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Chafic Karam, MD
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Professor of Clinical Neurology
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Neuromuscular Fellowship Director, University of Pennsylvania
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Neurology CME course director, University of Pennsylvania
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Chief, Neuromuscular Division, University of Pennsylvania
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Department: Neurology
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Contact information
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3400 Spruce St., 3 West Gates
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 2156153751
30 Fax: 2153495579
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30 Fax: 2153495579
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Publications
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Links
ad Search PubMed for articles
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ad Search PubMed for articles
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Education:
21 7 MD c
2d St Joseph University, 2006.
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Permanent link21 7 MD c
2d St Joseph University, 2006.
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Description of Clinical Expertise
2e CIDP, MMN, Amyloid Neuropathy.26 29
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1da Chakraborty R, Brailovsky Y, Hanna M, Witteles R, Vaishnav J, Hoffman JE, Griffin JM, Garcia-Pavia P, Wolinsky D, Karam C, Lachmann HJ, Gertz MA, Boursiquot BC, Bampatsias D, Hsu K, Johnson PT, Zigterman JL, Kazemzadeh AC, Maurer MS, Wechalekar AD.: Prognostic Factors and Progression Biomarkers in AL Amyloidosis: Mapping Current Knowledge and Critical Gaps Blood. 2026 Mar 4:blood.2025031651. 2026.
229 Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. : BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nat Med 2026.
240 Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team.: BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med. 2026.
151 Blein C, Karam C, Arvin-Berod C, Gelinas D, Barrera-Sierra S, Syed HUTA, Ward C, Goyal A, Guptill J.: Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States. Front Neurol. 2026 Jan 29;16:1726857 2026.
147 Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A.: Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis Journal of Clinical Medicine.(14(19):6821.), Sep 2025.
196 Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. : Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. Jun 2025.
e1 Hsu RT, Wilson J, Karam C. : Amyloid Spikes on Optical Coherence Tomography Demonstrating Ocular Involvement in ATTRv Amyloidosis Neurology. May 2025.
1a7 Bril V, Drużdż A, Grosskreutz J, Habib AA, Kaminski HJ, Mantegazza R, Sacconi S, Utsugisawa K, Vu T, Boehnlein M, Gayfieva M, Greve B, Woltering F, Vissing J; MG0004 study investigators. : Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study. J Neurol. March 2025.
c4 Morganroth J, Karam C. : Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments Neurol Clin Pract. Feb 2025.
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Selected Publications
ce Karam C.: Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy. Muscle Nerve. Page: 73(1):86-92. Jan 2026.1da Chakraborty R, Brailovsky Y, Hanna M, Witteles R, Vaishnav J, Hoffman JE, Griffin JM, Garcia-Pavia P, Wolinsky D, Karam C, Lachmann HJ, Gertz MA, Boursiquot BC, Bampatsias D, Hsu K, Johnson PT, Zigterman JL, Kazemzadeh AC, Maurer MS, Wechalekar AD.: Prognostic Factors and Progression Biomarkers in AL Amyloidosis: Mapping Current Knowledge and Critical Gaps Blood. 2026 Mar 4:blood.2025031651. 2026.
229 Fedak RR, Ruggerie RN, Shan Y, Curvino EJ, de Sousa JF, Daniel S, Ngo-Casi M, Kamboh H, Vu T, Durmuş H, Mozaffar T, Howard JF Jr, English EP, Benson A, Duvernay MT, Singer MS, Kalayoglu MV, Brunn C, Bodansky A, Anderson MS, DeRisi JL, Garcia ST, Yu DJL, Zorn KC, Kurtoglu M, Miljković MD, Stewart CA, Jewell CM; MG-001 Study Team. : BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nat Med 2026.
240 Vu T, Durmus H, Rivner M, Shroff S, Ragole T, Myers B, Pasnoor M, Small G, Karam C, Vullaganti M, Peltier A, Sahagian G, Feinberg MH, Slanksy A, Barnett-Tapia C, Siddiqi Z, Gwathmey K, Badruddoja MA, Kamboh H, Ruggerie RN, Fedak RR, Stewart CA, Kurtoglu M, Kalayoglu M, Singer M, Jewell CM, Miljkovic MD, Dimachkie M, Mozaffar T, Howard JF Jr; MG-001 Study Team.: BCMA-directed mRNA CAR T cell therapy for myasthenia gravis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med. 2026.
151 Blein C, Karam C, Arvin-Berod C, Gelinas D, Barrera-Sierra S, Syed HUTA, Ward C, Goyal A, Guptill J.: Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States. Front Neurol. 2026 Jan 29;16:1726857 2026.
147 Singh A, Wyatt J, Théaudin M, Karam C, Kasper D, Streubel B, Frascello K, Bondue A.: Effectiveness and Utility of Genetic Testing in Establishing a Diagnosis of Hereditary Transthyretin Amyloidosis Journal of Clinical Medicine.(14(19):6821.), Sep 2025.
196 Khandelwal N, Sanchirico M, Ajibade A, Munshi K, Vu M, Engel-Nitz N, Steiger C, Anderson AJ, Karam C. : Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs Among Patients with Multifocal Motor Neuropathy: A US Claims Database Cohort Study J Health Econ Outcomes Res. 2025 Jun 26;12(1):261-268. Jun 2025.
e1 Hsu RT, Wilson J, Karam C. : Amyloid Spikes on Optical Coherence Tomography Demonstrating Ocular Involvement in ATTRv Amyloidosis Neurology. May 2025.
1a7 Bril V, Drużdż A, Grosskreutz J, Habib AA, Kaminski HJ, Mantegazza R, Sacconi S, Utsugisawa K, Vu T, Boehnlein M, Gayfieva M, Greve B, Woltering F, Vissing J; MG0004 study investigators. : Safety and efficacy of chronic weekly rozanolixizumab in generalized myasthenia gravis: the randomized open-label extension MG0004 study. J Neurol. March 2025.
c4 Morganroth J, Karam C. : Anti-Myelin-Associated Glycoprotein Neuropathy: Recent Developments Neurol Clin Pract. Feb 2025.
2c