 2025.
